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Items: 1 to 50 of 158

1.

Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments.

Petrelli F, Dallérac G, Pucci L, Calì C, Zehnder T, Sultan S, Lecca S, Chicca A, Ivanov A, Asensio CS, Gundersen V, Toni N, Knott GW, Magara F, Gertsch J, Kirchhoff F, Déglon N, Giros B, Edwards RH, Mothet JP, Bezzi P.

Mol Psychiatry. 2018 Aug 20. doi: 10.1038/s41380-018-0226-y. [Epub ahead of print]

PMID:
30127471
2.

The Endocannabinoid Reuptake Inhibitor WOBE437 Is Orally Bioavailable and Exerts Indirect Polypharmacological Effects via Different Endocannabinoid Receptors.

Reynoso-Moreno I, Chicca A, Flores-Soto ME, Viveros-Paredes JM, Gertsch J.

Front Mol Neurosci. 2018 May 28;11:180. doi: 10.3389/fnmol.2018.00180. eCollection 2018.

3.

Polypharmacological profile of 1,2-dihydro-2-oxo-pyridine-3-carboxamides in the endocannabinoid system.

Chicca A, Arena C, Bertini S, Gado F, Ciaglia E, Abate M, Digiacomo M, Lapillo M, Poli G, Bifulco M, Macchia M, Tuccinardi T, Gertsch J, Manera C.

Eur J Med Chem. 2018 Jun 25;154:155-171. doi: 10.1016/j.ejmech.2018.05.019. Epub 2018 May 14.

PMID:
29793210
4.

Letter: Guidelines for the Use of Electrophysiological Monitoring for Surgery of the Human Spinal Column and Spinal Cord.

Vogel R, Balzer J, Gertsch J, Holdefer RN, Lee GR, Moreira JJ, Wilent B, Shils JL.

Neurosurgery. 2018 Jun 1;82(6):E190-E191. doi: 10.1093/neuros/nyy093. No abstract available.

PMID:
29608713
5.

Identification of potent and selective small molecule inhibitors of the cation channel TRPM4.

Ozhathil LC, Delalande C, Bianchi B, Nemeth G, Kappel S, Thomet U, Ross-Kaschitza D, Simonin C, Rubin M, Gertsch J, Lochner M, Peinelt C, Reymond JL, Abriel H.

Br J Pharmacol. 2018 Jun;175(12):2504-2519. doi: 10.1111/bph.14220. Epub 2018 Apr 29.

6.

New cycloartane-type ester triterpenes from Euphorbia pterococca and biological evaluation.

Benabdelaziz I, Gómez-Ruiz S, Benkhaled M, Carralero S, Schenker P, Salm A, Gertsch J, Haba H.

Fitoterapia. 2018 Jun;127:271-278. doi: 10.1016/j.fitote.2018.02.027. Epub 2018 Mar 7.

PMID:
29524564
7.

Endocannabinoid Tone Regulates Human Sebocyte Biology.

Zákány N, Oláh A, Markovics A, Takács E, Aranyász A, Nicolussi S, Piscitelli F, Allarà M, Pór Á, Kovács I, Zouboulis CC, Gertsch J, Di Marzo V, Bíró T, Szabó T.

J Invest Dermatol. 2018 Aug;138(8):1699-1706. doi: 10.1016/j.jid.2018.02.022. Epub 2018 Mar 6.

PMID:
29501385
8.

Analytical and Pharmacological Challenges in Cannabis Research.

Gertsch J.

Planta Med. 2018 Mar;84(4):213. doi: 10.1055/s-0044-101051. Epub 2018 Feb 21. No abstract available.

PMID:
29466823
9.

Discovery of 1,5-Diphenylpyrazole-3-Carboxamide Derivatives as Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors.

Aghazadeh Tabrizi M, Baraldi PG, Baraldi S, Ruggiero E, De Stefano L, Rizzolio F, Di Cesare Mannelli L, Ghelardini C, Chicca A, Lapillo M, Gertsch J, Manera C, Macchia M, Martinelli A, Granchi C, Minutolo F, Tuccinardi T.

J Med Chem. 2018 Feb 8;61(3):1340-1354. doi: 10.1021/acs.jmedchem.7b01845. Epub 2018 Jan 22.

PMID:
29309142
10.

Novel analogs of PSNCBAM-1 as allosteric modulators of cannabinoid CB1 receptor.

Bertini S, Chicca A, Gado F, Arena C, Nieri D, Digiacomo M, Saccomanni G, Zhao P, Abood ME, Macchia M, Gertsch J, Manera C.

Bioorg Med Chem. 2017 Dec 15;25(24):6427-6434. doi: 10.1016/j.bmc.2017.10.015. Epub 2017 Oct 16.

11.

An Endocannabinoid Uptake Inhibitor from Black Pepper Exerts Pronounced Anti-Inflammatory Effects in Mice.

Reynoso-Moreno I, Najar-Guerrero I, Escareño N, Flores-Soto ME, Gertsch J, Viveros-Paredes JM.

J Agric Food Chem. 2017 Nov 1;65(43):9435-9442. doi: 10.1021/acs.jafc.7b02979. Epub 2017 Oct 25.

12.

Pepcan-12 (RVD-hemopressin) is a CB2 receptor positive allosteric modulator constitutively secreted by adrenals and in liver upon tissue damage.

Petrucci V, Chicca A, Glasmacher S, Paloczi J, Cao Z, Pacher P, Gertsch J.

Sci Rep. 2017 Aug 25;7(1):9560. doi: 10.1038/s41598-017-09808-8.

13.

4-O'-methylhonokiol protects from alcohol/carbon tetrachloride-induced liver injury in mice.

Patsenker E, Chicca A, Petrucci V, Moghadamrad S, de Gottardi A, Hampe J, Gertsch J, Semmo N, Stickel F.

J Mol Med (Berl). 2017 Oct;95(10):1077-1089. doi: 10.1007/s00109-017-1556-y. Epub 2017 Jul 8.

PMID:
28689299
14.

Neuroprotective Effects of β-Caryophyllene against Dopaminergic Neuron Injury in a Murine Model of Parkinson's Disease Induced by MPTP.

Viveros-Paredes JM, González-Castañeda RE, Gertsch J, Chaparro-Huerta V, López-Roa RI, Vázquez-Valls E, Beas-Zarate C, Camins-Espuny A, Flores-Soto ME.

Pharmaceuticals (Basel). 2017 Jul 6;10(3). pii: E60. doi: 10.3390/ph10030060.

15.

Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake.

Chicca A, Nicolussi S, Bartholomäus R, Blunder M, Aparisi Rey A, Petrucci V, Reynoso-Moreno IDC, Viveros-Paredes JM, Dalghi Gens M, Lutz B, Schiöth HB, Soeberdt M, Abels C, Charles RP, Altmann KH, Gertsch J.

Proc Natl Acad Sci U S A. 2017 Jun 20;114(25):E5006-E5015. doi: 10.1073/pnas.1704065114. Epub 2017 Jun 5.

16.

Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo.

ElMokh O, Ruffieux-Daidié D, Roelli MA, Stooss A, Phillips WA, Gertsch J, Dettmer MS, Charles RP.

Oncotarget. 2017 Apr 11;8(15):24604-24620. doi: 10.18632/oncotarget.15599.

17.

Neuronal oscillations and synchronicity associated with gamma-hydroxybutyrate during resting-state in healthy male volunteers.

von Rotz R, Kometer M, Dornbierer D, Gertsch J, Salomé Gachet M, Vollenweider FX, Seifritz E, Bosch OG, Quednow BB.

Psychopharmacology (Berl). 2017 Jul;234(13):1957-1968. doi: 10.1007/s00213-017-4603-z. Epub 2017 Apr 20.

18.

Biological evaluation of pyridone alkaloids on the endocannabinoid system.

Chicca A, Berg R, Jessen HJ, Marck N, Schmid F, Burch P, Gertsch J, Gademann K.

Bioorg Med Chem. 2017 Nov 15;25(22):6102-6114. doi: 10.1016/j.bmc.2017.02.031. Epub 2017 Feb 17.

PMID:
28284861
19.

Targeted metabolomics shows plasticity in the evolution of signaling lipids and uncovers old and new endocannabinoids in the plant kingdom.

Gachet MS, Schubert A, Calarco S, Boccard J, Gertsch J.

Sci Rep. 2017 Jan 25;7:41177. doi: 10.1038/srep41177.

20.

β-Caryophyllene protects against alcoholic steatohepatitis by attenuating inflammation and metabolic dysregulation in mice.

Varga ZV, Matyas C, Erdelyi K, Cinar R, Nieri D, Chicca A, Nemeth BT, Paloczi J, Lajtos T, Corey L, Hasko G, Gao B, Kunos G, Gertsch J, Pacher P.

Br J Pharmacol. 2018 Jan;175(2):320-334. doi: 10.1111/bph.13722. Epub 2017 Feb 22.

21.

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.

Soethoudt M, Grether U, Fingerle J, Grim TW, Fezza F, de Petrocellis L, Ullmer C, Rothenhäusler B, Perret C, van Gils N, Finlay D, MacDonald C, Chicca A, Gens MD, Stuart J, de Vries H, Mastrangelo N, Xia L, Alachouzos G, Baggelaar MP, Martella A, Mock ED, Deng H, Heitman LH, Connor M, Di Marzo V, Gertsch J, Lichtman AH, Maccarrone M, Pacher P, Glass M, van der Stelt M.

Nat Commun. 2017 Jan 3;8:13958. doi: 10.1038/ncomms13958.

22.

Cannabimimetic phytochemicals in the diet - an evolutionary link to food selection and metabolic stress adaptation?

Gertsch J.

Br J Pharmacol. 2017 Jun;174(11):1464-1483. doi: 10.1111/bph.13676. Epub 2017 Jan 16. Review.

23.

Atomic layer deposition ultrathin film origami using focused ion beams.

Supekar OD, Brown JJ, Eigenfeld NT, Gertsch JC, Bright VM.

Nanotechnology. 2016 Dec 9;27(49):49LT02. Epub 2016 Nov 11.

PMID:
27834312
24.

Ultrathin thermoacoustic nanobridge loudspeakers from ALD on polyimide.

Brown JJ, Moore NC, Supekar OD, Gertsch JC, Bright VM.

Nanotechnology. 2016 Nov 25;27(47):475504. Epub 2016 Oct 25.

PMID:
27779111
25.

Docking and QSAR Studies of Aryl-valproic Acid Derivatives to Identify Antiproliferative Agents Targeting the HDAC8.

Martínez-Pacheco H, Ramírez-Galicia G, Vergara-Arias M, Gertsch J, Fragoso-Vazquez JM, Mendez-Luna D, Abujamra AL, Cristina CL, Cecilia RM, Mendoza-Lujambio I, Correa-Basurto J.

Anticancer Agents Med Chem. 2017;17(7):927-940. doi: 10.2174/1871520616666161019143219.

PMID:
27774878
26.

Synthesis, Biological Profiling and Determination of the Tubulin-Bound Conformation of 12-Aza-Epothilones (Azathilones).

Jantsch A, Nieto L, Gertsch J, Rodríguez-Salarichs J, Matesanz R, Jiménez-Barbero J, Díaz JF, Canales Á, Altmann KH.

Molecules. 2016 Aug 3;21(8). pii: E1010. doi: 10.3390/molecules21081010.

27.

Cannabinoid Receptor 2 Modulates Susceptibility to Experimental Cerebral Malaria through a CCL17-dependent Mechanism.

Alferink J, Specht S, Arends H, Schumak B, Schmidt K, Ruland C, Lundt R, Kemter A, Dlugos A, Kuepper JM, Poppensieker K, Findeiss M, Albayram Ö, Otte DM, Marazzi J, Gertsch J, Förster I, Maier W, Scheu S, Hoerauf A, Zimmer A.

J Biol Chem. 2016 Sep 9;291(37):19517-31. doi: 10.1074/jbc.M116.746594. Epub 2016 Jul 29.

28.

The Metabolic Plant Feedback Hypothesis: How Plant Secondary Metabolites Nonspecifically Impact Human Health.

Gertsch J.

Planta Med. 2016 Jul;82(11-12):920-9. doi: 10.1055/s-0042-108340. Epub 2016 Jun 10.

PMID:
27286339
29.

Assay of Endocannabinoid Uptake.

Rau M, Nicolussi S, Chicca A, Gertsch J.

Methods Mol Biol. 2016;1412:191-203. doi: 10.1007/978-1-4939-3539-0_20.

PMID:
27245905
30.

Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands.

Bertini S, Chicca A, Arena C, Chicca S, Saccomanni G, Gertsch J, Manera C, Macchia M.

Eur J Med Chem. 2016 Jun 30;116:252-266. doi: 10.1016/j.ejmech.2016.03.072. Epub 2016 Mar 30.

PMID:
27078864
31.

Editorial: Lung macrophages high on cannabinoids: jamming PAMs and taming TAMs?

Gertsch J.

J Leukoc Biol. 2016 Apr;99(4):518-20. doi: 10.1189/jlb.3CE0915-409RR. No abstract available.

PMID:
27034462
32.

Inhibition of fatty acid amide hydrolase exerts cutaneous anti-inflammatory effects both in vitro and in vivo.

Oláh A, Ambrus L, Nicolussi S, Gertsch J, Tubak V, Kemény L, Soeberdt M, Abels C, Bíró T.

Exp Dermatol. 2016 Apr;25(4):328-30. doi: 10.1111/exd.12930. Epub 2016 Feb 13. No abstract available.

PMID:
26738935
33.

Use of Posterior Root-Muscle Reflexes in Peripheral Nerve Surgery: A Case Report.

Mandeville RM, Brown JM, Gertsch JH, Allison DW.

Neurodiagn J. 2016;56(3):178-185. doi: 10.1080/21646821.2016.1202723.

PMID:
28436768
34.

Pharmacokinetics and pharmacodynamics of γ-hydroxybutyrate in healthy subjects.

Liechti ME, Quednow BB, Liakoni E, Dornbierer D, von Rotz R, Gachet MS, Gertsch J, Seifritz E, Bosch OG.

Br J Clin Pharmacol. 2016 May;81(5):980-8. doi: 10.1111/bcp.12863. Epub 2016 Feb 25.

35.

Vasculopathy, Ischemia, and the Lateral Lumbar Interbody Fusion Surgery: Report of Three Cases.

Allison DW, Allen RT, Kohanchi DD, Skousen CB, Lee YP, Gertsch JH.

J Clin Neurophysiol. 2015 Dec;32(6):e41-5. doi: 10.1097/WNP.0000000000000136.

PMID:
26629762
36.

Quantitative analysis of arachidonic acid, endocannabinoids, N-acylethanolamines and steroids in biological samples by LCMS/MS: Fit to purpose.

Gachet MS, Gertsch J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 15;1012-1013:215-21. doi: 10.1016/j.jchromb.2015.11.013. Epub 2015 Nov 21. No abstract available.

PMID:
26614403
37.

Electrical and thermal conduction in ultra-thin freestanding atomic layer deposited W nanobridges.

Eigenfeld NT, Gertsch JC, Skidmore GD, George SM, Bright VM.

Nanoscale. 2015 Nov 14;7(42):17923-8. doi: 10.1039/c5nr04885k. Epub 2015 Oct 14.

PMID:
26463738
38.

Gamma-hydroxybutyrate enhances mood and prosocial behavior without affecting plasma oxytocin and testosterone.

Bosch OG, Eisenegger C, Gertsch J, von Rotz R, Dornbierer D, Gachet MS, Heinrichs M, Wetter TC, Seifritz E, Quednow BB.

Psychoneuroendocrinology. 2015 Dec;62:1-10. doi: 10.1016/j.psyneuen.2015.07.167. Epub 2015 Jul 17.

39.

Reactions of CF3-enones with arenes under superelectrophilic activation: a pathway to trans-1,3-diaryl-1-CF3-indanes, new cannabinoid receptor ligands.

Iakovenko RO, Kazakova AN, Muzalevskiy VM, Ivanov AY, Boyarskaya IA, Chicca A, Petrucci V, Gertsch J, Krasavin M, Starova GL, Zolotarev AA, Avdontceva MS, Nenajdenko VG, Vasilyev AV.

Org Biomol Chem. 2015 Sep 7;13(33):8827-42. doi: 10.1039/c5ob01072a. Epub 2015 Jul 17.

PMID:
26186675
40.

4'-O-methylhonokiol increases levels of 2-arachidonoyl glycerol in mouse brain via selective inhibition of its COX-2-mediated oxygenation.

Chicca A, Gachet MS, Petrucci V, Schuehly W, Charles RP, Gertsch J.

J Neuroinflammation. 2015 May 13;12:89. doi: 10.1186/s12974-015-0307-7.

41.

Localization and production of peptide endocannabinoids in the rodent CNS and adrenal medulla.

Hofer SC, Ralvenius WT, Gachet MS, Fritschy JM, Zeilhofer HU, Gertsch J.

Neuropharmacology. 2015 Nov;98:78-89. doi: 10.1016/j.neuropharm.2015.03.021. Epub 2015 Mar 31.

PMID:
25839900
42.

Elevated levels of endocannabinoids in chronic hepatitis C may modulate cellular immune response and hepatic stellate cell activation.

Patsenker E, Sachse P, Chicca A, Gachet MS, Schneider V, Mattsson J, Lanz C, Worni M, de Gottardi A, Semmo M, Hampe J, Schafmayer C, Brenneisen R, Gertsch J, Stickel F, Semmo N.

Int J Mol Sci. 2015 Mar 27;16(4):7057-76. doi: 10.3390/ijms16047057.

43.

Endocannabinoid transport revisited.

Nicolussi S, Gertsch J.

Vitam Horm. 2015;98:441-85. doi: 10.1016/bs.vh.2014.12.011. Epub 2015 Feb 27. Review.

PMID:
25817877
44.

Development of an HPLC/UV assay for the evaluation of inhibitors of human recombinant monoacylglycerol lipase.

Del Carlo S, Manera C, Chicca A, Arena C, Bertini S, Burgalassi S, Tampucci S, Gertsch J, Macchia M, Saccomanni G.

J Pharm Biomed Anal. 2015 Apr 10;108:113-21. doi: 10.1016/j.jpba.2015.02.007. Epub 2015 Feb 13.

PMID:
25743577
45.

ASNM reply to letter of Eccher et al.

McAuliffe JJ, Lee GR, Hastings JD, Gertsch J, Balzer GK.

J Clin Monit Comput. 2015 Apr;29(2):315. doi: 10.1007/s10877-014-9655-6. Epub 2015 Jan 24. No abstract available.

PMID:
25616522
46.

Characterizing new fluorescent tools for studying 5-HT₃ receptor pharmacology.

Jack T, Simonin J, Ruepp MD, Thompson AJ, Gertsch J, Lochner M.

Neuropharmacology. 2015 Mar;90:63-73. doi: 10.1016/j.neuropharm.2014.11.007. Epub 2014 Nov 22.

PMID:
25460187
47.

A quantitiative LC-MS/MS method for the measurement of arachidonic acid, prostanoids, endocannabinoids, N-acylethanolamines and steroids in human plasma.

Gachet MS, Rhyn P, Bosch OG, Quednow BB, Gertsch J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 22;976-977:6-18. doi: 10.1016/j.jchromb.2014.11.001. Epub 2014 Nov 18.

48.

Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: from ultrapotent to hyperpotent.

Nicolussi S, Chicca A, Rau M, Rihs S, Soeberdt M, Abels C, Gertsch J.

Biochem Pharmacol. 2014 Dec 15;92(4):669-89. doi: 10.1016/j.bcp.2014.09.020. Epub 2014 Nov 4.

PMID:
25283614
49.

GaN nanowire coated with atomic layer deposition of tungsten: a probe for near-field scanning microwave microscopy.

Weber JC, Blanchard PT, Sanders AW, Gertsch JC, George SM, Berweger S, Imtiaz A, Coakley KJ, Wallis TM, Bertness KA, Kabos P, Sanford NA, Bright VM.

Nanotechnology. 2014 Oct 17;25(41):415502. Epub 2014 Sep 26.

PMID:
25258349
50.

One-pot heterogeneous synthesis of Δ(3)-tetrahydrocannabinol analogues and xanthenes showing differential binding to CB(1) and CB(2) receptors.

Rosati O, Messina F, Pelosi A, Curini M, Petrucci V, Gertsch J, Chicca A.

Eur J Med Chem. 2014 Oct 6;85:77-86. doi: 10.1016/j.ejmech.2014.07.062. Epub 2014 Jul 19.

PMID:
25072877

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