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Select item 301742271.

Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox.

Daemen S, Gemmink A, Brouwers B, Meex RCR, Huntjens PR, Schaart G, Moonen-Kornips E, Jörgensen J, Hoeks J, Schrauwen P, Hesselink MKC.

Mol Metab. 2018 Aug 18. pii: S2212-8778(18)30741-5. doi: 10.1016/j.molmet.2018.08.004. [Epub ahead of print]

PMID:: 30174227

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Select item 297205722.

Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity.

Lancel S, Hesselink MK, Woldt E, Rouillé Y, Dorchies E, Delhaye S, Duhem C, Thorel Q, Mayeuf-Louchart A, Pourcet B, Montel V, Schaart G, Beton N, Picquet F, Briand O, Salles JP, Duez H, Schrauwen P, Bastide B, Bailleul B, Staels B, Sebti Y.

JCI Insight. 2018 May 3;3(9). pii: 98081. doi: 10.1172/jci.insight.98081. [Epub ahead of print]

PMID:: 29720572

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Select item 297063213.

Resveratrol improves ex vivo mitochondrial function but does not affect insulin sensitivity or brown adipose tissue in first degree relatives of patients with type 2 diabetes.

de Ligt M, Bruls YMH, Hansen J, Habets MF, Havekes B, Nascimento EBM, Moonen-Kornips E, Schaart G, Schrauwen-Hinderling VB, van Marken Lichtenbelt W, Schrauwen P.

Mol Metab. 2018 Jun;12:39-47. doi: 10.1016/j.molmet.2018.04.004. Epub 2018 Apr 18.

PMID:: 29706321

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Select item 291786004.

Genetic Markers of Brown Adipose Tissue Identity and In Vitro Brown Adipose Tissue Activity in Humans.

Nascimento EBM, Sparks LM, Divoux A, van Gisbergen MW, Broeders EPM, Jörgensen JA, Schaart G, Bouvy ND, van Marken Lichtenbelt WD, Schrauwen P.

Obesity (Silver Spring). 2018 Jan;26(1):135-140. doi: 10.1002/oby.22062. Epub 2017 Nov 27.

PMID:: 29178600

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Select item 291103005.

Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5?

Gemmink A, Daemen S, Brouwers B, Huntjens PR, Schaart G, Moonen-Kornips E, Jörgensen J, Hoeks J, Schrauwen P, Hesselink MKC.

J Physiol. 2018 Mar 1;596(5):857-868. doi: 10.1113/JP275182. Epub 2017 Nov 23.

PMID:: 29110300

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Select item 281952176.

Lipid droplet dynamics and insulin sensitivity upon a 5-day high-fat diet in Caucasians and South Asians.

Gemmink A, Bakker LE, Guigas B, Kornips E, Schaart G, Meinders AE, Jazet IM, Hesselink MK.

Sci Rep. 2017 Feb 14;7:42393. doi: 10.1038/srep42393.

PMID:: 28195217

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Select item 278526847.

Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial.

Timmers S, de Ligt M, Phielix E, van de Weijer T, Hansen J, Moonen-Kornips E, Schaart G, Kunz I, Hesselink MK, Schrauwen-Hinderling VB, Schrauwen P.

Diabetes Care. 2016 Dec;39(12):2211-2217. Epub 2016 Oct 6.

PMID:: 27852684

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Select item 269732848.

A genistein-enriched diet neither improves skeletal muscle oxidative capacity nor prevents the transition towards advanced insulin resistance in ZDF rats.

van Bree BW, Lenaers E, Nabben M, Briedé JJ, Jörgensen JA, Schaart G, Schrauwen P, Hoeks J, Hesselink MK.

Sci Rep. 2016 Mar 14;6:22854. doi: 10.1038/srep22854.

PMID:: 26973284

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Select item 268861989.

ANT1-mediated fatty acid-induced uncoupling as a target for improving myocellular insulin sensitivity.

Sparks LM, Gemmink A, Phielix E, Bosma M, Schaart G, Moonen-Kornips E, Jörgensen JA, Nascimento EB, Hesselink MK, Schrauwen P, Hoeks J.

Diabetologia. 2016 May;59(5):1030-9. doi: 10.1007/s00125-016-3885-8. Epub 2016 Feb 17.

PMID:: 26886198

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Select item 2686443610.

Decoration of intramyocellular lipid droplets with PLIN5 modulates fasting-induced insulin resistance and lipotoxicity in humans.

Gemmink A, Bosma M, Kuijpers HJ, Hoeks J, Schaart G, van Zandvoort MA, Schrauwen P, Hesselink MK.

Diabetologia. 2016 May;59(5):1040-8. doi: 10.1007/s00125-016-3865-z. Epub 2016 Feb 10.

PMID:: 26864436

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Select item 2671849911.

Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans.

Hanssen MJ, van der Lans AA, Brans B, Hoeks J, Jardon KM, Schaart G, Mottaghy FM, Schrauwen P, van Marken Lichtenbelt WD.

Diabetes. 2016 May;65(5):1179-89. doi: 10.2337/db15-1372. Epub 2015 Dec 30.

PMID:: 26718499

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Select item 2647633612.

ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure.

Dijk W, Heine M, Vergnes L, Boon MR, Schaart G, Hesselink MK, Reue K, van Marken Lichtenbelt WD, Olivecrona G, Rensen PC, Heeren J, Kersten S.

Elife. 2015 Oct 17;4. pii: e08428. doi: 10.7554/eLife.08428.

PMID:: 26476336

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Select item 2623542113.

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity.

Broeders EP, Nascimento EB, Havekes B, Brans B, Roumans KH, Tailleux A, Schaart G, Kouach M, Charton J, Deprez B, Bouvy ND, Mottaghy F, Staels B, van Marken Lichtenbelt WD, Schrauwen P.

Cell Metab. 2015 Sep 1;22(3):418-26. doi: 10.1016/j.cmet.2015.07.002. Epub 2015 Jul 30.

PMID:: 26235421

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Select item 2614927714.

Cold acclimation affects immune composition in skeletal muscle of healthy lean subjects.

van der Lans AA, Boon MR, Haks MC, Quinten E, Schaart G, Ottenhoff TH, van Marken Lichtenbelt WD.

Physiol Rep. 2015 Jul;3(7). pii: e12394. doi: 10.14814/phy2.12394.

PMID:: 26149277

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Select item 2614776015.

Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus.

Hanssen MJ, Hoeks J, Brans B, van der Lans AA, Schaart G, van den Driessche JJ, Jörgensen JA, Boekschoten MV, Hesselink MK, Havekes B, Kersten S, Mottaghy FM, van Marken Lichtenbelt WD, Schrauwen P.

Nat Med. 2015 Aug;21(8):863-5. doi: 10.1038/nm.3891. Epub 2015 Jul 6.

PMID:: 26147760

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Select item 2570463116.

Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain.

Jiang J, Briedé JJ, Jennen DG, Van Summeren A, Saritas-Brauers K, Schaart G, Kleinjans JC, de Kok TM.

Toxicol Lett. 2015 Apr 16;234(2):139-50. doi: 10.1016/j.toxlet.2015.02.012. Epub 2015 Feb 19.

PMID:: 25704631

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Select item 2535317117.

Genetic analysis of intracapillary glomerular lipoprotein deposits in aging mice.

Noordmans GA, Huang Y, Savage H, van Dijk MC, Schaart G, van den Bergh Weerman MA, Heeringa P, Hillebrands JL, Korstanje R, van Goor H.

PLoS One. 2014 Oct 29;9(10):e111308. doi: 10.1371/journal.pone.0111308. eCollection 2014.

PMID:: 25353171

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Select item 2534408418.

Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death.

Nabben M, van Bree BWJ, Lenaers E, Hoeks J, Hesselink MKC, Schaart G, Gijbels MJJ, Glatz JFC, da Silva GJJ, de Windt LJ, Tian R, Mike E, Skapura DG, Wehrens XHT, Schrauwen P.

Basic Res Cardiol. 2014;109(6):447. doi: 10.1007/s00395-014-0447-4. Epub 2014 Oct 25.

PMID:: 25344084

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Select item 2514855119.

Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects.

Boon MR, Bakker LE, Haks MC, Quinten E, Schaart G, Van Beek L, Wang Y, Van Schinkel L, Van Harmelen V, Meinders AE, Ottenhoff TH, Van Dijk KW, Guigas B, Jazet IM, Rensen PC.

Clin Sci (Lond). 2015 Jan;128(2):143-51. doi: 10.1042/CS20140179.

PMID:: 25148551

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Select item 2459160020.

Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise.

Catoire M, Alex S, Paraskevopulos N, Mattijssen F, Evers-van Gogh I, Schaart G, Jeppesen J, Kneppers A, Mensink M, Voshol PJ, Olivecrona G, Tan NS, Hesselink MK, Berbée JF, Rensen PC, Kalkhoven E, Schrauwen P, Kersten S.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):E1043-52. doi: 10.1073/pnas.1400889111. Epub 2014 Mar 3.