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Items: 1 to 50 of 167

1.

Emerging Affinity Reagents for High Throughput Proteomics: Trust, but Verify.

Benson MD, Ngo D, Ganz P, Gerszten RE.

Circulation. 2019 Nov 12;140(20):1610-1612. doi: 10.1161/CIRCULATIONAHA.119.039912. Epub 2019 Nov 11. No abstract available.

PMID:
31710523
2.

Metabolite Profiles of Incident Diabetes and Heterogeneity of Treatment Effect in the Diabetes Prevention Program.

Chen ZZ, Liu J, Morningstar J, Heckman-Stoddard BM, Lee CG, Dagogo-Jack S, Ferguson JF, Hamman RF, Knowler WC, Mather KJ, Perreault L, Florez JC, Wang TJ, Clish C, Temprosa M, Gerszten RE; and the Diabetes Prevention Program Research Group.

Diabetes. 2019 Oct 3. pii: db190236. doi: 10.2337/db19-0236. [Epub ahead of print]

PMID:
31582408
3.

Perspective: Dietary Biomarkers of Intake and Exposure—Exploration with Omics Approaches

Maruvada P, Lampe JW, Wishart DS, Barupal D, Chester DN, Dodd D, Djoumbou-Feunang Y, Dorrestein PC, Dragsted LO, Draper J, Duffy LC, Dwyer JT, Emenaker NJ, Fiehn O, Gerszten RE, B Hu F, Karp RW, Klurfeld DM, Laughlin MR, Little AR, Lynch CJ, Moore SC, Nicastro HL, O'Brien DM, Ordovás JM, Osganian SK, Playdon M, Prentice R, Raftery D, Reisdorph N, Roche HM, Ross SA, Sang S, Scalbert A, Srinivas PR, Zeisel SH.

Adv Nutr. 2019 Aug 6. pii: nmz075. doi: 10.1093/advances/nmz075. [Epub ahead of print]

PMID:
31386148
4.

Intramuscular administration of hexachloroplatinate reverses cyanide-induced metabolic derangements and counteracts severe cyanide poisoning.

Morningstar J, Lee J, Hendry-Hofer T, Witeof A, Lyle LT, Knipp G, MacRae CA, Boss GR, Peterson RT, Davisson VJ, Gerszten RE, Bebarta VS, Mahon S, Brenner M, Nath AK.

FASEB Bioadv. 2019 Feb;1(2):81-92. doi: 10.1096/fba.1024. Epub 2018 Oct 8.

PMID:
31355359
5.

Changes in Citric Acid Cycle and Nucleoside Metabolism Are Associated with Anthracycline Cardiotoxicity in Patients with Breast Cancer.

Asnani A, Shi X, Farrell L, Lall R, Sebag IA, Plana JC, Gerszten RE, Scherrer-Crosbie M.

J Cardiovasc Transl Res. 2019 Jul 5. doi: 10.1007/s12265-019-09897-y. [Epub ahead of print]

PMID:
31278494
6.

Association of Dimethylguanidino Valeric Acid With Partial Resistance to Metabolic Health Benefits of Regular Exercise.

Robbins JM, Herzig M, Morningstar J, Sarzynski MA, Cruz DE, Wang TJ, Gao Y, Wilson JG, Bouchard C, Rankinen T, Gerszten RE.

JAMA Cardiol. 2019 Jul 1;4(7):636-643. doi: 10.1001/jamacardio.2019.1573.

PMID:
31166569
7.

Accelerating Biomarker Discovery Through Electronic Health Records, Automated Biobanking, and Proteomics.

Wells QS, Gupta DK, Smith JG, Collins SP, Storrow AB, Ferguson J, Smith ML, Pulley JM, Collier S, Wang X, Roden DM, Gerszten RE, Wang TJ.

J Am Coll Cardiol. 2019 May 7;73(17):2195-2205. doi: 10.1016/j.jacc.2019.01.074.

PMID:
31047008
8.

Clinical Metabolomics Identifies Blood Serum Branched Chain Amino Acids as Potential Predictive Biomarkers for Chronic Graft vs. Host Disease.

Alborghetti MR, Correa MEP, Whangbo J, Shi X, Aricetti JA, da Silva AA, Miranda ECM, Sforca ML, Caldana C, Gerszten RE, Ritz J, Zeri ACM.

Front Oncol. 2019 Mar 18;9:141. doi: 10.3389/fonc.2019.00141. eCollection 2019.

9.

Activin type II receptor signaling in cardiac aging and heart failure.

Roh JD, Hobson R, Chaudhari V, Quintero P, Yeri A, Benson M, Xiao C, Zlotoff D, Bezzerides V, Houstis N, Platt C, Damilano F, Lindman BR, Elmariah S, Biersmith M, Lee SJ, Seidman CE, Seidman JG, Gerszten RE, Lach-Trifilieff E, Glass DJ, Rosenzweig A.

Sci Transl Med. 2019 Mar 6;11(482). pii: eaau8680. doi: 10.1126/scitranslmed.aau8680.

PMID:
30842316
10.

Proteomics Profiling and Risk of New-Onset Atrial Fibrillation: Framingham Heart Study.

Ko D, Benson MD, Ngo D, Yang Q, Larson MG, Wang TJ, Trinquart L, McManus DD, Lubitz SA, Ellinor PT, Vasan RS, Gerszten RE, Benjamin EJ, Lin H.

J Am Heart Assoc. 2019 Mar 19;8(6):e010976. doi: 10.1161/JAHA.118.010976.

11.

Succinate links atrial dysfunction and cardioembolic stroke.

Nelson SE, Ament Z, Wolcott Z, Gerszten RE, Kimberly WT.

Neurology. 2019 Feb 19;92(8):e802-e810. doi: 10.1212/WNL.0000000000006957. Epub 2019 Jan 23.

PMID:
30674589
12.

Human PAH is characterized by a pattern of lipid-related insulin resistance.

Hemnes AR, Luther JM, Rhodes CJ, Burgess JP, Carlson J, Fan R, Fessel JP, Fortune N, Gerszten RE, Halliday SJ, Hekmat R, Howard L, Newman JH, Niswender KD, Pugh ME, Robbins IM, Sheng Q, Shibao CA, Shyr Y, Sumner S, Talati M, Wharton J, Wilkins MR, Ye F, Yu C, West J, Brittain EL.

JCI Insight. 2019 Jan 10;4(1). pii: 123611. doi: 10.1172/jci.insight.123611. [Epub ahead of print]

13.

Depot-Specific Adipose Tissue Metabolite Profiles and Corresponding Changes Following Aerobic Exercise.

Brennan AM, Tchernof A, Gerszten RE, Cowan TE, Ross R.

Front Endocrinol (Lausanne). 2018 Dec 11;9:759. doi: 10.3389/fendo.2018.00759. eCollection 2018.

14.

Probing the Virtual Proteome to Identify Novel Disease Biomarkers.

Mosley JD, Benson MD, Smith JG, Melander O, Ngo D, Shaffer CM, Ferguson JF, Herzig MS, McCarty CA, Chute CG, Jarvik GP, Gordon AS, Palmer MR, Crosslin DR, Larson EB, Carrell DS, Kullo IJ, Pacheco JA, Peissig PL, Brilliant MH, Kitchner TE, Linneman JG, Namjou B, Williams MS, Ritchie MD, Borthwick KM, Kiryluk K, Mentch FD, Sleiman PM, Karlson EW, Verma SS, Zhu Y, Vasan RS, Yang Q, Denny JC, Roden DM, Gerszten RE, Wang TJ.

Circulation. 2018 Nov 27;138(22):2469-2481. doi: 10.1161/CIRCULATIONAHA.118.036063.

PMID:
30571344
15.

A novel network-based approach for discovering dynamic metabolic biomarkers in cardiovascular disease.

Baumgartner C, Spath-Blass V, Niederkofler V, Bergmoser K, Langthaler S, Lassnig A, Rienmüller T, Baumgartner D, Asnani A, Gerszten RE.

PLoS One. 2018 Dec 11;13(12):e0208953. doi: 10.1371/journal.pone.0208953. eCollection 2018.

16.

l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism.

Adachi Y, De Sousa-Coelho AL, Harata I, Aoun C, Weimer S, Shi X, Gonzalez Herrera KN, Takahashi H, Doherty C, Noguchi Y, Goodyear LJ, Haigis MC, Gerszten RE, Patti ME.

Mol Metab. 2018 Nov;17:61-70. doi: 10.1016/j.molmet.2018.08.002. Epub 2018 Aug 11.

17.

Green tea consumption and risk of type 2 diabetes in Chinese adults: the Shanghai Women's Health Study and the Shanghai Men's Health Study.

Liu X, Xu W, Cai H, Gao YT, Li H, Ji BT, Shu X, Wang T, Gerszten RE, Zheng W, Xiang YB, Shu XO.

Int J Epidemiol. 2018 Dec 1;47(6):1887-1896. doi: 10.1093/ije/dyy173.

PMID:
30169796
18.

A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension.

Hemnes AR, Rathinasabapathy A, Austin EA, Brittain EL, Carrier EJ, Chen X, Fessel JP, Fike CD, Fong P, Fortune N, Gerszten RE, Johnson JA, Kaplowitz M, Newman JH, Piana R, Pugh ME, Rice TW, Robbins IM, Wheeler L, Yu C, Loyd JE, West J.

Eur Respir J. 2018 Jun 21;51(6). pii: 1702638. doi: 10.1183/13993003.02638-2017. Print 2018 Jun.

19.

Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning.

Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA.

PLoS One. 2018 Jun 7;13(6):e0193889. doi: 10.1371/journal.pone.0193889. eCollection 2018.

20.

Metabolic Effects of Betaine: A Randomized Clinical Trial of Betaine Supplementation in Prediabetes.

Grizales AM, Patti ME, Lin AP, Beckman JA, Sahni VA, Cloutier E, Fowler KM, Dreyfuss JM, Pan H, Kozuka C, Lee A, Basu R, Pober DM, Gerszten RE, Goldfine AB.

J Clin Endocrinol Metab. 2018 Aug 1;103(8):3038-3049. doi: 10.1210/jc.2018-00507.

21.

Metabolomics insights into early type 2 diabetes pathogenesis and detection in individuals with normal fasting glucose.

Merino J, Leong A, Liu CT, Porneala B, Walford GA, von Grotthuss M, Wang TJ, Flannick J, Dupuis J, Levy D, Gerszten RE, Florez JC, Meigs JB.

Diabetologia. 2018 Jun;61(6):1315-1324. doi: 10.1007/s00125-018-4599-x. Epub 2018 Apr 6.

22.

Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts.

Tynkkynen J, Chouraki V, van der Lee SJ, Hernesniemi J, Yang Q, Li S, Beiser A, Larson MG, Sääksjärvi K, Shipley MJ, Singh-Manoux A, Gerszten RE, Wang TJ, Havulinna AS, Würtz P, Fischer K, Demirkan A, Ikram MA, Amin N, Lehtimäki T, Kähönen M, Perola M, Metspalu A, Kangas AJ, Soininen P, Ala-Korpela M, Vasan RS, Kivimäki M, van Duijn CM, Seshadri S, Salomaa V.

Alzheimers Dement. 2018 Jun;14(6):723-733. doi: 10.1016/j.jalz.2018.01.003. Epub 2018 Mar 6.

23.

Plasma Metabolite Profiles in Response to Chronic Exercise.

Brennan AM, Benson M, Morningstar J, Herzig M, Robbins J, Gerszten RE, Ross R.

Med Sci Sports Exerc. 2018 Jul;50(7):1480-1486. doi: 10.1249/MSS.0000000000001594.

24.

A Role for Branched-Chain Amino Acids in the Pathophysiology of Diabetes: Using Data to Guide Discovery.

Katz DH, Gerszten RE.

Clin Chem. 2018 Aug;64(8):1250-1251. doi: 10.1373/clinchem.2017.273516. Epub 2018 Mar 5. Review. No abstract available.

25.

Association of Acylcarnitines With Left Ventricular Remodeling in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement.

Elmariah S, Farrell LA, Furman D, Lindman BR, Shi X, Morningstar JE, Rhee EP, Gerszten RE.

JAMA Cardiol. 2018 Mar 1;3(3):242-246. doi: 10.1001/jamacardio.2017.4873.

26.

Genetic Architecture of the Cardiovascular Risk Proteome.

Benson MD, Yang Q, Ngo D, Zhu Y, Shen D, Farrell LA, Sinha S, Keyes MJ, Vasan RS, Larson MG, Smith JG, Wang TJ, Gerszten RE.

Circulation. 2018 Mar 13;137(11):1158-1172. doi: 10.1161/CIRCULATIONAHA.117.029536. Epub 2017 Dec 19.

27.

Application of Large-Scale Aptamer-Based Proteomic Profiling to Planned Myocardial Infarctions.

Jacob J, Ngo D, Finkel N, Pitts R, Gleim S, Benson MD, Keyes MJ, Farrell LA, Morgan T, Jennings LL, Gerszten RE.

Circulation. 2018 Mar 20;137(12):1270-1277. doi: 10.1161/CIRCULATIONAHA.117.029443. Epub 2017 Dec 8.

28.

Dimethylguanidino valeric acid is a marker of liver fat and predicts diabetes.

O'Sullivan JF, Morningstar JE, Yang Q, Zheng B, Gao Y, Jeanfavre S, Scott J, Fernandez C, Zheng H, O'Connor S, Cohen P, Vasan RS, Long MT, Wilson JG, Melander O, Wang TJ, Fox C, Peterson RT, Clish CB, Corey KE, Gerszten RE.

J Clin Invest. 2017 Dec 1;127(12):4394-4402. doi: 10.1172/JCI95995. Epub 2017 Oct 30.

29.

Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy.

Fitzgibbons TP, Edwards YJK, Shaw P, Iskandar A, Ahmed M, Bote J, Shah T, Sinha S, Gerszten RE, Keaney JF Jr, Zile MR, Aurigemma GP.

Front Cardiovasc Med. 2017 Aug 3;4:49. doi: 10.3389/fcvm.2017.00049. eCollection 2017.

30.

Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis.

Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Burke MA, Zhang K, Musunuru K, Gerszten RE, Wu SM, Chen CS, Seidman JG, Seidman CE.

Cell Rep. 2017 Jun 13;19(11):2410. doi: 10.1016/j.celrep.2017.05.038. No abstract available.

31.

Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham Study.

Chouraki V, Preis SR, Yang Q, Beiser A, Li S, Larson MG, Weinstein G, Wang TJ, Gerszten RE, Vasan RS, Seshadri S.

Alzheimers Dement. 2017 Dec;13(12):1327-1336. doi: 10.1016/j.jalz.2017.04.009. Epub 2017 Jun 8.

32.

Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss.

Geidenstam N, Magnusson M, Danielsson APH, Gerszten RE, Wang TJ, Reinius LE, Mulder H, Melander O, Ridderstråle M.

Int J Endocrinol. 2017;2017:6490473. doi: 10.1155/2017/6490473. Epub 2017 Apr 16.

33.

Plasma metabolite profiles, cellular cholesterol efflux, and non-traditional cardiovascular risk in patients with CKD.

Ganda A, Yvan-Charvet L, Zhang Y, Lai EJ, Regunathan-Shenk R, Hussain FN, Avasare R, Chakraborty B, Febus AJ, Vernocchi L, Lantigua R, Wang Y, Shi X, Hsieh J, Murphy AJ, Wang N, Bijl N, Gordon KM, de Miguel MH, Singer JR, Hogan J, Cremers S, Magnusson M, Melander O, Gerszten RE, Tall AR.

J Mol Cell Cardiol. 2017 Nov;112:114-122. doi: 10.1016/j.yjmcc.2017.05.001. Epub 2017 May 4.

34.

Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis.

Kimberly WT, O'Sullivan JF, Nath AK, Keyes M, Shi X, Larson MG, Yang Q, Long MT, Vasan R, Peterson RT, Wang TJ, Corey KE, Gerszten RE.

JCI Insight. 2017 May 4;2(9). pii: 92989. doi: 10.1172/jci.insight.92989. eCollection 2017 May 4.

35.

Emerging Affinity-Based Proteomic Technologies for Large-Scale Plasma Profiling in Cardiovascular Disease.

Smith JG, Gerszten RE.

Circulation. 2017 Apr 25;135(17):1651-1664. doi: 10.1161/CIRCULATIONAHA.116.025446. Review.

36.

Activation of IRF1 in Human Adipocytes Leads to Phenotypes Associated with Metabolic Disease.

Friesen M, Camahort R, Lee YK, Xia F, Gerszten RE, Rhee EP, Deo RC, Cowan CA.

Stem Cell Reports. 2017 May 9;8(5):1164-1173. doi: 10.1016/j.stemcr.2017.03.014. Epub 2017 Apr 13.

37.

Cisplatin Analogs Confer Protection against Cyanide Poisoning.

Nath AK, Shi X, Harrison DL, Morningstar JE, Mahon S, Chan A, Sips P, Lee J, MacRae CA, Boss GR, Brenner M, Gerszten RE, Peterson RT.

Cell Chem Biol. 2017 May 18;24(5):565-575.e4. doi: 10.1016/j.chembiol.2017.03.013. Epub 2017 Apr 13.

38.

Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease.

Warren CR, O'Sullivan JF, Friesen M, Becker CE, Zhang X, Liu P, Wakabayashi Y, Morningstar JE, Shi X, Choi J, Xia F, Peters DT, Florido MHC, Tsankov AM, Duberow E, Comisar L, Shay J, Jiang X, Meissner A, Musunuru K, Kathiresan S, Daheron L, Zhu J, Gerszten RE, Deo RC, Vasan RS, O'Donnell CJ, Cowan CA.

Cell Stem Cell. 2017 Apr 6;20(4):547-557.e7. doi: 10.1016/j.stem.2017.01.010.

39.

Potential Impact and Study Considerations of Metabolomics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association.

Cheng S, Shah SH, Corwin EJ, Fiehn O, Fitzgerald RL, Gerszten RE, Illig T, Rhee EP, Srinivas PR, Wang TJ, Jain M; American Heart Association Council on Functional Genomics and Translational Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Stroke Council.

Circ Cardiovasc Genet. 2017 Apr;10(2). pii: e000032. doi: 10.1161/HCG.0000000000000032. Review.

40.

Urinary metabolites along with common and rare genetic variations are associated with incident chronic kidney disease.

McMahon GM, Hwang SJ, Clish CB, Tin A, Yang Q, Larson MG, Rhee EP, Li M; CKDGen Consortium, Levy D, O'Donnell CJ, Coresh J, Young JH, Gerszten RE, Fox CS.

Kidney Int. 2017 Jun;91(6):1426-1435. doi: 10.1016/j.kint.2017.01.007. Epub 2017 Mar 14.

PMID:
28302371
41.

HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus.

Fusco DN, Pratt H, Kandilas S, Cheon SS, Lin W, Cronkite DA, Basavappa M, Jeffrey KL, Anselmo A, Sadreyev R, Yapp C, Shi X, O'Sullivan JF, Gerszten RE, Tomaru T, Yoshino S, Satoh T, Chung RT.

Front Microbiol. 2017 Feb 20;8:240. doi: 10.3389/fmicb.2017.00240. eCollection 2017.

42.

Metabolites Associated With Lean Mass and Adiposity in Older Black Men.

Murphy RA, Moore SC, Playdon M, Meirelles O, Newman AB, Milijkovic I, Kritchevsky SB, Schwartz A, Goodpaster BH, Sampson J, Cawthon P, Simonsick EM, Gerszten RE, Clish CB, Harris TB; Health ABC Study.

J Gerontol A Biol Sci Med Sci. 2017 Oct 1;72(10):1352-1359. doi: 10.1093/gerona/glw245.

43.

Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis.

Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Burke MA, Zhang K, Musunuru K, Gerszten RE, Wu SM, Chen CS, Seidman JG, Seidman CE.

Cell Rep. 2016 Dec 20;17(12):3292-3304. doi: 10.1016/j.celrep.2016.11.066. Erratum in: Cell Rep. 2017 Jun 13;19(11):2410.

44.

The Emerging Role of Metabolomics in the Diagnosis and Prognosis of Cardiovascular Disease.

Ussher JR, Elmariah S, Gerszten RE, Dyck JR.

J Am Coll Cardiol. 2016 Dec 27;68(25):2850-2870. doi: 10.1016/j.jacc.2016.09.972. Review.

45.

A countermeasure development pipeline.

MacRae CA, Boss G, Brenner M, Gerszten RE, Mahon S, Peterson RT.

Ann N Y Acad Sci. 2016 Aug;1378(1):58-67. doi: 10.1111/nyas.13224. Review.

46.

Metabolomic Profiling in Relation to New-Onset Atrial Fibrillation (from the Framingham Heart Study).

Ko D, Riles EM, Marcos EG, Magnani JW, Lubitz SA, Lin H, Long MT, Schnabel RB, McManus DD, Ellinor PT, Ramachandran SV, Wang TJ, Gerszten RE, Benjamin EJ, Yin X, Rienstra M.

Am J Cardiol. 2016 Nov 15;118(10):1493-1496. doi: 10.1016/j.amjcard.2016.08.010. Epub 2016 Aug 24. Erratum in: Am J Cardiol. 2017 Jul 15;120(2):339.

47.

An exome array study of the plasma metabolome.

Rhee EP, Yang Q, Yu B, Liu X, Cheng S, Deik A, Pierce KA, Bullock K, Ho JE, Levy D, Florez JC, Kathiresan S, Larson MG, Vasan RS, Clish CB, Wang TJ, Boerwinkle E, O'Donnell CJ, Gerszten RE.

Nat Commun. 2016 Jul 25;7:12360. doi: 10.1038/ncomms12360.

48.

Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular Disease.

Ngo D, Sinha S, Shen D, Kuhn EW, Keyes MJ, Shi X, Benson MD, O'Sullivan JF, Keshishian H, Farrell LA, Fifer MA, Vasan RS, Sabatine MS, Larson MG, Carr SA, Wang TJ, Gerszten RE.

Circulation. 2016 Jul 26;134(4):270-85. doi: 10.1161/CIRCULATIONAHA.116.021803.

49.

The Prospects for Cardiovascular Proteomics: A Glass Approaching Half Full.

Benson MD, Sabatine MS, Gerszten RE.

JAMA Cardiol. 2016 Jun 1;1(3):245-6. doi: 10.1001/jamacardio.2016.0279. No abstract available.

PMID:
27438098
50.

Multimarker Risk Stratification in Patients With Acute Myocardial Infarction.

O'Donoghue ML, Morrow DA, Cannon CP, Jarolim P, Desai NR, Sherwood MW, Murphy SA, Gerszten RE, Sabatine MS.

J Am Heart Assoc. 2016 May 20;5(5). pii: e002586. doi: 10.1161/JAHA.115.002586.

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