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Radiotherapy-Activated Cancer-Associated Fibroblasts Promote Tumor Progression through Paracrine IGF1R Activation.

Tommelein J, De Vlieghere E, Verset L, Melsens E, Leenders J, Descamps B, Debucquoy A, Vanhove C, Pauwels P, Gespach CP, Vral A, De Boeck A, Haustermans K, de Tullio P, Ceelen W, Demetter P, Boterberg T, Bracke M, De Wever O.

Cancer Res. 2018 Feb 1;78(3):659-670. doi: 10.1158/0008-5472.CAN-17-0524. Epub 2017 Dec 7.


Insulin immuno-neutralization decreases food intake in chickens without altering hypothalamic transcripts involved in food intake and metabolism.

Proszkowiec-Weglarz M, Dupont J, Rideau N, Gespach C, Simon J, Porter TE.

Poult Sci. 2017 Dec 1;96(12):4409-4418. doi: 10.3382/ps/pex247.


Age and cellular context influence rectal prolapse formation in mice with caecal wall colorectal cancer xenografts.

Tommelein J, Gremonprez F, Verset L, De Vlieghere E, Wagemans G, Gespach C, Boterberg T, Demetter P, Ceelen W, Bracke M, De Wever O.

Oncotarget. 2016 Nov 15;7(46):75603-75615. doi: 10.18632/oncotarget.12312.


Regulation of cellular quiescence by YAP/TAZ and Cyclin E1 in colon cancer cells: Implication in chemoresistance and cancer relapse.

Corvaisier M, Bauzone M, Corfiotti F, Renaud F, El Amrani M, Monté D, Truant S, Leteurtre E, Formstecher P, Van Seuningen I, Gespach C, Huet G.

Oncotarget. 2016 Aug 30;7(35):56699-56712. doi: 10.18632/oncotarget.11057.


Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.

Bach AS, Derocq D, Laurent-Matha V, Montcourrier P, Sebti S, Orsetti B, Theillet C, Gongora C, Pattingre S, Ibing E, Roger P, Linares LK, Reinheckel T, Meurice G, Kaiser FJ, Gespach C, Liaudet-Coopman E.

Oncotarget. 2015 Sep 29;6(29):28084-103. doi: 10.18632/oncotarget.4394.


Reciprocity in breast cancer progression.

Gespach C.

Oncotarget. 2014 Nov 30;5(22):10967-8. No abstract available.


Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling.

Lapeire L, Hendrix A, Lambein K, Van Bockstal M, Braems G, Van Den Broecke R, Limame R, Mestdagh P, Vandesompele J, Vanhove C, Maynard D, Lehuédé C, Muller C, Valet P, Gespach CP, Bracke M, Cocquyt V, Denys H, De Wever O.

Cancer Res. 2014 Dec 1;74(23):6806-19. doi: 10.1158/0008-5472.CAN-14-0160. Epub 2014 Sep 24.


Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis.

Touil Y, Igoudjil W, Corvaisier M, Dessein AF, Vandomme J, Monté D, Stechly L, Skrypek N, Langlois C, Grard G, Millet G, Leteurtre E, Dumont P, Truant S, Pruvot FR, Hebbar M, Fan F, Ellis LM, Formstecher P, Van Seuningen I, Gespach C, Polakowska R, Huet G.

Clin Cancer Res. 2014 Feb 15;20(4):837-46. doi: 10.1158/1078-0432.CCR-13-1854. Epub 2013 Dec 9.


JAK3 deregulation by activating mutations confers invasive growth advantage in extranodal nasal-type natural killer cell lymphoma.

Bouchekioua A, Scourzic L, de Wever O, Zhang Y, Cervera P, Aline-Fardin A, Mercher T, Gaulard P, Nyga R, Jeziorowska D, Douay L, Vainchenker W, Louache F, Gespach C, Solary E, Coppo P.

Leukemia. 2014 Feb;28(2):338-48. doi: 10.1038/leu.2013.157. Epub 2013 May 21.


Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer.

Hendrix A, Sormunen R, Westbroek W, Lambein K, Denys H, Sys G, Braems G, Van den Broecke R, Cocquyt V, Gespach C, Bracke M, De Wever O.

Int J Cancer. 2013 Aug 15;133(4):843-54. doi: 10.1002/ijc.28079. Epub 2013 Mar 7.


Differential secretome analysis of cancer-associated fibroblasts and bone marrow-derived precursors to identify microenvironmental regulators of colon cancer progression.

De Boeck A, Hendrix A, Maynard D, Van Bockstal M, Daniëls A, Pauwels P, Gespach C, Bracke M, De Wever O.

Proteomics. 2013 Jan;13(2):379-88. doi: 10.1002/pmic.201200179. Epub 2013 Jan 6.


An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue.

Hendrix A, Lambein K, Westbroek W, Seabra MC, Cocquyt V, Pauwels P, Bracke M, Gespach C, De Wever O.

Int J Dev Biol. 2012;56(5):363-8. doi: 10.1387/ijdb.120008ah.


Guidance for life, cell death, and colorectal neoplasia by netrin dependence receptors.

Gespach C.

Adv Cancer Res. 2012;114:87-186. doi: 10.1016/B978-0-12-386503-8.00004-1. Review.


Identification of a GαGβγ, AKT and PKCα signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition.

Ouelaa-Benslama R, De Wever O, Hendrix A, Sabbah M, Lambein K, Land D, Prévost G, Bracke M, Hung MC, Larsen AK, Emami S, Gespach C.

Int J Oncol. 2012 Jul;41(1):189-200. doi: 10.3892/ijo.2012.1457. Epub 2012 Apr 30.


Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signalling.

De Boeck A, Pauwels P, Hensen K, Rummens JL, Westbroek W, Hendrix A, Maynard D, Denys H, Lambein K, Braems G, Gespach C, Bracke M, De Wever O.

Gut. 2013 Apr;62(4):550-60. doi: 10.1136/gutjnl-2011-301393. Epub 2012 Apr 25.


Characterization of major elements of insulin signaling cascade in chicken adipose tissue: apparent insulin refractoriness.

Dupont J, Métayer-Coustard S, Ji B, Ramé C, Gespach C, Voy B, Simon J.

Gen Comp Endocrinol. 2012 Mar 1;176(1):86-93. doi: 10.1016/j.ygcen.2011.12.030. Epub 2012 Jan 3.


Insulin immuno-neutralization in fed chickens: effects on liver and muscle transcriptome.

Simon J, Milenkovic D, Godet E, Cabau C, Collin A, Métayer-Coustard S, Rideau N, Tesseraud S, Derouet M, Crochet S, Cailleau-Audouin E, Hennequet-Antier C, Gespach C, Porter TE, Duclos MJ, Dupont J, Cogburn LA.

Physiol Genomics. 2012 Mar 1;44(5):283-92. doi: 10.1152/physiolgenomics.00057.2011. Epub 2012 Jan 3.


Increasing potential of HER3 signaling in colon cancer progression and therapy.

Gespach C.

Clin Cancer Res. 2012 Feb 15;18(4):917-9. doi: 10.1158/1078-0432.CCR-11-3143. Epub 2011 Dec 28.


Signaling networks in cancer--an interview with Christian Gespach. Interview by Olivier De Wever.

Gespach C.

Int J Dev Biol. 2011;55(7-9):713-8. doi: 10.1387/ijdb.113381ow.


Role of the focal adhesion protein kindlin-1 in breast cancer growth and lung metastasis.

Sin S, Bonin F, Petit V, Meseure D, Lallemand F, Bièche I, Bellahcène A, Castronovo V, de Wever O, Gespach C, Lidereau R, Driouch K.

J Natl Cancer Inst. 2011 Sep 7;103(17):1323-37. doi: 10.1093/jnci/djr290. Epub 2011 Aug 10.


Spectrum of cellular responses to pyriplatin, a monofunctional cationic antineoplastic platinum(II) compound, in human cancer cells.

Lovejoy KS, Serova M, Bieche I, Emami S, D'Incalci M, Broggini M, Erba E, Gespach C, Cvitkovic E, Faivre S, Raymond E, Lippard SJ.

Mol Cancer Ther. 2011 Sep;10(9):1709-19. doi: 10.1158/1535-7163.MCT-11-0250. Epub 2011 Jul 12.


The tumor ecosystem regulates the roads for invasion and metastasis.

Hendrix A, Gespach C, Bracke M, De Wever O.

Clin Res Hepatol Gastroenterol. 2011 Nov;35(11):714-9. doi: 10.1016/j.clinre.2011.05.003. Epub 2011 Jun 14. Review.


Priming and potentiation of DNA damage response by fibronectin in human colon cancer cells and tumor-derived myofibroblasts.

DE Wever O, Sobczak-Thépot J, Vercoutter-Edouart AS, Michalski JC, Ouelaa-Benslama R, Stupack DG, Bracke M, Wang JYJ, Gespach C, Emami S.

Int J Oncol. 2011 Aug;39(2):393-400. doi: 10.3892/ijo.2011.1034. Epub 2011 May 9.


Inhibition of cell survival, invasion, tumor growth and histone deacetylase activity by the dietary flavonoid luteolin in human epithelioid cancer cells.

Attoub S, Hassan AH, Vanhoecke B, Iratni R, Takahashi T, Gaben AM, Bracke M, Awad S, John A, Kamalboor HA, Al Sultan MA, Arafat K, Gespach C, Petroianu G.

Eur J Pharmacol. 2011 Jan 25;651(1-3):18-25. doi: 10.1016/j.ejphar.2010.10.063. Epub 2010 Nov 11.


Stem cells and colon cancer: the questionable cancer stem cell hypothesis.

Gespach C.

Gastroenterol Clin Biol. 2010 Dec;34(12):653-61. doi: 10.1016/j.gcb.2010.08.014. Epub 2010 Nov 3. Review.


Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells.

Boissan M, De Wever O, Lizarraga F, Wendum D, Poincloux R, Chignard N, Desbois-Mouthon C, Dufour S, Nawrocki-Raby B, Birembaut P, Bracke M, Chavrier P, Gespach C, Lacombe ML.

Cancer Res. 2010 Oct 1;70(19):7710-22. doi: 10.1158/0008-5472.CAN-10-1887. Epub 2010 Sep 14.


Neurotensin receptor 1 determines the outcome of non-small cell lung cancer.

Alifano M, Souazé F, Dupouy S, Camilleri-Broët S, Younes M, Ahmed-Zaïd SM, Takahashi T, Cancellieri A, Damiani S, Boaron M, Broët P, Miller LD, Gespach C, Regnard JF, Forgez P.

Clin Cancer Res. 2010 Sep 1;16(17):4401-10. doi: 10.1158/1078-0432.CCR-10-0659.


Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis.

Hendrix A, Maynard D, Pauwels P, Braems G, Denys H, Van den Broecke R, Lambert J, Van Belle S, Cocquyt V, Gespach C, Bracke M, Seabra MC, Gahl WA, De Wever O, Westbroek W.

J Natl Cancer Inst. 2010 Jun 16;102(12):866-80. doi: 10.1093/jnci/djq153. Epub 2010 May 18.


Autocrine induction of invasive and metastatic phenotypes by the MIF-CXCR4 axis in drug-resistant human colon cancer cells.

Dessein AF, Stechly L, Jonckheere N, Dumont P, Monté D, Leteurtre E, Truant S, Pruvot FR, Figeac M, Hebbar M, Lecellier CH, Lesuffleur T, Dessein R, Grard G, Dejonghe MJ, de Launoit Y, Furuichi Y, Prévost G, Porchet N, Gespach C, Huet G.

Cancer Res. 2010 Jun 1;70(11):4644-54. doi: 10.1158/0008-5472.CAN-09-3828. Epub 2010 May 11.


Epithelial-to-mesenchymal transition and oncogenic Ras expression in resistance to the protein kinase Cbeta inhibitor enzastaurin in colon cancer cells.

Serova M, Astorgues-Xerri L, Bieche I, Albert S, Vidaud M, Benhadji KA, Emami S, Vidaud D, Hammel P, Theou-Anton N, Gespach C, Faivre S, Raymond E.

Mol Cancer Ther. 2010 May;9(5):1308-17. doi: 10.1158/1535-7163.MCT-10-0167. Epub 2010 Apr 20.


Modeling and quantification of cancer cell invasion through collagen type I matrices.

De Wever O, Hendrix A, De Boeck A, Westbroek W, Braems G, Emami S, Sabbah M, Gespach C, Bracke M.

Int J Dev Biol. 2010;54(5):887-96. doi: 10.1387/ijdb.092948ow.


Inhibition of heterotrimeric G protein signaling by a small molecule acting on Galpha subunit.

Ayoub MA, Damian M, Gespach C, Ferrandis E, Lavergne O, De Wever O, Banères JL, Pin JP, Prévost GP.

J Biol Chem. 2009 Oct 16;284(42):29136-45. doi: 10.1074/jbc.M109.042333. Epub 2009 Jul 31.


The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression.

Dupouy S, Viardot-Foucault V, Alifano M, Souazé F, Plu-Bureau G, Chaouat M, Lavaur A, Hugol D, Gespach C, Gompel A, Forgez P.

PLoS One. 2009;4(1):e4223. doi: 10.1371/journal.pone.0004223. Epub 2009 Jan 19.


Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor.

Roperch JP, El Ouadrani K, Hendrix A, Emami S, De Wever O, Melino G, Gespach C.

Cancer Res. 2008 Oct 15;68(20):8231-9. doi: 10.1158/0008-5472.CAN-08-1483.


The transforming functions of PI3-kinase-gamma are linked to disruption of intercellular adhesion and promotion of cancer cell invasion.

Attoub S, De Wever O, Bruyneel E, Mareel M, Gespach C.

Ann N Y Acad Sci. 2008 Sep;1138:204-13. doi: 10.1196/annals.1414.027.


Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers.

Sabbah M, Emami S, Redeuilh G, Julien S, Prévost G, Zimber A, Ouelaa R, Bracke M, De Wever O, Gespach C.

Drug Resist Updat. 2008 Aug-Oct;11(4-5):123-51. doi: 10.1016/j.drup.2008.07.001. Epub 2008 Aug 20. Review.


Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front.

De Wever O, Pauwels P, De Craene B, Sabbah M, Emami S, Redeuilh G, Gespach C, Bracke M, Berx G.

Histochem Cell Biol. 2008 Sep;130(3):481-94. doi: 10.1007/s00418-008-0464-1. Epub 2008 Jul 22. Review.


Insulin immuno-neutralization in chicken: effects on insulin signaling and gene expression in liver and muscle.

Dupont J, Tesseraud S, Derouet M, Collin A, Rideau N, Crochet S, Godet E, Cailleau-Audouin E, Métayer-Coustard S, Duclos MJ, Gespach C, Porter TE, Cogburn LA, Simon J.

J Endocrinol. 2008 Jun;197(3):531-42. doi: 10.1677/JOE-08-0055.


Differential impact of TGF-beta and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion.

Denys H, Derycke L, Hendrix A, Westbroek W, Gheldof A, Narine K, Pauwels P, Gespach C, Bracke M, De Wever O.

Cancer Lett. 2008 Aug 8;266(2):263-74. doi: 10.1016/j.canlet.2008.02.068.


Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells.

Gouyer V, Fontaine D, Dumont P, de Wever O, Fontayne-Devaud H, Leteurtre E, Truant S, Delacour D, Drobecq H, Kerckaert JP, de Launoit Y, Bracke M, Gespach C, Desseyn JL, Huet G.

Oncogene. 2008 Jul 3;27(29):4024-33. doi: 10.1038/onc.2008.42. Epub 2008 Mar 3. Review.


Role of WISP-2/CCN5 in the maintenance of a differentiated and noninvasive phenotype in human breast cancer cells.

Fritah A, Saucier C, De Wever O, Bracke M, Bièche I, Lidereau R, Gespach C, Drouot S, Redeuilh G, Sabbah M.

Mol Cell Biol. 2008 Feb;28(3):1114-23. Epub 2007 Dec 10.


Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion.

Van Slambrouck S, Grijelmo C, De Wever O, Bruyneel E, Emami S, Gespach C, Steelant WF.

Int J Oncol. 2007 Dec;31(6):1501-8.


Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2.

Moniz S, Veríssimo F, Matos P, Brazão R, Silva E, Kotelevets L, Chastre E, Gespach C, Jordan P.

Oncogene. 2007 Sep 6;26(41):6071-81. Epub 2007 Jul 30. Erratum in: Oncogene. 2008 Jan 3;27(1):155. Kotevelets, L [corrected to Kotelevets, L].


Activated coagulation factors in human malignant effusions and their contribution to cancer cell metastasis and therapy.

Gieseler F, Lühr I, Kunze T, Mundhenke C, Maass N, Erhart T, Denker M, Beckmann D, Tiemann M, Schulte C, Dohrmann P, Cavaillé F, Godeau F, Gespach C.

Thromb Haemost. 2007 Jun;97(6):1023-30.


Proinvasive activity of BMP-7 through SMAD4/src-independent and ERK/Rac/JNK-dependent signaling pathways in colon cancer cells.

Grijelmo C, Rodrigue C, Svrcek M, Bruyneel E, Hendrix A, de Wever O, Gespach C.

Cell Signal. 2007 Aug;19(8):1722-32. Epub 2007 Mar 28.


Immunohistochemical staining for mismatch repair proteins, and its relevance in the diagnosis of hereditary non-polyposis colorectal cancer.

Ewald J, Rodrigue CM, Mourra N, Lefèvre JH, Fléjou JF, Tiret E, Gespach C, Parc YR.

Br J Surg. 2007 Aug;94(8):1020-7.


Opposing roles of netrin-1 and the dependence receptor DCC in cancer cell invasion, tumor growth and metastasis.

Rodrigues S, De Wever O, Bruyneel E, Rooney RJ, Gespach C.

Oncogene. 2007 Aug 16;26(38):5615-25. Epub 2007 Mar 5.


Implication of MYH in colorectal polyposis.

Lefevre JH, Rodrigue CM, Mourra N, Bennis M, Flejou JF, Parc R, Tiret E, Gespach C, Parc YR.

Ann Surg. 2006 Dec;244(6):874-9; discussion 879-80.


Anticancer activity of BIM-46174, a new inhibitor of the heterotrimeric Galpha/Gbetagamma protein complex.

Prévost GP, Lonchampt MO, Holbeck S, Attoub S, Zaharevitz D, Alley M, Wright J, Brezak MC, Coulomb H, Savola A, Huchet M, Chaumeron S, Nguyen QD, Forgez P, Bruyneel E, Bracke M, Ferrandis E, Roubert P, Demarquay D, Gespach C, Kasprzyk PG.

Cancer Res. 2006 Sep 15;66(18):9227-34.

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