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Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents.

Almaliti J, Miller B, Pietraszkiewicz H, Glukhov E, Naman CB, Kline T, Hanson J, Li X, Zhou S, Valeriote FA, Gerwick WH.

Eur J Med Chem. 2019 Jan 1;161:416-432. doi: 10.1016/j.ejmech.2018.10.024. Epub 2018 Oct 15.


The Metabolome of a Cyanobacterial Bloom Visualized by MS/MS-Based Molecular Networking Reveals New Neurotoxic Smenamide Analogs (C, D, and E).

Via CW, Glukhov E, Costa S, Zimba PV, Moeller PDR, Gerwick WH, Bertin MJ.

Front Chem. 2018 Jul 26;6:316. doi: 10.3389/fchem.2018.00316. eCollection 2018.


The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.

McAlpine JB, Chen SN, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI, Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam JW, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM, Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF.

Nat Prod Rep. 2018 Jul 13. doi: 10.1039/c7np00064b. [Epub ahead of print] Review.


Identification of a 3-Alkylpyridinium Compound from the Red Sea Sponge Amphimedon chloros with In Vitro Inhibitory Activity against the West Nile Virus NS3 Protease.

O'Rourke A, Kremb S, Duggan BM, Sioud S, Kharbatia N, Raji M, Emwas AH, Gerwick WH, Voolstra CR.

Molecules. 2018 Jun 18;23(6). pii: E1472. doi: 10.3390/molecules23061472.


Corrigendum to: "Alkaloids from Corydalis decumbens suppress neuronal excitability in primary cultures of mouse neocortical neurons" [Phytochemistry (2018) 150 85-92].

Huang Q, Chen J, Zhang W, Zhou B, Zhang C, Gerwick WH, Cao Z.

Phytochemistry. 2018 Oct;154:106-107. doi: 10.1016/j.phytochem.2018.06.004. Epub 2018 Jun 13. No abstract available.


Collection, Culturing, and Genome Analyses of Tropical Marine Filamentous Benthic Cyanobacteria.

Moss NA, Leao T, Glukhov E, Gerwick L, Gerwick WH.

Methods Enzymol. 2018;604:3-43. doi: 10.1016/bs.mie.2018.02.014. Epub 2018 Apr 27.


Characterization of Rhamnolipids Produced by an Arctic Marine Bacterium from the Pseudomonas fluorescence Group.

Kristoffersen V, Rämä T, Isaksson J, Andersen JH, Gerwick WH, Hansen E.

Mar Drugs. 2018 May 14;16(5). pii: E163. doi: 10.3390/md16050163.


Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module.

Skiba MA, Sikkema AP, Moss NA, Lowell AN, Su M, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL.

ACS Chem Biol. 2018 Jun 15;13(6):1640-1650. doi: 10.1021/acschembio.8b00252. Epub 2018 May 8.


Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β.

Wang J, Zheng J, Huang C, Zhao J, Lin J, Zhou X, Naman CB, Wang N, Gerwick WH, Wang Q, Yan X, Cui W, He S.

ACS Chem Neurosci. 2018 Jun 20;9(6):1349-1356. doi: 10.1021/acschemneuro.7b00527. Epub 2018 Apr 10.


Alkaloids from Corydalis decumbens suppress neuronal excitability in primary cultures of mouse neocortical neurons.

Huang Q, Chen J, Zhang W, Zhou B, Zhang C, Gerwick WH, Cao Z.

Phytochemistry. 2018 Jun;150:85-92. doi: 10.1016/j.phytochem.2018.03.006. Epub 2018 Mar 20. Erratum in: Phytochemistry. 2018 Oct;154:106-107.


Samholides, Swinholide-Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp.

Tao Y, Li P, Zhang D, Glukhov E, Gerwick L, Zhang C, Murray TF, Gerwick WH.

J Org Chem. 2018 Mar 16;83(6):3034-3046. doi: 10.1021/acs.joc.8b00028. Epub 2018 Mar 8.


Bastimolide B, an Antimalarial 24-Membered Marine Macrolide Possessing a tert-Butyl Group.

Shao CL, Mou XF, Cao F, Spadafora C, Glukhov E, Gerwick L, Wang CY, Gerwick WH.

J Nat Prod. 2018 Jan 26;81(1):211-215. doi: 10.1021/acs.jnatprod.7b00917. Epub 2018 Jan 12.


Marine Natural Product Honaucin A Attenuates Inflammation by Activating the Nrf2-ARE Pathway.

Mascuch SJ, Boudreau PD, Carland TM, Pierce NT, Olson J, Hensler ME, Choi H, Campanale J, Hamdoun A, Nizet V, Gerwick WH, Gaasterland T, Gerwick L.

J Nat Prod. 2018 Mar 23;81(3):506-514. doi: 10.1021/acs.jnatprod.7b00734. Epub 2017 Dec 7.


A Mononuclear Iron-Dependent Methyltransferase Catalyzes Initial Steps in Assembly of the Apratoxin A Polyketide Starter Unit.

Skiba MA, Sikkema AP, Moss NA, Tran CL, Sturgis RM, Gerwick L, Gerwick WH, Sherman DH, Smith JL.

ACS Chem Biol. 2017 Dec 15;12(12):3039-3048. doi: 10.1021/acschembio.7b00746. Epub 2017 Nov 14.


Small Molecule Accurate Recognition Technology (SMART) to Enhance Natural Products Research.

Zhang C, Idelbayev Y, Roberts N, Tao Y, Nannapaneni Y, Duggan BM, Min J, Lin EC, Gerwick EC, Cottrell GW, Gerwick WH.

Sci Rep. 2017 Oct 27;7(1):14243. doi: 10.1038/s41598-017-13923-x.


Fucoxanthin, a Marine Carotenoid, Attenuates β-Amyloid Oligomer-Induced Neurotoxicity Possibly via Regulating the PI3K/Akt and the ERK Pathways in SH-SY5Y Cells.

Lin J, Yu J, Zhao J, Zhang K, Zheng J, Wang J, Huang C, Zhang J, Yan X, Gerwick WH, Wang Q, Cui W, He S.

Oxid Med Cell Longev. 2017;2017:6792543. doi: 10.1155/2017/6792543. Epub 2017 Aug 8.


The Face of a Molecule.

Gerwick WH.

J Nat Prod. 2017 Sep 22;80(9):2583-2588. doi: 10.1021/acs.jnatprod.7b00624. Epub 2017 Sep 8.


5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34.

Fang F, Zhao J, Ding L, Huang C, Naman CB, He S, Wu B, Zhu P, Luo Q, Gerwick WH, Yan X, Wang Q, Zhang Z, Cui W.

Mar Drugs. 2017 Aug 19;15(8). pii: E260. doi: 10.3390/md15080260.


Discovery and Synthesis of Caracolamide A, an Ion Channel Modulating Dichlorovinylidene Containing Phenethylamide from a Panamanian Marine Cyanobacterium cf. Symploca Species.

Naman CB, Almaliti J, Armstrong L, Caro-Díaz EJ, Pierce ML, Glukhov E, Fenner A, Spadafora C, Debonsi HM, Dorrestein PC, Murray TF, Gerwick WH.

J Nat Prod. 2017 Aug 25;80(8):2328-2334. doi: 10.1021/acs.jnatprod.7b00367. Epub 2017 Aug 7.


Reply to Skinnider and Magarvey: Rates of novel natural product discovery remain high.

Pye CR, Bertin MJ, Lokey RS, Gerwick WH, Linington RG.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6273. doi: 10.1073/pnas.1711139114. Epub 2017 Jul 14. No abstract available.


Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity.

LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, Gerwick WH, Ottilie S.

J Med Chem. 2017 Aug 10;60(15):6721-6732. doi: 10.1021/acs.jmedchem.7b00671. Epub 2017 Jul 25.


Dudawalamides A-D, Antiparasitic Cyclic Depsipeptides from the Marine Cyanobacterium Moorea producens.

Almaliti J, Malloy KL, Glukhov E, Spadafora C, Gutiérrez M, Gerwick WH.

J Nat Prod. 2017 Jun 23;80(6):1827-1836. doi: 10.1021/acs.jnatprod.7b00034. Epub 2017 May 23.


Digitizing mass spectrometry data to explore the chemical diversity and distribution of marine cyanobacteria and algae.

Luzzatto-Knaan T, Garg N, Wang M, Glukhov E, Peng Y, Ackermann G, Amir A, Duggan BM, Ryazanov S, Gerwick L, Knight R, Alexandrov T, Bandeira N, Gerwick WH, Dorrestein PC.

Elife. 2017 May 11;6. pii: e24214. doi: 10.7554/eLife.24214.


Retrospective analysis of natural products provides insights for future discovery trends.

Pye CR, Bertin MJ, Lokey RS, Gerwick WH, Linington RG.

Proc Natl Acad Sci U S A. 2017 May 30;114(22):5601-5606. doi: 10.1073/pnas.1614680114. Epub 2017 May 1.


A Maldiisotopic Approach to Discover Natural Products: Cryptomaldamide, a Hybrid Tripeptide from the Marine Cyanobacterium Moorea producens.

Kinnel RB, Esquenazi E, Leao T, Moss N, Mevers E, Pereira AR, Monroe EA, Korobeynikov A, Murray TF, Sherman D, Gerwick L, Dorrestein PC, Gerwick WH.

J Nat Prod. 2017 May 26;80(5):1514-1521. doi: 10.1021/acs.jnatprod.7b00019. Epub 2017 Apr 27.


Laucysteinamide A, a Hybrid PKS/NRPS Metabolite from a Saipan Cyanobacterium, cf. Caldora penicillata.

Zhang C, Naman CB, Engene N, Gerwick WH.

Mar Drugs. 2017 Apr 14;15(4). pii: E121. doi: 10.3390/md15040121.


Streptomyces artemisiae MCCB 248 isolated from Arctic fjord sediments has unique PKS and NRPS biosynthetic genes and produces potential new anticancer natural products.

Dhaneesha M, Benjamin Naman C, Krishnan KP, Sinha RK, Jayesh P, Joseph V, Bright Singh IS, Gerwick WH, Sajeevan TP.

3 Biotech. 2017 May;7(1):32. doi: 10.1007/s13205-017-0610-3. Epub 2017 Apr 11.


Comparative genomics uncovers the prolific and distinctive metabolic potential of the cyanobacterial genus Moorea.

Leao T, Castelão G, Korobeynikov A, Monroe EA, Podell S, Glukhov E, Allen EE, Gerwick WH, Gerwick L.

Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3198-3203. doi: 10.1073/pnas.1618556114. Epub 2017 Mar 6.


Integrating Molecular Networking and Biological Assays To Target the Isolation of a Cytotoxic Cyclic Octapeptide, Samoamide A, from an American Samoan Marine Cyanobacterium.

Naman CB, Rattan R, Nikoulina SE, Lee J, Miller BW, Moss NA, Armstrong L, Boudreau PD, Debonsi HM, Valeriote FA, Dorrestein PC, Gerwick WH.

J Nat Prod. 2017 Mar 24;80(3):625-633. doi: 10.1021/acs.jnatprod.6b00907. Epub 2017 Jan 5.


Corrigendum: Biosynthesis-Assisted Structural Elucidation of the Bartolosides, Chlorinated Aromatic Glycolipids from Cyanobacteria.

Leão PN, Nakamura H, Costa M, Pereira AR, Martins R, Vasconcelos V, Gerwick WH, Balskus EP.

Angew Chem Int Ed Engl. 2016 Nov 21;55(48):14895. doi: 10.1002/anie.201609701. No abstract available.


Bissubvilides A and B, Cembrane-Capnosane Heterodimers from the Soft Coral Sarcophyton subviride.

Sun P, Yu Q, Li J, Riccio R, Lauro G, Bifulco G, Kurtán T, Mándi A, Tang H, Li TJ, Zhuang CL, Gerwick WH, Zhang W.

J Nat Prod. 2016 Oct 28;79(10):2552-2558. Epub 2016 Oct 5.


Domain Organization and Active Site Architecture of a Polyketide Synthase C-methyltransferase.

Skiba MA, Sikkema AP, Fiers WD, Gerwick WH, Sherman DH, Aldrich CC, Smith JL.

ACS Chem Biol. 2016 Dec 16;11(12):3319-3327. Epub 2016 Oct 18.


Bioactive new metabolites from the green alga Udotea orientalis growing on the Gorgonian coral Pseudopterogorgia rigida.

Sabry OM, Goeger DE, Gerwick WH.

Nat Prod Res. 2017 Jun;31(11):1245-1250. doi: 10.1080/14786419.2016.1236096. Epub 2016 Sep 22.


Cytotoxic halogenated monoterpenes from Plocamium cartilagineum.

Sabry OM, Goeger DE, Valeriote FA, Gerwick WH.

Nat Prod Res. 2017 Feb;31(3):261-267. Epub 2016 Sep 14.


A novel uncultured heterotrophic bacterial associate of the cyanobacterium Moorea producens JHB.

Cummings SL, Barbé D, Leao TF, Korobeynikov A, Engene N, Glukhov E, Gerwick WH, Gerwick L.

BMC Microbiol. 2016 Aug 30;16(1):198. doi: 10.1186/s12866-016-0817-1.


Anatomy of the β-branching enzyme of polyketide biosynthesis and its interaction with an acyl-ACP substrate.

Maloney FP, Gerwick L, Gerwick WH, Sherman DH, Smith JL.

Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):10316-21. doi: 10.1073/pnas.1607210113. Epub 2016 Aug 29.


Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking.

Wang M, Carver JJ, Phelan VV, Sanchez LM, Garg N, Peng Y, Nguyen DD, Watrous J, Kapono CA, Luzzatto-Knaan T, Porto C, Bouslimani A, Melnik AV, Meehan MJ, Liu WT, Crüsemann M, Boudreau PD, Esquenazi E, Sandoval-Calderón M, Kersten RD, Pace LA, Quinn RA, Duncan KR, Hsu CC, Floros DJ, Gavilan RG, Kleigrewe K, Northen T, Dutton RJ, Parrot D, Carlson EE, Aigle B, Michelsen CF, Jelsbak L, Sohlenkamp C, Pevzner P, Edlund A, McLean J, Piel J, Murphy BT, Gerwick L, Liaw CC, Yang YL, Humpf HU, Maansson M, Keyzers RA, Sims AC, Johnson AR, Sidebottom AM, Sedio BE, Klitgaard A, Larson CB, P CAB, Torres-Mendoza D, Gonzalez DJ, Silva DB, Marques LM, Demarque DP, Pociute E, O'Neill EC, Briand E, Helfrich EJN, Granatosky EA, Glukhov E, Ryffel F, Houson H, Mohimani H, Kharbush JJ, Zeng Y, Vorholt JA, Kurita KL, Charusanti P, McPhail KL, Nielsen KF, Vuong L, Elfeki M, Traxler MF, Engene N, Koyama N, Vining OB, Baric R, Silva RR, Mascuch SJ, Tomasi S, Jenkins S, Macherla V, Hoffman T, Agarwal V, Williams PG, Dai J, Neupane R, Gurr J, Rodríguez AMC, Lamsa A, Zhang C, Dorrestein K, Duggan BM, Almaliti J, Allard PM, Phapale P, Nothias LF, Alexandrov T, Litaudon M, Wolfender JL, Kyle JE, Metz TO, Peryea T, Nguyen DT, VanLeer D, Shinn P, Jadhav A, Müller R, Waters KM, Shi W, Liu X, Zhang L, Knight R, Jensen PR, Palsson BO, Pogliano K, Linington RG, Gutiérrez M, Lopes NP, Gerwick WH, Moore BS, Dorrestein PC, Bandeira N.

Nat Biotechnol. 2016 Aug 9;34(8):828-837. doi: 10.1038/nbt.3597.


Biologically active new metabolites from a Florida collection of Moorea producens.

Sabry OM, Goeger DE, Gerwick WH.

Nat Prod Res. 2017 Mar;31(5):555-561. doi: 10.1080/14786419.2016.1207074. Epub 2016 Jul 18.


Uprolides N, O and P from the Panamanian Octocoral Eunicea succinea.

Torres-Mendoza D, González Y, Gómez-Reyes JF, Guzmán HM, López-Perez JL, Gerwick WH, Fernandez PL, Gutiérrez M.

Molecules. 2016 Jun 22;21(6). pii: E819. doi: 10.3390/molecules21060819.


Small Molecule DFPM Derivative-Activated Plant Resistance Protein Signaling in Roots Is Unaffected by EDS1 Subcellular Targeting Signal and Chemical Genetic Isolation of victr R-Protein Mutants.

Kunz HH, Park J, Mevers E, García AV, Highhouse S, Gerwick WH, Parker JE, Schroeder JI.

PLoS One. 2016 May 24;11(5):e0155937. doi: 10.1371/journal.pone.0155937. eCollection 2016.


Apratoxin Kills Cells by Direct Blockade of the Sec61 Protein Translocation Channel.

Paatero AO, Kellosalo J, Dunyak BM, Almaliti J, Gestwicki JE, Gerwick WH, Taunton J, Paavilainen VO.

Cell Chem Biol. 2016 May 19;23(5):561-566. doi: 10.1016/j.chembiol.2016.04.008.


Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61.

Huang KC, Chen Z, Jiang Y, Akare S, Kolber-Simonds D, Condon K, Agoulnik S, Tendyke K, Shen Y, Wu KM, Mathieu S, Choi HW, Zhu X, Shimizu H, Kotake Y, Gerwick WH, Uenaka T, Woodall-Jappe M, Nomoto K.

Mol Cancer Ther. 2016 Jun;15(6):1208-16. doi: 10.1158/1535-7163.MCT-15-0648. Epub 2016 Mar 29.


Assessment of Anabaena sp. Strain PCC 7120 as a Heterologous Expression Host for Cyanobacterial Natural Products: Production of Lyngbyatoxin A.

Videau P, Wells KN, Singh AJ, Gerwick WH, Philmus B.

ACS Synth Biol. 2016 Sep 16;5(9):978-88. doi: 10.1021/acssynbio.6b00038. Epub 2016 Jun 1.


Role of bacteria in the production and degradation of Microcystis cyanopeptides.

Briand E, Humbert JF, Tambosco K, Bormans M, Gerwick WH.

Microbiologyopen. 2016 Jun;5(3):469-78. doi: 10.1002/mbo3.343. Epub 2016 Feb 25.


Alkaloids from the Sponge Stylissa carteri Present Prospective Scaffolds for the Inhibition of Human Immunodeficiency Virus 1 (HIV-1).

O'Rourke A, Kremb S, Bader TM, Helfer M, Schmitt-Kopplin P, Gerwick WH, Brack-Werner R, Voolstra CR.

Mar Drugs. 2016 Feb 4;14(2). pii: E28. doi: 10.3390/md14020028.


Medusamide A, a Panamanian Cyanobacterial Depsipeptide with Multiple β-Amino Acids.

Fenner AM, Engene N, Spadafora C, Gerwick WH, Balunas MJ.

Org Lett. 2016 Feb 5;18(3):352-5. doi: 10.1021/acs.orglett.5b03110. Epub 2016 Jan 19.


The Phormidolide Biosynthetic Gene Cluster: A trans-AT PKS Pathway Encoding a Toxic Macrocyclic Polyketide.

Bertin MJ, Vulpanovici A, Monroe EA, Korobeynikov A, Sherman DH, Gerwick L, Gerwick WH.

Chembiochem. 2016 Jan;17(2):164-73. doi: 10.1002/cbic.201500467. Epub 2015 Dec 23.


Unique marine derived cyanobacterial biosynthetic genes for chemical diversity.

Kleigrewe K, Gerwick L, Sherman DH, Gerwick WH.

Nat Prod Rep. 2016 Feb;33(2):348-64. doi: 10.1039/c5np00097a. Review.


Kalkipyrone B, a marine cyanobacterial γ-pyrone possessing cytotoxic and anti-fungal activities.

Bertin MJ, Demirkiran O, Navarro G, Moss NA, Lee J, Goldgof GM, Vigil E, Winzeler EA, Valeriote FA, Gerwick WH.

Phytochemistry. 2016 Feb;122:113-118. doi: 10.1016/j.phytochem.2015.11.011. Epub 2015 Nov 26.


Integrating mass spectrometry and genomics for cyanobacterial metabolite discovery.

Moss NA, Bertin MJ, Kleigrewe K, Leão TF, Gerwick L, Gerwick WH.

J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):313-24. doi: 10.1007/s10295-015-1705-7. Epub 2015 Nov 17. Review.

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