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Items: 1 to 50 of 92

1.

An Abstract Provides SeAFOod for Thought.

Gescher AJ, DeCensi A.

Cancer Prev Res (Phila). 2019 Jan 30. pii: canprevres.0033.2019. doi: 10.1158/1940-6207.CAPR-19-0033. [Epub ahead of print]

PMID:
30700438
2.

Effects of a Grapevine Shoot Extract Containing Resveratrol and Resveratrol Oligomers on Intestinal Adenoma Development in Mice: In Vitro and In Vivo Studies.

Empl MT, Cai H, Wang S, Junginger J, Kostka T, Hewicker-Trautwein M, Brown K, Gescher AJ, Steinberg P.

Mol Nutr Food Res. 2018 Jan;62(2). doi: 10.1002/mnfr.201700450. Epub 2018 Jan 9.

PMID:
29125219
3.

Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice.

Cai H, Scott E, Kholghi A, Andreadi C, Rufini A, Karmokar A, Britton RG, Horner-Glister E, Greaves P, Jawad D, James M, Howells L, Ognibene T, Malfatti M, Goldring C, Kitteringham N, Walsh J, Viskaduraki M, West K, Miller A, Hemingway D, Steward WP, Gescher AJ, Brown K.

Sci Transl Med. 2015 Jul 29;7(298):298ra117. doi: 10.1126/scitranslmed.aaa7619.

4.

Search for novel circulating cancer chemopreventive biomarkers of dietary rice bran intervention in Apc(Min) mice model of colorectal carcinogenesis, using proteomic and metabolic profiling strategies.

Norris L, Malkar A, Horner-Glister E, Hakimi A, Ng LL, Gescher AJ, Creaser C, Sale S, Jones DJ.

Mol Nutr Food Res. 2015 Sep;59(9):1827-36. doi: 10.1002/mnfr.201400818. Epub 2015 Jun 30.

PMID:
26033951
5.

Inhibition of prostate cancer cell growth by 3',4',5'-trimethoxyflavonol (TMFol).

Hill CU, Saad SE, Britton RG, Gescher AJ, Sale S, Brown K, Howells LM.

Cancer Chemother Pharmacol. 2015 Jul;76(1):179-85. doi: 10.1007/s00280-015-2771-2. Epub 2015 May 29.

PMID:
26017621
6.

Risk determination and prevention of breast cancer.

Howell A, Anderson AS, Clarke RB, Duffy SW, Evans DG, Garcia-Closas M, Gescher AJ, Key TJ, Saxton JM, Harvie MN.

Breast Cancer Res. 2014 Sep 28;16(5):446. doi: 10.1186/s13058-014-0446-2. Review.

7.

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE, Bundred NJ, Burchell JM, Campbell AM, Carroll JS, Clarke RB, Coles CE, Cook GJ, Cox A, Curtin NJ, Dekker LV, Silva Idos S, Duffy SW, Easton DF, Eccles DM, Edwards DR, Edwards J, Evans D, Fenlon DF, Flanagan JM, Foster C, Gallagher WM, Garcia-Closas M, Gee JM, Gescher AJ, Goh V, Groves AM, Harvey AJ, Harvie M, Hennessy BT, Hiscox S, Holen I, Howell SJ, Howell A, Hubbard G, Hulbert-Williams N, Hunter MS, Jasani B, Jones LJ, Key TJ, Kirwan CC, Kong A, Kunkler IH, Langdon SP, Leach MO, Mann DJ, Marshall JF, Martin L, Martin SG, Macdougall JE, Miles DW, Miller WR, Morris JR, Moss SM, Mullan P, Natrajan R, O'Connor JP, O'Connor R, Palmieri C, Pharoah PD, Rakha EA, Reed E, Robinson SP, Sahai E, Saxton JM, Schmid P, Smalley MJ, Speirs V, Stein R, Stingl J, Streuli CH, Tutt AN, Velikova G, Walker RA, Watson CJ, Williams KJ, Young LS, Thompson AM.

Breast Cancer Res. 2013 Oct 1;15(5):R92. doi: 10.1186/bcr3493. Review.

8.

Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence.

Patel KR, Andreadi C, Britton RG, Horner-Glister E, Karmokar A, Sale S, Brown VA, Brenner DE, Singh R, Steward WP, Gescher AJ, Brown K.

Sci Transl Med. 2013 Oct 2;5(205):205ra133. doi: 10.1126/scitranslmed.3005870.

9.

Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability.

Irving GR, Howells LM, Sale S, Kralj-Hans I, Atkin WS, Clark SK, Britton RG, Jones DJ, Scott EN, Berry DP, Hemingway D, Miller AS, Brown K, Gescher AJ, Steward WP.

Cancer Prev Res (Phila). 2013 Feb;6(2):119-28. doi: 10.1158/1940-6207.CAPR-12-0281. Epub 2012 Dec 11.

10.

Dose escalation and pharmacokinetic study of nanoparticle curcumin… by Kanai et al., CCP 69:65-70, 2012.

Gescher AJ.

Cancer Chemother Pharmacol. 2012 Sep;70(3):487. doi: 10.1007/s00280-012-1927-6. Epub 2012 Jul 19. No abstract available.

PMID:
22810806
11.

Dietary intake of rosmarinic acid by Apc(Min) mice, a model of colorectal carcinogenesis: levels of parent agent in the target tissue and effect on adenoma development.

Karmokar A, Marczylo TH, Cai H, Steward WP, Gescher AJ, Brown K.

Mol Nutr Food Res. 2012 May;56(5):775-83. doi: 10.1002/mnfr.201100617.

PMID:
22648624
12.

Tissue distribution and metabolism of the putative cancer chemopreventive agent 3',4',5'-trimethoxyflavonol (TMFol) in mice.

Saad SE, Jones DJ, Norris LM, Horner-Glister E, Patel KR, Britton RG, Steward WP, Gescher AJ, Brown K, Sale S.

Biomed Chromatogr. 2012 Dec;26(12):1559-66. doi: 10.1002/bmc.2732. Epub 2012 Mar 27.

PMID:
22454297
13.

Resveratrol in human cancer chemoprevention--choosing the 'right' dose.

Scott E, Steward WP, Gescher AJ, Brown K.

Mol Nutr Food Res. 2012 Jan;56(1):7-13. doi: 10.1002/mnfr.201100400. Epub 2011 Oct 7. Review.

PMID:
22218912
14.

Evaluation of urinary ribonucleoside profiling for clinical biomarker discovery using constant neutral loss scanning liquid chromatography/tandem mass spectrometry.

Teichert F, Winkler S, Keun HC, Steward WP, Gescher AJ, Farmer PB, Singh R.

Rapid Commun Mass Spectrom. 2011 Jul 30;25(14):2071-82. doi: 10.1002/rcm.5086.

PMID:
21698690
15.

Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics.

Howells LM, Berry DP, Elliott PJ, Jacobson EW, Hoffmann E, Hegarty B, Brown K, Steward WP, Gescher AJ.

Cancer Prev Res (Phila). 2011 Sep;4(9):1419-25. doi: 10.1158/1940-6207.CAPR-11-0148. Epub 2011 Jun 16.

16.

Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human colon cancer cells.

Esselen M, Fritz J, Hutter M, Teller N, Baechler S, Boettler U, Marczylo TH, Gescher AJ, Marko D.

Mol Nutr Food Res. 2011 May;55 Suppl 1:S143-53. doi: 10.1002/mnfr.201000315. Epub 2011 Jan 31.

PMID:
21280204
17.

Clinical trials of resveratrol.

Patel KR, Scott E, Brown VA, Gescher AJ, Steward WP, Brown K.

Ann N Y Acad Sci. 2011 Jan;1215:161-9. doi: 10.1111/j.1749-6632.2010.05853.x. Review.

PMID:
21261655
18.

Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.

Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, Brown K, Steward WP, Gescher AJ, Brenner DE.

Cancer Res. 2010 Nov 15;70(22):9003-11. doi: 10.1158/0008-5472.CAN-10-2364. Epub 2010 Oct 8.

19.

Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.

Patel KR, Brown VA, Jones DJ, Britton RG, Hemingway D, Miller AS, West KP, Booth TD, Perloff M, Crowell JA, Brenner DE, Steward WP, Gescher AJ, Brown K.

Cancer Res. 2010 Oct 1;70(19):7392-9. doi: 10.1158/0008-5472.CAN-10-2027. Epub 2010 Sep 14.

20.

Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract.

Cai H, Thomasset SC, P-Berry D, Garcea G, Brown K, Steward WP, Gescher AJ.

Biomed Chromatogr. 2011 Jun;25(6):660-3. doi: 10.1002/bmc.1499. Epub 2010 Aug 31.

PMID:
20812200
21.

Preclinical colorectal cancer chemopreventive efficacy and p53-modulating activity of 3',4',5'-trimethoxyflavonol, a quercetin analogue.

Howells LM, Britton RG, Mazzoletti M, Greaves P, Broggini M, Brown K, Steward WP, Gescher AJ, Sale S.

Cancer Prev Res (Phila). 2010 Aug;3(8):929-39. doi: 10.1158/1940-6207.CAPR-09-0236. Epub 2010 Jul 13.

22.

Plasma metabolic profiling reveals age-dependency of systemic effects of green tea polyphenols in mice with and without prostate cancer.

Teichert F, Verschoyle RD, Greaves P, Jones DJ, Wilson ID, Farmer PB, Steward WP, Gescher AJ, Keun HC.

Mol Biosyst. 2010 Oct;6(10):1911-6. doi: 10.1039/c004702c. Epub 2010 Jun 25.

PMID:
20577699
23.

Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone).

Cai H, Sale S, Britton RG, Brown K, Steward WP, Gescher AJ.

Cancer Chemother Pharmacol. 2011 Feb;67(2):255-63. doi: 10.1007/s00280-010-1313-1. Epub 2010 Apr 4.

PMID:
20364427
24.

Anthocyanin-rich red grape extract impedes adenoma development in the Apc(Min) mouse: pharmacodynamic changes and anthocyanin levels in the murine biophase.

Cai H, Marczylo TH, Teller N, Brown K, Steward WP, Marko D, Gescher AJ.

Eur J Cancer. 2010 Mar;46(4):811-7. doi: 10.1016/j.ejca.2009.12.017. Epub 2010 Jan 7.

PMID:
20060287
25.

APC10.1 cells as a model for assessing the efficacy of potential chemopreventive agents in the Apc(Min) mouse model in vivo.

Sale S, Fong IL, de Giovanni C, Landuzzi L, Brown K, Steward WP, Gescher AJ.

Eur J Cancer. 2009 Nov;45(16):2731-5. doi: 10.1016/j.ejca.2009.07.004. Epub 2009 Aug 18.

PMID:
19695862
26.

Flavones as colorectal cancer chemopreventive agents--phenol-o-methylation enhances efficacy.

Cai H, Sale S, Schmid R, Britton RG, Brown K, Steward WP, Gescher AJ.

Cancer Prev Res (Phila). 2009 Aug;2(8):743-50. doi: 10.1158/1940-6207.CAPR-09-0081. Epub 2009 Jul 28.

27.

Pilot study of oral anthocyanins for colorectal cancer chemoprevention.

Thomasset S, Berry DP, Cai H, West K, Marczylo TH, Marsden D, Brown K, Dennison A, Garcea G, Miller A, Hemingway D, Steward WP, Gescher AJ.

Cancer Prev Res (Phila). 2009 Jul;2(7):625-33. doi: 10.1158/1940-6207.CAPR-08-0201.

28.

Development of dietary phytochemical chemopreventive agents: biomarkers and choice of dose for early clinical trials.

Scott EN, Gescher AJ, Steward WP, Brown K.

Cancer Prev Res (Phila). 2009 Jun;2(6):525-30. doi: 10.1158/1940-6207.CAPR-08-0223. Epub 2009 May 26. Review.

29.

Pharmacokinetics and metabolism of the putative cancer chemopreventive agent cyanidin-3-glucoside in mice.

Marczylo TH, Cooke D, Brown K, Steward WP, Gescher AJ.

Cancer Chemother Pharmacol. 2009 Nov;64(6):1261-8. doi: 10.1007/s00280-009-0996-7. Epub 2009 Apr 11.

PMID:
19363608
30.

Suppression of the kinase activity of receptor tyrosine kinases by anthocyanin-rich mixtures extracted from bilberries and grapes.

Teller N, Thiele W, Marczylo TH, Gescher AJ, Boettler U, Sleeman J, Marko D.

J Agric Food Chem. 2009 Apr 22;57(8):3094-101. doi: 10.1021/jf803094a.

PMID:
19323506
31.

Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs?

Thomasset S, Teller N, Cai H, Marko D, Berry DP, Steward WP, Gescher AJ.

Cancer Chemother Pharmacol. 2009 Jun;64(1):201-11. doi: 10.1007/s00280-009-0976-y. Epub 2009 Mar 18. Review.

PMID:
19294386
32.

Rapid analysis of curcumin and curcumin metabolites in rat biomatrices using a novel ultraperformance liquid chromatography (UPLC) method.

Marczylo TH, Steward WP, Gescher AJ.

J Agric Food Chem. 2009 Feb 11;57(3):797-803. doi: 10.1021/jf803038f.

PMID:
19152267
33.

Determination of 8-oxo-2'-deoxyguanosine and creatinine in murine and human urine by liquid chromatography/tandem mass spectrometry: application to chemoprevention studies.

Teichert F, Verschoyle RD, Greaves P, Thorpe JF, Mellon JK, Steward WP, Farmer PB, Gescher AJ, Singh R.

Rapid Commun Mass Spectrom. 2009 Jan;23(2):258-66. doi: 10.1002/rcm.3873. Erratum in: Rapid Commun Mass Spectrom. 2010 Jul;24(14):2175.

PMID:
19072863
34.

Simultaneous determination of 8-oxo-2'-deoxyguanosine and 8-oxo-2'-deoxyadenosine in DNA using online column-switching liquid chromatography/tandem mass spectrometry.

Singh R, Teichert F, Verschoyle RD, Kaur B, Vives M, Sharma RA, Steward WP, Gescher AJ, Farmer PB.

Rapid Commun Mass Spectrom. 2009 Jan;23(1):151-60. doi: 10.1002/rcm.3866.

PMID:
19065576
35.

Determination of 3',4',5',5,7-pentamethoxyflavone in the plasma and intestinal mucosa of mice by HPLC with UV detection.

Cai H, Brown K, Steward WP, Gescher AJ.

Biomed Chromatogr. 2009 Apr;23(4):335-9. doi: 10.1002/bmc.1120.

PMID:
18800334
36.

Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.

Teichert F, Verschoyle RD, Greaves P, Edwards RE, Teahan O, Jones DJ, Wilson ID, Farmer PB, Steward WP, Gant TW, Gescher AJ, Keun HC.

Prostate. 2008 Jul 1;68(10):1035-47. doi: 10.1002/pros.20761.

PMID:
18459103
37.

Resveratrol from red grapes - pedestrian polyphenol or useful anticancer agent?

Gescher AJ.

Planta Med. 2008 Oct;74(13):1651-5. doi: 10.1055/s-2008-1074516. Epub 2008 Apr 29.

PMID:
18446674
38.

Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: relationship with silibinin levels.

Verschoyle RD, Greaves P, Patel K, Marsden DA, Brown K, Steward WP, Gescher AJ.

Eur J Cancer. 2008 Apr;44(6):898-906. doi: 10.1016/j.ejca.2008.02.020. Epub 2008 Mar 17.

PMID:
18343654
39.

Curcumin in cancer management: recent results of analogue design and clinical studies and desirable future research.

Steward WP, Gescher AJ.

Mol Nutr Food Res. 2008 Sep;52(9):1005-9. doi: 10.1002/mnfr.200700148. Review.

PMID:
18186103
40.

Androgen manipulation alters oxidative DNA adduct levels in androgen-sensitive prostate cancer cells grown in vitro and in vivo.

Pathak S, Singh R, Verschoyle RD, Greaves P, Farmer PB, Steward WP, Mellon JK, Gescher AJ, Sharma RA.

Cancer Lett. 2008 Mar 8;261(1):74-83. Epub 2007 Dec 21.

PMID:
18096312
41.

Putative cancer chemopreventive agents of dietary origin-how safe are they?

Verschoyle RD, Steward WP, Gescher AJ.

Nutr Cancer. 2007;59(2):152-62. Review.

PMID:
18001209
42.

Phytoestrogens and xenoestrogens: the contribution of diet and environment to endocrine disruption.

Waring RH, Ayers S, Gescher AJ, Glatt HR, Meinl W, Jarratt P, Kirk CJ, Pettitt T, Rea D, Harris RM.

J Steroid Biochem Mol Biol. 2008 Feb;108(3-5):213-20. Epub 2007 Sep 7. Review.

PMID:
17933522
43.

Consumption of silibinin, a flavonolignan from milk thistle, and mammary cancer development in the C3(1) SV40 T,t antigen transgenic multiple mammary adenocarcinoma (TAg) mouse.

Verschoyle RD, Brown K, Steward WP, Gescher AJ.

Cancer Chemother Pharmacol. 2008 Jul;62(2):369-72. Epub 2007 Oct 2.

PMID:
17909802
44.

Cytotoxic action of phorbol esters on human pancreatic cancer cells.

Bond JA, Gescher AJ, Verschoyle RD, Lemoine NR, Errington R, Wiltshire M, Smith PJ, Wynford-Thomas D.

Int J Cancer. 2007 Oct 1;121(7):1445-54.

45.

Pharmacokinetics and pharmacodynamics of curcumin.

Sharma RA, Steward WP, Gescher AJ.

Adv Exp Med Biol. 2007;595:453-70. Review.

PMID:
17569224
46.

Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent.

Boocock DJ, Faust GE, Patel KR, Schinas AM, Brown VA, Ducharme MP, Booth TD, Crowell JA, Perloff M, Gescher AJ, Steward WP, Brenner DE.

Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1246-52.

47.

Breast cancer prevention by green tea catechins and black tea theaflavins in the C3(1) SV40 T,t antigen transgenic mouse model is accompanied by increased apoptosis and a decrease in oxidative DNA adducts.

Kaur S, Greaves P, Cooke DN, Edwards R, Steward WP, Gescher AJ, Marczylo TH.

J Agric Food Chem. 2007 May 2;55(9):3378-85. Epub 2007 Apr 4.

PMID:
17407311
48.

A review of phase III clinical trials of prostate cancer chemoprevention.

Thorpe JF, Jain S, Marczylo TH, Gescher AJ, Steward WP, Mellon JK.

Ann R Coll Surg Engl. 2007 Apr;89(3):207-11. Review.

49.

Quantitation of silibinin, a putative cancer chemopreventive agent derived from milk thistle (Silybum marianum), in human plasma by high-performance liquid chromatography and identification of possible metabolites.

Hoh CS, Boocock DJ, Marczylo TH, Brown VA, Cai H, Steward WP, Berry DP, Gescher AJ.

J Agric Food Chem. 2007 Apr 4;55(7):2532-5. Epub 2007 Mar 14.

PMID:
17355141
50.

Modulation of response to cancer chemotherapeutic agents by diet constituents: is the available evidence sufficiently robust for rational advice for patients?

D'Incalci M, Steward WP, Gescher AJ.

Cancer Treat Rev. 2007 May;33(3):223-9. Epub 2007 Feb 27. Review.

PMID:
17329030

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