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Items: 9

1.

Enhanced GABAergic actions resulting from the coapplication of the steroid 3α-hydroxy-5α-pregnane-11,20-dione (alfaxalone) with propofol or diazepam.

Cao LQ, Montana MC, Germann AL, Shin DJ, Chakrabarti S, Mennerick S, Yuede CM, Wozniak DF, Evers AS, Akk G.

Sci Rep. 2018 Jul 9;8(1):10341. doi: 10.1038/s41598-018-28754-7.

2.

High Constitutive Activity Accounts for the Combination of Enhanced Direct Activation and Reduced Potentiation in Mutated GABAA Receptors.

Germann AL, Shin DJ, Kuhrau CR, Johnson AD, Evers AS, Akk G.

Mol Pharmacol. 2018 May;93(5):468-476. doi: 10.1124/mol.117.111435. Epub 2018 Feb 8.

PMID:
29439087
3.

Propofol Is an Allosteric Agonist with Multiple Binding Sites on Concatemeric Ternary GABAA Receptors.

Shin DJ, Germann AL, Johnson AD, Forman SA, Steinbach JH, Akk G.

Mol Pharmacol. 2018 Feb;93(2):178-189. doi: 10.1124/mol.117.110403. Epub 2017 Nov 30.

PMID:
29192122
4.

GABA Type A Receptor Activation in the Allosteric Coagonist Model Framework: Relationship between EC50 and Basal Activity.

Akk G, Shin DJ, Germann AL, Steinbach JH.

Mol Pharmacol. 2018 Feb;93(2):90-100. doi: 10.1124/mol.117.110569. Epub 2017 Nov 17.

PMID:
29150461
5.

The Actions of Drug Combinations on the GABAA Receptor Manifest as Curvilinear Isoboles of Additivity.

Shin DJ, Germann AL, Steinbach JH, Akk G.

Mol Pharmacol. 2017 Nov;92(5):556-563. doi: 10.1124/mol.117.109595. Epub 2017 Aug 8.

PMID:
28790148
6.

Determination of the Residues in the Extracellular Domain of the Nicotinic α Subunit Required for the Actions of Physostigmine on Neuronal Nicotinic Receptors.

Jin X, Germann AL, Shin DJ, Akk G, Steinbach JH.

Mol Pharmacol. 2017 Sep;92(3):318-326. doi: 10.1124/mol.117.108894. Epub 2017 Jun 19.

PMID:
28630263
7.

The E Loop of the Transmitter Binding Site Is a Key Determinant of the Modulatory Effects of Physostigmine on Neuronal Nicotinic α4β2 Receptors.

Jin X, McCollum MM, Germann AL, Akk G, Steinbach JH.

Mol Pharmacol. 2017 Feb;91(2):100-109. doi: 10.1124/mol.116.106484. Epub 2016 Nov 28.

8.

Activation and modulation of recombinant glycine and GABAA receptors by 4-halogenated analogues of propofol.

Germann AL, Shin DJ, Manion BD, Edge CJ, Smith EH, Franks NP, Evers AS, Akk G.

Br J Pharmacol. 2016 Nov;173(21):3110-3120. doi: 10.1111/bph.13566. Epub 2016 Sep 6.

9.

Multiple Non-Equivalent Interfaces Mediate Direct Activation of GABAA Receptors by Propofol.

Eaton MM, Germann AL, Arora R, Cao LQ, Gao X, Shin DJ, Wu A, Chiara DC, Cohen JB, Steinbach JH, Evers AS, Akk G.

Curr Neuropharmacol. 2016;14(7):772-80. Review.

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