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Items: 1 to 50 of 121

1.

Rel-Dependent Immune and Central Nervous System Mechanisms Control Viral Replication and Inflammation during Mouse Herpes Simplex Encephalitis.

Mancini M, Caignard G, Charbonneau B, Dumaine A, Wu N, Leiva-Torres GA, Gerondakis S, Pearson A, Qureshi ST, Sladek R, Vidal SM.

J Immunol. 2019 Mar 1;202(5):1479-1493. doi: 10.4049/jimmunol.1800063. Epub 2019 Jan 25.

PMID:
30683700
2.

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism.

Lancaster GI, Langley KG, Berglund NA, Kammoun HL, Reibe S, Estevez E, Weir J, Mellett NA, Pernes G, Conway JRW, Lee MKS, Timpson P, Murphy AJ, Masters SL, Gerondakis S, Bartonicek N, Kaczorowski DC, Dinger ME, Meikle PJ, Bond PJ, Febbraio MA.

Cell Metab. 2018 May 1;27(5):1096-1110.e5. doi: 10.1016/j.cmet.2018.03.014. Epub 2018 Apr 19.

3.

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner.

O'Reilly LA, Putoczki TL, Mielke LA, Low JT, Lin A, Preaudet A, Herold MJ, Yaprianto K, Tai L, Kueh A, Pacini G, Ferrero RL, Gugasyan R, Hu Y, Christie M, Wilcox S, Grumont R, Griffin MDW, O'Connor L, Smyth GK, Ernst M, Waring P, Gerondakis S, Strasser A.

Immunity. 2018 Mar 20;48(3):570-583.e8. doi: 10.1016/j.immuni.2018.03.003.

4.

Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis.

Deliyanti D, Talia DM, Zhu T, Maxwell MJ, Agrotis A, Jerome JR, Hargreaves EM, Gerondakis S, Hibbs ML, Mackay F, Wilkinson-Berka JL.

Nat Commun. 2017 Sep 29;8(1):748. doi: 10.1038/s41467-017-00751-w.

5.

Corrigendum: NF-κB control of T cell development.

Gerondakis S, Fulford TS, Messina NL, Grumont RJ.

Nat Immunol. 2017 Sep 19;18(10):1173. doi: 10.1038/ni1017-1173a. No abstract available.

PMID:
28926541
6.

The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8+ Thymocyte Selection.

Martinic MM, Caminschi I, O'Keeffe M, Thinnes TC, Grumont R, Gerondakis S, McKay DB, Nemazee D, Gavin AL.

J Immunol. 2017 Apr 1;198(7):2649-2660. doi: 10.4049/jimmunol.1601462. Epub 2017 Feb 15.

7.

The NF-κB transcription factor RelA is required for the tolerogenic function of Foxp3(+) regulatory T cells.

Messina N, Fulford T, O'Reilly L, Loh WX, Motyer JM, Ellis D, McLean C, Naeem H, Lin A, Gugasyan R, Slattery RM, Grumont RJ, Gerondakis S.

J Autoimmun. 2016 Jun;70:52-62. doi: 10.1016/j.jaut.2016.03.017. Epub 2016 Apr 7.

PMID:
27068879
8.

NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells.

de Valle E, Grigoriadis G, O'Reilly LA, Willis SN, Maxwell MJ, Corcoran LM, Tsantikos E, Cornish JK, Fairfax KA, Vasanthakumar A, Febbraio MA, Hibbs ML, Pellegrini M, Banerjee A, Hodgkin PD, Kallies A, Mackay F, Strasser A, Gerondakis S, Gugasyan R.

J Exp Med. 2016 Apr 4;213(4):621-41. doi: 10.1084/jem.20151182. Epub 2016 Mar 28.

9.

Understanding the Roles of the NF-κB Pathway in Regulatory T Cell Development, Differentiation and Function.

Fulford TS, Ellis D, Gerondakis S.

Prog Mol Biol Transl Sci. 2015;136:57-67. doi: 10.1016/bs.pmbts.2015.08.002. Epub 2015 Sep 3. Review.

PMID:
26615092
10.

Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice.

Low JT, Hughes P, Lin A, Siebenlist U, Jain R, Yaprianto K, Gray DH, Gerondakis S, Strasser A, O'Reilly LA.

Immunol Cell Biol. 2016 Jan;94(1):66-78. doi: 10.1038/icb.2015.66. Epub 2015 Jun 18.

PMID:
26084385
11.

The acetyltransferase HAT1 moderates the NF-κB response by regulating the transcription factor PLZF.

Sadler AJ, Suliman BA, Yu L, Yuan X, Wang D, Irving AT, Sarvestani ST, Banerjee A, Mansell AS, Liu JP, Gerondakis S, Williams BR, Xu D.

Nat Commun. 2015 Apr 13;6:6795. doi: 10.1038/ncomms7795.

PMID:
25865065
12.

MYB elongation is regulated by the nucleic acid binding of NFκB p50 to the intronic stem-loop region.

Pereira LA, Hugo HJ, Malaterre J, Huiling X, Sonza S, Cures A, Purcell DF, Ramsland PA, Gerondakis S, Gonda TJ, Ramsay RG.

PLoS One. 2015 Apr 8;10(4):e0122919. doi: 10.1371/journal.pone.0122919. eCollection 2015.

13.

NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice.

Burkitt MD, Hanedi AF, Duckworth CA, Williams JM, Tang JM, O'Reilly LA, Putoczki TL, Gerondakis S, Dimaline R, Caamano JH, Pritchard DM.

J Pathol. 2015 Jul;236(3):326-36. doi: 10.1002/path.4527. Epub 2015 Apr 21.

14.

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs.

Sadler AJ, Rossello FJ, Yu L, Deane JA, Yuan X, Wang D, Irving AT, Kaparakis-Liaskos M, Gantier MP, Ying H, Yim HC, Hartland EL, Notini AJ, de Boer S, White SJ, Mansell A, Liu JP, Watkins DN, Gerondakis S, Williams BR, Xu D.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1535-40. doi: 10.1073/pnas.1409728112. Epub 2015 Jan 20.

15.

The dual-specificity phosphatase 2 (DUSP2) does not regulate obesity-associated inflammation or insulin resistance in mice.

Lancaster GI, Kraakman MJ, Kammoun HL, Langley KG, Estevez E, Banerjee A, Grumont RJ, Febbraio MA, Gerondakis S.

PLoS One. 2014 Nov 6;9(11):e111524. doi: 10.1371/journal.pone.0111524. eCollection 2014.

16.

Loss of c-REL but not NF-κB2 prevents autoimmune disease driven by FasL mutation.

O'Reilly LA, Hughes P, Lin A, Waring P, Siebenlist U, Jain R, Gray DH, Gerondakis S, Strasser A.

Cell Death Differ. 2015 May;22(5):767-78. doi: 10.1038/cdd.2014.168. Epub 2014 Oct 31.

17.

c-Rel regulates Ezh2 expression in activated lymphocytes and malignant lymphoid cells.

Neo WH, Lim JF, Grumont R, Gerondakis S, Su IH.

J Biol Chem. 2014 Nov 14;289(46):31693-707. doi: 10.1074/jbc.M114.574517. Epub 2014 Sep 29.

18.

NF-κB control of T cell development.

Gerondakis S, Fulford TS, Messina NL, Grumont RJ.

Nat Immunol. 2014 Jan;15(1):15-25. doi: 10.1038/ni.2785. Review. Erratum in: Nat Immunol. 2017 Sep 19;18(10 ):1173.

PMID:
24352326
19.

Foxo-mediated Bim transcription is dispensable for the apoptosis of hematopoietic cells that is mediated by this BH3-only protein.

Herold MJ, Rohrbeck L, Lang MJ, Grumont R, Gerondakis S, Tai L, Bouillet P, Kaufmann T, Strasser A.

EMBO Rep. 2013 Nov;14(11):992-8. doi: 10.1038/embor.2013.152. Epub 2013 Sep 24.

20.

The TACI receptor regulates T-cell-independent marginal zone B cell responses through innate activation-induced cell death.

Figgett WA, Fairfax K, Vincent FB, Le Page MA, Katik I, Deliyanti D, Quah PS, Verma P, Grumont R, Gerondakis S, Hertzog P, O'Reilly LA, Strasser A, Mackay F.

Immunity. 2013 Sep 19;39(3):573-83. doi: 10.1016/j.immuni.2013.05.019. Epub 2013 Sep 5.

21.

MEK inhibitors as a chemotherapeutic intervention in multiple myeloma.

Chang-Yew Leow C, Gerondakis S, Spencer A.

Blood Cancer J. 2013 Mar 22;3:e105. doi: 10.1038/bcj.2013.1.

22.

c-Rel: shaping CD4 regulatory T cell development in unexpected ways.

Gerondakis S, Fulford T, Grumont RJ.

Transcription. 2012 Sep-Oct;3(5):245-9. doi: 10.4161/trns.21309. Epub 2012 Sep 1.

23.

Tumor progression locus 2 (Tpl2) deficiency does not protect against obesity-induced metabolic disease.

Lancaster GI, Kowalski GM, Estevez E, Kraakman MJ, Grigoriadis G, Febbraio MA, Gerondakis S, Banerjee A.

PLoS One. 2012;7(6):e39100. doi: 10.1371/journal.pone.0039100. Epub 2012 Jun 11.

24.

NF-κB subunit specificity in hemopoiesis.

Gerondakis S, Banerjee A, Grigoriadis G, Vasanthakumar A, Gugasyan R, Sidwell T, Grumont RJ.

Immunol Rev. 2012 Mar;246(1):272-85. doi: 10.1111/j.1600-065X.2011.01090.x. Review.

PMID:
22435561
25.

Combined loss of cRel/p50 subunits of NF-κB leads to impaired innate host response in sepsis.

Courtine E, Cagnard N, Mazzolini J, Antona M, Pène F, Fitting C, Jacques S, Rousseau C, Niedergang F, Gerondakis S, Chiche JD, Ouaaz F, Mira JP.

Innate Immun. 2012 Oct;18(5):753-63. Epub 2012 Mar 9.

PMID:
22408080
26.

The c-Rel Transcription Factor in Development and Disease.

Gilmore TD, Gerondakis S.

Genes Cancer. 2011 Jul;2(7):695-711. doi: 10.1177/1947601911421925.

27.

The NF-κB1 transcription factor prevents the intrathymic development of CD8 T cells with memory properties.

Gugasyan R, Horat E, Kinkel SA, Ross F, Grigoriadis G, Gray D, O'Keeffe M, Berzins SP, Belz GT, Grumont RJ, Banerjee A, Strasser A, Godfrey DI, Tsichlis PN, Gerondakis S.

EMBO J. 2012 Feb 1;31(3):692-706. doi: 10.1038/emboj.2011.435. Epub 2011 Nov 29.

28.

c-Rel controls multiple discrete steps in the thymic development of Foxp3+ CD4 regulatory T cells.

Grigoriadis G, Vasanthakumar A, Banerjee A, Grumont R, Overall S, Gleeson P, Shannon F, Gerondakis S.

PLoS One. 2011;6(10):e26851. doi: 10.1371/journal.pone.0026851. Epub 2011 Oct 31.

29.

The NF-κB transcription factor c-Rel is required for Th17 effector cell development in experimental autoimmune encephalomyelitis.

Chen G, Hardy K, Pagler E, Ma L, Lee S, Gerondakis S, Daley S, Shannon MF.

J Immunol. 2011 Nov 1;187(9):4483-91. doi: 10.4049/jimmunol.1101757. Epub 2011 Sep 21.

30.

Immunotherapy with costimulatory dendritic cells to control autoimmune inflammation.

O'Sullivan BJ, Pai S, Street S, An X, MacDonald KP, Wong M, Strutton G, Gerondakis S, Steptoe RJ, de St Groth BF, Hill GR, Thomas R.

J Immunol. 2011 Oct 15;187(8):4018-30. doi: 10.4049/jimmunol.1101727. Epub 2011 Sep 7.

31.

Differentiation of inflammatory dendritic cells is mediated by NF-κB1-dependent GM-CSF production in CD4 T cells.

Campbell IK, van Nieuwenhuijze A, Segura E, O'Donnell K, Coghill E, Hommel M, Gerondakis S, Villadangos JA, Wicks IP.

J Immunol. 2011 May 1;186(9):5468-77. doi: 10.4049/jimmunol.1002923. Epub 2011 Mar 18.

32.

Critical role of cRel subunit of NF-κB in sepsis survival.

Courtine E, Pène F, Cagnard N, Toubiana J, Fitting C, Brocheton J, Rousseau C, Gerondakis S, Chiche JD, Ouaaz F, Mira JP.

Infect Immun. 2011 May;79(5):1848-54. doi: 10.1128/IAI.00021-11. Epub 2011 Feb 22.

33.

Distinct roles in NKT cell maturation and function for the different transcription factors in the classical NF-κB pathway.

Stankovic S, Gugasyan R, Kyparissoudis K, Grumont R, Banerjee A, Tsichlis P, Gerondakis S, Godfrey DI.

Immunol Cell Biol. 2011 Feb;89(2):294-303. doi: 10.1038/icb.2010.93. Epub 2010 Aug 10.

PMID:
20697425
34.

Roles of the NF-kappaB pathway in lymphocyte development and function.

Gerondakis S, Siebenlist U.

Cold Spring Harb Perspect Biol. 2010 May;2(5):a000182. doi: 10.1101/cshperspect.a000182. Epub 2009 Dec 23. Review.

35.

c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells.

Isomura I, Palmer S, Grumont RJ, Bunting K, Hoyne G, Wilkinson N, Banerjee A, Proietto A, Gugasyan R, Wu L, McNally A, Steptoe RJ, Thomas R, Shannon MF, Gerondakis S.

J Exp Med. 2009 Dec 21;206(13):3001-14. doi: 10.1084/jem.20091411. Epub 2009 Dec 7. Erratum in: J Exp Med.2010 Apr 12;207(4):899. Li, Wu [corrected to Wu, Li].

36.

c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance.

Deenick EK, Po L, Chapatte L, Murakami K, Lu YC, Elford AR, Saibil SD, Ruland J, Gerondakis S, Mak TW, Ohashi PS.

Eur J Immunol. 2010 Mar;40(3):867-77. doi: 10.1002/eji.200939445.

37.

Illumina WG-6 BeadChip strips should be normalized separately.

Shi W, Banerjee A, Ritchie ME, Gerondakis S, Smyth GK.

BMC Bioinformatics. 2009 Nov 11;10:372. doi: 10.1186/1471-2105-10-372.

38.

Differential role for c-Rel and C/EBPbeta/delta in TLR-mediated induction of proinflammatory cytokines.

Lu YC, Kim I, Lye E, Shen F, Suzuki N, Suzuki S, Gerondakis S, Akira S, Gaffen SL, Yeh WC, Ohashi PS.

J Immunol. 2009 Jun 1;182(11):7212-21. doi: 10.4049/jimmunol.0802971.

39.

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.

Kaufmann T, Jost PJ, Pellegrini M, Puthalakath H, Gugasyan R, Gerondakis S, Cretney E, Smyth MJ, Silke J, Hakem R, Bouillet P, Mak TW, Dixit VM, Strasser A.

Immunity. 2009 Jan 16;30(1):56-66. doi: 10.1016/j.immuni.2008.10.017.

40.

Glucocorticoid-induced TNF receptor expression by T cells is reciprocally regulated by NF-kappaB and NFAT.

Zhan Y, Gerondakis S, Coghill E, Bourges D, Xu Y, Brady JL, Lew AM.

J Immunol. 2008 Oct 15;181(8):5405-13.

41.

NF-kappaB1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms.

Banerjee A, Grumont R, Gugasyan R, White C, Strasser A, Gerondakis S.

Blood. 2008 Dec 15;112(13):5063-73. doi: 10.1182/blood-2007-10-120832. Epub 2008 Sep 19.

42.

The nuclear factor-kappaB and p53 pathways function independently in primary cells and transformed fibroblasts responding to genotoxic damage.

Nesic D, Grumont R, Gerondakis S.

Mol Cancer Res. 2008 Jul;6(7):1193-203. doi: 10.1158/1541-7786.MCR-07-2125. Epub 2008 Jun 26.

43.

NFAT but not NF-kappaB is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cells.

Ullerås E, Karlberg M, Möller Westerberg C, Alfredsson J, Gerondakis S, Strasser A, Nilsson G.

Blood. 2008 Mar 15;111(6):3081-9. doi: 10.1182/blood-2006-10-053371. Epub 2008 Jan 8.

44.

Regulating B-cell activation and survival in response to TLR signals.

Gerondakis S, Grumont RJ, Banerjee A.

Immunol Cell Biol. 2007 Aug-Sep;85(6):471-5. Epub 2007 Jul 17. Review.

PMID:
17637697
45.

Coordinating TLR-activated signaling pathways in cells of the immune system.

Banerjee A, Gerondakis S.

Immunol Cell Biol. 2007 Aug-Sep;85(6):420-4. Epub 2007 Jul 17. Review.

PMID:
17637696
46.

Tissue-specific effects of the nuclear factor kappaB subunit p50 on myocardial ischemia-reperfusion injury.

Frantz S, Tillmanns J, Kuhlencordt PJ, Schmidt I, Adamek A, Dienesch C, Thum T, Gerondakis S, Ertl G, Bauersachs J.

Am J Pathol. 2007 Aug;171(2):507-12. Epub 2007 Jun 7.

47.

Genome-wide analysis of gene expression in T cells to identify targets of the NF-kappa B transcription factor c-Rel.

Bunting K, Rao S, Hardy K, Woltring D, Denyer GS, Wang J, Gerondakis S, Shannon MF.

J Immunol. 2007 Jun 1;178(11):7097-109.

48.

CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Ctheta, c-Rel, and protein kinase B.

Saibil SD, Jones RG, Deenick EK, Liadis N, Elford AR, Vainberg MG, Baerg H, Woodgett JR, Gerondakis S, Ohashi PS.

J Immunol. 2007 Mar 1;178(5):2932-9.

49.

Loss of the BH3-only protein Bid does not rescue RelA-deficient embryos from TNF-R1-mediated fatal hepatocyte destruction.

Kaufmann T, Gugasyan R, Gerondakis S, Dixit VM, Strasser A.

Cell Death Differ. 2007 Mar;14(3):637-9. Epub 2006 Nov 10. No abstract available.

50.

Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.

Gerondakis S, Grumont R, Gugasyan R, Wong L, Isomura I, Ho W, Banerjee A.

Oncogene. 2006 Oct 30;25(51):6781-99. Review.

PMID:
17072328

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