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Items: 1 to 50 of 143

1.

NECTIN4 (PVRL4) as Putative Therapeutic Target for a Specific Subtype of High Grade Serous Ovarian Cancer-An Integrative Multi-Omics Approach.

Bekos C, Muqaku B, Dekan S, Horvat R, Polterauer S, Gerner C, Aust S, Pils D.

Cancers (Basel). 2019 May 20;11(5). pii: E698. doi: 10.3390/cancers11050698.

2.

Metabolic, Anti-apoptotic and Immune Evasion Strategies of Primary Human Myeloma Cells Indicate Adaptations to Hypoxia.

Janker L, Mayer RL, Bileck A, Kreutz D, Mader JC, Utpatel K, Heudobler D, Agis H, Gerner C, Slany A.

Mol Cell Proteomics. 2019 May;18(5):936-953. doi: 10.1074/mcp.RA119.001390. Epub 2019 Feb 21.

PMID:
30792264
3.

Combined transcriptome and proteome profiling reveals specific molecular brain signatures for sex, maturation and circalunar clock phase.

Schenk S, Bannister SC, Sedlazeck FJ, Anrather D, Minh BQ, Bileck A, Hartl M, von Haeseler A, Gerner C, Raible F, Tessmar-Raible K.

Elife. 2019 Feb 15;8. pii: e41556. doi: 10.7554/eLife.41556.

4.

Glycated hemoglobin concentrations of red blood cells minimally increase during storage under standard blood banking conditions.

Prosenz J, Öhlinger T, Müllner EW, Marculescu R, Gerner C, Salzer U, Kiefer FW, Baron DM.

Transfusion. 2019 Feb;59(2):454-457. doi: 10.1111/trf.14956. Epub 2018 Oct 1.

PMID:
30727042
5.

Clinical Efficacy of a Novel Therapeutic Principle, Anakoinosis.

Heudobler D, Rechenmacher M, Lüke F, Vogelhuber M, Klobuch S, Thomas S, Pukrop T, Hackl C, Herr W, Ghibelli L, Gerner C, Reichle A.

Front Pharmacol. 2018 Nov 28;9:1357. doi: 10.3389/fphar.2018.01357. eCollection 2018. Review.

6.

Peroxisome Proliferator-Activated Receptors (PPAR)γ Agonists as Master Modulators of Tumor Tissue.

Heudobler D, Rechenmacher M, Lüke F, Vogelhuber M, Pukrop T, Herr W, Ghibelli L, Gerner C, Reichle A.

Int J Mol Sci. 2018 Nov 9;19(11). pii: E3540. doi: 10.3390/ijms19113540. Review.

7.

Time-dependent shotgun proteomics revealed distinct effects of an organoruthenium prodrug and its activation product on colon carcinoma cells.

Meier-Menches SM, Zappe K, Bileck A, Kreutz D, Tahir A, Cichna-Markl M, Gerner C.

Metallomics. 2019 Jan 23;11(1):118-127. doi: 10.1039/c8mt00152a.

PMID:
30106070
8.

Deoxynivalenol induces structural alterations in epidermoid carcinoma cells A431 and impairs the response to biomechanical stimulation.

Del Favero G, Woelflingseder L, Janker L, Neuditschko B, Seriani S, Gallina P, Sbaizero O, Gerner C, Marko D.

Sci Rep. 2018 Jul 27;8(1):11351. doi: 10.1038/s41598-018-29728-5.

9.

Fetal articular cartilage regeneration versus adult fibrocartilaginous repair: secretome proteomics unravels molecular mechanisms in an ovine model.

Ribitsch I, Mayer RL, Egerbacher M, Gabner S, Kańduła MM, Rosser J, Haltmayer E, Auer U, Gültekin S, Huber J, Bileck A, Kreil DP, Gerner C, Jenner F.

Dis Model Mech. 2018 Jul 6;11(7). pii: dmm033092. doi: 10.1242/dmm.033092.

10.

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.

Oikonomidi I, Burbridge E, Cavadas M, Sullivan G, Collis B, Naegele H, Clancy D, Brezinova J, Hu T, Bileck A, Gerner C, Bolado A, von Kriegsheim A, Martin SJ, Steinberg F, Strisovsky K, Adrain C.

Elife. 2018 Jun 13;7. pii: e35032. doi: 10.7554/eLife.35032.

11.

Curcumin exerts its antitumor effects in a context dependent fashion.

Kreutz D, Sinthuvanich C, Bileck A, Janker L, Muqaku B, Slany A, Gerner C.

J Proteomics. 2018 Jun 30;182:65-72. doi: 10.1016/j.jprot.2018.05.007. Epub 2018 May 9.

PMID:
29751106
12.

Mobile phone specific electromagnetic fields induce transient DNA damage and nucleotide excision repair in serum-deprived human glioblastoma cells.

Al-Serori H, Ferk F, Kundi M, Bileck A, Gerner C, Mišík M, Nersesyan A, Waldherr M, Murbach M, Lah TT, Herold-Mende C, Collins AR, Knasmüller S.

PLoS One. 2018 Apr 12;13(4):e0193677. doi: 10.1371/journal.pone.0193677. eCollection 2018.

13.

Hepatocyte specific expression of an oncogenic variant of β-catenin results in lethal metabolic dysfunction in mice.

Lemberger UJ, Fuchs CD, Schöfer C, Bileck A, Gerner C, Stojakovic T, Taketo MM, Trauner M, Egger G, Österreicher CH.

Oncotarget. 2018 Jan 30;9(13):11243-11257. doi: 10.18632/oncotarget.24346. eCollection 2018 Feb 16.

14.

Proteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases.

Zila N, Bileck A, Muqaku B, Janker L, Eichhoff OM, Cheng PF, Dummer R, Levesque MP, Gerner C, Paulitschke V.

Clin Proteomics. 2018 Mar 9;15:13. doi: 10.1186/s12014-018-9189-x. eCollection 2018.

15.

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia.

Mayer RL, Schwarzmeier JD, Gerner MC, Bileck A, Mader JC, Meier-Menches SM, Gerner SM, Schmetterer KG, Pukrop T, Reichle A, Slany A, Gerner C.

Mol Cell Proteomics. 2018 Feb;17(2):290-303. doi: 10.1074/mcp.RA117.000425. Epub 2017 Dec 1.

16.

Transplantation of human amnion prevents recurring adhesions and ameliorates fibrosis in a rat model of sciatic nerve scarring.

Lemke A, Ferguson J, Gross K, Penzenstadler C, Bradl M, Mayer RL, Gerner C, Redl H, Wolbank S.

Acta Biomater. 2018 Jan 15;66:335-349. doi: 10.1016/j.actbio.2017.11.042. Epub 2017 Nov 28.

PMID:
29191510
17.

Proteomic profiling identifies markers for inflammation-related tumor-fibroblast interaction.

Drev D, Bileck A, Erdem ZN, Mohr T, Timelthaler G, Beer A, Gerner C, Marian B.

Clin Proteomics. 2017 Oct 6;14:33. doi: 10.1186/s12014-017-9168-7. eCollection 2017.

18.

Structure-activity relationships for ruthenium and osmium anticancer agents - towards clinical development.

Meier-Menches SM, Gerner C, Berger W, Hartinger CG, Keppler BK.

Chem Soc Rev. 2018 Feb 5;47(3):909-928. doi: 10.1039/c7cs00332c. Review.

PMID:
29170783
19.

Randomised clinical study: the effects of oral taurine 6g/day vs placebo on portal hypertension.

Schwarzer R, Kivaranovic D, Mandorfer M, Paternostro R, Wolrab D, Heinisch B, Reiberger T, Ferlitsch M, Gerner C, Trauner M, Peck-Radosavljevic M, Ferlitsch A.

Aliment Pharmacol Ther. 2018 Jan;47(1):86-94. doi: 10.1111/apt.14377. Epub 2017 Nov 3.

PMID:
29105115
20.

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE.

Cavadas M, Oikonomidi I, Gaspar CJ, Burbridge E, Badenes M, Félix I, Bolado A, Hu T, Bileck A, Gerner C, Domingos PM, von Kriegsheim A, Adrain C.

Cell Rep. 2017 Oct 17;21(3):745-757. doi: 10.1016/j.celrep.2017.09.074.

21.

Consequences of transition from liquid chromatography to supercritical fluid chromatography on the overall performance of a chiral zwitterionic ion-exchanger.

Wolrab D, Frühauf P, Gerner C, Kohout M, Lindner W.

J Chromatogr A. 2017 Sep 29;1517:165-175. doi: 10.1016/j.chroma.2017.08.022. Epub 2017 Aug 16.

PMID:
28847582
22.

Covalent dimerization of interleukin-like epithelial-to-mesenchymal transition (EMT) inducer (ILEI) facilitates EMT, invasion, and late aspects of metastasis.

Kral M, Klimek C, Kutay B, Timelthaler G, Lendl T, Neuditschko B, Gerner C, Sibilia M, Csiszar A.

FEBS J. 2017 Oct;284(20):3484-3505. doi: 10.1111/febs.14207. Epub 2017 Sep 14.

23.

Sensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis.

Schoenhacker-Alte B, Mohr T, Pirker C, Kryeziu K, Kuhn PS, Buck A, Hofmann T, Gerner C, Hermann G, Koellensperger G, Keppler BK, Berger W, Heffeter P.

Cancer Lett. 2017 Sep 28;404:79-88. doi: 10.1016/j.canlet.2017.07.009. Epub 2017 Jul 14.

PMID:
28716523
24.
25.

Proteome profiling in IL-1β and VEGF-activated human umbilical vein endothelial cells delineates the interlink between inflammation and angiogenesis.

Mohr T, Haudek-Prinz V, Slany A, Grillari J, Micksche M, Gerner C.

PLoS One. 2017 Jun 15;12(6):e0179065. doi: 10.1371/journal.pone.0179065. eCollection 2017.

26.

An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin.

Meier SM, Kreutz D, Winter L, Klose MHM, Cseh K, Weiss T, Bileck A, Alte B, Mader JC, Jana S, Chatterjee A, Bhattacharyya A, Hejl M, Jakupec MA, Heffeter P, Berger W, Hartinger CG, Keppler BK, Wiche G, Gerner C.

Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8267-8271. doi: 10.1002/anie.201702242. Epub 2017 May 26.

PMID:
28547791
27.

Absence of PD-L1 on tumor cells is associated with reduced MHC I expression and PD-L1 expression increases in recurrent serous ovarian cancer.

Aust S, Felix S, Auer K, Bachmayr-Heyda A, Kenner L, Dekan S, Meier SM, Gerner C, Grimm C, Pils D.

Sci Rep. 2017 Mar 7;7:42929. doi: 10.1038/srep42929.

28.

Combined Proteome and Eicosanoid Profiling Approach for Revealing Implications of Human Fibroblasts in Chronic Inflammation.

Tahir A, Bileck A, Muqaku B, Niederstaetter L, Kreutz D, Mayer RL, Wolrab D, Meier SM, Slany A, Gerner C.

Anal Chem. 2017 Feb 7;89(3):1945-1954. doi: 10.1021/acs.analchem.6b04433. Epub 2017 Jan 20.

PMID:
28208246
29.

Response Profiling Using Shotgun Proteomics Enables Global Metallodrug Mechanisms of Action To Be Established.

Kreutz D, Bileck A, Plessl K, Wolrab D, Groessl M, Keppler BK, Meier SM, Gerner C.

Chemistry. 2017 Feb 3;23(8):1881-1890. doi: 10.1002/chem.201604516. Epub 2017 Jan 10.

PMID:
28071820
30.

Discovery of methylfarnesoate as the annelid brain hormone reveals an ancient role of sesquiterpenoids in reproduction.

Schenk S, Krauditsch C, Frühauf P, Gerner C, Raible F.

Elife. 2016 Nov 29;5. pii: e17126. doi: 10.7554/eLife.17126.

31.

Multi-omics Analysis of Serum Samples Demonstrates Reprogramming of Organ Functions Via Systemic Calcium Mobilization and Platelet Activation in Metastatic Melanoma.

Muqaku B, Eisinger M, Meier SM, Tahir A, Pukrop T, Haferkamp S, Slany A, Reichle A, Gerner C.

Mol Cell Proteomics. 2017 Jan;16(1):86-99. doi: 10.1074/mcp.M116.063313. Epub 2016 Nov 22.

32.

Evaluation of inflammation-related signaling events covering phosphorylation and nuclear translocation of proteins based on mass spectrometry data.

Bileck A, Mayer RL, Kreutz D, Weiss T, Taschner-Mandl S, Meier SM, Slany A, Gerner C.

J Proteomics. 2017 Jan 30;152:161-171. doi: 10.1016/j.jprot.2016.11.008. Epub 2016 Nov 13.

PMID:
27851987
33.

Integrative Systemic and Local Metabolomics with Impact on Survival in High-Grade Serous Ovarian Cancer.

Bachmayr-Heyda A, Aust S, Auer K, Meier SM, Schmetterer KG, Dekan S, Gerner C, Pils D.

Clin Cancer Res. 2017 Apr 15;23(8):2081-2092. doi: 10.1158/1078-0432.CCR-16-1647. Epub 2016 Oct 19.

34.

Novel non-canonical role of STAT1 in Natural Killer cell cytotoxicity.

Putz EM, Majoros A, Gotthardt D, Prchal-Murphy M, Zebedin-Brandl EM, Fux DA, Schlattl A, Schreiber RD, Carotta S, Müller M, Gerner C, Decker T, Sexl V.

Oncoimmunology. 2016 May 19;5(9):e1186314. eCollection 2016.

35.

Proteomics and transcriptomics of peripheral nerve tissue and cells unravel new aspects of the human Schwann cell repair phenotype.

Weiss T, Taschner-Mandl S, Bileck A, Slany A, Kromp F, Rifatbegovic F, Frech C, Windhager R, Kitzinger H, Tzou CH, Ambros PF, Gerner C, Ambros IM.

Glia. 2016 Dec;64(12):2133-2153. doi: 10.1002/glia.23045. Epub 2016 Aug 22.

PMID:
27545331
36.

Role of the immune system in the peritoneal tumor spread of high grade serous ovarian cancer.

Auer K, Bachmayr-Heyda A, Sukhbaatar N, Aust S, Schmetterer KG, Meier SM, Gerner C, Grimm C, Horvat R, Pils D.

Oncotarget. 2016 Sep 20;7(38):61336-61354. doi: 10.18632/oncotarget.11038.

37.

Quantification of the neurotransmitters melatonin and N-acetyl-serotonin in human serum by supercritical fluid chromatography coupled with tandem mass spectrometry.

Wolrab D, Frühauf P, Gerner C.

Anal Chim Acta. 2016 Sep 21;937:168-74. doi: 10.1016/j.aca.2016.08.012. Epub 2016 Aug 16.

PMID:
27590559
38.

Coffee consumption modulates inflammatory processes in an individual fashion.

Muqaku B, Tahir A, Klepeisz P, Bileck A, Kreutz D, Mayer RL, Meier SM, Gerner M, Schmetterer K, Gerner C.

Mol Nutr Food Res. 2016 Dec;60(12):2529-2541. doi: 10.1002/mnfr.201600328. Epub 2016 Aug 30.

PMID:
27425673
39.

Proteome analysis identifies L1CAM/CD171 and DPP4/CD26 as novel markers of human skin mast cells.

Gschwandtner M, Paulitschke V, Mildner M, Brunner PM, Hacker S, Eisenwort G, Sperr WR, Valent P, Gerner C, Tschachler E.

Allergy. 2017 Jan;72(1):85-97. doi: 10.1111/all.12919. Epub 2016 May 25.

PMID:
27091730
40.

Contribution of Human Fibroblasts and Endothelial Cells to the Hallmarks of Inflammation as Determined by Proteome Profiling.

Slany A, Bileck A, Kreutz D, Mayer RL, Muqaku B, Gerner C.

Mol Cell Proteomics. 2016 Jun;15(6):1982-97. doi: 10.1074/mcp.M116.058099. Epub 2016 Mar 29.

41.

Exploring the role of sphingolipid machinery during the epithelial to mesenchymal transition program using an integrative approach.

Meshcheryakova A, Svoboda M, Tahir A, Köfeler HC, Triebl A, Mungenast F, Heinze G, Gerner C, Zimmermann P, Jaritz M, Mechtcheriakova D.

Oncotarget. 2016 Apr 19;7(16):22295-323. doi: 10.18632/oncotarget.7947.

42.

Mass Spectrometry Uncovers Molecular Reactivities of Coordination and Organometallic Gold(III) Drug Candidates in Competitive Experiments That Correlate with Their Biological Effects.

Meier SM, Gerner C, Keppler BK, Cinellu MA, Casini A.

Inorg Chem. 2016 May 2;55(9):4248-59. doi: 10.1021/acs.inorgchem.5b03000. Epub 2016 Feb 11.

PMID:
26866307
43.

Chiral separation of new designer drugs (Cathinones) on chiral ion-exchange type stationary phases.

Wolrab D, Frühauf P, Moulisová A, Kuchař M, Gerner C, Lindner W, Kohout M.

J Pharm Biomed Anal. 2016 Feb 20;120:306-15. doi: 10.1016/j.jpba.2015.12.023. Epub 2015 Dec 24.

PMID:
26765268
44.

Quantitative proteomics reveals protein kinases and phosphatases in the individual phases of contextual fear conditioning in the C57BL/6J mouse.

Šmidák R, Mayer RL, Bileck A, Gerner C, Mechtcheriakova D, Stork O, Lubec G, Li L.

Behav Brain Res. 2016 Apr 15;303:208-17. doi: 10.1016/j.bbr.2015.12.033. Epub 2015 Dec 31.

PMID:
26748257
45.

The Royal Free Hospital-Nutritional Prioritizing Tool Is an Independent Predictor of Deterioration of Liver Function and Survival in Cirrhosis.

Borhofen SM, Gerner C, Lehmann J, Fimmers R, Görtzen J, Hey B, Geiser F, Strassburg CP, Trebicka J.

Dig Dis Sci. 2016 Jun;61(6):1735-43. doi: 10.1007/s10620-015-4015-z. Epub 2016 Jan 2.

PMID:
26725059
46.

Proteomic and Metabolomic Analyses Reveal Contrasting Anti-Inflammatory Effects of an Extract of Mucor Racemosus Secondary Metabolites Compared to Dexamethasone.

Meier SM, Muqaku B, Ullmann R, Bileck A, Kreutz D, Mader JC, Knasmüller S, Gerner C.

PLoS One. 2015 Oct 23;10(10):e0140367. doi: 10.1371/journal.pone.0140367. eCollection 2015.

47.

Targeting breast cancer-associated fibroblasts to improve anti-cancer therapy.

Slany A, Bileck A, Muqaku B, Gerner C.

Breast. 2015 Oct;24(5):532-8. doi: 10.1016/j.breast.2015.06.009. Epub 2015 Jul 22.

PMID:
26210685
48.

Impact of a synthetic cannabinoid (CP-47,497-C8) on protein expression in human cells: evidence for induction of inflammation and DNA damage.

Bileck A, Ferk F, Al-Serori H, Koller VJ, Muqaku B, Haslberger A, Auwärter V, Gerner C, Knasmüller S.

Arch Toxicol. 2016 Jun;90(6):1369-82. doi: 10.1007/s00204-015-1569-7. Epub 2015 Jul 21.

PMID:
26194647
49.

Quantification of cytokines secreted by primary human cells using multiple reaction monitoring: evaluation of analytical parameters.

Muqaku B, Slany A, Bileck A, Kreutz D, Gerner C.

Anal Bioanal Chem. 2015 Aug;407(21):6525-36. doi: 10.1007/s00216-015-8817-9. Epub 2015 Jun 20.

PMID:
26092402
50.

Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells.

Karlic H, Thaler R, Gerner C, Grunt T, Proestling K, Haider F, Varga F.

Cancer Genet. 2015 May;208(5):241-52. doi: 10.1016/j.cancergen.2015.03.008. Epub 2015 Mar 18.

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