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Items: 18

1.

Suppressors and activators of JAK-STAT signaling at diagnosis and relapse of acute lymphoblastic leukemia in Down syndrome.

Schwartzman O, Savino AM, Gombert M, Palmi C, Cario G, Schrappe M, Eckert C, von Stackelberg A, Huang JY, Hameiri-Grossman M, Avigad S, Te Kronnie G, Geron I, Birger Y, Rein A, Zarfati G, Fischer U, Mukamel Z, Stanulla M, Biondi A, Cazzaniga G, Vetere A, Wagner BK, Chen Z, Chen SJ, Tanay A, Borkhardt A, Izraeli S.

Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4030-E4039. doi: 10.1073/pnas.1702489114. Epub 2017 May 1.

2.

ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis.

Zipeto MA, Court AC, Sadarangani A, Delos Santos NP, Balaian L, Chun HJ, Pineda G, Morris SR, Mason CN, Geron I, Barrett C, Goff DJ, Wall R, Pellecchia M, Minden M, Frazer KA, Marra MA, Crews LA, Jiang Q, Jamieson CHM.

Cell Stem Cell. 2016 Aug 4;19(2):177-191. doi: 10.1016/j.stem.2016.05.004. Epub 2016 Jun 9.

3.

GLI2 inhibition abrogates human leukemia stem cell dormancy.

Sadarangani A, Pineda G, Lennon KM, Chun HJ, Shih A, Schairer AE, Court AC, Goff DJ, Prashad SL, Geron I, Wall R, McPherson JD, Moore RA, Pu M, Bao L, Jackson-Fisher A, Munchhof M, VanArsdale T, Reya T, Morris SR, Minden MD, Messer K, Mikkola HK, Marra MA, Hudson TJ, Jamieson CH.

J Transl Med. 2015 Mar 21;13:98. doi: 10.1186/s12967-015-0453-9.

4.

MicroRNA-486-5p is an erythroid oncomiR of the myeloid leukemias of Down syndrome.

Shaham L, Vendramini E, Ge Y, Goren Y, Birger Y, Tijssen MR, McNulty M, Geron I, Schwartzman O, Goldberg L, Chou ST, Pitman H, Weiss MJ, Michaeli S, Sredni B, Göttgens B, Crispino JD, Taub JW, Izraeli S.

Blood. 2015 Feb 19;125(8):1292-301. doi: 10.1182/blood-2014-06-581892. Epub 2014 Dec 22. Erratum in: Blood. 2016 Apr 21;127(16):2042. Erratum in: Blood. 2016 Apr 21;127(16):2042.

5.

The activating STAT5B N642H mutation is a common abnormality in pediatric T-cell acute lymphoblastic leukemia and confers a higher risk of relapse.

Bandapalli OR, Schuessele S, Kunz JB, Rausch T, Stütz AM, Tal N, Geron I, Gershman N, Izraeli S, Eilers J, Vaezipour N, Kirschner-Schwabe R, Hof J, von Stackelberg A, Schrappe M, Stanulla M, Zimmermann M, Koehler R, Avigad S, Handgretinger R, Frismantas V, Bourquin JP, Bornhauser B, Korbel JO, Muckenthaler MU, Kulozik AE.

Haematologica. 2014 Oct;99(10):e188-92. doi: 10.3324/haematol.2014.104992. Epub 2014 Jun 27. No abstract available.

6.

Towards precision medicine in childhood leukemia--insights from mutationally activated cytokine receptor pathways in acute lymphoblastic leukemia.

Izraeli S, Shochat C, Tal N, Geron I.

Cancer Lett. 2014 Sep 28;352(1):15-20. doi: 10.1016/j.canlet.2014.02.009. Epub 2014 Feb 22. Review.

PMID:
24569093
7.

Interleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia.

Tal N, Shochat C, Geron I, Bercovich D, Izraeli S.

Cell Mol Life Sci. 2014 Feb;71(3):365-78. doi: 10.1007/s00018-013-1337-x. Epub 2013 Apr 27. Review.

PMID:
23625073
8.

A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition.

Goff DJ, Court Recart A, Sadarangani A, Chun HJ, Barrett CL, Krajewska M, Leu H, Low-Marchelli J, Ma W, Shih AY, Wei J, Zhai D, Geron I, Pu M, Bao L, Chuang R, Balaian L, Gotlib J, Minden M, Martinelli G, Rusert J, Dao KH, Shazand K, Wentworth P, Smith KM, Jamieson CA, Morris SR, Messer K, Goldstein LS, Hudson TJ, Marra M, Frazer KA, Pellecchia M, Reed JC, Jamieson CH.

Cell Stem Cell. 2013 Mar 7;12(3):316-28. doi: 10.1016/j.stem.2012.12.011. Epub 2013 Jan 17.

9.

NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.

Ma W, Gutierrez A, Goff DJ, Geron I, Sadarangani A, Jamieson CA, Court AC, Shih AY, Jiang Q, Wu CC, Li K, Smith KM, Crews LA, Gibson NW, Deichaite I, Morris SR, Wei P, Carson DA, Look AT, Jamieson CH.

PLoS One. 2012;7(6):e39725. doi: 10.1371/journal.pone.0039725. Epub 2012 Jun 29.

10.

Phenothiazine neuroleptics signal to the human insulin promoter as revealed by a novel high-throughput screen.

Kiselyuk A, Farber-Katz S, Cohen T, Lee SH, Geron I, Azimi B, Heynen-Genel S, Singer O, Price J, Mercola M, Itkin-Ansari P, Levine F.

J Biomol Screen. 2010 Jul;15(6):663-70. doi: 10.1177/1087057110372257. Epub 2010 Jun 14.

11.

Human beta-cell precursors mature into functional insulin-producing cells in an immunoisolation device: implications for diabetes cell therapies.

Lee SH, Hao E, Savinov AY, Geron I, Strongin AY, Itkin-Ansari P.

Transplantation. 2009 Apr 15;87(7):983-91. doi: 10.1097/TP.0b013e31819c86ea.

12.

Glycogen synthase kinase 3beta missplicing contributes to leukemia stem cell generation.

Abrahamsson AE, Geron I, Gotlib J, Dao KH, Barroga CF, Newton IG, Giles FJ, Durocher J, Creusot RS, Karimi M, Jones C, Zehnder JL, Keating A, Negrin RS, Weissman IL, Jamieson CH.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3925-9. doi: 10.1073/pnas.0900189106. Epub 2009 Feb 23.

13.

Islet specific Wnt activation in human type II diabetes.

Lee SH, Demeterco C, Geron I, Abrahamsson A, Levine F, Itkin-Ansari P.

Exp Diabetes Res. 2008;2008:728763. doi: 10.1155/2008/728763. Epub 2009 Jan 20.

14.

Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors.

Geron I, Abrahamsson AE, Barroga CF, Kavalerchik E, Gotlib J, Hood JD, Durocher J, Mak CC, Noronha G, Soll RM, Tefferi A, Kaushansky K, Jamieson CH.

Cancer Cell. 2008 Apr;13(4):321-30. doi: 10.1016/j.ccr.2008.02.017.

15.

Beta-cell differentiation from nonendocrine epithelial cells of the adult human pancreas.

Hao E, Tyrberg B, Itkin-Ansari P, Lakey JR, Geron I, Monosov EZ, Barcova M, Mercola M, Levine F.

Nat Med. 2006 Mar;12(3):310-6. Epub 2006 Feb 19.

PMID:
16491084
16.

NeuroD1 in the endocrine pancreas: localization and dual function as an activator and repressor.

Itkin-Ansari P, Marcora E, Geron I, Tyrberg B, Demeterco C, Hao E, Padilla C, Ratineau C, Leiter A, Lee JE, Levine F.

Dev Dyn. 2005 Jul;233(3):946-53.

17.

Cell-based therapies for diabetes: progress towards a transplantable human beta cell line.

Itkin-Ansari P, Geron I, Hao E, Demeterco C, Tyrberg B, Levine F.

Ann N Y Acad Sci. 2003 Nov;1005:138-47.

PMID:
14679048
18.

Interactions between endothelial cells and smooth muscle cells after their activation by hypoxia. A possible etiology for venous disease.

Michiels C, Arnould T, Janssens D, Bajou K, Geron I, Remacle J.

Int Angiol. 1996 Jun;15(2):124-30. Review.

PMID:
8803636

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