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Myocardial Ischemic Burden and Differences in Prognosis Among Patients With and Without Diabetes: Results From the Multicenter International REFINE SPECT Registry.

Han D, Rozanski A, Gransar H, Sharir T, Einstein AJ, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli M, Liang JX, Hu LH, Germano G, Dey D, Berman DS, Slomka PJ.

Diabetes Care. 2019 Nov 27. pii: dc191360. doi: 10.2337/dc19-1360. [Epub ahead of print]


Quantitative Clinical Nuclear Cardiology, Part 1: Established Applications.

Garcia EV, Slomka P, Moody JB, Germano G, Ficaro EP.

J Nucl Cardiol. 2019 Oct 25. doi: 10.1007/s12350-019-01906-6. [Epub ahead of print] Review.


Alexithymia: A facet of uncontrolled hypertension.

Casagrande M, Mingarelli A, Guarino A, Favieri F, Boncompagni I, Germanò R, Germanò G, Forte G.

Int J Psychophysiol. 2019 Dec;146:180-189. doi: 10.1016/j.ijpsycho.2019.09.006. Epub 2019 Oct 19.


Radiosynthesis and Preclinical Evaluation of 11C-VA426, a Cyclooxygenase-2 Selective Ligand.

Carpinelli A, Rainone P, Belloli S, Reale A, Cappelli A, Germano G, Murtaj V, Coliva A, Di Grigoli G, Valeri A, Gilardi MC, Gianolli L, Anzini M, Moresco RM.

Contrast Media Mol Imaging. 2019 Sep 24;2019:5823261. doi: 10.1155/2019/5823261. eCollection 2019.


Next-generation sequencing of PTEN mutations for monitoring minimal residual disease in T-cell acute lymphoblastic leukemia.

Germano G, Valsecchi MG, Buldini B, Cazzaniga G, Zanon C, Silvestri D, Te Kronnie G, Basso G, Paganin M.

Pediatr Blood Cancer. 2020 Jan;67(1):e28025. doi: 10.1002/pbc.28025. Epub 2019 Oct 1.


Quantification of myocardial blood flow by CZT-SPECT with motion correction and comparison with 15O-water PET.

Otaki Y, Manabe O, Miller RJH, Manrique A, Nganoa C, Roth N, Berman DS, Germano G, Slomka PJ, Agostini D.

J Nucl Cardiol. 2019 Aug 26. doi: 10.1007/s12350-019-01854-1. [Epub ahead of print]


Coping styles in individuals with hypertension of varying severity.

Casagrande M, Boncompagni I, Mingarelli A, Favieri F, Forte G, Germanò R, Germanò G, Guarino A.

Stress Health. 2019 Oct;35(4):560-568. doi: 10.1002/smi.2889. Epub 2019 Aug 20.


Triple-gated motion and blood pool clearance corrections improve reproducibility of coronary 18F-NaF PET.

Lassen ML, Kwiecinski J, Dey D, Cadet S, Germano G, Berman DS, Adamson PD, Moss AJ, Dweck MR, Newby DE, Slomka PJ.

Eur J Nucl Med Mol Imaging. 2019 Nov;46(12):2610-2620. doi: 10.1007/s00259-019-04437-x. Epub 2019 Aug 5.


Quantitative Clinical Nuclear Cardiology, Part 1: Established Applications.

Garcia EV, Slomka P, Moody JB, Germano G, Ficaro EP.

J Nucl Med. 2019 Nov;60(11):1507-1516. doi: 10.2967/jnumed.119.229799. Review.


Solid-State Detector SPECT Myocardial Perfusion Imaging.

Slomka PJ, Miller RJH, Hu LH, Germano G, Berman DS.

J Nucl Med. 2019 Sep;60(9):1194-1204. doi: 10.2967/jnumed.118.220657. Epub 2019 Aug 2.


Machine learning predicts per-vessel early coronary revascularization after fast myocardial perfusion SPECT: results from multicentre REFINE SPECT registry.

Hu LH, Betancur J, Sharir T, Einstein AJ, Bokhari S, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli M, Germano G, Commandeur F, Liang JX, Otaki Y, Tamarappoo BK, Dey D, Berman DS, Slomka PJ.

Eur Heart J Cardiovasc Imaging. 2019 Jul 16. pii: jez177. doi: 10.1093/ehjci/jez177. [Epub ahead of print]


Transient ischaemic dilation and post-stress wall motion abnormality increase risk in patients with less than moderate ischaemia: analysis of the REFINE SPECT registry.

Miller RJH, Hu LH, Gransar H, Betancur J, Eisenberg E, Otaki Y, Sharir T, Fish MB, Ruddy TD, Dorbala S, Carli MD, Einstein AJ, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman T, Germano G, Tamarappoo BK, Dey D, Berman DS, Slomka PJ.

Eur Heart J Cardiovasc Imaging. 2019 Jul 13. pii: jez172. doi: 10.1093/ehjci/jez172. [Epub ahead of print]


Evolving neoantigen profiles in colorectal cancers with DNA repair defects.

Rospo G, Lorenzato A, Amirouchene-Angelozzi N, Magrì A, Cancelliere C, Corti G, Negrino C, Amodio V, Montone M, Bartolini A, Barault L, Novara L, Isella C, Medico E, Bertotti A, Trusolino L, Germano G, Di Nicolantonio F, Bardelli A.

Genome Med. 2019 Jun 28;11(1):42. doi: 10.1186/s13073-019-0654-6.


5-Year Prognostic Value of Quantitative Versus Visual MPI in Subtle Perfusion Defects: Results From REFINE SPECT.

Otaki Y, Betancur J, Sharir T, Hu LH, Gransar H, Liang JX, Azadani PN, Einstein AJ, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli M, Tamarappoo BK, Germano G, Dey D, Berman DS, Slomka PJ.

JACC Cardiovasc Imaging. 2019 Jun 8. pii: S1936-878X(19)30348-1. doi: 10.1016/j.jcmg.2019.02.028. [Epub ahead of print]


Upper reference limits of transient ischemic dilation ratio for different protocols on new-generation cadmium zinc telluride cameras: A report from REFINE SPECT registry.

Hu LH, Sharir T, Miller RJH, Einstein AJ, Fish MB, Ruddy TD, Dorbala S, Di Carli M, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Betancur J, Germano G, Liang JX, Commandeur F, Azadani PN, Gransar H, Otaki Y, Tamarappoo BK, Dey D, Berman DS, Slomka PJ.

J Nucl Cardiol. 2019 May 13. doi: 10.1007/s12350-019-01730-y. [Epub ahead of print]


Use of technological tools to evaluate handwriting production of the alphabet and pseudocharacters by Brazilian students.

Germano GD, Capellini SA.

Clinics (Sao Paulo). 2019 Mar 25;74:e840. doi: 10.6061/clinics/2019/e840.


Inactivation of DNA repair-prospects for boosting cancer immune surveillance.

Truini A, Germano G, Bardelli A.

Genome Med. 2018 Nov 28;10(1):91. doi: 10.1186/s13073-018-0603-9.


Data-Driven Gross Patient Motion Detection and Compensation: Implications for Coronary 18F-NaF PET Imaging.

Lassen ML, Kwiecinski J, Cadet S, Dey D, Wang C, Dweck MR, Berman DS, Germano G, Newby DE, Slomka PJ.

J Nucl Med. 2019 Jun;60(6):830-836. doi: 10.2967/jnumed.118.217877. Epub 2018 Nov 15.


The Clinical Impact of the Genomic Landscape of Mismatch Repair-Deficient Cancers.

Germano G, Amirouchene-Angelozzi N, Rospo G, Bardelli A.

Cancer Discov. 2018 Dec;8(12):1518-1528. doi: 10.1158/2159-8290.CD-18-0150. Epub 2018 Nov 15. Review.


New Trends in Quantitative Nuclear Cardiology Methods.

Gomez J, Doukky R, Germano G, Slomka P.

Curr Cardiovasc Imaging Rep. 2018 Jan;11(1). pii: 1. doi: 10.1007/s12410-018-9443-7. Epub 2018 Jan 19.


Deep Learning Analysis of Upright-Supine High-Efficiency SPECT Myocardial Perfusion Imaging for Prediction of Obstructive Coronary Artery Disease: A Multicenter Study.

Betancur J, Hu LH, Commandeur F, Sharir T, Einstein AJ, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli M, Germano G, Otaki Y, Liang JX, Tamarappoo BK, Dey D, Berman DS, Slomka PJ.

J Nucl Med. 2019 May;60(5):664-670. doi: 10.2967/jnumed.118.213538. Epub 2018 Sep 27.


Three-Hour Delayed Imaging Improves Assessment of Coronary 18F-Sodium Fluoride PET.

Kwiecinski J, Berman DS, Lee SE, Dey D, Cadet S, Lassen ML, Germano G, Jansen MA, Dweck MR, Newby DE, Chang HJ, Yun M, Slomka PJ.

J Nucl Med. 2019 Apr;60(4):530-535. doi: 10.2967/jnumed.118.217885. Epub 2018 Sep 13.


Biventricular assessment of light-chain amyloidosis using 3D speckle tracking echocardiography: Differentiation from other forms of myocardial hypertrophy.

Vitarelli A, Lai S, Petrucci MT, Gaudio C, Capotosto L, Mangieri E, Ricci S, Germanò G, De Sio S, Truscelli G, Vozella F, Pergolini MS, Giordano M.

Int J Cardiol. 2018 Nov 15;271:371-377. doi: 10.1016/j.ijcard.2018.03.088. Epub 2018 Jul 23.


Rationale and design of the REgistry of Fast Myocardial Perfusion Imaging with NExt generation SPECT (REFINE SPECT).

Slomka PJ, Betancur J, Liang JX, Otaki Y, Hu LH, Sharir T, Dorbala S, Di Carli M, Fish MB, Ruddy TD, Bateman TM, Einstein AJ, Kaufmann PA, Miller EJ, Sinusas AJ, Azadani PN, Gransar H, Tamarappoo BK, Dey D, Berman DS, Germano G.

J Nucl Cardiol. 2018 Jun 19. doi: 10.1007/s12350-018-1326-4. [Epub ahead of print]


SHP2 is required for growth of KRAS-mutant non-small-cell lung cancer in vivo.

Mainardi S, Mulero-Sánchez A, Prahallad A, Germano G, Bosma A, Krimpenfort P, Lieftink C, Steinberg JD, de Wit N, Gonçalves-Ribeiro S, Nadal E, Bardelli A, Villanueva A, Bernards R.

Nat Med. 2018 Jul;24(7):961-967. doi: 10.1038/s41591-018-0023-9. Epub 2018 May 28.


Deep Learning for Prediction of Obstructive Disease From Fast Myocardial Perfusion SPECT: A Multicenter Study.

Betancur J, Commandeur F, Motlagh M, Sharir T, Einstein AJ, Bokhari S, Fish MB, Ruddy TD, Kaufmann P, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli M, Germano G, Otaki Y, Tamarappoo BK, Dey D, Berman DS, Slomka PJ.

JACC Cardiovasc Imaging. 2018 Nov;11(11):1654-1663. doi: 10.1016/j.jcmg.2018.01.020. Epub 2018 Mar 14.


Prediction of cardiac death after adenosine myocardial perfusion SPECT based on machine learning.

Haro Alonso D, Wernick MN, Yang Y, Germano G, Berman DS, Slomka P.

J Nucl Cardiol. 2019 Oct;26(5):1746-1754. doi: 10.1007/s12350-018-1250-7. Epub 2018 Mar 14.


The atypical chemokine receptor ACKR2 drives pulmonary fibrosis by tuning influx of CCR2+ and CCR5+ IFNγ-producing γδT cells in mice.

Russo RC, Savino B, Mirolo M, Buracchi C, Germano G, Anselmo A, Zammataro L, Pasqualini F, Mantovani A, Locati M, Teixeira MM.

Am J Physiol Lung Cell Mol Physiol. 2018 Jun 1;314(6):L1010-L1025. doi: 10.1152/ajplung.00233.2017. Epub 2018 Feb 22.


Antitumor Activity of Entrectinib, a Pan-TRK, ROS1, and ALK Inhibitor, in ETV6-NTRK3-Positive Acute Myeloid Leukemia.

Smith KM, Fagan PC, Pomari E, Germano G, Frasson C, Walsh C, Silverman I, Bonvini P, Li G.

Mol Cancer Ther. 2018 Feb;17(2):455-463. doi: 10.1158/1535-7163.MCT-17-0419. Epub 2017 Dec 13.


Impact of incomplete ventricular coverage on diagnostic performance of myocardial perfusion imaging.

Sharif B, Motwani M, Arsanjani R, Dharmakumar R, Fish MB, Germano G, Li D, Berman DS, Slomka P.

Int J Cardiovasc Imaging. 2018 Apr;34(4):661-669. doi: 10.1007/s10554-017-1265-1. Epub 2017 Dec 1.


Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer.

Germano G, Mauri G, Siravegna G, Dive C, Pierce J, Di Nicolantonio F, D'Incalci M, Bardelli A, Siena S, Sartore-Bianchi A.

Clin Colorectal Cancer. 2018 Mar;17(1):80-83. doi: 10.1016/j.clcc.2017.10.017. Epub 2017 Nov 1.


Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth.

Germano G, Lamba S, Rospo G, Barault L, Magrì A, Maione F, Russo M, Crisafulli G, Bartolini A, Lerda G, Siravegna G, Mussolin B, Frapolli R, Montone M, Morano F, de Braud F, Amirouchene-Angelozzi N, Marsoni S, D'Incalci M, Orlandi A, Giraudo E, Sartore-Bianchi A, Siena S, Pietrantonio F, Di Nicolantonio F, Bardelli A.

Nature. 2017 Dec 7;552(7683):116-120. doi: 10.1038/nature24673. Epub 2017 Nov 29.


Prognostic value of vasodilator response using rubidium-82 positron emission tomography myocardial perfusion imaging in patients with coronary artery disease.

Arasaratnam P, Sadreddini M, Yam Y, Kansal V, Dorbala S, Di Carli MF, Beanlands RS, Merhige ME, Williams BA, Veledar E, Min JK, Chen L, Ruddy TD, Germano G, Berman DS, Shaw LJ, Chow BJW.

Eur J Nucl Med Mol Imaging. 2018 Apr;45(4):538-548. doi: 10.1007/s00259-017-3878-y. Epub 2017 Nov 27.


Screening Protocol for Early Identification of Brazilian Children at Risk for Dyslexia.

Germano GD, César ABPC, Capellini SA.

Front Psychol. 2017 Oct 27;8:1763. doi: 10.3389/fpsyg.2017.01763. eCollection 2017.


Comparison of the Coronary Artery Calcium Score and Number of Calcified Coronary Plaques for Predicting Patient Mortality Risk.

Arnson Y, Rozanski A, Gransar H, Friedman JD, Hayes SW, Thomson LE, Tamarappoo B, Slomka P, Wang F, Germano G, Dey D, Berman DS.

Am J Cardiol. 2017 Dec 15;120(12):2154-2159. doi: 10.1016/j.amjcard.2017.09.001. Epub 2017 Sep 18.


Added prognostic value of left ventricular shape by gated SPECT imaging in patients with suspected coronary artery disease and normal myocardial perfusion.

Gaudieri V, Nappi C, Acampa W, Zampella E, Assante R, Mannarino T, Genova A, De Simini G, Klain M, Germano G, Petretta M, Cuocolo A.

J Nucl Cardiol. 2019 Aug;26(4):1148-1156. doi: 10.1007/s12350-017-1090-x. Epub 2017 Oct 25.


Prognostic Value of Combined Clinical and Myocardial Perfusion Imaging Data Using Machine Learning.

Betancur J, Otaki Y, Motwani M, Fish MB, Lemley M, Dey D, Gransar H, Tamarappoo B, Germano G, Sharir T, Berman DS, Slomka PJ.

JACC Cardiovasc Imaging. 2018 Jul;11(7):1000-1009. doi: 10.1016/j.jcmg.2017.07.024. Epub 2017 Oct 18.


Novel SPECT Technologies and Approaches in Cardiac Imaging.

Slomka P, Hung GU, Germano G, Berman DS.

Cardiovasc Innov Appl. 2016 Dec 1;2(1):31-46. doi: 10.15212/CVIA.2016.0052.


Comparison of left ventricular shape by gated SPECT imaging in diabetic and nondiabetic patients with normal myocardial perfusion: A propensity score analysis.

Nappi C, Gaudieri V, Acampa W, Assante R, Zampella E, Mainolfi CG, Petretta M, Germano G, Cuocolo A.

J Nucl Cardiol. 2018 Apr;25(2):394-403. doi: 10.1007/s12350-017-1009-6. Epub 2017 Aug 14.


Detection and quantitation of right ventricular reversible perfusion defects by stress SPECT myocardial perfusion imaging: A proof-of-principle study.

Farag AA, Heo J, Tauxe L, Bhambhvani P, Germano G, Kavanagh P, Iskandrian AE, Hage FG.

J Nucl Cardiol. 2019 Feb;26(1):266-271. doi: 10.1007/s12350-017-0954-4. Epub 2017 Jul 6.


Assessing LV remodeling in nuclear cardiology.

Germano G, Slomka PJ.

J Nucl Cardiol. 2019 Feb;26(1):233-235. doi: 10.1007/s12350-017-0957-1. Epub 2017 Jun 14. No abstract available.


ZNF521 sustains the differentiation block in MLL-rearranged acute myeloid leukemia.

Germano G, Morello G, Aveic S, Pinazza M, Minuzzo S, Frasson C, Persano L, Bonvini P, Viola G, Bresolin S, Tregnago C, Paganin M, Pigazzi M, Indraccolo S, Basso G.

Oncotarget. 2017 Apr 18;8(16):26129-26141. doi: 10.18632/oncotarget.15387.


The role of ultrasound in the diagnosis and follow-up of large-vessel vasculitis: an update.

Germanò G, Monti S, Ponte C, Possemato N, Caporali R, Salvarani C, Macchioni P, Pipitone N.

Clin Exp Rheumatol. 2017 Mar-Apr;35 Suppl 103(1):194-198. Epub 2017 Mar 29. Review.


Factors affecting appearance of a normal myocardial perfusion scan.

Slomka P, Germano G.

J Nucl Cardiol. 2018 Oct;25(5):1655-1657. doi: 10.1007/s12350-017-0857-4. Epub 2017 Mar 30. No abstract available.


Fully automated analysis of attenuation-corrected SPECT for the long-term prediction of acute myocardial infarction.

Motwani M, Leslie WD, Goertzen AL, Otaki Y, Germano G, Berman DS, Slomka PJ.

J Nucl Cardiol. 2018 Aug;25(4):1353-1360. doi: 10.1007/s12350-017-0840-0. Epub 2017 Mar 13.


Cardiac imaging: working towards fully-automated machine analysis & interpretation.

Slomka PJ, Dey D, Sitek A, Motwani M, Berman DS, Germano G.

Expert Rev Med Devices. 2017 Mar;14(3):197-212. doi: 10.1080/17434440.2017.1300057. Review.


Normal Databases for the Relative Quantification of Myocardial Perfusion.

Rubeaux M, Xu Y, Germano G, Berman DS, Slomka PJ.

Curr Cardiovasc Imaging Rep. 2016 Aug;9. pii: 22. doi: 10.1007/s12410-016-9385-x. Epub 2016 Jun 30.


Quantitative plaque features from coronary computed tomography angiography to identify regional ischemia by myocardial perfusion imaging.

Diaz-Zamudio M, Fuchs TA, Slomka P, Otaki Y, Arsanjani R, Gransar H, Germano G, Berman DS, Kaufmann PA, Dey D.

Eur Heart J Cardiovasc Imaging. 2017 May 1;18(5):499-507. doi: 10.1093/ehjci/jew274.


Quantitative measurements of myocardial perfusion and function from SPECT (and PET) studies depend on the method used to perform those measurements.

Germano G.

J Nucl Cardiol. 2018 Jun;25(3):925-928. doi: 10.1007/s12350-016-0757-z. Epub 2016 Dec 21. No abstract available.


Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer.

Van Emburgh BO, Arena S, Siravegna G, Lazzari L, Crisafulli G, Corti G, Mussolin B, Baldi F, Buscarino M, Bartolini A, Valtorta E, Vidal J, Bellosillo B, Germano G, Pietrantonio F, Ponzetti A, Albanell J, Siena S, Sartore-Bianchi A, Di Nicolantonio F, Montagut C, Bardelli A.

Nat Commun. 2016 Dec 8;7:13665. doi: 10.1038/ncomms13665.

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