Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 170


Total Synthesis of the Endocannabinoid Uptake Inhibitor Guineensine and SAR Studies.

Bartholomäus R, Nicolussi S, Baumann A, Rau M, Simão AC, Gertsch J, Altmann KH.

ChemMedChem. 2019 Sep 4;14(17):1590-1596. doi: 10.1002/cmdc.201900390. Epub 2019 Aug 23.


In Situ Thermal Atomic Layer Etching for Sub-5 nm InGaAs Multigate MOSFETs.

Lu W, Lee Y, Gertsch JC, Murdzek JA, Cavanagh AS, Kong L, Del Alamo JA, George SM.

Nano Lett. 2019 Aug 14;19(8):5159-5166. doi: 10.1021/acs.nanolett.9b01525. Epub 2019 Jul 2.


Cultural perception of triatomine bugs and Chagas disease in Bolivia: a cross-sectional field study.

Salm A, Gertsch J.

Parasit Vectors. 2019 Jun 10;12(1):291. doi: 10.1186/s13071-019-3546-0.


Paradoxical effects of JZL184, an inhibitor of monoacylglycerol lipase, on bone remodelling in healthy and cancer-bearing mice.

Marino S, de Ridder D, Bishop RT, Renema N, Ponzetti M, Sophocleous A, Capulli M, Aljeffery A, Carrasco G, Gens MD, Khogeer A, Ralston SH, Gertsch J, Lamoureux F, Heymann D, Rucci N, Idris AI.

EBioMedicine. 2019 Jun;44:452-466. doi: 10.1016/j.ebiom.2019.05.048. Epub 2019 May 29.


Scaffold and organism hopping with chemical probes.

Gertsch J.

Nat Chem Biol. 2019 May;15(5):428-429. doi: 10.1038/s41589-019-0275-9. No abstract available.


Effects of gamma-hydroxybutyrate on neurophysiological correlates of performance and conflict monitoring.

Dornbierer DA, Kometer M, Von Rotz R, Studerus E, Gertsch J, Gachet MS, Vollenweider FX, Seifritz E, Bosch OG, Quednow BB.

Eur Neuropsychopharmacol. 2019 Apr;29(4):539-548. doi: 10.1016/j.euroneuro.2019.02.004. Epub 2019 Feb 26.


Response to: Is the new ASNM intraoperative neuromonitoring supervision "guideline" a trustworthy guideline? A commentary.

Gertsch JH, Moreira JJ, Lee GR, Hastings JD, Ritzl E, Eccher MA, Shils JL, Balzer GK, Balzer JR, Boucharel W, Guo L, Hanson LL, Hemmer LB, Jahangiri FR, Mendez Vigil JA, Vogel RW, Wierzbowski LR, Wilent WB, Zuccaro JS, Yingling CD.

J Clin Monit Comput. 2019 Apr;33(2):193-194. doi: 10.1007/s10877-019-00288-x. Epub 2019 Feb 26. No abstract available.


Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor.

Granchi C, Lapillo M, Glasmacher S, Bononi G, Licari C, Poli G, El Boustani M, Caligiuri I, Rizzolio F, Gertsch J, Macchia M, Minutolo F, Tuccinardi T, Chicca A.

J Med Chem. 2019 Feb 28;62(4):1932-1958. doi: 10.1021/acs.jmedchem.8b01483. Epub 2019 Feb 11.


Optimizing TRPM4 inhibitors in the MHFP6 chemical space.

Delalande C, Awale M, Rubin M, Probst D, Ozhathil LC, Gertsch J, Abriel H, Reymond JL.

Eur J Med Chem. 2019 Mar 15;166:167-177. doi: 10.1016/j.ejmech.2019.01.048. Epub 2019 Jan 24.


Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high.

Chicca A, Schafroth MA, Reynoso-Moreno I, Erni R, Petrucci V, Carreira EM, Gertsch J.

Sci Adv. 2018 Oct 24;4(10):eaat2166. doi: 10.1126/sciadv.aat2166. eCollection 2018 Oct.


Practice guidelines for the supervising professional: intraoperative neurophysiological monitoring.

Gertsch JH, Moreira JJ, Lee GR, Hastings JD, Ritzl E, Eccher MA, Cohen BA, Shils JL, McCaffrey MT, Balzer GK, Balzer JR, Boucharel W, Guo L, Hanson LL, Hemmer LB, Jahangiri FR, Mendez Vigil JA, Vogel RW, Wierzbowski LR, Wilent WB, Zuccaro JS, Yingling CD; membership of the ASNM.

J Clin Monit Comput. 2019 Apr;33(2):175-183. doi: 10.1007/s10877-018-0201-9. Epub 2018 Oct 30.


The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model.

Häfliger P, Graff J, Rubin M, Stooss A, Dettmer MS, Altmann KH, Gertsch J, Charles RP.

J Exp Clin Cancer Res. 2018 Sep 21;37(1):234. doi: 10.1186/s13046-018-0907-z.


Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments.

Petrelli F, Dallérac G, Pucci L, Calì C, Zehnder T, Sultan S, Lecca S, Chicca A, Ivanov A, Asensio CS, Gundersen V, Toni N, Knott GW, Magara F, Gertsch J, Kirchhoff F, Déglon N, Giros B, Edwards RH, Mothet JP, Bezzi P.

Mol Psychiatry. 2018 Aug 20. doi: 10.1038/s41380-018-0226-y. [Epub ahead of print]


The Endocannabinoid Reuptake Inhibitor WOBE437 Is Orally Bioavailable and Exerts Indirect Polypharmacological Effects via Different Endocannabinoid Receptors.

Reynoso-Moreno I, Chicca A, Flores-Soto ME, Viveros-Paredes JM, Gertsch J.

Front Mol Neurosci. 2018 May 28;11:180. doi: 10.3389/fnmol.2018.00180. eCollection 2018.


Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system.

Chicca A, Arena C, Bertini S, Gado F, Ciaglia E, Abate M, Digiacomo M, Lapillo M, Poli G, Bifulco M, Macchia M, Tuccinardi T, Gertsch J, Manera C.

Eur J Med Chem. 2018 Jun 25;154:155-171. doi: 10.1016/j.ejmech.2018.05.019. Epub 2018 May 14.


Letter: Guidelines for the Use of Electrophysiological Monitoring for Surgery of the Human Spinal Column and Spinal Cord.

Vogel R, Balzer J, Gertsch J, Holdefer RN, Lee GR, Moreira JJ, Wilent B, Shils JL.

Neurosurgery. 2018 Jun 1;82(6):E190-E191. doi: 10.1093/neuros/nyy093. No abstract available.


Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.

Ozhathil LC, Delalande C, Bianchi B, Nemeth G, Kappel S, Thomet U, Ross-Kaschitza D, Simonin C, Rubin M, Gertsch J, Lochner M, Peinelt C, Reymond JL, Abriel H.

Br J Pharmacol. 2018 Jun;175(12):2504-2519. doi: 10.1111/bph.14220. Epub 2018 Apr 29.


New cycloartane-type ester triterpenes from Euphorbia pterococca and biological evaluation.

Benabdelaziz I, Gómez-Ruiz S, Benkhaled M, Carralero S, Schenker P, Salm A, Gertsch J, Haba H.

Fitoterapia. 2018 Jun;127:271-278. doi: 10.1016/j.fitote.2018.02.027. Epub 2018 Mar 7.


Endocannabinoid Tone Regulates Human Sebocyte Biology.

Zákány N, Oláh A, Markovics A, Takács E, Aranyász A, Nicolussi S, Piscitelli F, Allarà M, Pór Á, Kovács I, Zouboulis CC, Gertsch J, Di Marzo V, Bíró T, Szabó T.

J Invest Dermatol. 2018 Aug;138(8):1699-1706. doi: 10.1016/j.jid.2018.02.022. Epub 2018 Mar 6.


Analytical and Pharmacological Challenges in Cannabis Research.

Gertsch J.

Planta Med. 2018 Mar;84(4):213. doi: 10.1055/s-0044-101051. Epub 2018 Feb 21. No abstract available.


Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

Aghazadeh Tabrizi M, Baraldi PG, Baraldi S, Ruggiero E, De Stefano L, Rizzolio F, Di Cesare Mannelli L, Ghelardini C, Chicca A, Lapillo M, Gertsch J, Manera C, Macchia M, Martinelli A, Granchi C, Minutolo F, Tuccinardi T.

J Med Chem. 2018 Feb 8;61(3):1340-1354. doi: 10.1021/acs.jmedchem.7b01845. Epub 2018 Jan 22.


Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor.

Bertini S, Chicca A, Gado F, Arena C, Nieri D, Digiacomo M, Saccomanni G, Zhao P, Abood ME, Macchia M, Gertsch J, Manera C.

Bioorg Med Chem. 2017 Dec 15;25(24):6427-6434. doi: 10.1016/j.bmc.2017.10.015. Epub 2017 Oct 16.


An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice.

Reynoso-Moreno I, Najar-Guerrero I, Escareño N, Flores-Soto ME, Gertsch J, Viveros-Paredes JM.

J Agric Food Chem. 2017 Nov 1;65(43):9435-9442. doi: 10.1021/acs.jafc.7b02979. Epub 2017 Oct 25.


Pepcan-12 (RVD-hemopressin) is a CB2 receptor positive allosteric modulator constitutively secreted by adrenals and in liver upon tissue damage.

Petrucci V, Chicca A, Glasmacher S, Paloczi J, Cao Z, Pacher P, Gertsch J.

Sci Rep. 2017 Aug 25;7(1):9560. doi: 10.1038/s41598-017-09808-8.


4-O'-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice.

Patsenker E, Chicca A, Petrucci V, Moghadamrad S, de Gottardi A, Hampe J, Gertsch J, Semmo N, Stickel F.

J Mol Med (Berl). 2017 Oct;95(10):1077-1089. doi: 10.1007/s00109-017-1556-y. Epub 2017 Jul 8.


Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson's Disease Induced by MPTP.

Viveros-Paredes JM, González-Castañeda RE, Gertsch J, Chaparro-Huerta V, López-Roa RI, Vázquez-Valls E, Beas-Zarate C, Camins-Espuny A, Flores-Soto ME.

Pharmaceuticals (Basel). 2017 Jul 6;10(3). pii: E60. doi: 10.3390/ph10030060.


Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake.

Chicca A, Nicolussi S, Bartholomäus R, Blunder M, Aparisi Rey A, Petrucci V, Reynoso-Moreno IDC, Viveros-Paredes JM, Dalghi Gens M, Lutz B, Schiöth HB, Soeberdt M, Abels C, Charles RP, Altmann KH, Gertsch J.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E5006-E5015. doi: 10.1073/pnas.1704065114. Epub 2017 Jun 5.


Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo.

ElMokh O, Ruffieux-Daidié D, Roelli MA, Stooss A, Phillips WA, Gertsch J, Dettmer MS, Charles RP.

Oncotarget. 2017 Apr 11;8(15):24604-24620. doi: 10.18632/oncotarget.15599.


Neuronal oscillations and synchronicity associated with gamma-hydroxybutyrate during resting-state in healthy male volunteers.

von Rotz R, Kometer M, Dornbierer D, Gertsch J, Salomé Gachet M, Vollenweider FX, Seifritz E, Bosch OG, Quednow BB.

Psychopharmacology (Berl). 2017 Jul;234(13):1957-1968. doi: 10.1007/s00213-017-4603-z. Epub 2017 Apr 20.


Biological evaluation of pyridone alkaloids on the endocannabinoid system.

Chicca A, Berg R, Jessen HJ, Marck N, Schmid F, Burch P, Gertsch J, Gademann K.

Bioorg Med Chem. 2017 Nov 15;25(22):6102-6114. doi: 10.1016/j.bmc.2017.02.031. Epub 2017 Feb 17.


Targeted metabolomics shows plasticity in the evolution of signaling lipids and uncovers old and new endocannabinoids in the plant kingdom.

Gachet MS, Schubert A, Calarco S, Boccard J, Gertsch J.

Sci Rep. 2017 Jan 25;7:41177. doi: 10.1038/srep41177.


β-Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice.

Varga ZV, Matyas C, Erdelyi K, Cinar R, Nieri D, Chicca A, Nemeth BT, Paloczi J, Lajtos T, Corey L, Hasko G, Gao B, Kunos G, Gertsch J, Pacher P.

Br J Pharmacol. 2018 Jan;175(2):320-334. doi: 10.1111/bph.13722. Epub 2017 Feb 22.


Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.

Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, de Petrocellis L, Ullmer C, Rothenhäusler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M.

Nat Commun. 2017 Jan 3;8:13958. doi: 10.1038/ncomms13958.


Cannabimimetic phytochemicals in the diet - an evolutionary link to food selection and metabolic stress adaptation?

Gertsch J.

Br J Pharmacol. 2017 Jun;174(11):1464-1483. doi: 10.1111/bph.13676. Epub 2017 Jan 16. Review.


Atomic layer deposition ultrathin film origami using focused ion beams.

Supekar OD, Brown JJ, Eigenfeld NT, Gertsch JC, Bright VM.

Nanotechnology. 2016 Dec 9;27(49):49LT02. Epub 2016 Nov 11.


Ultrathin thermoacoustic nanobridge loudspeakers from ALD on polyimide.

Brown JJ, Moore NC, Supekar OD, Gertsch JC, Bright VM.

Nanotechnology. 2016 Nov 25;27(47):475504. Epub 2016 Oct 25.


Docking and QSAR Studies of Aryl-valproic Acid Derivatives to Identify Antiproliferative Agents Targeting the HDAC8.

Martínez-Pacheco H, Ramírez-Galicia G, Vergara-Arias M, Gertsch J, Fragoso-Vazquez JM, Mendez-Luna D, Abujamra AL, Cristina CL, Cecilia RM, Mendoza-Lujambio I, Correa-Basurto J.

Anticancer Agents Med Chem. 2017;17(7):927-940. doi: 10.2174/1871520616666161019143219.


Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones).

Jantsch A, Nieto L, Gertsch J, Rodríguez-Salarichs J, Matesanz R, Jiménez-Barbero J, Díaz JF, Canales Á, Altmann KH.

Molecules. 2016 Aug 3;21(8). pii: E1010. doi: 10.3390/molecules21081010.


Cannabinoid Receptor 2 Modulates Susceptibility to Experimental Cerebral Malaria through a CCL17-dependent Mechanism.

Alferink J, Specht S, Arends H, Schumak B, Schmidt K, Ruland C, Lundt R, Kemter A, Dlugos A, Kuepper JM, Poppensieker K, Findeiss M, Albayram Ö, Otte DM, Marazzi J, Gertsch J, Förster I, Maier W, Scheu S, Hoerauf A, Zimmer A.

J Biol Chem. 2016 Sep 9;291(37):19517-31. doi: 10.1074/jbc.M116.746594. Epub 2016 Jul 29.


The Metabolic Plant Feedback Hypothesis: How Plant Secondary Metabolites Nonspecifically Impact Human Health.

Gertsch J.

Planta Med. 2016 Jul;82(11-12):920-9. doi: 10.1055/s-0042-108340. Epub 2016 Jun 10.


Assay of Endocannabinoid Uptake.

Rau M, Nicolussi S, Chicca A, Gertsch J.

Methods Mol Biol. 2016;1412:191-203. doi: 10.1007/978-1-4939-3539-0_20.


Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands.

Bertini S, Chicca A, Arena C, Chicca S, Saccomanni G, Gertsch J, Manera C, Macchia M.

Eur J Med Chem. 2016 Jun 30;116:252-266. doi: 10.1016/j.ejmech.2016.03.072. Epub 2016 Mar 30.


Editorial: Lung macrophages high on cannabinoids: jamming PAMs and taming TAMs?

Gertsch J.

J Leukoc Biol. 2016 Apr;99(4):518-20. doi: 10.1189/jlb.3CE0915-409RR. No abstract available.


Inhibition of fatty acid amide hydrolase exerts cutaneous anti-inflammatory effects both in vitro and in vivo.

Oláh A, Ambrus L, Nicolussi S, Gertsch J, Tubak V, Kemény L, Soeberdt M, Abels C, Bíró T.

Exp Dermatol. 2016 Apr;25(4):328-30. doi: 10.1111/exd.12930. Epub 2016 Feb 13. No abstract available.


Use of Posterior Root-Muscle Reflexes in Peripheral Nerve Surgery: A Case Report.

Mandeville RM, Brown JM, Gertsch JH, Allison DW.

Neurodiagn J. 2016;56(3):178-185. doi: 10.1080/21646821.2016.1202723.


Pharmacokinetics and pharmacodynamics of γ-hydroxybutyrate in healthy subjects.

Liechti ME, Quednow BB, Liakoni E, Dornbierer D, von Rotz R, Gachet MS, Gertsch J, Seifritz E, Bosch OG.

Br J Clin Pharmacol. 2016 May;81(5):980-8. doi: 10.1111/bcp.12863. Epub 2016 Feb 25.


Vasculopathy, Ischemia, and the Lateral Lumbar Interbody Fusion Surgery: Report of Three Cases.

Allison DW, Allen RT, Kohanchi DD, Skousen CB, Lee YP, Gertsch JH.

J Clin Neurophysiol. 2015 Dec;32(6):e41-5. doi: 10.1097/WNP.0000000000000136.


Quantitative analysis of arachidonic acid, endocannabinoids, N-acylethanolamines and steroids in biological samples by LCMS/MS: Fit to purpose.

Gachet MS, Gertsch J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 15;1012-1013:215-21. doi: 10.1016/j.jchromb.2015.11.013. Epub 2015 Nov 21. No abstract available.


Electrical and thermal conduction in ultra-thin freestanding atomic layer deposited W nanobridges.

Eigenfeld NT, Gertsch JC, Skidmore GD, George SM, Bright VM.

Nanoscale. 2015 Nov 14;7(42):17923-8. doi: 10.1039/c5nr04885k. Epub 2015 Oct 14.


Gamma-hydroxybutyrate enhances mood and prosocial behavior without affecting plasma oxytocin and testosterone.

Bosch OG, Eisenegger C, Gertsch J, von Rotz R, Dornbierer D, Gachet MS, Heinrichs M, Wetter TC, Seifritz E, Quednow BB.

Psychoneuroendocrinology. 2015 Dec;62:1-10. doi: 10.1016/j.psyneuen.2015.07.167. Epub 2015 Jul 17.

Supplemental Content

Loading ...
Support Center