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Type I Interferon Therapy Limits CNS Autoimmunity by Inhibiting CXCR3-Mediated Trafficking of Pathogenic Effector T Cells.

Wang W, Chong WP, Li C, Chen Z, Wu S, Zhou H, Wan Y, Chen W, Gery I, Liu Y, Caspi RR, Chen J.

Cell Rep. 2019 Jul 9;28(2):486-497.e4. doi: 10.1016/j.celrep.2019.06.021.


Tolerance Induction in Relation to the Eye.

Gery I, Caspi RR.

Front Immunol. 2018 Oct 9;9:2304. doi: 10.3389/fimmu.2018.02304. eCollection 2018. Review.


TMP778, a selective inhibitor of RORγt, suppresses experimental autoimmune uveitis development, but affects both Th17 and Th1 cell populations.

Lyu C, Bing SJ, Wandu WS, Xu B, Shi G, Hinshaw SJ, Lobera M, Caspi RR, Lu L, Yang J, Gery I.

Eur J Immunol. 2018 Nov;48(11):1810-1816. doi: 10.1002/eji.201747029. Epub 2018 Oct 9.


Unlike Th1/Th17 cells, Th2/Th9 cells selectively migrate to the limbus/conjunctiva and initiate an eosinophilic infiltration process.

Tan C, Wandu WS, St Leger A, Kielczewski J, Wawrousek EF, Chan CC, Gery I.

Exp Eye Res. 2018 Jan;166:116-119. doi: 10.1016/j.exer.2017.10.019. Epub 2017 Oct 24.


Chronic, Systemic Interleukin-18 Does Not Promote Macular Degeneration or Choroidal Neovascularization.

Canna SW, Shi G, Gery I, Sen HN.

Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1764-1765. doi: 10.1167/iovs.17-21697. No abstract available.


Robert Burton Nussenblatt, MD, MPH (1948-2016), Physician-Scientist, Leading Ophthalmologist and Exemplary Teacher.

Gery I.

J Ocul Pharmacol Ther. 2017 May;33(4):211-212. doi: 10.1089/ Epub 2017 Mar 7. No abstract available.


Shedding New Light on the Process of "Licensing" for Pathogenicity by Th Lymphocytes.

Tan C, Wandu WS, Lee RS, Hinshaw SH, Klinman DM, Wawrousek E, Gery I.

J Immunol. 2017 Jan 15;198(2):681-690. doi: 10.4049/jimmunol.1502108. Epub 2016 Dec 16.


Digoxin Inhibits Induction of Experimental Autoimmune Uveitis in Mice, but Causes Severe Retinal Degeneration.

Hinshaw SJ, Ogbeifun O, Wandu WS, Lyu C, Shi G, Li Y, Qian H, Gery I.

Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1441-7. doi: 10.1167/iovs.15-19040.


Correction: The TNF-Family Ligand TL1A and Its Receptor DR3 Promote T Cell-Mediated Allergic Immunopathology by Enhancing Differentiation and Pathogenicity of IL-9-Producing T Cells.

Richard AC, Tan C, Hawley ET, Gomez-Rodriguez J, Goswami R, Yang XP, Cruz AC, Penumetcha P, Hayes ET, Pelletier M, Gabay O, Walsh M, Ferdinand JR, Keane-Myers A, Choi Y, O'Shea JJ, Al-Shamkhani A, Kaplan MH, Gery I, Siegel RM, Meylan F.

J Immunol. 2015 Dec 15;195(12):5839-40. doi: 10.4049/jimmunol.1502026. No abstract available.


Leucine-Rich Repeat Kinase 2 (Lrrk2) Deficiency Diminishes the Development of Experimental Autoimmune Uveitis (EAU) and the Adaptive Immune Response.

Wandu WS, Tan C, Ogbeifun O, Vistica BP, Shi G, Hinshaw SJ, Xie C, Chen X, Klinman DM, Cai H, Gery I.

PLoS One. 2015 Jun 11;10(6):e0128906. doi: 10.1371/journal.pone.0128906. eCollection 2015.


The TNF-family ligand TL1A and its receptor DR3 promote T cell-mediated allergic immunopathology by enhancing differentiation and pathogenicity of IL-9-producing T cells.

Richard AC, Tan C, Hawley ET, Gomez-Rodriguez J, Goswami R, Yang XP, Cruz AC, Penumetcha P, Hayes ET, Pelletier M, Gabay O, Walsh M, Ferdinand JR, Keane-Myers A, Choi Y, O'Shea JJ, Al-Shamkhani A, Kaplan MH, Gery I, Siegel RM, Meylan F.

J Immunol. 2015 Apr 15;194(8):3567-82. doi: 10.4049/jimmunol.1401220. Epub 2015 Mar 18. Erratum in: J Immunol. 2015 Dec 15;195(12):5839-40.


Glucocorticoid-resistant Th17 cells are selectively attenuated by cyclosporine A.

Schewitz-Bowers LP, Lait PJ, Copland DA, Chen P, Wu W, Dhanda AD, Vistica BP, Williams EL, Liu B, Jawad S, Li Z, Tucker W, Hirani S, Wakabayashi Y, Zhu J, Sen N, Conway-Campbell BL, Gery I, Dick AD, Wei L, Nussenblatt RB, Lee RW.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4080-5. doi: 10.1073/pnas.1418316112. Epub 2015 Mar 16.


Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1β and IL-18.

Shi G, Chen S, Wandu WS, Ogbeifun O, Nugent LF, Maminishkis A, Hinshaw SJ, Rodriguez IR, Gery I.

Invest Ophthalmol Vis Sci. 2015 Feb 12;56(3):1658-64. doi: 10.1167/iovs.14-14557.


The definition of lymphocyte activating factor: giving a helping hand to serendipity.

Gery I.

Front Immunol. 2014 Nov 28;5:610. doi: 10.3389/fimmu.2014.00610. eCollection 2014. No abstract available.


Induced regulatory T-cells (iTregs) generated by activation with anti-CD3/CD28 antibodies differ from those generated by the physiological-like activation with antigen/APC.

Zhao C, Shi G, Vistica BP, Hinshaw SJ, Wandu WS, Tan C, Zhang M, Gery I.

Cell Immunol. 2014 Aug;290(2):179-84. doi: 10.1016/j.cellimm.2014.06.004. Epub 2014 Jun 27.


Phenotypes of Th lineages generated by the commonly used activation with anti-CD3/CD28 antibodies differ from those generated by the physiological activation with the specific antigen.

Tan C, Wei L, Vistica BP, Shi G, Wawrousek EF, Gery I.

Cell Mol Immunol. 2014 May;11(3):305-13. doi: 10.1038/cmi.2014.8. Epub 2014 Mar 3.


ITE, a novel endogenous nontoxic aryl hydrocarbon receptor ligand, efficiently suppresses EAU and T-cell-mediated immunity.

Nugent LF, Shi G, Vistica BP, Ogbeifun O, Hinshaw SJ, Gery I.

Invest Ophthalmol Vis Sci. 2013 Nov 13;54(12):7463-9. doi: 10.1167/iovs.12-11479.


Environmental factors determine DAP12 deficiency to either enhance or suppress immunopathogenic processes.

Montalvo V, Quigley L, Vistica BP, Boelte KC, Nugent LF, Takai T, McVicar DW, Gery I.

Immunology. 2013 Dec;140(4):475-82. doi: 10.1111/imm.12158.


Differential involvement of Th1 and Th17 in pathogenic autoimmune processes triggered by different TLR ligands.

Shi G, Vistica BP, Nugent LF, Tan C, Wawrousek EF, Klinman DM, Gery I.

J Immunol. 2013 Jul 1;191(1):415-23. doi: 10.4049/jimmunol.1201732. Epub 2013 May 29.


SLAT/Def6 plays a critical role in the pathogenic process of experimental autoimmune uveitis (EAU).

Vistica BP, Shi G, Nugent L, Tan C, Altman A, Gery I.

Mol Vis. 2012;18:1858-64. Epub 2012 Jul 7.


Cell-cell interaction with APC, not IL-23, is required for naive CD4 cells to acquire pathogenicity during Th17 lineage commitment.

Shi G, Lovaas JD, Tan C, Vistica BP, Wawrousek EF, Aziz MK, Rigden RC, Caspi RR, Gery I.

J Immunol. 2012 Aug 1;189(3):1220-7. doi: 10.4049/jimmunol.1103033. Epub 2012 Jun 27.


The unique features of Th9 cells and their products.

Tan C, Gery I.

Crit Rev Immunol. 2012;32(1):1-10. Review.


Inflammation-inducing Th1 and Th17 cells differ in their expression patterns of apoptosis-related molecules.

Tan C, Ramaswamy M, Shi G, Vistica BP, Siegel RM, Gery I.

Cell Immunol. 2011;271(2):210-3. doi: 10.1016/j.cellimm.2011.08.006. Epub 2011 Aug 17.


Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site.

Tan C, Aziz MK, Lovaas JD, Vistica BP, Shi G, Wawrousek EF, Gery I.

J Immunol. 2010 Dec 1;185(11):6795-801. doi: 10.4049/jimmunol.1001676. Epub 2010 Oct 22.


Remembering Professor David BenEzra, M.D., Ph.D., 1942-2008.

Gery I, Alio JL.

J Ophthalmic Inflamm Infect. 2010 Nov 17;1(1):3-5. doi: 10.1007/s12348-010-0006-6. No abstract available.


Unlike Th1, Th17 cells mediate sustained autoimmune inflammation and are highly resistant to restimulation-induced cell death.

Shi G, Ramaswamy M, Vistica BP, Cox CA, Tan C, Wawrousek EF, Siegel RM, Gery I.

J Immunol. 2009 Dec 1;183(11):7547-56. doi: 10.4049/jimmunol.0900519. Epub 2009 Nov 4.


Inhibition of experimental autoimmune uveitis by amino acid copolymers.

Yin H, Vistica BP, Chan CC, Strominger JL, Gery I.

J Neuroimmunol. 2009 Oct 30;215(1-2):43-8. doi: 10.1016/j.jneuroim.2009.08.002. Epub 2009 Sep 11.


A suppressive oligodeoxynucleotide inhibits ocular inflammation.

Fujimoto C, Klinman DM, Shi G, Yin H, Vistica BP, Lovaas JD, Wawrousek EF, Igarashi T, Chan CC, Gery I.

Clin Exp Immunol. 2009 Jun;156(3):528-34. doi: 10.1111/j.1365-2249.2009.03918.x.


Constitutive pro-apoptotic molecules are differentially expressed in the fetal and adult mouse eye.

Montalvo V, Gery I.

Curr Eye Res. 2009 Apr;34(4):328-32. doi: 10.1080/02713680902741688.


Empathy and recognition of facial expressions of emotion in sex offenders, non-sex offenders and normal controls.

Gery I, Miljkovitch R, Berthoz S, Soussignan R.

Psychiatry Res. 2009 Feb 28;165(3):252-62. doi: 10.1016/j.psychres.2007.11.006. Epub 2009 Jan 22.


Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cells.

Shi G, Cox CA, Vistica BP, Tan C, Wawrousek EF, Gery I.

J Immunol. 2008 Nov 15;181(10):7205-13.


Both Th1 and Th17 are immunopathogenic but differ in other key biological activities.

Cox CA, Shi G, Yin H, Vistica BP, Wawrousek EF, Chan CC, Gery I.

J Immunol. 2008 Jun 1;180(11):7414-22.


Microbial products trigger autoimmune ocular inflammation.

Fujimoto C, Shi G, Gery I.

Ophthalmic Res. 2008;40(3-4):193-9. doi: 10.1159/000119875. Epub 2008 Apr 18.


Complement deposits on ocular tissues adjacent to sites of inflammation.

Montalvo V, Campos MM, Chan CC, Wawrousek EF, Bush RA, Lambris JD, Gery I.

Curr Eye Res. 2007 Nov;32(11):917-22. Erratum in: Curr Eye Res. 2008 Jan;33(1):109.


Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link?

Ganguly S, Grodzki C, Sugden D, Møller M, Odom S, Gaildrat P, Gery I, Siraganian RP, Rivera J, Klein DC.

J Biol Chem. 2007 Nov 9;282(45):32758-64. Epub 2007 Aug 29.


TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1.

Amadi-Obi A, Yu CR, Liu X, Mahdi RM, Clarke GL, Nussenblatt RB, Gery I, Lee YS, Egwuagu CE.

Nat Med. 2007 Jun;13(6):711-8. Epub 2007 May 13.


Pertussis toxin is superior to TLR ligands in enhancing pathogenic autoimmunity, targeted at a neo-self antigen, by triggering robust expansion of Th1 cells and their cytokine production.

Fujimoto C, Yu CR, Shi G, Vistica BP, Wawrousek EF, Klinman DM, Chan CC, Egwuagu CE, Gery I.

J Immunol. 2006 Nov 15;177(10):6896-903.


Osteopontin is proinflammatory in experimental autoimmune uveitis.

Hikita ST, Vistica BP, Jones HR, Keswani JR, Watson MM, Ericson VR, Ayoub GS, Gery I, Clegg DO.

Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4435-43.


Active participation of antigen-nonspecific lymphoid cells in immune-mediated inflammation.

Chen J, Fujimoto C, Vistica BP, He J, Wawrousek EF, Kelsall B, Gery I.

J Immunol. 2006 Sep 1;177(5):3362-8. Erratum in: J Immunol. 2007 Apr 15;178(8):5398. He, JianPing [added].


Inflammatory processes triggered by TCR engagement or by local cytokine expression: differences in profiles of gene expression and infiltrating cell populations.

Takase H, Yu CR, Ham DI, Chan CC, Chen J, Vistica BP, Wawrousek EF, Durum SK, Egwuagu CE, Gery I.

J Leukoc Biol. 2006 Sep;80(3):538-45. Epub 2006 Jun 22.


The level of thymic expression of RPE65 inversely correlates with its capacity to induce experimental autoimmune uveitis (EAU) in different rodent strains.

Ham DI, Fujimoto C, Gentleman S, Chan CC, Yu CR, Yu S, Egwuagu CE, Michael Redmond T, Gery I.

Exp Eye Res. 2006 Oct;83(4):897-902. Epub 2006 Jun 13.


Thymic expression of peripheral tissue antigens in humans: a remarkable variability among individuals.

Takase H, Yu CR, Mahdi RM, Douek DC, Dirusso GB, Midgley FM, Dogra R, Allende G, Rosenkranz E, Pugliese A, Egwuagu CE, Gery I.

Int Immunol. 2005 Aug;17(8):1131-40. Epub 2005 Jul 19.


Suppression of immune-mediated ocular inflammation in mice by interleukin 1 receptor antagonist administration.

Lim WK, Fujimoto C, Ursea R, Mahesh SP, Silver P, Chan CC, Gery I, Nussenblatt RB.

Arch Ophthalmol. 2005 Jul;123(7):957-63.


The immunomodulator vasoactive intestinal peptide (VIP) does not affect experimental autoimmune uveitis (EAU) in B10.RIII mice.

Chen J, Vistica B, Wiggert B, Chan CC, Gery I.

Ocul Immunol Inflamm. 2005 Feb;13(1):13-7.


Differential expression of splice variants of chemokine CCL27 mRNA in lens, cornea, and retina of the normal mouse eye.

Ledee DR, Chen J, Tonelli LH, Takase H, Gery I, Zelenka PS.

Mol Vis. 2004 Sep 14;10:663-7.


A unique pattern of up- and down-regulation of chemokine receptor CXCR3 on inflammation-inducing Th1 cells.

Chen J, Vistica BP, Takase H, Ham DI, Fariss RN, Wawrousek EF, Chan CC, DeMartino JA, Farber JM, Gery I.

Eur J Immunol. 2004 Oct;34(10):2885-94.


Cell proliferation and STAT6 pathways are negatively regulated in T cells by STAT1 and suppressors of cytokine signaling.

Yu CR, Mahdi RM, Ebong S, Vistica BP, Chen J, Guo Y, Gery I, Egwuagu CE.

J Immunol. 2004 Jul 15;173(2):737-46.


The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration.

Tuo J, Smith BC, Bojanowski CM, Meleth AD, Gery I, Csaky KG, Chew EY, Chan CC.

FASEB J. 2004 Aug;18(11):1297-9. Epub 2004 Jun 18.


Central immunotolerance in transgenic mice expressing a foreign antigen under control of the rhodopsin promoter.

Ham DI, Kim SJ, Chen J, Vistica BP, Fariss RN, Lee RS, Wawrousek EF, Takase H, Yu CR, Egwuagu CE, Chan CC, Gery I.

Invest Ophthalmol Vis Sci. 2004 Mar;45(3):857-62.


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