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Items: 1 to 50 of 125

1.

A Requirement for Mena, an Actin Regulator, in Local mRNA Translation in Developing Neurons.

Vidaki M, Drees F, Saxena T, Lanslots E, Taliaferro MJ, Tatarakis A, Burge CB, Wang ET, Gertler FB.

Neuron. 2017 Aug 2;95(3):608-622.e5. doi: 10.1016/j.neuron.2017.06.048. Epub 2017 Jul 20.

2.

Signatures of Breast Cancer Metastasis: aMENAble to Interpretation?

Oudin MJ, Gertler FB.

Trends Cancer. 2017 Jan;3(1):7-9. doi: 10.1016/j.trecan.2016.11.004. Epub 2016 Dec 7.

PMID:
28718427
3.

Cutting Edge: Loss of T Cell RIAM Precludes Conjugate Formation with APC and Prevents Immune-Mediated Diabetes.

Lagarrigue F, Gertler FB, Ginsberg MH, Cantor JM.

J Immunol. 2017 May 1;198(9):3410-3415. doi: 10.4049/jimmunol.1601743. Epub 2017 Mar 27.

4.

MenaINV dysregulates cortactin phosphorylation to promote invadopodium maturation.

Weidmann MD, Surve CR, Eddy RJ, Chen X, Gertler FB, Sharma VP, Condeelis JS.

Sci Rep. 2016 Nov 8;6:36142. doi: 10.1038/srep36142.

5.

MENA Confers Resistance to Paclitaxel in Triple-Negative Breast Cancer.

Oudin MJ, Barbier L, Schäfer C, Kosciuk T, Miller MA, Han S, Jonas O, Lauffenburger DA, Gertler FB.

Mol Cancer Ther. 2017 Jan;16(1):143-155. doi: 10.1158/1535-7163.MCT-16-0413. Epub 2016 Nov 3.

6.

The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior.

Balsamo M, Mondal C, Carmona G, McClain LM, Riquelme DN, Tadros J, Ma D, Vasile E, Condeelis JS, Lauffenburger DA, Gertler FB.

Sci Rep. 2016 Oct 17;6:35298. doi: 10.1038/srep35298.

7.

5'-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion.

Rajadurai CV, Havrylov S, Coelho PP, Ratcliffe CD, Zaoui K, Huang BH, Monast A, Chughtai N, Sangwan V, Gertler FB, Siegel PM, Park M.

J Cell Biol. 2016 Sep 12;214(6):719-34. doi: 10.1083/jcb.201501003. Epub 2016 Sep 5.

8.

MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis.

Oudin MJ, Miller MA, Klazen JA, Kosciuk T, Lussiez A, Hughes SK, Tadros J, Bear JE, Lauffenburger DA, Gertler FB.

Mol Biol Cell. 2016 Oct 15;27(20):3085-3094. Epub 2016 Aug 24.

9.

A requirement for filopodia extension toward Slit during Robo-mediated axon repulsion.

McConnell RE, Edward van Veen J, Vidaki M, Kwiatkowski AV, Meyer AS, Gertler FB.

J Cell Biol. 2016 Apr 25;213(2):261-74. doi: 10.1083/jcb.201509062. Epub 2016 Apr 18.

10.

Parallel In Vivo Assessment of Drug Phenotypes at Various Time Points during Systemic BRAF Inhibition Reveals Tumor Adaptation and Altered Treatment Vulnerabilities.

Jonas O, Oudin MJ, Kosciuk T, Whitman M, Gertler FB, Cima MJ, Flaherty KT, Langer R.

Clin Cancer Res. 2016 Dec 15;22(24):6031-6038. Epub 2016 Apr 18.

11.

Lamellipodin-Deficient Mice: A Model of Rectal Carcinoma.

Miller CL, Muthupalani S, Shen Z, Drees F, Ge Z, Feng Y, Chen X, Gong G, Nagar KK, Wang TC, Gertler FB, Fox JG.

PLoS One. 2016 Apr 5;11(4):e0152940. doi: 10.1371/journal.pone.0152940. eCollection 2016.

12.

Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE.

Carmona G, Perera U, Gillett C, Naba A, Law AL, Sharma VP, Wang J, Wyckoff J, Balsamo M, Mosis F, De Piano M, Monypenny J, Woodman N, McConnell RE, Mouneimne G, Van Hemelrijck M, Cao Y, Condeelis J, Hynes RO, Gertler FB, Krause M.

Oncogene. 2016 Sep 29;35(39):5155-69. doi: 10.1038/onc.2016.47. Epub 2016 Mar 21.

13.

Reduced Proteolytic Shedding of Receptor Tyrosine Kinases Is a Post-Translational Mechanism of Kinase Inhibitor Resistance.

Miller MA, Oudin MJ, Sullivan RJ, Wang SJ, Meyer AS, Im H, Frederick DT, Tadros J, Griffith LG, Lee H, Weissleder R, Flaherty KT, Gertler FB, Lauffenburger DA.

Cancer Discov. 2016 Apr;6(4):382-99. doi: 10.1158/2159-8290.CD-15-0933. Epub 2016 Mar 16.

14.

Distal Alternative Last Exons Localize mRNAs to Neural Projections.

Taliaferro JM, Vidaki M, Oliveira R, Olson S, Zhan L, Saxena T, Wang ET, Graveley BR, Gertler FB, Swanson MS, Burge CB.

Mol Cell. 2016 Mar 17;61(6):821-33. doi: 10.1016/j.molcel.2016.01.020. Epub 2016 Feb 18.

15.

Tumor Cell-Driven Extracellular Matrix Remodeling Drives Haptotaxis during Metastatic Progression.

Oudin MJ, Jonas O, Kosciuk T, Broye LC, Guido BC, Wyckoff J, Riquelme D, Lamar JM, Asokan SB, Whittaker C, Ma D, Langer R, Cima MJ, Wisinski KB, Hynes RO, Lauffenburger DA, Keely PJ, Bear JE, Gertler FB.

Cancer Discov. 2016 May;6(5):516-31. doi: 10.1158/2159-8290.CD-15-1183. Epub 2016 Jan 25.

16.

Characterization of the expression of the pro-metastatic Mena(INV) isoform during breast tumor progression.

Oudin MJ, Hughes SK, Rohani N, Moufarrej MN, Jones JG, Condeelis JS, Lauffenburger DA, Gertler FB.

Clin Exp Metastasis. 2016 Mar;33(3):249-61. doi: 10.1007/s10585-015-9775-5. Epub 2015 Dec 17.

17.

Time series modeling of live-cell shape dynamics for image-based phenotypic profiling.

Gordonov S, Hwang MK, Wells A, Gertler FB, Lauffenburger DA, Bathe M.

Integr Biol (Camb). 2016 Jan;8(1):73-90. doi: 10.1039/c5ib00283d. Epub 2015 Dec 11.

18.

Vasodilator-stimulated phosphoprotein restricts cell-to-cell spread of Shigella flexneri at the cell periphery.

Lee SY, Gertler FB, Goldberg MB.

Microbiology. 2015 Nov;161(11):2149-60. doi: 10.1099/mic.0.000173. Epub 2015 Sep 9.

19.

Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis.

Li CM, Gocheva V, Oudin MJ, Bhutkar A, Wang SY, Date SR, Ng SR, Whittaker CA, Bronson RT, Snyder EL, Gertler FB, Jacks T.

Genes Dev. 2015 Sep 1;29(17):1850-62. doi: 10.1101/gad.267393.115.

20.

Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice.

Klapproth S, Sperandio M, Pinheiro EM, Prünster M, Soehnlein O, Gertler FB, Fässler R, Moser M.

Blood. 2015 Dec 17;126(25):2704-12. doi: 10.1182/blood-2015-05-647453. Epub 2015 Sep 3.

21.

PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena.

Hughes SK, Oudin MJ, Tadros J, Neil J, Del Rosario A, Joughin BA, Ritsma L, Wyckoff J, Vasile E, Eddy R, Philippar U, Lussiez A, Condeelis JS, van Rheenen J, White F, Lauffenburger DA, Gertler FB.

Mol Biol Cell. 2015 Nov 1;26(21):3867-78. doi: 10.1091/mbc.E15-06-0442. Epub 2015 Sep 2.

22.

Rap1 and its effector RIAM are required for lymphocyte trafficking.

Su W, Wynne J, Pinheiro EM, Strazza M, Mor A, Montenont E, Berger J, Paul DS, Bergmeier W, Gertler FB, Philips MR.

Blood. 2015 Dec 17;126(25):2695-703. doi: 10.1182/blood-2015-05-644104. Epub 2015 Aug 31.

23.

Selectivity in subunit composition of Ena/VASP tetramers.

Riquelme DN, Meyer AS, Barzik M, Keating A, Gertler FB.

Biosci Rep. 2015 Jul 28;35(5). pii: e00246. doi: 10.1042/BSR20150149.

24.

Lamellipodin Is Important for Cell-to-Cell Spread and Actin-Based Motility in Listeria monocytogenes.

Wang J, King JE, Goldrick M, Lowe M, Gertler FB, Roberts IS.

Infect Immun. 2015 Sep;83(9):3740-8. doi: 10.1128/IAI.00193-15. Epub 2015 Jul 13.

25.

Correction: eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF).

Menna E, Disanza A, Cagnoli C, Schenk U, Gelsomino G, Frittoli E, Hertzog M, Offenhauser N, Sawallisch C, Kreienkamp HJ, Gertler FB, Di Fiore PP, Scita G, Matteoli M.

PLoS Biol. 2015 Jun 3;13(6):e1002184. doi: 10.1371/journal.pbio.1002184. eCollection 2015 Jun. No abstract available.

26.

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway.

Kumari S, Depoil D, Martinelli R, Judokusumo E, Carmona G, Gertler FB, Kam LC, Carman CV, Burkhardt JK, Irvine DJ, Dustin ML.

Elife. 2015 Mar 11;4. doi: 10.7554/eLife.04953.

27.

Invasive breast carcinoma cells from patients exhibit MenaINV- and macrophage-dependent transendothelial migration.

Pignatelli J, Goswami S, Jones JG, Rohan TE, Pieri E, Chen X, Adler E, Cox D, Maleki S, Bresnick A, Gertler FB, Condeelis JS, Oktay MH.

Sci Signal. 2014 Nov 25;7(353):ra112. doi: 10.1126/scisignal.2005329.

28.

Ena/VASP regulates mDia2-initiated filopodial length, dynamics, and function.

Barzik M, McClain LM, Gupton SL, Gertler FB.

Mol Biol Cell. 2014 Sep 1;25(17):2604-19. doi: 10.1091/mbc.E14-02-0712. Epub 2014 Jul 2.

29.

Tumor microenvironment of metastasis and risk of distant metastasis of breast cancer.

Rohan TE, Xue X, Lin HM, D'Alfonso TM, Ginter PS, Oktay MH, Robinson BD, Ginsberg M, Gertler FB, Glass AG, Sparano JA, Condeelis JS, Jones JG.

J Natl Cancer Inst. 2014 Jun 3;106(8). pii: dju136. doi: 10.1093/jnci/dju136. Print 2014 Aug.

30.

Tks5 and SHIP2 regulate invadopodium maturation, but not initiation, in breast carcinoma cells.

Sharma VP, Eddy R, Entenberg D, Kai M, Gertler FB, Condeelis J.

Curr Biol. 2013 Nov 4;23(21):2079-89. doi: 10.1016/j.cub.2013.08.044. Epub 2013 Oct 24.

31.

The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells.

Meyer AS, Miller MA, Gertler FB, Lauffenburger DA.

Sci Signal. 2013 Aug 6;6(287):ra66. doi: 10.1126/scisignal.2004155.

32.

Cardiac overexpression of Mammalian enabled (Mena) exacerbates heart failure in mice.

Belmonte SL, Ram R, Mickelsen DM, Gertler FB, Blaxall BC.

Am J Physiol Heart Circ Physiol. 2013 Sep 15;305(6):H875-84. doi: 10.1152/ajpheart.00342.2013. Epub 2013 Jul 5.

33.

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion.

Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS.

Cancer Cell. 2012 Nov 13;22(5):615-30. doi: 10.1016/j.ccr.2012.09.027.

34.

Quantitative assessment of invasive mena isoforms (Menacalc) as an independent prognostic marker in breast cancer.

Agarwal S, Gertler FB, Balsamo M, Condeelis JS, Camp RL, Xue X, Lin J, Rohan TE, Rimm DL.

Breast Cancer Res. 2012 Sep 12;14(5):R124. doi: 10.1186/bcr3318.

35.

Mena binds α5 integrin directly and modulates α5β1 function.

Gupton SL, Riquelme D, Hughes-Alford SK, Tadros J, Rudina SS, Hynes RO, Lauffenburger D, Gertler FB.

J Cell Biol. 2012 Aug 20;198(4):657-76. doi: 10.1083/jcb.201202079.

36.

Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function.

Zervantonakis IK, Hughes-Alford SK, Charest JL, Condeelis JS, Gertler FB, Kamm RD.

Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13515-20. doi: 10.1073/pnas.1210182109. Epub 2012 Aug 6.

37.

2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen.

Meyer AS, Hughes-Alford SK, Kay JE, Castillo A, Wells A, Gertler FB, Lauffenburger DA.

J Cell Biol. 2012 Jun 11;197(6):721-9. doi: 10.1083/jcb.201201003. Epub 2012 Jun 4.

38.

Peptide array X-linking (PAX): a new peptide-protein identification approach.

Okada H, Uezu A, Soderblom EJ, Moseley MA 3rd, Gertler FB, Soderling SH.

PLoS One. 2012;7(5):e37035. doi: 10.1371/journal.pone.0037035. Epub 2012 May 14.

39.

Development path and current status of the NANIVID: a new device for cancer cell studies.

Raja WK, Padgen MR, Williams JK, Gertler FB, Wyckoff JB, Condeelis JS, Castracane J.

J Micro Nanolithogr MEMS MOEMS. 2012 Mar 29;11(1). pii: 013013.

40.

Correlated immunohistochemical and cytological assays for the prediction of hematogenous dissemination of breast cancer.

Oktay MH, Gertler FB, Liu YF, Rohan TE, Condeelis JS, Jones JG.

J Histochem Cytochem. 2012 Mar;60(3):168-73. doi: 10.1369/0022155411435153. Epub 2012 Jan 3. Review.

41.

An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.

Shapiro IM, Cheng AW, Flytzanis NC, Balsamo M, Condeelis JS, Oktay MH, Burge CB, Gertler FB.

PLoS Genet. 2011 Aug;7(8):e1002218. doi: 10.1371/journal.pgen.1002218. Epub 2011 Aug 18.

42.

Signaling network state predicts twist-mediated effects on breast cell migration across diverse growth factor contexts.

Kim HD, Meyer AS, Wagner JP, Alford SK, Wells A, Gertler FB, Lauffenburger DA.

Mol Cell Proteomics. 2011 Nov;10(11):M111.008433. doi: 10.1074/mcp.M111.008433. Epub 2011 Aug 10.

43.

Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons.

Pinheiro EM, Xie Z, Norovich AL, Vidaki M, Tsai LH, Gertler FB.

Nat Cell Biol. 2011 Jul 24;13(8):989-95. doi: 10.1038/ncb2292.

44.

Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer.

Roussos ET, Balsamo M, Alford SK, Wyckoff JB, Gligorijevic B, Wang Y, Pozzuto M, Stobezki R, Goswami S, Segall JE, Lauffenburger DA, Bresnick AR, Gertler FB, Condeelis JS.

J Cell Sci. 2011 Jul 1;124(Pt 13):2120-31. doi: 10.1242/jcs.086231.

45.

Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM.

Roussos ET, Goswami S, Balsamo M, Wang Y, Stobezki R, Adler E, Robinson BD, Jones JG, Gertler FB, Condeelis JS, Oktay MH.

Clin Exp Metastasis. 2011 Aug;28(6):515-27. doi: 10.1007/s10585-011-9388-6. Epub 2011 Apr 12.

46.

Mammalian enabled (Mena) is a critical regulator of cardiac function.

Aguilar F, Belmonte SL, Ram R, Noujaim SF, Dunaevsky O, Protack TL, Jalife J, Todd Massey H, Gertler FB, Blaxall BC.

Am J Physiol Heart Circ Physiol. 2011 May;300(5):H1841-52. doi: 10.1152/ajpheart.01127.2010. Epub 2011 Feb 18.

47.

Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors.

Roussos ET, Wang Y, Wyckoff JB, Sellers RS, Wang W, Li J, Pollard JW, Gertler FB, Condeelis JS.

Breast Cancer Res. 2010;12(6):R101. doi: 10.1186/bcr2784. Epub 2010 Nov 25.

48.

A high-throughput microfluidic assay to study neurite response to growth factor gradients.

Kothapalli CR, van Veen E, de Valence S, Chung S, Zervantonakis IK, Gertler FB, Kamm RD.

Lab Chip. 2011 Feb 7;11(3):497-507. doi: 10.1039/c0lc00240b. Epub 2010 Nov 25.

PMID:
21107471
49.

The growth cone cytoskeleton in axon outgrowth and guidance.

Dent EW, Gupton SL, Gertler FB.

Cold Spring Harb Perspect Biol. 2011 Mar 1;3(3). pii: a001800. doi: 10.1101/cshperspect.a001800. Review.

50.

The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics.

Nakatsu F, Perera RM, Lucast L, Zoncu R, Domin J, Gertler FB, Toomre D, De Camilli P.

J Cell Biol. 2010 Aug 9;190(3):307-15. doi: 10.1083/jcb.201005018. Epub 2010 Aug 2.

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