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Items: 1 to 50 of 111


Brivaracetam attenuates pain behaviors in a murine model of neuropathic pain.

Tsymbalyuk S, Smith M, Gore C, Tsymbalyuk O, Ivanova S, Sansur C, Gerzanich V, Simard JM.

Mol Pain. 2019 Jan-Dec;15:1744806919886503. doi: 10.1177/1744806919886503. No abstract available.


Chronic pain after blast-induced traumatic brain injury in awake rats.

Uddin O, Studlack PE, Parihar S, Keledjian K, Cruz A, Farooq T, Shin N, Gerzanich V, Simard JM, Keller A.

Neurobiol Pain. 2019 Apr 2;6:100030. doi: 10.1016/j.ynpai.2019.100030. eCollection 2019 Aug-Dec.


Blast-induced brain injury in rats leads to transient vestibulomotor deficits and persistent orofacial pain.

Studlack PE, Keledjian K, Farooq T, Akintola T, Gerzanich V, Simard JM, Keller A.

Brain Inj. 2018;32(13-14):1866-1878. doi: 10.1080/02699052.2018.1536282. Epub 2018 Oct 22.


Sulfonylurea Receptor 1, Transient Receptor Potential Cation Channel Subfamily M Member 4, and KIR6.2:Role in Hemorrhagic Progression of Contusion.

Gerzanich V, Stokum JA, Ivanova S, Woo SK, Tsymbalyuk O, Sharma A, Akkentli F, Imran Z, Aarabi B, Sahuquillo J, Simard JM.

J Neurotrauma. 2019 Apr 1;36(7):1060-1079. doi: 10.1089/neu.2018.5986. Epub 2018 Oct 4.


Correction: Cerebral microbleeds in a neonatal rat model.

Theriault BC, Woo SK, Karimy JK, Keledjian K, Stokum JA, Sarkar A, Coksaygan T, Ivanova S, Gerzanich V, Simard JM.

PLoS One. 2018 Jul 31;13(7):e0201831. doi: 10.1371/journal.pone.0201831. eCollection 2018.


Mannitol and Hypertonic Saline Reduce Swelling and Modulate Inflammatory Markers in a Rat Model of Intracerebral Hemorrhage.

Schreibman DL, Hong CM, Keledjian K, Ivanova S, Tsymbalyuk S, Gerzanich V, Simard JM.

Neurocrit Care. 2018 Oct;29(2):253-263. doi: 10.1007/s12028-018-0535-7.


SUR1-TRPM4 channel activation and phasic secretion of MMP-9 induced by tPA in brain endothelial cells.

Gerzanich V, Kwon MS, Woo SK, Ivanov A, Simard JM.

PLoS One. 2018 Apr 4;13(4):e0195526. doi: 10.1371/journal.pone.0195526. eCollection 2018.


Selective Vulnerability of the Foramen Magnum in a Rat Blast Traumatic Brain Injury Model.

Hayman E, Keledjian K, Stokum JA, Pampori A, Gerzanich V, Simard JM.

J Neurotrauma. 2018 Sep 1;35(17):2136-2142. doi: 10.1089/neu.2017.5435. Epub 2018 Jun 5.


Pharmacological induced target temperature management after cardiac arrest: the capsaicinoids.

Simard JM, Jia X, Gerzanich V.

Neural Regen Res. 2017 Oct;12(10):1623-1624. doi: 10.4103/1673-5374.217334. No abstract available.


TRPM4 and the Emperor.

Simard JM, Gerzanich V.

Channels (Austin). 2018 Jan 1;12(1):174-175. doi: 10.1080/19336950.2017.1398967. No abstract available.


α-Endosulfine (ARPP-19e) Expression in a Rat Model of Stroke.

Mehta RI, Tsymbalyuk N, Ivanova S, Stokum JA, Woo K, Gerzanich V, Simard JM.

J Neuropathol Exp Neurol. 2017 Oct 1;76(10):898-907. doi: 10.1093/jnen/nlx074.


SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling.

Stokum JA, Kwon MS, Woo SK, Tsymbalyuk O, Vennekens R, Gerzanich V, Simard JM.

Glia. 2018 Jan;66(1):108-125. doi: 10.1002/glia.23231. Epub 2017 Sep 14.


Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.

Hashiguchi H, Sheng Z, Routh V, Gerzanich V, Simard JM, Bryan J.

PLoS One. 2017 Sep 6;12(9):e0184261. doi: 10.1371/journal.pone.0184261. eCollection 2017.


Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis.

Gerzanich V, Makar TK, Guda PR, Kwon MS, Stokum JA, Woo SK, Ivanova S, Ivanov A, Mehta RI, Morris AB, Bryan J, Bever CT, Simard JM.

J Neuroinflammation. 2017 Sep 2;14(1):177. doi: 10.1186/s12974-017-0953-z.


Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus.

Karimy JK, Zhang J, Kurland DB, Theriault BC, Duran D, Stokum JA, Furey CG, Zhou X, Mansuri MS, Montejo J, Vera A, DiLuna ML, Delpire E, Alper SL, Gunel M, Gerzanich V, Medzhitov R, Simard JM, Kahle KT.

Nat Med. 2017 Aug;23(8):997-1003. doi: 10.1038/nm.4361. Epub 2017 Jul 10.


Glibenclamide pretreatment protects against chronic memory dysfunction and glial activation in rat cranial blast traumatic brain injury.

Stokum JA, Keledjian K, Hayman E, Karimy JK, Pampori A, Imran Z, Woo SK, Gerzanich V, Simard JM.

Behav Brain Res. 2017 Aug 30;333:43-53. doi: 10.1016/j.bbr.2017.06.038. Epub 2017 Jun 27.


Cerebral microbleeds in a neonatal rat model.

Theriault BC, Woo SK, Karimy JK, Keledjian K, Stokum JA, Sarkar A, Coksaygan T, Ivanova S, Gerzanich V, Simard JM.

PLoS One. 2017 Feb 3;12(2):e0171163. doi: 10.1371/journal.pone.0171163. eCollection 2017. Erratum in: PLoS One. 2018 Jul 31;13(7):e0201831.


Mechanisms of Global Cerebral Edema Formation in Aneurysmal Subarachnoid Hemorrhage.

Hayman EG, Wessell A, Gerzanich V, Sheth KN, Simard JM.

Neurocrit Care. 2017 Apr;26(2):301-310. doi: 10.1007/s12028-016-0354-7. Review.


Cerebrospinal fluid hypersecretion in pediatric hydrocephalus.

Karimy JK, Duran D, Hu JK, Gavankar C, Gaillard JR, Bayri Y, Rice H, DiLuna ML, Gerzanich V, Marc Simard J, Kahle KT.

Neurosurg Focus. 2016 Nov;41(5):E10. Review.


Inducible nitric oxide synthase (NOS-2) in subarachnoid hemorrhage: Regulatory mechanisms and therapeutic implications.

Iqbal S, Hayman EG, Hong C, Stokum JA, Kurland DB, Gerzanich V, Simard JM.

Brain Circ. 2016;2(1):8-19.


The Sur1-Trpm4 channel regulates NOS2 transcription in TLR4-activated microglia.

Kurland DB, Gerzanich V, Karimy JK, Woo SK, Vennekens R, Freichel M, Nilius B, Bryan J, Simard JM.

J Neuroinflammation. 2016 Jun 1;13(1):130. doi: 10.1186/s12974-016-0599-2.


Molecular pathophysiology of cerebral edema.

Stokum JA, Gerzanich V, Simard JM.

J Cereb Blood Flow Metab. 2016 Mar;36(3):513-38. doi: 10.1177/0271678X15617172. Epub 2015 Nov 16. Review.


Silencing of Abcc8 or inhibition of newly upregulated Sur1-Trpm4 reduce inflammation and disease progression in experimental autoimmune encephalomyelitis.

Makar TK, Gerzanich V, Nimmagadda VK, Jain R, Lam K, Mubariz F, Trisler D, Ivanova S, Woo SK, Kwon MS, Bryan J, Bever CT, Simard JM.

J Neuroinflammation. 2015 Nov 18;12:210. doi: 10.1186/s12974-015-0432-3.


Heterogeneity of aquaporin-4 localization and expression after focal cerebral ischemia underlies differences in white versus grey matter swelling.

Stokum JA, Mehta RI, Ivanova S, Yu E, Gerzanich V, Simard JM.

Acta Neuropathol Commun. 2015 Sep 30;3:61. doi: 10.1186/s40478-015-0239-6.


Changes in Diffusion Kurtosis Imaging and Magnetic Resonance Spectroscopy in a Direct Cranial Blast Traumatic Brain Injury (dc-bTBI) Model.

Zhuo J, Keledjian K, Xu S, Pampori A, Gerzanich V, Simard JM, Gullapalli RP.

PLoS One. 2015 Aug 24;10(8):e0136151. doi: 10.1371/journal.pone.0136151. eCollection 2015.


A Direct Comparison of Three Clinically Relevant Treatments in a Rat Model of Cervical Spinal Cord Injury.

Hosier H, Peterson D, Tsymbalyuk O, Keledjian K, Smith BR, Ivanova S, Gerzanich V, Popovich PG, Simard JM.

J Neurotrauma. 2015 Nov 1;32(21):1633-44. doi: 10.1089/neu.2015.3892. Epub 2015 Jul 20.


Sur1-Trpm4 Cation Channel Expression in Human Cerebral Infarcts.

Mehta RI, Tosun C, Ivanova S, Tsymbalyuk N, Famakin BM, Kwon MS, Castellani RJ, Gerzanich V, Simard JM.

J Neuropathol Exp Neurol. 2015 Aug;74(8):835-49. doi: 10.1097/NEN.0000000000000223.


Complications Associated with Decompressive Craniectomy: A Systematic Review.

Kurland DB, Khaladj-Ghom A, Stokum JA, Carusillo B, Karimy JK, Gerzanich V, Sahuquillo J, Simard JM.

Neurocrit Care. 2015 Oct;23(2):292-304. doi: 10.1007/s12028-015-0144-7. Review.


Methemoglobin is an endogenous toll-like receptor 4 ligand-relevance to subarachnoid hemorrhage.

Kwon MS, Woo SK, Kurland DB, Yoon SH, Palmer AF, Banerjee U, Iqbal S, Ivanova S, Gerzanich V, Simard JM.

Int J Mol Sci. 2015 Mar 5;16(3):5028-46. doi: 10.3390/ijms16035028.


Glibenclamide for the treatment of ischemic and hemorrhagic stroke.

Caffes N, Kurland DB, Gerzanich V, Simard JM.

Int J Mol Sci. 2015 Mar 4;16(3):4973-84. doi: 10.3390/ijms16034973. Review.


Angiogenesis induced by prenatal ischemia predisposes to periventricular hemorrhage during postnatal mechanical ventilation.

Tosun C, Hong C, Carusillo B, Ivanova S, Gerzanich V, Simard JM.

Pediatr Res. 2015 May;77(5):663-73. doi: 10.1038/pr.2015.34. Epub 2015 Feb 9.


A novel method to study cerebrospinal fluid dynamics in rats.

Karimy JK, Kahle KT, Kurland DB, Yu E, Gerzanich V, Simard JM.

J Neurosci Methods. 2015 Feb 15;241:78-84. doi: 10.1016/j.jneumeth.2014.12.015. Epub 2014 Dec 30.


Mechanisms of astrocyte-mediated cerebral edema.

Stokum JA, Kurland DB, Gerzanich V, Simard JM.

Neurochem Res. 2015 Feb;40(2):317-28. doi: 10.1007/s11064-014-1374-3. Epub 2014 Jul 5. Review.


The Sur1-Trpm4 Channel in Spinal Cord Injury.

Simard JM, Woo SK, Aarabi B, Gerzanich V.

J Spine. 2013 Aug 17;Suppl 4. pii: 002.


Exposure of the thorax to a sublethal blast wave causes a hydrodynamic pulse that leads to perivenular inflammation in the brain.

Simard JM, Pampori A, Keledjian K, Tosun C, Schwartzbauer G, Ivanova S, Gerzanich V.

J Neurotrauma. 2014 Jul 15;31(14):1292-304. doi: 10.1089/neu.2013.3016. Epub 2014 Jun 3.


Biomarkers as outcome predictors in subarachnoid hemorrhage--a systematic review.

Hong CM, Tosun C, Kurland DB, Gerzanich V, Schreibman D, Simard JM.

Biomarkers. 2014 Mar;19(2):95-108. doi: 10.3109/1354750X.2014.881418. Epub 2014 Feb 5. Review.


Disruption of ion homeostasis in the neurogliovascular unit underlies the pathogenesis of ischemic cerebral edema.

Khanna A, Kahle KT, Walcott BP, Gerzanich V, Simard JM.

Transl Stroke Res. 2014 Feb;5(1):3-16. doi: 10.1007/s12975-013-0307-9. Epub 2013 Nov 22. Review.


Glibenclamide for the treatment of acute CNS injury.

Kurland DB, Tosun C, Pampori A, Karimy JK, Caffes NM, Gerzanich V, Simard JM.

Pharmaceuticals (Basel). 2013 Oct 11;6(10):1287-303. doi: 10.3390/ph6101287.


Complex N-glycosylation stabilizes surface expression of transient receptor potential melastatin 4b protein.

Woo SK, Kwon MS, Ivanov A, Geng Z, Gerzanich V, Simard JM.

J Biol Chem. 2013 Dec 20;288(51):36409-17. doi: 10.1074/jbc.M113.530584. Epub 2013 Nov 8.


Glibenclamide in cerebral ischemia and stroke.

Simard JM, Sheth KN, Kimberly WT, Stern BJ, del Zoppo GJ, Jacobson S, Gerzanich V.

Neurocrit Care. 2014 Apr;20(2):319-33. doi: 10.1007/s12028-013-9923-1. Review.


Inhibition of the Sur1-Trpm4 channel reduces neuroinflammation and cognitive impairment in subarachnoid hemorrhage.

Tosun C, Kurland DB, Mehta R, Castellani RJ, deJong JL, Kwon MS, Woo SK, Gerzanich V, Simard JM.

Stroke. 2013 Dec;44(12):3522-8. doi: 10.1161/STROKEAHA.113.002904. Epub 2013 Oct 10.


MRI evidence that glibenclamide reduces acute lesion expansion in a rat model of spinal cord injury.

Simard JM, Popovich PG, Tsymbalyuk O, Caridi J, Gullapalli RP, Kilbourne MJ, Gerzanich V.

Spinal Cord. 2013 Nov;51(11):823-7. doi: 10.1038/sc.2013.99. Epub 2013 Sep 17.


Sulfonylurea receptor 1 expression in human cerebral infarcts.

Mehta RI, Ivanova S, Tosun C, Castellani RJ, Gerzanich V, Simard JM.

J Neuropathol Exp Neurol. 2013 Sep;72(9):871-83. doi: 10.1097/NEN.0b013e3182a32e40.


The protective effect of glibenclamide in a model of hemorrhagic encephalopathy of prematurity.

Tosun C, Koltz MT, Kurland DB, Ijaz H, Gurakar M, Schwartzbauer G, Coksaygan T, Ivanova S, Gerzanich V, Simard JM.

Brain Sci. 2013 Mar 7;3(1):215-38. doi: 10.3390/brainsci3010215.


The sulfonylurea receptor 1 (Sur1)-transient receptor potential melastatin 4 (Trpm4) channel.

Woo SK, Kwon MS, Ivanov A, Gerzanich V, Simard JM.

J Biol Chem. 2013 Feb 1;288(5):3655-67. doi: 10.1074/jbc.M112.428219. Epub 2012 Dec 19.


Transient receptor potential melastatin 4 and cell death.

Simard JM, Woo SK, Gerzanich V.

Pflugers Arch. 2012 Dec;464(6):573-82. doi: 10.1007/s00424-012-1166-z. Epub 2012 Oct 13. Review.


Does inhibiting Sur1 complement rt-PA in cerebral ischemia?

Simard JM, Geng Z, Silver FL, Sheth KN, Kimberly WT, Stern BJ, Colucci M, Gerzanich V.

Ann N Y Acad Sci. 2012 Sep;1268:95-107. doi: 10.1111/j.1749-6632.2012.06705.x. Review.


Sulfonylurea receptor 1 in central nervous system injury: a focused review.

Simard JM, Woo SK, Schwartzbauer GT, Gerzanich V.

J Cereb Blood Flow Metab. 2012 Sep;32(9):1699-717. doi: 10.1038/jcbfm.2012.91. Epub 2012 Jun 20. Review.


Heparin reduces neuroinflammation and transsynaptic neuronal apoptosis in a model of subarachnoid hemorrhage.

Simard JM, Tosun C, Ivanova S, Kurland DB, Hong C, Radecki L, Gisriel C, Mehta R, Schreibman D, Gerzanich V.

Transl Stroke Res. 2012 Jul;3(Suppl 1):155-65. doi: 10.1007/s12975-012-0166-9. Epub 2012 Apr 14.


Glibenclamide-10-h Treatment Window in a Clinically Relevant Model of Stroke.

Simard JM, Woo SK, Tsymbalyuk N, Voloshyn O, Yurovsky V, Ivanova S, Lee R, Gerzanich V.

Transl Stroke Res. 2012 Jun;3(2):286-95. doi: 10.1007/s12975-012-0149-x. Epub 2012 Mar 7.

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