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Items: 1 to 50 of 117

1.

Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.

Moon JH, Kim YG, Kim K, Osonoi S, Wang S, Saunders DC, Wang J, Yang K, Kim H, Lee J, Jeong JS, Banerjee RR, Kim SK, Wu Y, Mizukami H, Powers AC, German MS, Kim H.

Diabetes. 2019 Dec 5. pii: db190546. doi: 10.2337/db19-0546. [Epub ahead of print]

PMID:
31806625
2.

Null mutations of NEUROG3 are associated with delayed onset diabetes mellitus.

Solorzano-Vargas RS, Bjerknes M, Wang J, Wu SV, Garcia-Careaga MG, Pisit D, Cheng H, German MS, Georgia S, Martín MG.

JCI Insight. 2019 Dec 5. pii: 127657. doi: 10.1172/jci.insight.127657. [Epub ahead of print]

3.

Elastase 3B mutation links to familial pancreatitis with diabetes and pancreatic adenocarcinoma.

Moore PC, Cortez JT, Chamberlain CE, Alba D, Berger AC, Quandt Z, Chan A, Cheng MH, Bautista JL, Peng J, German MS, Anderson MS, Oakes SA.

J Clin Invest. 2019 Aug 1;130:4676-4681. doi: 10.1172/JCI129961.

4.

Evidence of Economically Sustainable Village-Scale Microenterprises for Arsenic Remediation in Developing Countries.

German MS, Watkins TA, Chowdhury M, Chatterjee P, Rahman M, Seingheng H, SenGupta AK.

Environ Sci Technol. 2019 Feb 5;53(3):1078-1086. doi: 10.1021/acs.est.8b02523. Epub 2019 Jan 23.

PMID:
30620879
5.

A Patient-derived Xenograft Model of Pancreatic Neuroendocrine Tumors Identifies Sapanisertib as a Possible New Treatment for Everolimus-resistant Tumors.

Chamberlain CE, German MS, Yang K, Wang J, VanBrocklin H, Regan M, Shokat KM, Ducker GS, Kim GE, Hann B, Donner DB, Warren RS, Venook AP, Bergsland EK, Lee D, Wang Y, Nakakura EK.

Mol Cancer Ther. 2018 Dec;17(12):2702-2709. doi: 10.1158/1535-7163.MCT-17-1204. Epub 2018 Sep 25.

6.

A Genetic Interaction Map of Insulin Production Identifies Mfi as an Inhibitor of Mitochondrial Fission.

Lee J, Pappalardo Z, Chopra DG, Hennings TG, Vaughn I, Lan C, Choe JJ, Ang K, Chen S, Arkin M, McManus MT, German MS, Ku GM.

Endocrinology. 2018 Sep 1;159(9):3321-3330. doi: 10.1210/en.2018-00426.

7.

(Re)generating Human Beta Cells: Status, Pitfalls, and Perspectives.

Baeyens L, Lemper M, Staels W, De Groef S, De Leu N, Heremans Y, German MS, Heimberg H.

Physiol Rev. 2018 Jul 1;98(3):1143-1167. doi: 10.1152/physrev.00034.2016. Review.

8.

Ectopic serotonin production in β-cell specific transgenic mice.

Kim H, Kim H, Kim K, German MS, Kim H.

Biochem Biophys Res Commun. 2018 Jan 8;495(2):1986-1991. doi: 10.1016/j.bbrc.2017.12.005. Epub 2017 Dec 6.

PMID:
29223399
9.

A new familial form of a late-onset, persistent hyperinsulinemic hypoglycemia of infancy caused by a novel mutation in KCNJ11.

Yang YY, Long RK, Ferrara CT, Gitelman SE, German MS, Yang SB.

Channels (Austin). 2017 Nov 2;11(6):636-647. doi: 10.1080/19336950.2017.1393131. Epub 2017 Dec 12.

10.

Effects of Biotin Supplementation During the First Week Postweaning Increases Pancreatic Islet Area, Beta-Cell Proportion, Islets Number, and Beta-Cell Proliferation.

Tixi-Verdugo W, Contreras-Ramos J, Sicilia-Argumedo G, German MS, Fernandez-Mejia C.

J Med Food. 2018 Mar;21(3):274-281. doi: 10.1089/jmf.2017.0077. Epub 2017 Oct 25.

11.

Effects of dietary biotin supplementation on glucagon production, secretion, and action.

Lazo-de-la-Vega-Monroy ML, Larrieta E, Tixi-Verdugo W, Ramírez-Mondragón R, Hernández-Araiza I, German MS, Fernandez-Mejia C.

Nutrition. 2017 Nov - Dec;43-44:47-53. doi: 10.1016/j.nut.2017.06.014. Epub 2017 Jul 6.

PMID:
28935144
12.

Human pancreatic neuro-insular network in health and fatty infiltration.

Tang SC, Baeyens L, Shen CN, Peng SJ, Chien HJ, Scheel DW, Chamberlain CE, German MS.

Diabetologia. 2018 Jan;61(1):168-181. doi: 10.1007/s00125-017-4409-x. Epub 2017 Aug 29.

PMID:
28852792
13.

Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors.

Krentz NAJ, van Hoof D, Li Z, Watanabe A, Tang M, Nian C, German MS, Lynn FC.

Dev Cell. 2017 Apr 24;41(2):129-142.e6. doi: 10.1016/j.devcel.2017.02.006.

14.

A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response.

Pappalardo Z, Gambhir Chopra D, Hennings TG, Richards H, Choe J, Yang K, Baeyens L, Ang K, Chen S, Arkin M, German MS, McManus MT, Ku GM.

Diabetes. 2017 Jun;66(6):1703-1712. doi: 10.2337/db16-0962. Epub 2017 Feb 28.

15.

β-Cell adaptation in pregnancy.

Baeyens L, Hindi S, Sorenson RL, German MS.

Diabetes Obes Metab. 2016 Sep;18 Suppl 1:63-70. doi: 10.1111/dom.12716. Review.

16.

A Path to Insulin Independence: "The End of the Beginning".

Stock PG, German MS.

Cell Stem Cell. 2016 Apr 7;18(4):431-3. doi: 10.1016/j.stem.2016.03.010.

17.

Generation of a Conditional Allele of the Transcription Factor Atonal Homolog 8 (Atoh8).

Ejarque M, Mir-Coll J, Gomis R, German MS, Lynn FC, Gasa R.

PLoS One. 2016 Jan 11;11(1):e0146273. doi: 10.1371/journal.pone.0146273. eCollection 2016.

18.

Activation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice.

Sasaki S, Miyatsuka T, Matsuoka TA, Takahara M, Yamamoto Y, Yasuda T, Kaneto H, Fujitani Y, German MS, Akiyama H, Watada H, Shimomura I.

Diabetologia. 2015 Nov;58(11):2582-91. doi: 10.1007/s00125-015-3728-z. Epub 2015 Aug 20.

PMID:
26290048
19.

Follicle dynamics and global organization in the intact mouse ovary.

Faire M, Skillern A, Arora R, Nguyen DH, Wang J, Chamberlain C, German MS, Fung JC, Laird DJ.

Dev Biol. 2015 Jul 1;403(1):69-79. doi: 10.1016/j.ydbio.2015.04.006. Epub 2015 Apr 16.

20.

Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion.

Berger M, Scheel DW, Macias H, Miyatsuka T, Kim H, Hoang P, Ku GM, Honig G, Liou A, Tang Y, Regard JB, Sharifnia P, Yu L, Wang J, Coughlin SR, Conklin BR, Deneris ES, Tecott LH, German MS.

Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2888-93. doi: 10.1073/pnas.1319378112. Epub 2015 Feb 18.

21.

Reprogramming of human pancreatic exocrine cells to β-like cells.

Lemper M, Leuckx G, Heremans Y, German MS, Heimberg H, Bouwens L, Baeyens L.

Cell Death Differ. 2015 Jul;22(7):1117-30. doi: 10.1038/cdd.2014.193. Epub 2014 Dec 5.

22.

Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state.

Kim K, Oh CM, Ohara-Imaizumi M, Park S, Namkung J, Yadav VK, Tamarina NA, Roe MW, Philipson LH, Karsenty G, Nagamatsu S, German MS, Kim H.

Endocrinology. 2015 Feb;156(2):444-52. doi: 10.1210/en.2014-1687. Epub 2014 Nov 26.

23.

Menin determines K-RAS proliferative outputs in endocrine cells.

Chamberlain CE, Scheel DW, McGlynn K, Kim H, Miyatsuka T, Wang J, Nguyen V, Zhao S, Mavropoulos A, Abraham AG, O'Neill E, Ku GM, Cobb MH, Martin GR, German MS.

J Clin Invest. 2014 Sep;124(9):4093-101. doi: 10.1172/JCI69004. Epub 2014 Aug 18.

24.

Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.

Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR.

Cell. 2014 Jul 31;158(3):534-48. doi: 10.1016/j.cell.2014.07.002. Epub 2014 Jul 10.

25.

Chronological analysis with fluorescent timer reveals unique features of newly generated β-cells.

Miyatsuka T, Matsuoka TA, Sasaki S, Kubo F, Shimomura I, Watada H, German MS, Hara M.

Diabetes. 2014 Oct;63(10):3388-93. doi: 10.2337/db13-1312. Epub 2014 May 16.

26.

Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.

Baeyens L, Lemper M, Leuckx G, De Groef S, Bonfanti P, Stangé G, Shemer R, Nord C, Scheel DW, Pan FC, Ahlgren U, Gu G, Stoffers DA, Dor Y, Ferrer J, Gradwohl G, Wright CV, Van de Casteele M, German MS, Bouwens L, Heimberg H.

Nat Biotechnol. 2014 Jan;32(1):76-83. doi: 10.1038/nbt.2747. Epub 2013 Nov 17.

27.

Serotonin regulates glucose-stimulated insulin secretion from pancreatic β cells during pregnancy.

Ohara-Imaizumi M, Kim H, Yoshida M, Fujiwara T, Aoyagi K, Toyofuku Y, Nakamichi Y, Nishiwaki C, Okamura T, Uchida T, Fujitani Y, Akagawa K, Kakei M, Watada H, German MS, Nagamatsu S.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19420-5. doi: 10.1073/pnas.1310953110. Epub 2013 Nov 11.

28.

Anonymous sources: where do adult β cells come from?

German MS.

J Clin Invest. 2013 May;123(5):1936-8. doi: 10.1172/JCI69297. Epub 2013 Apr 24.

29.

Research resource: RNA-Seq reveals unique features of the pancreatic β-cell transcriptome.

Ku GM, Kim H, Vaughn IW, Hangauer MJ, Myung Oh C, German MS, McManus MT.

Mol Endocrinol. 2012 Oct;26(10):1783-92. Epub 2012 Aug 21.

30.

Effects of biotin supplementation in the diet on insulin secretion, islet gene expression, glucose homeostasis and beta-cell proportion.

Lazo de la Vega-Monroy ML, Larrieta E, German MS, Baez-Saldana A, Fernandez-Mejia C.

J Nutr Biochem. 2013 Jan;24(1):169-77. doi: 10.1016/j.jnutbio.2012.03.020. Epub 2012 Jul 25.

PMID:
22841397
31.

Adenosine signaling promotes regeneration of pancreatic β cells in vivo.

Andersson O, Adams BA, Yoo D, Ellis GC, Gut P, Anderson RM, German MS, Stainier DY.

Cell Metab. 2012 Jun 6;15(6):885-94. doi: 10.1016/j.cmet.2012.04.018. Epub 2012 May 17.

32.

An siRNA screen in pancreatic beta cells reveals a role for Gpr27 in insulin production.

Ku GM, Pappalardo Z, Luo CC, German MS, McManus MT.

PLoS Genet. 2012 Jan;8(1):e1002449. doi: 10.1371/journal.pgen.1002449. Epub 2012 Jan 12.

33.

Convergence of the insulin and serotonin programs in the pancreatic β-cell.

Ohta Y, Kosaka Y, Kishimoto N, Wang J, Smith SB, Honig G, Kim H, Gasa RM, Neubauer N, Liou A, Tecott LH, Deneris ES, German MS.

Diabetes. 2011 Dec;60(12):3208-16. doi: 10.2337/db10-1192. Epub 2011 Oct 19.

34.

Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice.

Yao LJ, McCormick JA, Wang J, Yang KY, Kidwai A, Colussi GL, Boini KM, Birnbaum MJ, Lang F, German MS, Pearce D.

Mol Endocrinol. 2011 Dec;25(12):2106-18. doi: 10.1210/me.2010-0329. Epub 2011 Oct 6.

35.

Association of variations in TPH1 and HTR2B with gestational weight gain and measures of obesity.

Kwak SH, Park BL, Kim H, German MS, Go MJ, Jung HS, Koo BK, Cho YM, Choi SH, Cho YS, Shin HD, Jang HC, Park KS.

Obesity (Silver Spring). 2012 Jan;20(1):233-8. doi: 10.1038/oby.2011.253. Epub 2011 Aug 11.

36.

Chromatin insulator elements block transgene silencing in engineered human embryonic stem cell lines at a defined chromosome 13 locus.

Macarthur CC, Xue H, Van Hoof D, Lieu PT, Dudas M, Fontes A, Swistowski A, Touboul T, Seerke R, Laurent LC, Loring JF, German MS, Zeng X, Rao MS, Lakshmipathy U, Chesnut JD, Liu Y.

Stem Cells Dev. 2012 Jan 20;21(2):191-205. doi: 10.1089/scd.2011.0163. Epub 2011 Aug 4.

37.

Effects of biotin deficiency on pancreatic islet morphology, insulin sensitivity and glucose homeostasis.

Larrieta E, Vega-Monroy ML, Vital P, Aguilera A, German MS, Hafidi ME, Fernandez-Mejia C.

J Nutr Biochem. 2012 Apr;23(4):392-9. doi: 10.1016/j.jnutbio.2011.01.003. Epub 2011 May 18.

PMID:
21596550
38.

Differentiation of human embryonic stem cells into pancreatic endoderm in patterned size-controlled clusters.

Van Hoof D, Mendelsohn AD, Seerke R, Desai TA, German MS.

Stem Cell Res. 2011 May;6(3):276-85. doi: 10.1016/j.scr.2011.02.004. Epub 2011 Mar 2.

39.

Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a.

Miyatsuka T, Kosaka Y, Kim H, German MS.

Proc Natl Acad Sci U S A. 2011 Jan 4;108(1):185-90. doi: 10.1073/pnas.1004842108. Epub 2010 Dec 20.

40.

A mouse model for monitoring islet cell genesis and developing therapies for diabetes.

Shimajiri Y, Kosaka Y, Scheel DW, Lynn FC, Kishimoto N, Wang J, Zhao S, German MS.

Dis Model Mech. 2011 Mar;4(2):268-76. doi: 10.1242/dmm.002998. Epub 2010 Dec 6.

41.

Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line.

Honig G, Liou A, Berger M, German MS, Tecott LH.

J Biomed Sci. 2010 Oct 17;17:82. doi: 10.1186/1423-0127-17-82.

42.

Dachshund homologues play a conserved role in islet cell development.

Kalousova A, Mavropoulos A, Adams BA, Nekrep N, Li Z, Krauss S, Stainier DY, German MS.

Dev Biol. 2010 Dec 15;348(2):143-52. doi: 10.1016/j.ydbio.2010.09.007. Epub 2010 Sep 30.

43.

Serotonin regulates pancreatic beta cell mass during pregnancy.

Kim H, Toyofuku Y, Lynn FC, Chak E, Uchida T, Mizukami H, Fujitani Y, Kawamori R, Miyatsuka T, Kosaka Y, Yang K, Honig G, van der Hart M, Kishimoto N, Wang J, Yagihashi S, Tecott LH, Watada H, German MS.

Nat Med. 2010 Jul;16(7):804-8. doi: 10.1038/nm.2173. Epub 2010 Jun 27.

44.

Rfx6 directs islet formation and insulin production in mice and humans.

Smith SB, Qu HQ, Taleb N, Kishimoto NY, Scheel DW, Lu Y, Patch AM, Grabs R, Wang J, Lynn FC, Miyatsuka T, Mitchell J, Seerke R, Désir J, Vanden Eijnden S, Abramowicz M, Kacet N, Weill J, Renard ME, Gentile M, Hansen I, Dewar K, Hattersley AT, Wang R, Wilson ME, Johnson JD, Polychronakos C, German MS.

Nature. 2010 Feb 11;463(7282):775-80. doi: 10.1038/nature08748.

45.

Current status of islet cell replacement and regeneration therapy.

Halban PA, German MS, Kahn SE, Weir GC.

J Clin Endocrinol Metab. 2010 Mar;95(3):1034-43. doi: 10.1210/jc.2009-1819. Epub 2010 Jan 8. Review.

46.

The ETS oncogene family transcription factor FEV identifies serotonin-producing cells in normal and neoplastic small intestine.

Wang YC, Zuraek MB, Kosaka Y, Ota Y, German MS, Deneris ES, Bergsland EK, Donner DB, Warren RS, Nakakura EK.

Endocr Relat Cancer. 2010 Feb 18;17(1):283-91. doi: 10.1677/ERC-09-0243. Print 2010 Mar.

PMID:
20048018
47.

Derivation of insulin-producing cells from human embryonic stem cells.

Van Hoof D, D'Amour KA, German MS.

Stem Cell Res. 2009 Sep-Nov;3(2-3):73-87. doi: 10.1016/j.scr.2009.08.003. Epub 2009 Aug 26. Review.

48.

Chronology of islet differentiation revealed by temporal cell labeling.

Miyatsuka T, Li Z, German MS.

Diabetes. 2009 Aug;58(8):1863-8. doi: 10.2337/db09-0390. Epub 2009 May 28.

49.

Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors.

Wang YC, Gallego-Arteche E, Iezza G, Yuan X, Matli MR, Choo SP, Zuraek MB, Gogia R, Lynn FC, German MS, Bergsland EK, Donner DB, Warren RS, Nakakura EK.

Endocr Relat Cancer. 2009 Mar;16(1):267-79. doi: 10.1677/ERC-08-0127. Epub 2008 Nov 5.

PMID:
18987169
50.

New beta-cells from old acini.

German MS.

Nat Biotechnol. 2008 Oct;26(10):1092-3. doi: 10.1038/nbt1008-1092. No abstract available.

PMID:
18846076

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