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Items: 1 to 50 of 153

1.

Neutrophil Extracellular Trap Formation Correlates with Favorable Overall Survival in High Grade Ovarian Cancer.

Muqaku B, Pils D, Mader JC, Aust S, Mangold A, Muqaku L, Slany A, Del Favero G, Gerner C.

Cancers (Basel). 2020 Feb 21;12(2). pii: E505. doi: 10.3390/cancers12020505.

2.

Lipid droplet-mediated scavenging as novel intrinsic and adaptive resistance factor against the multikinase inhibitor ponatinib.

Englinger B, Laemmerer A, Moser P, Kallus S, Röhrl C, Pirker C, Baier D, Mohr T, Niederstaetter L, Meier-Menches SM, Gerner C, Gabler L, Gojo J, Timelthaler G, Senkiv J, Jäger W, Kowol CR, Heffeter P, Berger W.

Int J Cancer. 2020 Feb 16. doi: 10.1002/ijc.32924. [Epub ahead of print]

PMID:
32064608
3.

Proteomics-Enriched Prediction Model for Poor Neurologic Outcome in Cardiac Arrest Survivors.

Distelmaier K, Muqaku B, Wurm R, Arfsten H, Seidel S, Kovacs GG, Mayer RL, Szekeres T, Wallisch C, Hubner P, Goliasch G, Heinze G, Heinz G, Sterz F, Gerner C, Adlbrecht C.

Crit Care Med. 2020 Feb;48(2):167-175. doi: 10.1097/CCM.0000000000004105.

PMID:
31939784
4.

Anakoinosis: Correcting Aberrant Homeostasis of Cancer Tissue-Going Beyond Apoptosis Induction.

Heudobler D, Lüke F, Vogelhuber M, Klobuch S, Pukrop T, Herr W, Gerner C, Pantziarka P, Ghibelli L, Reichle A.

Front Oncol. 2019 Dec 20;9:1408. doi: 10.3389/fonc.2019.01408. eCollection 2019. Review.

5.

The Challenge of Classifying Metastatic Cell Properties by Molecular Profiling Exemplified with Cutaneous Melanoma Cells and Their Cerebral Metastasis from Patient Derived Mouse Xenografts.

Neuditschko B, Janker L, Niederstaetter L, Brunmair J, Krivanek K, Izraely S, Sagi-Assif O, Meshel T, Keppler BK, Del Favero G, Witz IP, Gerner C.

Mol Cell Proteomics. 2020 Mar;19(3):478-489. doi: 10.1074/mcp.RA119.001886. Epub 2019 Dec 31.

6.

Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in Platynereis.

Andreatta G, Broyart C, Borghgraef C, Vadiwala K, Kozin V, Polo A, Bileck A, Beets I, Schoofs L, Gerner C, Raible F.

Proc Natl Acad Sci U S A. 2020 Jan 14;117(2):1097-1106. doi: 10.1073/pnas.1910262116. Epub 2019 Dec 16.

7.

MULTIOMIC PATTERNS IN BODY FLUIDS: TECHNOLOGICAL CHALLENGE WITH A GREAT POTENTIAL TO IMPLEMENT THE ADVANCED PARADIGM OF 3P MEDICINE.

Gerner C, Costigliola V, Golubnitschaja O.

Mass Spectrom Rev. 2019 Nov 18. doi: 10.1002/mas.21612. [Epub ahead of print] Review.

PMID:
31737933
8.

Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer.

Unterleuthner D, Neuhold P, Schwarz K, Janker L, Neuditschko B, Nivarthi H, Crncec I, Kramer N, Unger C, Hengstschläger M, Eferl R, Moriggl R, Sommergruber W, Gerner C, Dolznig H.

Angiogenesis. 2019 Oct 30. doi: 10.1007/s10456-019-09688-8. [Epub ahead of print]

PMID:
31667643
9.

Proteome Analysis Reveals Distinct Mitochondrial Functions Linked to Interferon Response Patterns in Activated CD4+ and CD8+ T Cells.

Gerner MC, Niederstaetter L, Ziegler L, Bileck A, Slany A, Janker L, Schmidt RLJ, Gerner C, Del Favero G, Schmetterer KG.

Front Pharmacol. 2019 Jul 10;10:727. doi: 10.3389/fphar.2019.00727. eCollection 2019.

10.

Proteomic identification of a marker signature for MAPKi resistance in melanoma.

Paulitschke V, Eichhoff O, Gerner C, Paulitschke P, Bileck A, Mohr T, Cheng PF, Leitner A, Guenova E, Saulite I, Freiberger SN, Irmisch A, Knapp B, Zila N, Chatziisaak TP, Stephan J, Mangana J, Kunstfeld R, Pehamberger H, Aebersold R, Dummer R, Levesque MP.

EMBO J. 2019 Aug 1;38(15):e95874. doi: 10.15252/embj.201695874. Epub 2019 Jun 26.

PMID:
31267558
11.

NECTIN4 (PVRL4) as Putative Therapeutic Target for a Specific Subtype of High Grade Serous Ovarian Cancer-An Integrative Multi-Omics Approach.

Bekos C, Muqaku B, Dekan S, Horvat R, Polterauer S, Gerner C, Aust S, Pils D.

Cancers (Basel). 2019 May 20;11(5). pii: E698. doi: 10.3390/cancers11050698.

12.

Metabolic, Anti-apoptotic and Immune Evasion Strategies of Primary Human Myeloma Cells Indicate Adaptations to Hypoxia.

Janker L, Mayer RL, Bileck A, Kreutz D, Mader JC, Utpatel K, Heudobler D, Agis H, Gerner C, Slany A.

Mol Cell Proteomics. 2019 May;18(5):936-953. doi: 10.1074/mcp.RA119.001390. Epub 2019 Feb 21.

PMID:
30792264
13.

Combined transcriptome and proteome profiling reveals specific molecular brain signatures for sex, maturation and circalunar clock phase.

Schenk S, Bannister SC, Sedlazeck FJ, Anrather D, Minh BQ, Bileck A, Hartl M, von Haeseler A, Gerner C, Raible F, Tessmar-Raible K.

Elife. 2019 Feb 15;8. pii: e41556. doi: 10.7554/eLife.41556.

14.

Glycated hemoglobin concentrations of red blood cells minimally increase during storage under standard blood banking conditions.

Prosenz J, Öhlinger T, Müllner EW, Marculescu R, Gerner C, Salzer U, Kiefer FW, Baron DM.

Transfusion. 2019 Feb;59(2):454-457. doi: 10.1111/trf.14956. Epub 2018 Oct 1.

PMID:
30727042
15.

Clinical Efficacy of a Novel Therapeutic Principle, Anakoinosis.

Heudobler D, Rechenmacher M, Lüke F, Vogelhuber M, Klobuch S, Thomas S, Pukrop T, Hackl C, Herr W, Ghibelli L, Gerner C, Reichle A.

Front Pharmacol. 2018 Nov 28;9:1357. doi: 10.3389/fphar.2018.01357. eCollection 2018. Review.

16.

Peroxisome Proliferator-Activated Receptors (PPAR)γ Agonists as Master Modulators of Tumor Tissue.

Heudobler D, Rechenmacher M, Lüke F, Vogelhuber M, Pukrop T, Herr W, Ghibelli L, Gerner C, Reichle A.

Int J Mol Sci. 2018 Nov 9;19(11). pii: E3540. doi: 10.3390/ijms19113540. Review.

17.

Time-dependent shotgun proteomics revealed distinct effects of an organoruthenium prodrug and its activation product on colon carcinoma cells.

Meier-Menches SM, Zappe K, Bileck A, Kreutz D, Tahir A, Cichna-Markl M, Gerner C.

Metallomics. 2019 Jan 23;11(1):118-127. doi: 10.1039/c8mt00152a.

PMID:
30106070
18.

Deoxynivalenol induces structural alterations in epidermoid carcinoma cells A431 and impairs the response to biomechanical stimulation.

Del Favero G, Woelflingseder L, Janker L, Neuditschko B, Seriani S, Gallina P, Sbaizero O, Gerner C, Marko D.

Sci Rep. 2018 Jul 27;8(1):11351. doi: 10.1038/s41598-018-29728-5.

19.

Fetal articular cartilage regeneration versus adult fibrocartilaginous repair: secretome proteomics unravels molecular mechanisms in an ovine model.

Ribitsch I, Mayer RL, Egerbacher M, Gabner S, Kańduła MM, Rosser J, Haltmayer E, Auer U, Gültekin S, Huber J, Bileck A, Kreil DP, Gerner C, Jenner F.

Dis Model Mech. 2018 Jul 6;11(7). pii: dmm033092. doi: 10.1242/dmm.033092.

20.

iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.

Oikonomidi I, Burbridge E, Cavadas M, Sullivan G, Collis B, Naegele H, Clancy D, Brezinova J, Hu T, Bileck A, Gerner C, Bolado A, von Kriegsheim A, Martin SJ, Steinberg F, Strisovsky K, Adrain C.

Elife. 2018 Jun 13;7. pii: e35032. doi: 10.7554/eLife.35032.

21.

Curcumin exerts its antitumor effects in a context dependent fashion.

Kreutz D, Sinthuvanich C, Bileck A, Janker L, Muqaku B, Slany A, Gerner C.

J Proteomics. 2018 Jun 30;182:65-72. doi: 10.1016/j.jprot.2018.05.007. Epub 2018 May 9.

PMID:
29751106
22.

Mobile phone specific electromagnetic fields induce transient DNA damage and nucleotide excision repair in serum-deprived human glioblastoma cells.

Al-Serori H, Ferk F, Kundi M, Bileck A, Gerner C, Mišík M, Nersesyan A, Waldherr M, Murbach M, Lah TT, Herold-Mende C, Collins AR, Knasmüller S.

PLoS One. 2018 Apr 12;13(4):e0193677. doi: 10.1371/journal.pone.0193677. eCollection 2018.

23.

Hepatocyte specific expression of an oncogenic variant of β-catenin results in lethal metabolic dysfunction in mice.

Lemberger UJ, Fuchs CD, Schöfer C, Bileck A, Gerner C, Stojakovic T, Taketo MM, Trauner M, Egger G, Österreicher CH.

Oncotarget. 2018 Jan 30;9(13):11243-11257. doi: 10.18632/oncotarget.24346. eCollection 2018 Feb 16.

24.

Proteomics-based insights into mitogen-activated protein kinase inhibitor resistance of cerebral melanoma metastases.

Zila N, Bileck A, Muqaku B, Janker L, Eichhoff OM, Cheng PF, Dummer R, Levesque MP, Gerner C, Paulitschke V.

Clin Proteomics. 2018 Mar 9;15:13. doi: 10.1186/s12014-018-9189-x. eCollection 2018.

25.

Proteomics and metabolomics identify molecular mechanisms of aging potentially predisposing for chronic lymphocytic leukemia.

Mayer RL, Schwarzmeier JD, Gerner MC, Bileck A, Mader JC, Meier-Menches SM, Gerner SM, Schmetterer KG, Pukrop T, Reichle A, Slany A, Gerner C.

Mol Cell Proteomics. 2018 Feb;17(2):290-303. doi: 10.1074/mcp.RA117.000425. Epub 2017 Dec 1.

26.

Transplantation of human amnion prevents recurring adhesions and ameliorates fibrosis in a rat model of sciatic nerve scarring.

Lemke A, Ferguson J, Gross K, Penzenstadler C, Bradl M, Mayer RL, Gerner C, Redl H, Wolbank S.

Acta Biomater. 2018 Jan 15;66:335-349. doi: 10.1016/j.actbio.2017.11.042. Epub 2017 Nov 28.

PMID:
29191510
27.

Proteomic profiling identifies markers for inflammation-related tumor-fibroblast interaction.

Drev D, Bileck A, Erdem ZN, Mohr T, Timelthaler G, Beer A, Gerner C, Marian B.

Clin Proteomics. 2017 Oct 6;14:33. doi: 10.1186/s12014-017-9168-7. eCollection 2017.

28.

Structure-activity relationships for ruthenium and osmium anticancer agents - towards clinical development.

Meier-Menches SM, Gerner C, Berger W, Hartinger CG, Keppler BK.

Chem Soc Rev. 2018 Feb 5;47(3):909-928. doi: 10.1039/c7cs00332c. Review.

PMID:
29170783
29.

Randomised clinical study: the effects of oral taurine 6g/day vs placebo on portal hypertension.

Schwarzer R, Kivaranovic D, Mandorfer M, Paternostro R, Wolrab D, Heinisch B, Reiberger T, Ferlitsch M, Gerner C, Trauner M, Peck-Radosavljevic M, Ferlitsch A.

Aliment Pharmacol Ther. 2018 Jan;47(1):86-94. doi: 10.1111/apt.14377. Epub 2017 Nov 3.

30.

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE.

Cavadas M, Oikonomidi I, Gaspar CJ, Burbridge E, Badenes M, Félix I, Bolado A, Hu T, Bileck A, Gerner C, Domingos PM, von Kriegsheim A, Adrain C.

Cell Rep. 2017 Oct 17;21(3):745-757. doi: 10.1016/j.celrep.2017.09.074.

31.

Consequences of transition from liquid chromatography to supercritical fluid chromatography on the overall performance of a chiral zwitterionic ion-exchanger.

Wolrab D, Frühauf P, Gerner C, Kohout M, Lindner W.

J Chromatogr A. 2017 Sep 29;1517:165-175. doi: 10.1016/j.chroma.2017.08.022. Epub 2017 Aug 16.

PMID:
28847582
32.

Covalent dimerization of interleukin-like epithelial-to-mesenchymal transition (EMT) inducer (ILEI) facilitates EMT, invasion, and late aspects of metastasis.

Kral M, Klimek C, Kutay B, Timelthaler G, Lendl T, Neuditschko B, Gerner C, Sibilia M, Csiszar A.

FEBS J. 2017 Oct;284(20):3484-3505. doi: 10.1111/febs.14207. Epub 2017 Sep 14.

33.

Sensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis.

Schoenhacker-Alte B, Mohr T, Pirker C, Kryeziu K, Kuhn PS, Buck A, Hofmann T, Gerner C, Hermann G, Koellensperger G, Keppler BK, Berger W, Heffeter P.

Cancer Lett. 2017 Sep 28;404:79-88. doi: 10.1016/j.canlet.2017.07.009. Epub 2017 Jul 14.

PMID:
28716523
34.
35.

Proteome profiling in IL-1β and VEGF-activated human umbilical vein endothelial cells delineates the interlink between inflammation and angiogenesis.

Mohr T, Haudek-Prinz V, Slany A, Grillari J, Micksche M, Gerner C.

PLoS One. 2017 Jun 15;12(6):e0179065. doi: 10.1371/journal.pone.0179065. eCollection 2017.

36.

An Organoruthenium Anticancer Agent Shows Unexpected Target Selectivity For Plectin.

Meier SM, Kreutz D, Winter L, Klose MHM, Cseh K, Weiss T, Bileck A, Alte B, Mader JC, Jana S, Chatterjee A, Bhattacharyya A, Hejl M, Jakupec MA, Heffeter P, Berger W, Hartinger CG, Keppler BK, Wiche G, Gerner C.

Angew Chem Int Ed Engl. 2017 Jul 3;56(28):8267-8271. doi: 10.1002/anie.201702242. Epub 2017 May 26.

PMID:
28547791
37.

Absence of PD-L1 on tumor cells is associated with reduced MHC I expression and PD-L1 expression increases in recurrent serous ovarian cancer.

Aust S, Felix S, Auer K, Bachmayr-Heyda A, Kenner L, Dekan S, Meier SM, Gerner C, Grimm C, Pils D.

Sci Rep. 2017 Mar 7;7:42929. doi: 10.1038/srep42929.

38.

Combined Proteome and Eicosanoid Profiling Approach for Revealing Implications of Human Fibroblasts in Chronic Inflammation.

Tahir A, Bileck A, Muqaku B, Niederstaetter L, Kreutz D, Mayer RL, Wolrab D, Meier SM, Slany A, Gerner C.

Anal Chem. 2017 Feb 7;89(3):1945-1954. doi: 10.1021/acs.analchem.6b04433. Epub 2017 Jan 20.

PMID:
28208246
39.

Response Profiling Using Shotgun Proteomics Enables Global Metallodrug Mechanisms of Action To Be Established.

Kreutz D, Bileck A, Plessl K, Wolrab D, Groessl M, Keppler BK, Meier SM, Gerner C.

Chemistry. 2017 Feb 3;23(8):1881-1890. doi: 10.1002/chem.201604516. Epub 2017 Jan 10.

PMID:
28071820
40.

Discovery of methylfarnesoate as the annelid brain hormone reveals an ancient role of sesquiterpenoids in reproduction.

Schenk S, Krauditsch C, Frühauf P, Gerner C, Raible F.

Elife. 2016 Nov 29;5. pii: e17126. doi: 10.7554/eLife.17126.

41.

Multi-omics Analysis of Serum Samples Demonstrates Reprogramming of Organ Functions Via Systemic Calcium Mobilization and Platelet Activation in Metastatic Melanoma.

Muqaku B, Eisinger M, Meier SM, Tahir A, Pukrop T, Haferkamp S, Slany A, Reichle A, Gerner C.

Mol Cell Proteomics. 2017 Jan;16(1):86-99. doi: 10.1074/mcp.M116.063313. Epub 2016 Nov 22.

42.

Evaluation of inflammation-related signaling events covering phosphorylation and nuclear translocation of proteins based on mass spectrometry data.

Bileck A, Mayer RL, Kreutz D, Weiss T, Taschner-Mandl S, Meier SM, Slany A, Gerner C.

J Proteomics. 2017 Jan 30;152:161-171. doi: 10.1016/j.jprot.2016.11.008. Epub 2016 Nov 13.

PMID:
27851987
43.

Integrative Systemic and Local Metabolomics with Impact on Survival in High-Grade Serous Ovarian Cancer.

Bachmayr-Heyda A, Aust S, Auer K, Meier SM, Schmetterer KG, Dekan S, Gerner C, Pils D.

Clin Cancer Res. 2017 Apr 15;23(8):2081-2092. doi: 10.1158/1078-0432.CCR-16-1647. Epub 2016 Oct 19.

44.

Novel non-canonical role of STAT1 in Natural Killer cell cytotoxicity.

Putz EM, Majoros A, Gotthardt D, Prchal-Murphy M, Zebedin-Brandl EM, Fux DA, Schlattl A, Schreiber RD, Carotta S, Müller M, Gerner C, Decker T, Sexl V.

Oncoimmunology. 2016 May 19;5(9):e1186314. eCollection 2016.

45.

Proteomics and transcriptomics of peripheral nerve tissue and cells unravel new aspects of the human Schwann cell repair phenotype.

Weiss T, Taschner-Mandl S, Bileck A, Slany A, Kromp F, Rifatbegovic F, Frech C, Windhager R, Kitzinger H, Tzou CH, Ambros PF, Gerner C, Ambros IM.

Glia. 2016 Dec;64(12):2133-2153. doi: 10.1002/glia.23045. Epub 2016 Aug 22.

PMID:
27545331
46.

Role of the immune system in the peritoneal tumor spread of high grade serous ovarian cancer.

Auer K, Bachmayr-Heyda A, Sukhbaatar N, Aust S, Schmetterer KG, Meier SM, Gerner C, Grimm C, Horvat R, Pils D.

Oncotarget. 2016 Sep 20;7(38):61336-61354. doi: 10.18632/oncotarget.11038.

47.

Quantification of the neurotransmitters melatonin and N-acetyl-serotonin in human serum by supercritical fluid chromatography coupled with tandem mass spectrometry.

Wolrab D, Frühauf P, Gerner C.

Anal Chim Acta. 2016 Sep 21;937:168-74. doi: 10.1016/j.aca.2016.08.012. Epub 2016 Aug 16.

PMID:
27590559
48.

Coffee consumption modulates inflammatory processes in an individual fashion.

Muqaku B, Tahir A, Klepeisz P, Bileck A, Kreutz D, Mayer RL, Meier SM, Gerner M, Schmetterer K, Gerner C.

Mol Nutr Food Res. 2016 Dec;60(12):2529-2541. doi: 10.1002/mnfr.201600328. Epub 2016 Aug 30.

PMID:
27425673
49.

Proteome analysis identifies L1CAM/CD171 and DPP4/CD26 as novel markers of human skin mast cells.

Gschwandtner M, Paulitschke V, Mildner M, Brunner PM, Hacker S, Eisenwort G, Sperr WR, Valent P, Gerner C, Tschachler E.

Allergy. 2017 Jan;72(1):85-97. doi: 10.1111/all.12919. Epub 2016 May 25.

PMID:
27091730
50.

Contribution of Human Fibroblasts and Endothelial Cells to the Hallmarks of Inflammation as Determined by Proteome Profiling.

Slany A, Bileck A, Kreutz D, Mayer RL, Muqaku B, Gerner C.

Mol Cell Proteomics. 2016 Jun;15(6):1982-97. doi: 10.1074/mcp.M116.058099. Epub 2016 Mar 29.

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