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Items: 1 to 50 of 72

1.

Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.

Gersch M, Wagstaff JL, Toms AV, Graves B, Freund SMV, Komander D.

Mol Cell. 2019 May 2;74(3):436-451.e7. doi: 10.1016/j.molcel.2019.02.030. Epub 2019 Mar 26.

2.

Sharing Frailty-related information in perioperative care: an analysis from a temporal perspective.

Fürstenau D, Spies C, Gersch M, Vogel A, Mörgeli R, Poncette AS, Müller-Werdan U, Balzer F.

BMC Health Serv Res. 2019 Feb 7;19(1):105. doi: 10.1186/s12913-019-3890-y.

3.

Selective Activation of Human Caseinolytic Protease P (ClpP).

Stahl M, Korotkov VS, Balogh D, Kick LM, Gersch M, Pahl A, Kielkowski P, Richter K, Schneider S, Sieber SA.

Angew Chem Int Ed Engl. 2018 Oct 26;57(44):14602-14607. doi: 10.1002/anie.201808189. Epub 2018 Sep 19.

PMID:
30129683
4.

Transition from in-hospital ventilation to home ventilation: process description and quality indicators.

Kastrup M, Tittmann B, Sawatzki T, Gersch M, Vogt C, Rosenthal M, Rosseau S, Spies C.

Ger Med Sci. 2017 Dec 19;15:Doc18. doi: 10.3205/000259. eCollection 2017.

5.

Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

Turnbull AP, Ioannidis S, Krajewski WW, Pinto-Fernandez A, Heride C, Martin ACL, Tonkin LM, Townsend EC, Buker SM, Lancia DR, Caravella JA, Toms AV, Charlton TM, Lahdenranta J, Wilker E, Follows BC, Evans NJ, Stead L, Alli C, Zarayskiy VV, Talbot AC, Buckmelter AJ, Wang M, McKinnon CL, Saab F, McGouran JF, Century H, Gersch M, Pittman MS, Marshall CG, Raynham TM, Simcox M, Stewart LMD, McLoughlin SB, Escobedo JA, Bair KW, Dinsmore CJ, Hammonds TR, Kim S, Urbé S, Clague MJ, Kessler BM, Komander D.

Nature. 2017 Oct 26;550(7677):481-486. doi: 10.1038/nature24451. Epub 2017 Oct 18.

6.

Mechanism and regulation of the Lys6-selective deubiquitinase USP30.

Gersch M, Gladkova C, Schubert AF, Michel MA, Maslen S, Komander D.

Nat Struct Mol Biol. 2017 Nov;24(11):920-930. doi: 10.1038/nsmb.3475. Epub 2017 Sep 25.

7.

Deuteration of Hyperpolarized 13 C-Labeled Zymonic Acid Enables Sensitivity-Enhanced Dynamic MRI of pH.

Hundshammer C, Düwel S, Köcher SS, Gersch M, Feuerecker B, Scheurer C, Haase A, Glaser SJ, Schwaiger M, Schilling F.

Chemphyschem. 2017 Sep 20;18(18):2422-2425. doi: 10.1002/cphc.201700779. Epub 2017 Aug 17.

PMID:
28719100
8.

Imaging of pH in vivo using hyperpolarized 13C-labelled zymonic acid.

Düwel S, Hundshammer C, Gersch M, Feuerecker B, Steiger K, Buck A, Walch A, Haase A, Glaser SJ, Schwaiger M, Schilling F.

Nat Commun. 2017 May 11;8:15126. doi: 10.1038/ncomms15126.

9.

Insights into ClpXP proteolysis: heterooligomerization and partial deactivation enhance chaperone affinity and substrate turnover in Listeria monocytogenes.

Balogh D, Dahmen M, Stahl M, Poreba M, Gersch M, Drag M, Sieber SA.

Chem Sci. 2017 Feb 1;8(2):1592-1600. doi: 10.1039/c6sc03438a. Epub 2016 Oct 28.

10.

Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.

Mevissen TET, Kulathu Y, Mulder MPC, Geurink PP, Maslen SL, Gersch M, Elliott PR, Burke JE, van Tol BDM, Akutsu M, Oualid FE, Kawasaki M, Freund SMV, Ovaa H, Komander D.

Nature. 2016 Oct 20;538(7625):402-405. doi: 10.1038/nature19836. Epub 2016 Oct 12.

11.

Barrel-shaped ClpP Proteases Display Attenuated Cleavage Specificities.

Gersch M, Stahl M, Poreba M, Dahmen M, Dziedzic A, Drag M, Sieber SA.

ACS Chem Biol. 2016 Feb 19;11(2):389-99. doi: 10.1021/acschembio.5b00757. Epub 2015 Dec 9.

PMID:
26606371
12.

A mass spectrometry platform for a streamlined investigation of proteasome integrity, posttranslational modifications, and inhibitor binding.

Gersch M, Hackl MW, Dubiella C, Dobrinevski A, Groll M, Sieber SA.

Chem Biol. 2015 Mar 19;22(3):404-11. doi: 10.1016/j.chembiol.2015.01.004. Epub 2015 Feb 26.

13.

AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control.

Gersch M, Famulla K, Dahmen M, Göbl C, Malik I, Richter K, Korotkov VS, Sass P, Rübsamen-Schaeff H, Madl T, Brötz-Oesterhelt H, Sieber SA.

Nat Commun. 2015 Feb 19;6:6320. doi: 10.1038/ncomms7320.

PMID:
25695750
14.

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.

Wauer T, Swatek KN, Wagstaff JL, Gladkova C, Pruneda JN, Michel MA, Gersch M, Johnson CM, Freund SM, Komander D.

EMBO J. 2015 Feb 3;34(3):307-25. doi: 10.15252/embj.201489847. Epub 2014 Dec 19.

15.

Selective inhibition of the immunoproteasome by ligand-induced crosslinking of the active site.

Dubiella C, Cui H, Gersch M, Brouwer AJ, Sieber SA, Krüger A, Liskamp RM, Groll M.

Angew Chem Int Ed Engl. 2014 Oct 27;53(44):11969-73. doi: 10.1002/anie.201406964. Epub 2014 Sep 22.

PMID:
25244435
16.

Disruption of oligomerization and dehydroalanine formation as mechanisms for ClpP protease inhibition.

Gersch M, Kolb R, Alte F, Groll M, Sieber SA.

J Am Chem Soc. 2014 Jan 29;136(4):1360-6. doi: 10.1021/ja4082793. Epub 2013 Oct 24.

PMID:
24106749
17.

Structural and functional insights into caseinolytic proteases reveal an unprecedented regulation principle of their catalytic triad.

Zeiler E, List A, Alte F, Gersch M, Wachtel R, Poreba M, Drag M, Groll M, Sieber SA.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11302-7. doi: 10.1073/pnas.1219125110. Epub 2013 Jun 24.

18.

The mechanism of caseinolytic protease (ClpP) inhibition.

Gersch M, Gut F, Korotkov VS, Lehmann J, Böttcher T, Rusch M, Hedberg C, Waldmann H, Klebe G, Sieber SA.

Angew Chem Int Ed Engl. 2013 Mar 4;52(10):3009-14. doi: 10.1002/anie.201204690. Epub 2013 Jan 30. No abstract available.

PMID:
23361916
19.

Electrophilic natural products and their biological targets.

Gersch M, Kreuzer J, Sieber SA.

Nat Prod Rep. 2012 Jun;29(6):659-82. doi: 10.1039/c2np20012k. Epub 2012 Apr 16. Review.

PMID:
22504336
20.

Insights into structural network responsible for oligomerization and activity of bacterial virulence regulator caseinolytic protease P (ClpP) protein.

Gersch M, List A, Groll M, Sieber SA.

J Biol Chem. 2012 Mar 16;287(12):9484-94. doi: 10.1074/jbc.M111.336222. Epub 2012 Jan 30.

21.

Defining an allosteric circuit in the cysteine protease domain of Clostridium difficile toxins.

Shen A, Lupardus PJ, Gersch MM, Puri AW, Albrow VE, Garcia KC, Bogyo M.

Nat Struct Mol Biol. 2011 Mar;18(3):364-71. doi: 10.1038/nsmb.1990. Epub 2011 Feb 13.

22.

Disarming Clostridium difficile.

Gersch M, Sieber SA.

Chem Biol. 2010 Nov 24;17(11):1165-6. doi: 10.1016/j.chembiol.2010.11.003.

23.

Dietary fructose causes tubulointerstitial injury in the normal rat kidney.

Nakayama T, Kosugi T, Gersch M, Connor T, Sanchez-Lozada LG, Lanaspa MA, Roncal C, Perez-Pozo SE, Johnson RJ, Nakagawa T.

Am J Physiol Renal Physiol. 2010 Mar;298(3):F712-20. doi: 10.1152/ajprenal.00433.2009. Epub 2010 Jan 13.

24.

Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells.

Cirillo P, Gersch MS, Mu W, Scherer PM, Kim KM, Gesualdo L, Henderson GN, Johnson RJ, Sautin YY.

J Am Soc Nephrol. 2009 Mar;20(3):545-53. doi: 10.1681/ASN.2008060576. Epub 2009 Jan 21.

25.

Clopidogrel decreases arteriovenous fistula thrombosis but does not improve fistula maturation.

Gersch MS.

Nat Clin Pract Nephrol. 2008 Sep;4(9):476-7. doi: 10.1038/ncpneph0908. Epub 2008 Jul 29.

PMID:
18665140
26.

The conundrum of hyperuricemia, metabolic syndrome, and renal disease.

Nakagawa T, Cirillo P, Sato W, Gersch M, Sautin Y, Roncal C, Mu W, Sánchez-Lozada LG, Johnson RJ.

Intern Emerg Med. 2008 Dec;3(4):313-8. doi: 10.1007/s11739-008-0141-3. Epub 2008 Mar 5. Review.

27.

Business evolution or revolution? Mail-order pharmacies in Germany.

Gersch M.

Int J Electron Healthc. 2004;1(1):17-32.

PMID:
18048201
28.

Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.

Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang DH, Gersch MS, Benner S, Sánchez-Lozada LG.

Am J Clin Nutr. 2007 Oct;86(4):899-906. Review.

PMID:
17921363
29.

Fructose, but not dextrose, accelerates the progression of chronic kidney disease.

Gersch MS, Mu W, Cirillo P, Reungjui S, Zhang L, Roncal C, Sautin YY, Johnson RJ, Nakagawa T.

Am J Physiol Renal Physiol. 2007 Oct;293(4):F1256-61. Epub 2007 Aug 1.

30.

Uric acid, the metabolic syndrome, and renal disease.

Cirillo P, Sato W, Reungjui S, Heinig M, Gersch M, Sautin Y, Nakagawa T, Johnson RJ.

J Am Soc Nephrol. 2006 Dec;17(12 Suppl 3):S165-8. Review.

31.

Uric acid and the immune response.

Gersch MS, Johnson RJ.

Nephrol Dial Transplant. 2006 Nov;21(11):3046-7. Epub 2006 Sep 8. Review. No abstract available.

PMID:
16963481
32.

Does Tamm-Horsfall protein-uric acid binding play a significant role in urate homeostasis?

Gersch MS, Sautin YY, Gersch CM, Henderson G, Bankir L, Johnson RJ.

Nephrol Dial Transplant. 2006 Oct;21(10):2938-42. Epub 2006 Jul 21.

PMID:
16861244
33.

Treatment of dialysis catheter infections in 2004.

Gersch MS.

J Vasc Access. 2004 Jul-Sep;5(3):99-108.

PMID:
16596549
34.

Is salt-wasting the long awaited answer to the hyperuricaemia seen in uromodulin storage diseases?

Gersch M, Mutig K, Bachmann S, Kumar S, Ouyang X, Johnson R.

Nephrol Dial Transplant. 2006 Jul;21(7):2028-9. Epub 2006 Jan 18. No abstract available.

PMID:
16421156
35.

Focal segmental glomerular sclerosis in a patient with neurofibromatosis type I.

Gersch MS, Talor Z.

Am J Kidney Dis. 2006 Jan;47(1):e17-9. Review.

PMID:
16377376
36.

Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?

Johnson RJ, Segal MS, Srinivas T, Ejaz A, Mu W, Roncal C, Sánchez-Lozada LG, Gersch M, Rodriguez-Iturbe B, Kang DH, Acosta JH.

J Am Soc Nephrol. 2005 Jul;16(7):1909-19. Epub 2005 Apr 20. Review.

37.

Kinetochore "memory" of spindle checkpoint signaling in lysed mitotic cells.

Campbell MS, Daum JR, Gersch MS, Nicklas RB, Gorbsky GJ.

Cell Motil Cytoskeleton. 2000 Jun;46(2):146-56.

PMID:
10891860
38.

MPM-2 antibody-reactive phosphorylations can be created in detergent-extracted cells by kinetochore-bound and soluble kinases.

Renzi L, Gersch MS, Campbell MS, Wu L, Osmani SA, Gorbsky GJ.

J Cell Sci. 1997 Sep;110 ( Pt 17):2013-25.

39.

Patient-Controlled Analgesia Following Vertical Gastroplasty: a Comparison with Intramuscular Narcotics.

Kyzer S, Ramadan E, Gersch M, Chaimoff C.

Obes Surg. 1995 Feb;5(1):18-21.

PMID:
10733789
40.

The hemopoietic character of the "cephalic gland" in the crayfish Orconectes limosus.

Böhm GA, Gersch M.

Gen Comp Endocrinol. 1983 Oct;52(1):102-7.

PMID:
6628973
41.

Ecdysteroid production by the cephalic gland of the crayfish Orconectes limosus.

Gersch M, Eibisch H, Böhm GA, Koolman J.

Gen Comp Endocrinol. 1979 Dec;39(4):505-11. No abstract available.

PMID:
520813
42.

The ultrastructure of a hitherto unrecognized gland, the cephalic gland in the head of Orconectes limosus which produces ecdysteroids.

Gersch M, Birkenbeil H.

Gen Comp Endocrinol. 1979 Dec;39(4):498-504. No abstract available.

PMID:
520812
43.

A new endocrine gland in the antennal segment of the crayfishes Orconectes limosus and Astacus astacus.

Gersch M.

Gen Comp Endocrinol. 1979 Dec;39(4):490-7. No abstract available.

PMID:
520811
44.
45.

Ultrastructure of the Y-organ of Astacus astacus (L.) (Crustacea) in relation to the moult cycle.

Birkenbeil H, Gersch M.

Cell Tissue Res. 1979 Feb 28;196(3):519-24.

PMID:
455392
46.

[Information transmission by means of neurosecretory peptides as mediators].

Gersch M.

Naturwissenschaften. 1977 Aug;64(8):417-26. Review. German.

PMID:
21354
48.
49.
50.

[Selective release of the hyperglycemic factor from the corpora cardiaca of Periplaneta americana in vivo].

Gersch M.

Experientia. 1974 Jul 15;30(7):767. German. No abstract available.

PMID:
4847662

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