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Items: 1 to 50 of 254

1.

An Abstract Provides "seAFOod" for Thought.

DeCensi A, Gescher A.

Cancer Prev Res (Phila). 2019 Mar;12(3):123-124. doi: 10.1158/1940-6207.CAPR-19-0033. Epub 2019 Jan 30.

PMID:
30700438
2.

Effects of a Grapevine Shoot Extract Containing Resveratrol and Resveratrol Oligomers on Intestinal Adenoma Development in Mice: In Vitro and In Vivo Studies.

Empl MT, Cai H, Wang S, Junginger J, Kostka T, Hewicker-Trautwein M, Brown K, Gescher AJ, Steinberg P.

Mol Nutr Food Res. 2018 Jan;62(2). doi: 10.1002/mnfr.201700450. Epub 2018 Jan 9.

PMID:
29125219
3.

Response to comment on "Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice".

Brown K, Rufini A, Gescher A.

Sci Transl Med. 2016 Aug 3;8(350):350lr2. doi: 10.1126/scitranslmed.aag2816.

PMID:
27488895
4.

Targeting cancer stem-like cells using dietary-derived agents - Where are we now?

Khan S, Karmokar A, Howells L, Thomas AL, Bayliss R, Gescher A, Brown K.

Mol Nutr Food Res. 2016 Jun;60(6):1295-309. doi: 10.1002/mnfr.201500887. Epub 2016 May 11. Review.

PMID:
27060283
5.

Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice.

Cai H, Scott E, Kholghi A, Andreadi C, Rufini A, Karmokar A, Britton RG, Horner-Glister E, Greaves P, Jawad D, James M, Howells L, Ognibene T, Malfatti M, Goldring C, Kitteringham N, Walsh J, Viskaduraki M, West K, Miller A, Hemingway D, Steward WP, Gescher AJ, Brown K.

Sci Transl Med. 2015 Jul 29;7(298):298ra117. doi: 10.1126/scitranslmed.aaa7619.

6.

Search for novel circulating cancer chemopreventive biomarkers of dietary rice bran intervention in Apc(Min) mice model of colorectal carcinogenesis, using proteomic and metabolic profiling strategies.

Norris L, Malkar A, Horner-Glister E, Hakimi A, Ng LL, Gescher AJ, Creaser C, Sale S, Jones DJ.

Mol Nutr Food Res. 2015 Sep;59(9):1827-36. doi: 10.1002/mnfr.201400818. Epub 2015 Jun 30.

PMID:
26033951
7.

Inhibition of prostate cancer cell growth by 3',4',5'-trimethoxyflavonol (TMFol).

Hill CU, Saad SE, Britton RG, Gescher AJ, Sale S, Brown K, Howells LM.

Cancer Chemother Pharmacol. 2015 Jul;76(1):179-85. doi: 10.1007/s00280-015-2771-2. Epub 2015 May 29.

PMID:
26017621
8.

Do not throw out the resveratrol with the bath water.

Brown K, Rufini A, Gescher A.

JAMA Intern Med. 2015 Jan;175(1):140-1. doi: 10.1001/jamainternmed.2014.7000. No abstract available.

PMID:
25560944
9.

Risk determination and prevention of breast cancer.

Howell A, Anderson AS, Clarke RB, Duffy SW, Evans DG, Garcia-Closas M, Gescher AJ, Key TJ, Saxton JM, Harvie MN.

Breast Cancer Res. 2014 Sep 28;16(5):446. doi: 10.1186/s13058-014-0446-2. Review.

10.

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.

Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown NJ, Bryant HE, Bundred NJ, Burchell JM, Campbell AM, Carroll JS, Clarke RB, Coles CE, Cook GJ, Cox A, Curtin NJ, Dekker LV, Silva Idos S, Duffy SW, Easton DF, Eccles DM, Edwards DR, Edwards J, Evans D, Fenlon DF, Flanagan JM, Foster C, Gallagher WM, Garcia-Closas M, Gee JM, Gescher AJ, Goh V, Groves AM, Harvey AJ, Harvie M, Hennessy BT, Hiscox S, Holen I, Howell SJ, Howell A, Hubbard G, Hulbert-Williams N, Hunter MS, Jasani B, Jones LJ, Key TJ, Kirwan CC, Kong A, Kunkler IH, Langdon SP, Leach MO, Mann DJ, Marshall JF, Martin L, Martin SG, Macdougall JE, Miles DW, Miller WR, Morris JR, Moss SM, Mullan P, Natrajan R, O'Connor JP, O'Connor R, Palmieri C, Pharoah PD, Rakha EA, Reed E, Robinson SP, Sahai E, Saxton JM, Schmid P, Smalley MJ, Speirs V, Stein R, Stingl J, Streuli CH, Tutt AN, Velikova G, Walker RA, Watson CJ, Williams KJ, Young LS, Thompson AM.

Breast Cancer Res. 2013 Oct 1;15(5):R92. doi: 10.1186/bcr3493. Review.

11.

Sulfate metabolites provide an intracellular pool for resveratrol generation and induce autophagy with senescence.

Patel KR, Andreadi C, Britton RG, Horner-Glister E, Karmokar A, Sale S, Brown VA, Brenner DE, Singh R, Steward WP, Gescher AJ, Brown K.

Sci Transl Med. 2013 Oct 2;5(205):205ra133. doi: 10.1126/scitranslmed.3005870.

12.

Editorial: curcumin: recent insights,novel developments, new challenges.

Gescher A.

Mol Nutr Food Res. 2013 Sep;57(9):1509. doi: 10.1002/mnfr.201370084. No abstract available.

PMID:
23996845
13.

Pharmacology in the high tech age--new developments, opportunities and limitations.

Gescher A, Gobbi M.

Curr Opin Pharmacol. 2013 Oct;13(5):775-7. doi: 10.1016/j.coph.2013.08.001. Epub 2013 Aug 17. No abstract available.

PMID:
23962920
14.

The role of cancer stem cells in the anti-carcinogenicity of curcumin.

Norris L, Karmokar A, Howells L, Steward WP, Gescher A, Brown K.

Mol Nutr Food Res. 2013 Sep;57(9):1630-7. doi: 10.1002/mnfr.201300120. Epub 2013 Jul 31. Review.

PMID:
23900994
15.

Resveratrol in the management of human cancer: how strong is the clinical evidence?

Gescher A, Steward WP, Brown K.

Ann N Y Acad Sci. 2013 Jul;1290:12-20. doi: 10.1111/nyas.12205. Review.

PMID:
23855461
16.

Prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability.

Irving GR, Howells LM, Sale S, Kralj-Hans I, Atkin WS, Clark SK, Britton RG, Jones DJ, Scott EN, Berry DP, Hemingway D, Miller AS, Brown K, Gescher AJ, Steward WP.

Cancer Prev Res (Phila). 2013 Feb;6(2):119-28. doi: 10.1158/1940-6207.CAPR-12-0281. Epub 2012 Dec 11.

17.

Dose escalation and pharmacokinetic study of nanoparticle curcumin… by Kanai et al., CCP 69:65-70, 2012.

Gescher AJ.

Cancer Chemother Pharmacol. 2012 Sep;70(3):487. doi: 10.1007/s00280-012-1927-6. Epub 2012 Jul 19. No abstract available.

PMID:
22810806
18.

Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents.

Britton RG, Horner-Glister E, Pomenya OA, Smith EE, Denton R, Jenkins PR, Steward WP, Brown K, Gescher A, Sale S.

Eur J Med Chem. 2012 Aug;54:952-8. doi: 10.1016/j.ejmech.2012.06.031. Epub 2012 Jun 22.

PMID:
22789812
19.

Dietary intake of rosmarinic acid by Apc(Min) mice, a model of colorectal carcinogenesis: levels of parent agent in the target tissue and effect on adenoma development.

Karmokar A, Marczylo TH, Cai H, Steward WP, Gescher AJ, Brown K.

Mol Nutr Food Res. 2012 May;56(5):775-83. doi: 10.1002/mnfr.201100617.

PMID:
22648624
20.

Tissue distribution and metabolism of the putative cancer chemopreventive agent 3',4',5'-trimethoxyflavonol (TMFol) in mice.

Saad SE, Jones DJ, Norris LM, Horner-Glister E, Patel KR, Britton RG, Steward WP, Gescher AJ, Brown K, Sale S.

Biomed Chromatogr. 2012 Dec;26(12):1559-66. doi: 10.1002/bmc.2732. Epub 2012 Mar 27.

PMID:
22454297
21.

Resveratrol in human cancer chemoprevention--choosing the 'right' dose.

Scott E, Steward WP, Gescher AJ, Brown K.

Mol Nutr Food Res. 2012 Jan;56(1):7-13. doi: 10.1002/mnfr.201100400. Epub 2011 Oct 7. Review.

PMID:
22218912
22.

Evaluation of urinary ribonucleoside profiling for clinical biomarker discovery using constant neutral loss scanning liquid chromatography/tandem mass spectrometry.

Teichert F, Winkler S, Keun HC, Steward WP, Gescher AJ, Farmer PB, Singh R.

Rapid Commun Mass Spectrom. 2011 Jul 30;25(14):2071-82. doi: 10.1002/rcm.5086.

PMID:
21698690
23.

Phase I randomized, double-blind pilot study of micronized resveratrol (SRT501) in patients with hepatic metastases--safety, pharmacokinetics, and pharmacodynamics.

Howells LM, Berry DP, Elliott PJ, Jacobson EW, Hoffmann E, Hegarty B, Brown K, Steward WP, Gescher AJ.

Cancer Prev Res (Phila). 2011 Sep;4(9):1419-25. doi: 10.1158/1940-6207.CAPR-11-0148. Epub 2011 Jun 16.

24.

Anthocyanin-rich extracts suppress the DNA-damaging effects of topoisomerase poisons in human colon cancer cells.

Esselen M, Fritz J, Hutter M, Teller N, Baechler S, Boettler U, Marczylo TH, Gescher AJ, Marko D.

Mol Nutr Food Res. 2011 May;55 Suppl 1:S143-53. doi: 10.1002/mnfr.201000315. Epub 2011 Jan 31.

PMID:
21280204
25.

Clinical trials of resveratrol.

Patel KR, Scott E, Brown VA, Gescher AJ, Steward WP, Brown K.

Ann N Y Acad Sci. 2011 Jan;1215:161-9. doi: 10.1111/j.1749-6632.2010.05853.x. Review.

PMID:
21261655
26.

Repeat dose study of the cancer chemopreventive agent resveratrol in healthy volunteers: safety, pharmacokinetics, and effect on the insulin-like growth factor axis.

Brown VA, Patel KR, Viskaduraki M, Crowell JA, Perloff M, Booth TD, Vasilinin G, Sen A, Schinas AM, Piccirilli G, Brown K, Steward WP, Gescher AJ, Brenner DE.

Cancer Res. 2010 Nov 15;70(22):9003-11. doi: 10.1158/0008-5472.CAN-10-2364. Epub 2010 Oct 8.

27.

Clinical pharmacology of resveratrol and its metabolites in colorectal cancer patients.

Patel KR, Brown VA, Jones DJ, Britton RG, Hemingway D, Miller AS, West KP, Booth TD, Perloff M, Crowell JA, Brenner DE, Steward WP, Gescher AJ, Brown K.

Cancer Res. 2010 Oct 1;70(19):7392-9. doi: 10.1158/0008-5472.CAN-10-2027. Epub 2010 Sep 14.

28.

Curcumin ameliorates oxaliplatin-induced chemoresistance in HCT116 colorectal cancer cells in vitro and in vivo.

Howells LM, Sale S, Sriramareddy SN, Irving GR, Jones DJ, Ottley CJ, Pearson DG, Mann CD, Manson MM, Berry DP, Gescher A, Steward WP, Brown K.

Int J Cancer. 2011 Jul 15;129(2):476-86. doi: 10.1002/ijc.25670. Epub 2010 Nov 3.

29.

Determination of anthocyanins in the urine of patients with colorectal liver metastases after administration of bilberry extract.

Cai H, Thomasset SC, P-Berry D, Garcea G, Brown K, Steward WP, Gescher AJ.

Biomed Chromatogr. 2011 Jun;25(6):660-3. doi: 10.1002/bmc.1499. Epub 2010 Aug 31.

PMID:
20812200
30.

New perspectives on dietary polyphenols: taking stock, more to come.

Gescher A.

Mol Nutr Food Res. 2010 Jul;54 Suppl 2:S125-6. doi: 10.1002/mnfr.201090027. No abstract available.

PMID:
20669162
31.

Preclinical colorectal cancer chemopreventive efficacy and p53-modulating activity of 3',4',5'-trimethoxyflavonol, a quercetin analogue.

Howells LM, Britton RG, Mazzoletti M, Greaves P, Broggini M, Brown K, Steward WP, Gescher AJ, Sale S.

Cancer Prev Res (Phila). 2010 Aug;3(8):929-39. doi: 10.1158/1940-6207.CAPR-09-0236. Epub 2010 Jul 13.

32.

Plasma metabolic profiling reveals age-dependency of systemic effects of green tea polyphenols in mice with and without prostate cancer.

Teichert F, Verschoyle RD, Greaves P, Jones DJ, Wilson ID, Farmer PB, Steward WP, Gescher AJ, Keun HC.

Mol Biosyst. 2010 Oct;6(10):1911-6. doi: 10.1039/c004702c. Epub 2010 Jun 25.

PMID:
20577699
33.

Pharmacokinetics in mice and metabolism in murine and human liver fractions of the putative cancer chemopreventive agents 3',4',5',5,7-pentamethoxyflavone and tricin (4',5,7-trihydroxy-3',5'-dimethoxyflavone).

Cai H, Sale S, Britton RG, Brown K, Steward WP, Gescher AJ.

Cancer Chemother Pharmacol. 2011 Feb;67(2):255-63. doi: 10.1007/s00280-010-1313-1. Epub 2010 Apr 4.

PMID:
20364427
34.

Anthocyanin-rich red grape extract impedes adenoma development in the Apc(Min) mouse: pharmacodynamic changes and anthocyanin levels in the murine biophase.

Cai H, Marczylo TH, Teller N, Brown K, Steward WP, Marko D, Gescher AJ.

Eur J Cancer. 2010 Mar;46(4):811-7. doi: 10.1016/j.ejca.2009.12.017. Epub 2010 Jan 7.

PMID:
20060287
35.

APC10.1 cells as a model for assessing the efficacy of potential chemopreventive agents in the Apc(Min) mouse model in vivo.

Sale S, Fong IL, de Giovanni C, Landuzzi L, Brown K, Steward WP, Gescher AJ.

Eur J Cancer. 2009 Nov;45(16):2731-5. doi: 10.1016/j.ejca.2009.07.004. Epub 2009 Aug 18.

PMID:
19695862
36.

Flavones as colorectal cancer chemopreventive agents--phenol-o-methylation enhances efficacy.

Cai H, Sale S, Schmid R, Britton RG, Brown K, Steward WP, Gescher AJ.

Cancer Prev Res (Phila). 2009 Aug;2(8):743-50. doi: 10.1158/1940-6207.CAPR-09-0081. Epub 2009 Jul 28.

37.

Pilot study of oral anthocyanins for colorectal cancer chemoprevention.

Thomasset S, Berry DP, Cai H, West K, Marczylo TH, Marsden D, Brown K, Dennison A, Garcea G, Miller A, Hemingway D, Steward WP, Gescher AJ.

Cancer Prev Res (Phila). 2009 Jul;2(7):625-33. doi: 10.1158/1940-6207.CAPR-08-0201.

38.

Development of dietary phytochemical chemopreventive agents: biomarkers and choice of dose for early clinical trials.

Scott EN, Gescher AJ, Steward WP, Brown K.

Cancer Prev Res (Phila). 2009 Jun;2(6):525-30. doi: 10.1158/1940-6207.CAPR-08-0223. Epub 2009 May 26. Review.

39.

Pharmacokinetics and metabolism of the putative cancer chemopreventive agent cyanidin-3-glucoside in mice.

Marczylo TH, Cooke D, Brown K, Steward WP, Gescher AJ.

Cancer Chemother Pharmacol. 2009 Nov;64(6):1261-8. doi: 10.1007/s00280-009-0996-7. Epub 2009 Apr 11.

PMID:
19363608
40.

Suppression of the kinase activity of receptor tyrosine kinases by anthocyanin-rich mixtures extracted from bilberries and grapes.

Teller N, Thiele W, Marczylo TH, Gescher AJ, Boettler U, Sleeman J, Marko D.

J Agric Food Chem. 2009 Apr 22;57(8):3094-101. doi: 10.1021/jf803094a.

PMID:
19323506
41.

Do anthocyanins and anthocyanidins, cancer chemopreventive pigments in the diet, merit development as potential drugs?

Thomasset S, Teller N, Cai H, Marko D, Berry DP, Steward WP, Gescher AJ.

Cancer Chemother Pharmacol. 2009 Jun;64(1):201-11. doi: 10.1007/s00280-009-0976-y. Epub 2009 Mar 18. Review.

PMID:
19294386
42.

Synthesis of the flavonoid 3',4',5'-trimethoxyflavonol and its determination in plasma and tissues of mice by HPLC with fluorescence detection.

Britton RG, Fong I, Saad S, Brown K, Steward WP, Gescher A, Sale S.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Apr 1;877(10):939-42. doi: 10.1016/j.jchromb.2009.02.043. Epub 2009 Feb 24.

PMID:
19282252
43.

Rapid analysis of curcumin and curcumin metabolites in rat biomatrices using a novel ultraperformance liquid chromatography (UPLC) method.

Marczylo TH, Steward WP, Gescher AJ.

J Agric Food Chem. 2009 Feb 11;57(3):797-803. doi: 10.1021/jf803038f.

PMID:
19152267
44.

Determination of 8-oxo-2'-deoxyguanosine and creatinine in murine and human urine by liquid chromatography/tandem mass spectrometry: application to chemoprevention studies.

Teichert F, Verschoyle RD, Greaves P, Thorpe JF, Mellon JK, Steward WP, Farmer PB, Gescher AJ, Singh R.

Rapid Commun Mass Spectrom. 2009 Jan;23(2):258-66. doi: 10.1002/rcm.3873. Erratum in: Rapid Commun Mass Spectrom. 2010 Jul;24(14):2175.

PMID:
19072863
45.

Simultaneous determination of 8-oxo-2'-deoxyguanosine and 8-oxo-2'-deoxyadenosine in DNA using online column-switching liquid chromatography/tandem mass spectrometry.

Singh R, Teichert F, Verschoyle RD, Kaur B, Vives M, Sharma RA, Steward WP, Gescher AJ, Farmer PB.

Rapid Commun Mass Spectrom. 2009 Jan;23(1):151-60. doi: 10.1002/rcm.3866.

PMID:
19065576
46.

Cancer chemopreventive agents in plants - a continuing challenge.

Gescher A, Gerhäuser C.

Planta Med. 2008 Oct;74(13):1523-5. doi: 10.1055/s-0028-1088305. Epub 2008 Oct 8. No abstract available.

PMID:
18843591
47.

Determination of 3',4',5',5,7-pentamethoxyflavone in the plasma and intestinal mucosa of mice by HPLC with UV detection.

Cai H, Brown K, Steward WP, Gescher AJ.

Biomed Chromatogr. 2009 Apr;23(4):335-9. doi: 10.1002/bmc.1120.

PMID:
18800334
48.

Metabolic profiling of transgenic adenocarcinoma of mouse prostate (TRAMP) tissue by 1H-NMR analysis: evidence for unusual phospholipid metabolism.

Teichert F, Verschoyle RD, Greaves P, Edwards RE, Teahan O, Jones DJ, Wilson ID, Farmer PB, Steward WP, Gant TW, Gescher AJ, Keun HC.

Prostate. 2008 Jul 1;68(10):1035-47. doi: 10.1002/pros.20761.

PMID:
18459103
49.

Resveratrol from red grapes - pedestrian polyphenol or useful anticancer agent?

Gescher AJ.

Planta Med. 2008 Oct;74(13):1651-5. doi: 10.1055/s-2008-1074516. Epub 2008 Apr 29.

PMID:
18446674
50.

Evaluation of the cancer chemopreventive efficacy of silibinin in genetic mouse models of prostate and intestinal carcinogenesis: relationship with silibinin levels.

Verschoyle RD, Greaves P, Patel K, Marsden DA, Brown K, Steward WP, Gescher AJ.

Eur J Cancer. 2008 Apr;44(6):898-906. doi: 10.1016/j.ejca.2008.02.020. Epub 2008 Mar 17.

PMID:
18343654

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