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Items: 46

1.

Differential Roles of IL-2 Signaling in Developing versus Mature Tregs.

Fan MY, Low JS, Tanimine N, Finn KK, Priyadharshini B, Germana SK, Kaech SM, Turka LA.

Cell Rep. 2018 Oct 30;25(5):1204-1213.e4. doi: 10.1016/j.celrep.2018.10.002.

2.

On the elusive TCR specificity of thymic regulatory T cells.

LeGuern C, Germana S.

Am J Transplant. 2019 Jan;19(1):15-20. doi: 10.1111/ajt.15165. Epub 2018 Dec 10. Review.

PMID:
30378738
3.

Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation.

Marino J, Babiker-Mohamed MH, Crosby-Bertorini P, Paster JT, LeGuern C, Germana S, Abdi R, Uehara M, Kim JI, Markmann JF, Tocco G, Benichou G.

Sci Immunol. 2016 Jul 14;1(1):aaf8759. doi: 10.1126/sciimmunol.aaf8759. Epub 2016 Jun 23.

PMID:
28783676
4.

Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation.

Marino J, Babiker-Mohamed MH, Crosby-Bertorini P, Paster JT, LeGuern C, Germana S, Abdi R, Uehara M, Kim JI, Markmann JF, Tocco G, Benichou G.

Sci Immunol. 2016 Jul 14;1(1). pii: aaf8759.

5.

Selective Sparing of Human Tregs by Pharmacologic Inhibitors of the Phosphatidylinositol 3-Kinase and MEK Pathways.

Zwang NA, Zhang R, Germana S, Fan MY, Hastings WD, Cao A, Turka LA.

Am J Transplant. 2016 Sep;16(9):2624-38. doi: 10.1111/ajt.13805. Epub 2016 May 23.

6.

Diphtheria-toxin based anti-human CCR4 immunotoxin for targeting human CCR4(+) cells in vivo.

Wang Z, Wei M, Zhang H, Chen H, Germana S, Huang CA, Madsen JC, Sachs DH, Wang Z.

Mol Oncol. 2015 Aug;9(7):1458-70. doi: 10.1016/j.molonc.2015.04.004. Epub 2015 Apr 25.

7.

Transgenic expression of human CD47 markedly increases engraftment in a murine model of pig-to-human hematopoietic cell transplantation.

Tena A, Kurtz J, Leonard DA, Dobrinsky JR, Terlouw SL, Mtango N, Verstegen J, Germana S, Mallard C, Arn JS, Sachs DH, Hawley RJ.

Am J Transplant. 2014 Dec;14(12):2713-22. doi: 10.1111/ajt.12918. Epub 2014 Oct 2. Erratum in: Am J Transplant. 2015 Jan;15(1):289.

8.

Screening for critical congenital heart disease in newborns using pulse oximetry: evaluation of nurses' knowledge and adherence.

Ryan DJ, Mikula EB, Germana S, Silva SG, Derouin A.

Adv Neonatal Care. 2014 Apr;14(2):119-28. doi: 10.1097/ANC.0000000000000047.

PMID:
24675632
9.

Primary vascularization of allografts governs their immunogenicity and susceptibility to tolerogenesis.

Kant CD, Akiyama Y, Tanaka K, Shea S, Connolly SE, Germana S, Winn HJ, LeGuern C, Tocco G, Benichou G.

J Immunol. 2013 Aug 15;191(4):1948-56. doi: 10.4049/jimmunol.1202092. Epub 2013 Jul 5.

10.

Expansion of polyreactive B cells cross-reactive to HLA and self in the blood of a patient with kidney graft rejection.

Porcheray F, DeVito J, Helou Y, Dargon I, Fraser JW, Nobecourt P, Ferdman J, Germana S, Girouard TC, Kawai T, Saidman SL, Wong W, Colvin RB, Leguern C, Zorn E.

Am J Transplant. 2012 Aug;12(8):2088-97. doi: 10.1111/j.1600-6143.2012.04053.x. Epub 2012 Apr 17.

11.

Intracellular MHC class II controls regulatory tolerance to allogeneic transplants.

LeGuern C, Akiyama Y, Germana S, Tanaka K, Fernandez L, Iwamoto Y, Houser S, Benichou G.

J Immunol. 2010 Mar 1;184(5):2394-400. doi: 10.4049/jimmunol.0803664. Epub 2010 Jan 25.

12.

Engraftment of quiescent progenitors and conversion to full chimerism after nonmyelosuppressive conditioning and hematopoietic cell transplantation in miniature swine.

Lima B, Gleit ZL, Cameron AM, Germana S, Murphy MC, Consorti R, Chang Q, Down JD, LeGuern C, Sachs DH, Huang CA.

Biol Blood Marrow Transplant. 2003 Sep;9(9):571-82.

13.

Expression of MHC class II DQ alpha/beta heterodimers from recombinant polycistronic retroviral genomes.

Shimada H, Germana S, Hayashi H, Sachs DH, LeGuern C.

Surg Today. 2003;33(3):183-9.

PMID:
12658383
14.

MHC alloantigens elicit secondary, but not primary, indirect in vitro proliferative responses.

Haller GW, Lima B, Kunisaki SM, Germana S, Leguern C, Huang CA, Sachs DH.

J Immunol. 2002 Oct 1;169(7):3613-21.

15.

Expression of xenogeneic MHC class II molecules in HLA-DR(+) and -DR(-) cells: influence of retrovirus vector design and cellular context.

Denaro M, Kolber-Simonds D, Schad V, Muthukumar S, Germana S, White-Scharf ME, Banerjee PT, LeGuern C, Andersson G.

Xenotransplantation. 2002 Mar;9(2):115-24.

PMID:
11897004
16.

Immortalized bone-marrow derived pig endothelial cells.

Seebach JD, Schneider MK, Comrack CA, LeGuern A, Kolb SA, Knolle PA, Germana S, DerSimonian H, LeGuern C, Sachs DH.

Xenotransplantation. 2001 Feb;8(1):48-61.

PMID:
11208191
17.

Tolerance to solid organ transplants through transfer of MHC class II genes.

Sonntag KC, Emery DW, Yasumoto A, Haller G, Germana S, Sablinski T, Shimizu A, Yamada K, Shimada H, Arn S, Sachs DH, LeGuern C.

J Clin Invest. 2001 Jan;107(1):65-71.

18.

Regulated expression of an MHC class II gene from a promoter-inducible retrovirus.

Sonntag KC, Haller GW, Giauffret D, Germana S, Reeves SA, Levy J, Sachs DH, LeGuern C.

Hum Gene Ther. 2000 Sep 20;11(14):1961-9.

PMID:
11020796
19.
20.

MHC class II alpha/beta heterodimeric cell surface molecules expressed from a single proviral genome.

Shimada H, Germana S, Sonntag KC, Banerjee P, Moore D, Sachs DH, LeGuern C.

Hum Gene Ther. 1999 Sep 20;10(14):2397-405.

PMID:
10515459
21.

Recombinant retrovirus vectors for the expression of MHC class II heterodimers.

Shimada H, Alexander RC, Germana S, Sachs DH, LeGuern C.

Surg Today. 1999;29(6):533-41.

PMID:
10385368
22.

HLA-G expression on porcine endothelial cells protects partially against direct human NK cytotoxicity but not against ADCC.

Seebach JD, Pazmany L, Waneck GL, Minja F, Germana S, LeGuern C, Sachs DH.

Transplant Proc. 1999 Jun;31(4):1864-5. No abstract available.

PMID:
10371975
23.

Transfer of porcine MHC DRalpha into IEalpha-deficient murine bone marrow results in reduced IE-restricted Vbeta usage.

Emery DW, Shimada H, Germana S, Sachs DH, LeGuern C.

Transplantation. 1998 Oct 27;66(8):1081-8.

PMID:
9808495
24.

Expression of an allogeneic MHC DRB transgene, through retroviral transduction of bone marrow, induces specific reduction of alloreactivity.

Emery DW, Sablinski T, Shimada H, Germana S, Gianello P, Foley A, Shulman S, Arn S, Fishman J, Lorf T, Nickeleit V, Colvin RB, Sachs DH, LeGuern C.

Transplantation. 1997 Nov 27;64(10):1414-23.

PMID:
9392304
25.

HLA-Cw3 expression on porcine endothelial cells protects against xenogeneic cytotoxicity mediated by a subset of human NK cells.

Seebach JD, Comrack C, Germana S, LeGuern C, Sachs DH, DerSimonian H.

J Immunol. 1997 Oct 1;159(7):3655-61.

PMID:
9317166
26.

Tolerant cells infiltrating class I mismatched swine kidney allografts lack the CD4 single positive subset and down regulate TCR gene expression.

Giangrande I, Yamada K, Germana S, Sachs D, LeGuern C.

Transplant Proc. 1997 Feb-Mar;29(1-2):1164. No abstract available.

PMID:
9123254
27.

Role of the thymus in donor specific hyporesponsiveness induced by retroviral transduction of bone marrow using an MHC class I gene.

Hayashi H, Mayfield RS, Sawada T, Germana S, Sykes M, Iacomini J, Sachs DH, LeGuern C.

Transplant Proc. 1997 Feb-Mar;29(1-2):1133. No abstract available.

PMID:
9123234
28.

Retroviral vectors transfer functional MHC class II heterodimers into bone marrow: a genetic approach to tolerance induction.

Germana S, Shimada H, Sachs DH, LeGuern C.

Transplant Proc. 1997 Feb-Mar;29(1-2):1129. No abstract available.

PMID:
9123230
29.

Molecular and cellular events implicated in local tolerance to kidney allografts in miniature swine.

Blancho G, Gianello PR, Lorf T, Germana S, Giangrande I, Mourad G, Colvin RB, Sachs DH, LeGuern C.

Transplantation. 1997 Jan 15;63(1):26-33.

PMID:
9000656
30.

Miniature swine MHC class II heterodimers expressed through double-copy retroviral vectors.

Shimada H, Emery DW, Shafer G, Germana S, Sachs DH, LeGuern C.

Transplant Proc. 1996 Jun;28(3):1986-9. No abstract available.

PMID:
8658969
31.

Derivation of immortalized swine stromal cell lines.

Paguio CG, Germana S, LeGuern C, Jubinsky P, Sachs DH, Emery DW.

Transplant Proc. 1996 Apr;28(2):791. No abstract available.

PMID:
8623401
32.

Retrovirus-mediated transfer of MHC class II cDNA into swine bone marrow cells.

LeGuern C, Shimada H, Emery DW, Germana S, Shafer GE, Sachs DH.

J Mol Med (Berl). 1995 Jun;73(6):269-78. Review. No abstract available.

PMID:
7583449
33.

Molecular identification of porcine interleukin 10: regulation of expression in a kidney allograft model.

Blancho G, Gianello P, Germana S, Baetscher M, Sachs DH, LeGuern C.

Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2800-4.

34.

A single retroviral vector for transfer of multiple major histocompatibility complex genes: a genetic tool for transplantation tolerance.

Shimada H, Germana S, Banerjee P, Hayashi H, Sachs DH, LeGuern C.

Transplant Proc. 1995 Feb;27(1):180-1. No abstract available.

PMID:
7878964
35.

Retroviral vectors for long-term expression of allogeneic major histocompatibility complex transduced into syngeneic bone marrow cells.

Hayashi H, Lee RS, Germana S, Fraser C, Sykes M, Sachs DH, LeGuern C.

Transplant Proc. 1995 Feb;27(1):178-9. No abstract available.

PMID:
7878962
36.

Extensive allelic polymorphism in the CDR2-like region of the miniature swine CD4 molecule.

Gustafsson K, Germana S, Sundt TM 3rd, Sachs DH, LeGuern C.

J Immunol. 1993 Aug 1;151(3):1365-70.

PMID:
8335933
37.

Structure and expression of class II alpha genes in miniature swine.

Hirsch F, Germana S, Gustafsson K, Pratt K, Sachs DH, Leguern C.

J Immunol. 1992 Aug 1;149(3):841-6.

PMID:
1634772
38.

Characterization of a polymorphism of CD4 in miniature swine.

Sundt TM 3rd, LeGuern C, Germana S, Smith CV, Nakajima K, Lunney JK, Sachs DH.

J Immunol. 1992 May 15;148(10):3195-201.

PMID:
1578144
39.

Qa-1/Tla region alloantigen-specific CTL with alpha beta receptor.

Germana S, Shinohara N.

Immunology. 1991 Dec;74(4):578-82.

40.

Expression of a swine class II gene in murine bone marrow hematopoietic cells by retroviral-mediated gene transfer.

Shafer GE, Emery DW, Gustafsson K, Germana S, Anderson WF, Sachs DH, LeGuern C.

Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9760-4.

41.

Expression of swine class II genes using recombinant retroviral vectors.

LeGuern C, Shafer GE, Alexander RC, Germana S, Gustafsson K, el-Gamil M, Sachs DH.

Transplant Proc. 1991 Feb;23(1 Pt 1):427-8. No abstract available.

PMID:
1846714
42.

Structure of miniature swine class II DRB genes: conservation of hypervariable amino acid residues between distantly related mammalian species.

Gustafsson K, Germana S, Hirsch F, Pratt K, LeGuern C, Sachs DH.

Proc Natl Acad Sci U S A. 1990 Dec;87(24):9798-802.

43.

Class II genes of miniature swine. IV. Characterization and expression of two allelic class II DQB cDNA clones.

Gustafsson K, LeGuern C, Hirsch F, Germana S, Pratt K, Sachs DH.

J Immunol. 1990 Sep 15;145(6):1946-51.

PMID:
2391424
44.

Class II genes of miniature swine. III. Characterization of an expressed pig class II gene homologous to HLA-DQA.

Hirsch F, Sachs DH, Gustafsson K, Pratt K, Germana S, LeGuern C.

Immunogenetics. 1990;31(1):52-6. No abstract available.

PMID:
2298465
45.

Class II genes of miniature swine. II. Molecular identification and characterization of B (beta) genes from the SLAc haplotype.

Pratt K, Sachs DH, Germana S, el-Gamil M, Hirsch F, Gustafsson K, LeGuern C.

Immunogenetics. 1990;31(1):1-6.

PMID:
2298461
46.

Class II genes of miniature swine. I. Class II gene characterization by RFLP and by isolation from a genomic library.

Sachs DH, Germana S, el-Gamil M, Gustafsson K, Hirsch F, Pratt K.

Immunogenetics. 1988;28(1):22-9.

PMID:
2897949

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