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Items: 1 to 50 of 161


Hypophosphatemia Regulates Molecular Mechanisms of Circadian Rhythm.

Noguchi T, Hussein AI, Horowitz N, Carroll D, Gower AC, Demissie S, Gerstenfeld LC.

Sci Rep. 2018 Sep 13;8(1):13756. doi: 10.1038/s41598-018-31830-7.


Clustering of temporal gene expression data with mixtures of mixed effects models with a penalized likelihood.

Lu D, Tripodis Y, Gerstenfeld LC, Demissie S.

Bioinformatics. 2019 Mar 1;35(5):778-786. doi: 10.1093/bioinformatics/bty696.


Erratum: "BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing" [J Orthop Res. Vol 34, 2096-2105 (2016)].

Morgan EF, Pittman J, DeGiacomo A, Cusher D, de Bakker CMJ, Mroszczyk KA, Grinstaff MW, Gerstenfeld LC.

J Orthop Res. 2018 Mar;36(3):1040. doi: 10.1002/jor.23677. Epub 2017 Sep 20. No abstract available.


Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice.

Watt J, Baker AH, Meeks B, Pajevic PD, Morgan EF, Gerstenfeld LC, Schlezinger JJ.

J Cell Physiol. 2018 Sep;233(9):7007-7021. doi: 10.1002/jcp.26495. Epub 2018 Mar 25.


Serum proteomic assessment of the progression of fracture healing.

Hussein AI, Mancini C, Lybrand KE, Cooke ME, Matheny HE, Hogue BL, Tornetta P 3rd, Gerstenfeld LC.

J Orthop Res. 2018 Apr;36(4):1153-1163. doi: 10.1002/jor.23754. Epub 2017 Nov 22.


AMPK downregulates ALK2 via increasing the interaction between Smurf1 and Smad6, leading to inhibition of osteogenic differentiation.

Lin H, Ying Y, Wang YY, Wang G, Jiang SS, Huang D, Luo L, Chen YG, Gerstenfeld LC, Luo Z.

Biochim Biophys Acta Mol Cell Res. 2017 Dec;1864(12):2369-2377. doi: 10.1016/j.bbamcr.2017.08.009. Epub 2017 Aug 25.


Correlation between RUST assessments of fracture healing to structural and biomechanical properties.

Cooke ME, Hussein AI, Lybrand KE, Wulff A, Simmons E, Choi JH, Litrenta J, Ricci WM, Nascone JW, O'Toole RV, Morgan EF, Gerstenfeld LC, Tornetta P 3rd.

J Orthop Res. 2018 Mar;36(3):945-953. doi: 10.1002/jor.23710. Epub 2017 Sep 20.


Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis.

Alshenibr W, Tashkandi MM, Alsaqer SF, Alkheriji Y, Wise A, Fulzele S, Mehra P, Goldring MB, Gerstenfeld LC, Bais MV.

Arthritis Res Ther. 2017 Aug 2;19(1):179. doi: 10.1186/s13075-017-1388-8.


Local Changes to the Distal Femoral Growth Plate Following Injury in Mice.

Drenkard LMM, Kupratis ME, Li K, Gerstenfeld LC, Morgan EF.

J Biomech Eng. 2017 Jul 1;139(7). doi: 10.1115/1.4036686.


Earliest phases of chondrogenesis are dependent upon angiogenesis during ectopic bone formation in mice.

Bragdon B, Lam S, Aly S, Femia A, Clark A, Hussein A, Morgan EF, Gerstenfeld LC.

Bone. 2017 Aug;101:49-61. doi: 10.1016/j.bone.2017.04.002. Epub 2017 Apr 12.


From the Cover: Tributyltin Alters the Bone Marrow Microenvironment and Suppresses B Cell Development.

Baker AH, Wu TH, Bolt AM, Gerstenfeld LC, Mann KK, Schlezinger JJ.

Toxicol Sci. 2017 Jul 1;158(1):63-75. doi: 10.1093/toxsci/kfx067.


TNFα contributes to diabetes impaired angiogenesis in fracture healing.

Lim JC, Ko KI, Mattos M, Fang M, Zhang C, Feinberg D, Sindi H, Li S, Alblowi J, Kayal RA, Einhorn TA, Gerstenfeld LC, Graves DT.

Bone. 2017 Jun;99:26-38. doi: 10.1016/j.bone.2017.02.014. Epub 2017 Mar 8.


Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice.

Ko FC, Martins JS, Reddy P, Bragdon B, Hussein AI, Gerstenfeld LC, Demay MB.

J Bone Miner Res. 2016 Dec;31(12):2204-2214. doi: 10.1002/jbmr.2891. Epub 2016 Nov 7.


BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing.

Morgan EF, Pittman J, DeGiacomo A, Cusher D, de Bakker CM, Mroszczyk KA, Grinstaff MW, Gerstenfeld LC.

J Orthop Res. 2016 Dec;34(12):2096-2105. doi: 10.1002/jor.23233. Epub 2016 Apr 6. Erratum in: J Orthop Res. 2018 Mar;36(3):1040.


Sex-Linked Skeletal Phenotype of Lysyl Oxidase Like-1 Mutant Mice.

Alsofi L, Daley E, Hornstra I, Morgan EF, Mason ZD, Acevedo JF, Word RA, Gerstenfeld LC, Trackman PC.

Calcif Tissue Int. 2016 Feb;98(2):172-85. doi: 10.1007/s00223-015-0076-4. Epub 2015 Nov 5.


Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells.

Baker AH, Watt J, Huang CK, Gerstenfeld LC, Schlezinger JJ.

Chem Res Toxicol. 2015 Jun 15;28(6):1156-66. doi: 10.1021/tx500433r. Epub 2015 May 13.


Mechanical microenvironments and protein expression associated with formation of different skeletal tissues during bone healing.

Miller GJ, Gerstenfeld LC, Morgan EF.

Biomech Model Mechanobiol. 2015 Nov;14(6):1239-53. doi: 10.1007/s10237-015-0670-4. Epub 2015 Mar 31.


Diabetes reduces mesenchymal stem cells in fracture healing through a TNFα-mediated mechanism.

Ko KI, Coimbra LS, Tian C, Alblowi J, Kayal RA, Einhorn TA, Gerstenfeld LC, Pignolo RJ, Graves DT.

Diabetologia. 2015 Mar;58(3):633-642. doi: 10.1007/s00125-014-3470-y. Epub 2015 Jan 7.


Fracture healing: mechanisms and interventions.

Einhorn TA, Gerstenfeld LC.

Nat Rev Rheumatol. 2015 Jan;11(1):45-54. doi: 10.1038/nrrheum.2014.164. Epub 2014 Sep 30. Review.


Intrinsic Sex-Linked Variations in Osteogenic and Adipogenic Differentiation Potential of Bone Marrow Multipotent Stromal Cells.

Bragdon B, Burns R, Baker AH, Belkina AC, Morgan EF, Denis GV, Gerstenfeld LC, Schlezinger JJ.

J Cell Physiol. 2015 Feb;230(2):296-307. doi: 10.1002/jcp.24705.


Role of Fas and Treg cells in fracture healing as characterized in the fas-deficient (lpr) mouse model of lupus.

Al-Sebaei MO, Daukss DM, Belkina AC, Kakar S, Wigner NA, Cusher D, Graves D, Einhorn T, Morgan E, Gerstenfeld LC.

J Bone Miner Res. 2014 Jun;29(6):1478-91. doi: 10.1002/jbmr.2169.


Generation of closed transverse fractures in small animals.

De Giacomo A, Morgan EF, Gerstenfeld LC.

Methods Mol Biol. 2014;1130:35-44. doi: 10.1007/978-1-62703-989-5_3.


Overview of skeletal repair (fracture healing and its assessment).

Morgan EF, De Giacomo A, Gerstenfeld LC.

Methods Mol Biol. 2014;1130:13-31. doi: 10.1007/978-1-62703-989-5_2. Review.


Erratum to: Overview of Skeletal Repair (Fracture Healing and Its Assessment).

Morgan EF, De Giacomo A, Gerstenfeld LC.

Methods Mol Biol. 2014;1130:E5. doi: 10.1007/978-1-62703-989-5_27. No abstract available.


Skeletal trauma generates systemic BMP2 activation that is temporally related to the mobilization of CD73+ cells.

Marsell R, Steen B, Bais MV, Mortlock DP, Einhorn TA, Gerstenfeld LC.

J Orthop Res. 2014 Jan;32(1):17-23. doi: 10.1002/jor.22487. Epub 2013 Sep 9.


Functional role of Runx3 in the regulation of aggrecan expression during cartilage development.

Wigner NA, Soung do Y, Einhorn TA, Drissi H, Gerstenfeld LC.

J Cell Physiol. 2013 Nov;228(11):2232-42. doi: 10.1002/jcp.24396.


Assessment of contrast-enhanced computed tomography for imaging of cartilage during fracture healing.

Hayward LN, de Bakker CM, Gerstenfeld LC, Grinstaff MW, Morgan EF.

J Orthop Res. 2013 Apr;31(4):567-73. doi: 10.1002/jor.22265. Epub 2012 Nov 19.


VEGF and bone cell signalling: an essential vessel for communication?

Clarkin CE, Gerstenfeld LC.

Cell Biochem Funct. 2013 Jan;31(1):1-11. doi: 10.1002/cbf.2911. Epub 2012 Nov 5. Review.


Vascular development during distraction osteogenesis proceeds by sequential intramuscular arteriogenesis followed by intraosteal angiogenesis.

Morgan EF, Hussein AI, Al-Awadhi BA, Hogan DE, Matsubara H, Al-Alq Z, Fitch J, Andre B, Hosur K, Gerstenfeld LC.

Bone. 2012 Sep;51(3):535-45. doi: 10.1016/j.bone.2012.05.008. Epub 2012 May 19.


A2B adenosine receptor promotes mesenchymal stem cell differentiation to osteoblasts and bone formation in vivo.

Carroll SH, Wigner NA, Kulkarni N, Johnston-Cox H, Gerstenfeld LC, Ravid K.

J Biol Chem. 2012 May 4;287(19):15718-27. doi: 10.1074/jbc.M112.344994. Epub 2012 Mar 8.


Vascular tissues are a primary source of BMP2 expression during bone formation induced by distraction osteogenesis.

Matsubara H, Hogan DE, Morgan EF, Mortlock DP, Einhorn TA, Gerstenfeld LC.

Bone. 2012 Jul;51(1):168-80. doi: 10.1016/j.bone.2012.02.017. Epub 2012 Feb 25.


MRT letter: Contrast-enhanced computed tomographic imaging of soft callus formation in fracture healing.

Hayward LN, de Bakker CM, Lusic H, Gerstenfeld LC, Grinstaff MW, Morgan EF.

Microsc Res Tech. 2012 Jan;75(1):7-14. doi: 10.1002/jemt.21100. Epub 2011 Oct 28.


The transcriptome of fracture healing defines mechanisms of coordination of skeletal and vascular development during endochondral bone formation.

Grimes R, Jepsen KJ, Fitch JL, Einhorn TA, Gerstenfeld LC.

J Bone Miner Res. 2011 Nov;26(11):2597-609. doi: 10.1002/jbmr.486.


Urine matrix metalloproteinases (MMPs) as biomarkers for the progression of fracture healing.

Wigner NA, Kulkarni N, Yakavonis M, Young M, Tinsley B, Meeks B, Einhorn TA, Gerstenfeld LC.

Injury. 2012 Mar;43(3):274-8. doi: 10.1016/j.injury.2011.05.038.


Mechanism of action and morphologic changes in the alveolar bone in response to selective alveolar decortication-facilitated tooth movement.

Baloul SS, Gerstenfeld LC, Morgan EF, Carvalho RS, Van Dyke TE, Kantarci A.

Am J Orthod Dentofacial Orthop. 2011 Apr;139(4 Suppl):S83-101. doi: 10.1016/j.ajodo.2010.09.026.


Lysyl oxidase-like-2 (LOXL2) is a major isoform in chondrocytes and is critically required for differentiation.

Iftikhar M, Hurtado P, Bais MV, Wigner N, Stephens DN, Gerstenfeld LC, Trackman PC.

J Biol Chem. 2011 Jan 14;286(2):909-18. doi: 10.1074/jbc.M110.155622. Epub 2010 Nov 11.


The effects of injury magnitude on the kinetics of the acute phase response.

Bauzá G, Miller G, Kaseje N, Wigner NA, Wang Z, Gerstenfeld LC, Burke PA.

J Trauma. 2011 Apr;70(4):948-53. doi: 10.1097/TA.0b013e3181e1d27b.


TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1.

Kayal RA, Siqueira M, Alblowi J, McLean J, Krothapalli N, Faibish D, Einhorn TA, Gerstenfeld LC, Graves DT.

J Bone Miner Res. 2010 Jul;25(7):1604-15. doi: 10.1002/jbmr.59.


Genetic variation in the structural pattern of osteoclast activity during post-natal growth of mouse femora.

Gerstenfeld LC, McLean J, Healey DS, Stapleton SN, Silkman LJ, Price C, Jepsen KJ.

Bone. 2010 Jun;46(6):1546-54. doi: 10.1016/j.bone.2010.02.016. Epub 2010 Feb 21.


Transcriptional profiling and biochemical analysis of mechanically induced cartilaginous tissues in a rat model.

Salisbury Palomares KT, Gerstenfeld LC, Wigner NA, Lenburg ME, Einhorn TA, Morgan EF.

Arthritis Rheum. 2010 Apr;62(4):1108-18. doi: 10.1002/art.27343.


Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage.

Evans CH, Liu FJ, Glatt V, Hoyland JA, Kirker-Head C, Walsh A, Betz O, Wells JW, Betz V, Porter RM, Saad FA, Gerstenfeld LC, Einhorn TA, Harris MB, Vrahas MS.

Eur Cell Mater. 2009 Dec 31;18:96-111.


Acute phosphate restriction leads to impaired fracture healing and resistance to BMP-2.

Wigner NA, Luderer HF, Cox MK, Sooy K, Gerstenfeld LC, Demay MB.

J Bone Miner Res. 2010 Apr;25(4):724-33. doi: 10.1359/jbmr.091021.


Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes.

Bais M, McLean J, Sebastiani P, Young M, Wigner N, Smith T, Kotton DN, Einhorn TA, Gerstenfeld LC.

PLoS One. 2009;4(5):e5393. doi: 10.1371/journal.pone.0005393. Epub 2009 May 5.


BMP2 is essential for post natal osteogenesis but not for recruitment of osteogenic stem cells.

Bais MV, Wigner N, Young M, Toholka R, Graves DT, Morgan EF, Gerstenfeld LC, Einhorn TA.

Bone. 2009 Aug;45(2):254-66. doi: 10.1016/j.bone.2009.04.239. Epub 2009 May 3.


Mechanical stimulation alters tissue differentiation and molecular expression during bone healing.

Palomares KT, Gleason RE, Mason ZD, Cullinane DM, Einhorn TA, Gerstenfeld LC, Morgan EF.

J Orthop Res. 2009 Sep;27(9):1123-32. doi: 10.1002/jor.20863.


Role of hypoxia inducible factor-1 alpha pathway in bone regeneration.

Wan C, Gilbert SR, Wang Y, Cao XM, Shen X, Ramaswamy G, Jacobsen KA, Alaql ZS, Gerstenfeld LC, Einhorn TA, Eberhardt AW, Deng L, Guldberg RE, Clemens TL.

J Musculoskelet Neuronal Interact. 2008 Oct-Dec;8(4):323-4. Review. No abstract available.


Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing.

Gerstenfeld LC, Sacks DJ, Pelis M, Mason ZD, Graves DT, Barrero M, Ominsky MS, Kostenuik PJ, Morgan EF, Einhorn TA.

J Bone Miner Res. 2009 Feb;24(2):196-208. doi: 10.1359/jbmr.081113.


Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function.

Morgan EF, Mason ZD, Chien KB, Pfeiffer AJ, Barnes GL, Einhorn TA, Gerstenfeld LC.

Bone. 2009 Feb;44(2):335-44. doi: 10.1016/j.bone.2008.10.039. Epub 2008 Oct 25.


Experiments with osteoblasts cultured under varying orientations with respect to the gravity vector.

Kacena MA, Todd P, Gerstenfeld LC, Landis WJ.

Cytotechnology. 2002 Sep;39(3):147-54. doi: 10.1023/A:1023936503105.


Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone (1-34) in metaphyseal bone healing.

Morgan EF, Mason ZD, Bishop G, Davis AD, Wigner NA, Gerstenfeld LC, Einhorn TA.

Bone. 2008 Dec;43(6):1031-8. doi: 10.1016/j.bone.2008.07.251. Epub 2008 Aug 9.


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