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Items: 1 to 50 of 51

1.

Targeting the MAPK Signaling Pathway in Cancer: Promising Preclinical Activity with the Novel Selective ERK1/2 Inhibitor BVD-523 (Ulixertinib).

Germann UA, Furey BF, Markland W, Hoover RR, Aronov AM, Roix JJ, Hale M, Boucher DM, Sorrell DA, Martinez-Botella G, Fitzgibbon M, Shapiro P, Wick MJ, Samadani R, Meshaw K, Groover A, DeCrescenzo G, Namchuk M, Emery CM, Saha S, Welsch DJ.

Mol Cancer Ther. 2017 Nov;16(11):2351-2363. doi: 10.1158/1535-7163.MCT-17-0456. Epub 2017 Sep 22.

2.

Novel Ranking System for Identifying Efficacious Anti-Influenza Virus PB2 Inhibitors.

Tsai AW, McNeil CF, Leeman JR, Bennett HB, Nti-Addae K, Huang C, Germann UA, Byrn RA, Berlioz-Seux F, Rijnbrand R, Clark MP, Charifson PS, Jones SM.

Antimicrob Agents Chemother. 2015 Oct;59(10):6007-16. doi: 10.1128/AAC.00781-15. Epub 2015 Jul 13.

3.

The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.

Duffy JP, Harrington EM, Salituro FG, Cochran JE, Green J, Gao H, Bemis GW, Evindar G, Galullo VP, Ford PJ, Germann UA, Wilson KP, Bellon SF, Chen G, Taslimi P, Jones P, Huang C, Pazhanisamy S, Wang YM, Murcko MA, Su MS.

ACS Med Chem Lett. 2011 Jul 28;2(10):758-63. doi: 10.1021/ml2001455. eCollection 2011 Oct 13.

4.

Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole.

Wang T, Duffy JP, Wang J, Halas S, Salituro FG, Pierce AC, Zuccola HJ, Black JR, Hogan JK, Jepson S, Shlyakter D, Mahajan S, Gu Y, Hoock T, Wood M, Furey BF, Frantz JD, Dauffenbach LM, Germann UA, Fan B, Namchuk M, Bennani YL, Ledeboer MW.

J Med Chem. 2009 Dec 24;52(24):7938-41. doi: 10.1021/jm901383u.

PMID:
20014869
5.

Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control.

Aronov AM, Tang Q, Martinez-Botella G, Bemis GW, Cao J, Chen G, Ewing NP, Ford PJ, Germann UA, Green J, Hale MR, Jacobs M, Janetka JW, Maltais F, Markland W, Namchuk MN, Nanthakumar S, Poondru S, Straub J, ter Haar E, Xie X.

J Med Chem. 2009 Oct 22;52(20):6362-8. doi: 10.1021/jm900630q.

PMID:
19827834
6.

Molecular analysis of the multidrug transporter, P-glycoprotein.

Germann UA, Chambers TC.

Cytotechnology. 1998 Sep;27(1-3):31-60. doi: 10.1023/A:1008023629269.

7.

Flipped out: structure-guided design of selective pyrazolylpyrrole ERK inhibitors.

Aronov AM, Baker C, Bemis GW, Cao J, Chen G, Ford PJ, Germann UA, Green J, Hale MR, Jacobs M, Janetka JW, Maltais F, Martinez-Botella G, Namchuk MN, Straub J, Tang Q, Xie X.

J Med Chem. 2007 Mar 22;50(6):1280-7. Epub 2007 Feb 15.

PMID:
17300186
9.

Regulation of inosine monophosphate dehydrogenase type I and type II isoforms in human lymphocytes.

Jain J, Almquist SJ, Ford PJ, Shlyakhter D, Wang Y, Nimmesgern E, Germann UA.

Biochem Pharmacol. 2004 Feb 15;67(4):767-76.

PMID:
14757177
10.

Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation.

Yao Y, Li W, Wu J, Germann UA, Su MS, Kuida K, Boucher DM.

Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12759-64. Epub 2003 Oct 17.

11.

Detection of recombinant P-glycoprotein in multidrug resistant cultured cells.

Germann UA.

Mol Biotechnol. 2000 Feb;14(2):131-45.

PMID:
10872505
12.

Both ATP sites of human P-glycoprotein are essential but not symmetric.

Hrycyna CA, Ramachandra M, Germann UA, Cheng PW, Pastan I, Gottesman MM.

Biochemistry. 1999 Oct 19;38(42):13887-99.

PMID:
10529234
13.

Inhibitors of p38 MAP kinase: therapeutic intervention in cytokine-mediated diseases.

Salituro FG, Germann UA, Wilson KP, Bemis GW, Fox T, Su MS.

Curr Med Chem. 1999 Sep;6(9):807-23. Review.

PMID:
10495353
14.

A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase.

Fox T, Coll JT, Xie X, Ford PJ, Germann UA, Porter MD, Pazhanisamy S, Fleming MA, Galullo V, Su MS, Wilson KP.

Protein Sci. 1998 Nov;7(11):2249-55.

15.

Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport.

Hrycyna CA, Airan LE, Germann UA, Ambudkar SV, Pastan I, Gottesman MM.

Biochemistry. 1998 Sep 29;37(39):13660-73.

PMID:
9753453
16.
18.

Cellular and biochemical characterization of VX-710 as a chemosensitizer: reversal of P-glycoprotein-mediated multidrug resistance in vitro.

Germann UA, Shlyakhter D, Mason VS, Zelle RE, Duffy JP, Galullo V, Armistead DM, Saunders JO, Boger J, Harding MW.

Anticancer Drugs. 1997 Feb;8(2):125-40.

PMID:
9073309
19.

Detection of expressed recombinant protein based on multidrug resistance: P-glycoprotein.

Germann UA.

Methods Mol Biol. 1997;63:139-59. No abstract available.

PMID:
9113648
20.

P-glycoprotein--a mediator of multidrug resistance in tumour cells.

Germann UA.

Eur J Cancer. 1996 Jun;32A(6):927-44. Review. No abstract available.

PMID:
8763334
21.

Construction and characterization of a selectable multidrug resistance-glucocerebrosidase fusion gene.

Aran JM, Germann UA, Gottesman MM, Pastan I.

Cytokines Mol Ther. 1996 Mar;2(1):47-57.

PMID:
9384689
22.

Altered drug-stimulated ATPase activity in mutants of the human multidrug resistance protein.

Müller M, Bakos E, Welker E, Váradi A, Germann UA, Gottesman MM, Morse BS, Roninson IB, Sarkadi B.

J Biol Chem. 1996 Jan 26;271(4):1877-83.

23.

Characterization of phosphorylation-defective mutants of human P-glycoprotein expressed in mammalian cells.

Germann UA, Chambers TC, Ambudkar SV, Licht T, Cardarelli CO, Pastan I, Gottesman MM.

J Biol Chem. 1996 Jan 19;271(3):1708-16.

24.

Chemosensitizers to overcome and prevent multidrug resistance?

Germann UA, Harding MW.

J Natl Cancer Inst. 1995 Nov 1;87(21):1573-5. No abstract available.

PMID:
7563195
25.

Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites.

Chambers TC, Germann UA, Gottesman MM, Pastan I, Kuo JF, Ambudkar SV.

Biochemistry. 1995 Oct 31;34(43):14156-62.

PMID:
7578013
26.

Effects of phosphorylation of P-glycoprotein on multidrug resistance.

Germann UA, Chambers TC, Ambudkar SV, Pastan I, Gottesman MM.

J Bioenerg Biomembr. 1995 Feb;27(1):53-61. Review.

PMID:
7629052
27.

Heterologous expression systems for P-glycoprotein: E. coli, yeast, and baculovirus.

Evans GL, Ni B, Hrycyna CA, Chen D, Ambudkar SV, Pastan I, Germann UA, Gottesman MM.

J Bioenerg Biomembr. 1995 Feb;27(1):43-52. Review.

PMID:
7629051
28.

Genetic analysis of the multidrug transporter.

Gottesman MM, Hrycyna CA, Schoenlein PV, Germann UA, Pastan I.

Annu Rev Genet. 1995;29:607-49. Review.

PMID:
8825488
29.

Putative "MDR enhancer" is located on human chromosome 20 and not linked to the MDR1 gene on chromosome 7.

Germann UA, Schoenlein PV, Zimonjic DB, Popescu NC, Pastan I, Gottesman MM.

Genes Chromosomes Cancer. 1994 Aug;10(4):267-74.

PMID:
7522541
30.

Interaction of bioactive hydrophobic peptides with the human multidrug transporter.

Sarkadi B, Müller M, Homolya L, Holló Z, Seprödi J, Germann UA, Gottesman MM, Price EM, Boucher RC.

FASEB J. 1994 Jul;8(10):766-70.

PMID:
7914178
31.

Gene transfer of drug resistance genes. Implications for cancer therapy.

Gottesman MM, Germann UA, Aksentijevich I, Sugimoto Y, Cardarelli CO, Pastan I.

Ann N Y Acad Sci. 1994 May 31;716:126-38; discussion 138-43.

PMID:
7912913
32.

Fluorescent cellular indicators are extruded by the multidrug resistance protein.

Homolya L, Holló Z, Germann UA, Pastan I, Gottesman MM, Sarkadi B.

J Biol Chem. 1993 Oct 15;268(29):21493-6.

33.

P-glycoproteins: mediators of multidrug resistance.

Germann UA, Pastan I, Gottesman MM.

Semin Cell Biol. 1993 Feb;4(1):63-76. Review.

PMID:
8095827
34.

Molecular analysis of the multidrug transporter.

Germann UA.

Cytotechnology. 1993;12(1-3):33-62. Review.

PMID:
7765331
35.

Expression of the human multidrug resistance cDNA in insect cells generates a high activity drug-stimulated membrane ATPase.

Sarkadi B, Price EM, Boucher RC, Germann UA, Scarborough GA.

J Biol Chem. 1992 Mar 5;267(7):4854-8.

36.

Regulation of laccase synthesis in induced Neurospora crassa cultures.

Linden RM, Schilling BC, Germann UA, Lerch K.

Curr Genet. 1991 May;19(5):375-81.

PMID:
1833078
37.

Characterization by somatic cell genetics of a monoclonal antibody to the MDR1 gene product (P-glycoprotein): determination of P-glycoprotein expression in multi-drug-resistant KB and CEM cell variants.

Cenciarelli C, Currier SJ, Willingham MC, Thiebaut F, Germann UA, Rutherford AV, Gottesman MM, Barca S, Tombesi M, Morrone S, Santoni A, Mariani M, Ramoni C, Dupuis ML, Cianfriglia M.

Int J Cancer. 1991 Feb 20;47(4):533-43.

PMID:
1704872
38.

Expression of the human multidrug transporter in insect cells by a recombinant baculovirus.

Germann UA, Willingham MC, Pastan I, Gottesman MM.

Biochemistry. 1990 Mar 6;29(9):2295-303.

PMID:
1970935
39.

Retroviral transfer of a chimeric multidrug resistance-adenosine deaminase gene.

Germann UA, Chin KV, Pastan I, Gottesman MM.

FASEB J. 1990 Mar;4(5):1501-7.

PMID:
1968408
40.

Use of recombinant P-glycoprotein fragments to produce antibodies to the multidrug transporter.

Tanaka S, Currier SJ, Bruggemann EP, Ueda K, Germann UA, Pastan I, Gottesman MM.

Biochem Biophys Res Commun. 1990 Jan 15;166(1):180-6.

PMID:
1967936
41.

Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine.

Bruggemann EP, Germann UA, Gottesman MM, Pastan I.

J Biol Chem. 1989 Sep 15;264(26):15483-8. Erratum in: J Biol Chem 1990 Mar 5;265(7):4172.

42.

Expression of a multidrug resistance-adenosine deaminase fusion gene.

Germann UA, Gottesman MM, Pastan I.

J Biol Chem. 1989 May 5;264(13):7418-24.

43.
44.

Evolutionary relationships among copper proteins containing coupled binuclear copper sites.

Lerch K, Germann UA.

Prog Clin Biol Res. 1988;274:331-48. Review.

PMID:
3136463
46.

The Neurospora crassa metallothionein gene. Regulation of expression and chromosomal location.

Münger K, Germann UA, Lerch K.

J Biol Chem. 1987 May 25;262(15):7363-7.

47.

Isolation and regulation of expression of the Neurospora crassa copper metallothionein gene.

Münger K, Germann UA, Lerch K.

Experientia Suppl. 1987;52:393-400.

PMID:
2959528
48.

Luminescence emission from the Cu(I)-thiolate complex in metallothioneins.

Beltramini M, Münger K, Germann UA, Lerch K.

Experientia Suppl. 1987;52:237-41.

PMID:
2959510
50.

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