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ILC2s - resident lymphocytes pre-adapted to a specific tissue or migratory effectors that adapt to where they move?

Germain RN, Huang Y.

Curr Opin Immunol. 2018 Nov 22;56:76-81. doi: 10.1016/j.coi.2018.11.001. [Epub ahead of print] Review.


AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization.

Khurana S, Coyle EM, Manischewitz J, King LR, Gao J, Germain RN, Schwartzberg PL, Tsang JS, Golding H; and the CHI Consortium.

NPJ Vaccines. 2018 Oct 1;3:40. doi: 10.1038/s41541-018-0076-2. eCollection 2018.


Thinking differently about ILCs-Not just tissue resident and not just the same as CD4+ T-cell effectors.

Huang Y, Mao K, Germain RN.

Immunol Rev. 2018 Nov;286(1):160-171. doi: 10.1111/imr.12704. Review.


Prime and target immunization protects against liver-stage malaria in mice.

Gola A, Silman D, Walters AA, Sridhar S, Uderhardt S, Salman AM, Halbroth BR, Bellamy D, Bowyer G, Powlson J, Baker M, Venkatraman N, Poulton I, Berrie E, Roberts R, Lawrie AM, Angus B, Khan SM, Janse CJ, Ewer KJ, Germain RN, Spencer AJ, Hill AVS.

Sci Transl Med. 2018 Sep 26;10(460). pii: eaap9128. doi: 10.1126/scitranslmed.aap9128.


Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.

Preite S, Cannons JL, Radtke AJ, Vujkovic-Cvijin I, Gomez-Rodriguez J, Volpi S, Huang B, Cheng J, Collins N, Reilley J, Handon R, Dobbs K, Huq L, Raman I, Zhu C, Li QZ, Li MO, Pittaluga S, Uzel G, Notarangelo LD, Belkaid Y, Germain RN, Schwartzberg PL.

Nat Immunol. 2018 Sep;19(9):986-1000. doi: 10.1038/s41590-018-0182-3. Epub 2018 Aug 20.


In Vivo Intradermal Delivery of Bacteria by Using Microneedle Arrays.

Chandler CE, Harberts EM, Laemmermann T, Zeng Q, Opene BN, Germain RN, Jewell CM, Scott AJ, Ernst RK.

Infect Immun. 2018 Aug 22;86(9). pii: e00406-18. doi: 10.1128/IAI.00406-18. Print 2018 Sep.


Spatial distribution and function of T follicular regulatory cells in human lymph nodes.

Sayin I, Radtke AJ, Vella LA, Jin W, Wherry EJ, Buggert M, Betts MR, Herati RS, Germain RN, Canaday DH.

J Exp Med. 2018 Jun 4;215(6):1531-1542. doi: 10.1084/jem.20171940. Epub 2018 May 16.


Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism.

Mao K, Baptista AP, Tamoutounour S, Zhuang L, Bouladoux N, Martins AJ, Huang Y, Gerner MY, Belkaid Y, Germain RN.

Nature. 2018 Feb 8;554(7691):255-259. doi: 10.1038/nature25437. Epub 2018 Jan 22.


S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense.

Huang Y, Mao K, Chen X, Sun MA, Kawabe T, Li W, Usher N, Zhu J, Urban JF Jr, Paul WE, Germain RN.

Science. 2018 Jan 5;359(6371):114-119. doi: 10.1126/science.aam5809.


Robust control of the adaptive immune system.

Wong HS, Germain RN.

Semin Immunol. 2018 Apr;36:17-27. doi: 10.1016/j.smim.2017.12.009. Epub 2017 Dec 29. Review.


Migrating Myeloid Cells Sense Temporal Dynamics of Chemoattractant Concentrations.

Petrie Aronin CE, Zhao YM, Yoon JS, Morgan NY, Prüstel T, Germain RN, Meier-Schellersheim M.

Immunity. 2017 Nov 21;47(5):862-874.e3. doi: 10.1016/j.immuni.2017.10.020.


Dendritic cell and antigen dispersal landscapes regulate T cell immunity.

Gerner MY, Casey KA, Kastenmuller W, Germain RN.

J Exp Med. 2017 Oct 2;214(10):3105-3122. doi: 10.1084/jem.20170335. Epub 2017 Aug 28.


Immune Modulation Therapy and Imaging: Workshop Report.

Shields AF, Jacobs PM, Sznol M, Graham MM, Germain RN, Lum LG, Jaffee EM, de Vries EGE, Nimmagadda S, Van den Abbeele AD, Leung DK, Wu AM, Sharon E, Shankar LK.

J Nucl Med. 2018 Mar;59(3):410-417. doi: 10.2967/jnumed.117.195610. Epub 2017 Aug 17.


Multiplex, quantitative cellular analysis in large tissue volumes with clearing-enhanced 3D microscopy (Ce3D).

Li W, Germain RN, Gerner MY.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7321-E7330. doi: 10.1073/pnas.1708981114. Epub 2017 Aug 14.


Memory-phenotype CD4+ T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function.

Kawabe T, Jankovic D, Kawabe S, Huang Y, Lee PH, Yamane H, Zhu J, Sher A, Germain RN, Paul WE.

Sci Immunol. 2017 Jun 16;2(12). pii: eaam9304. doi: 10.1126/sciimmunol.aam9304.


Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells.

Watanabe M, Fujihara C, Radtke AJ, Chiang YJ, Bhatia S, Germain RN, Hodes RJ.

J Exp Med. 2017 Sep 4;214(9):2795-2810. doi: 10.1084/jem.20161955. Epub 2017 Aug 2.


A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System.

Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, Liu Z, Germain RN, Huse M, Altan-Bonnet G, Krichevsky O.

Immunity. 2017 Apr 18;46(4):609-620. doi: 10.1016/j.immuni.2017.03.011. Epub 2017 Apr 4.


Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy.

Veres TZ, Kopcsányi T, Tirri M, Braun A, Miyasaka M, Germain RN, Jalkanen S, Salmi M.

Sci Rep. 2017 Apr 6;7(1):694. doi: 10.1038/s41598-017-00769-6.


CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming.

Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W.

Immunity. 2017 Feb 21;46(2):205-219. doi: 10.1016/j.immuni.2017.01.003. Epub 2017 Feb 9.


Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity.

Levine AG, Hemmers S, Baptista AP, Schizas M, Faire MB, Moltedo B, Konopacki C, Schmidt-Supprian M, Germain RN, Treuting PM, Rudensky AY.

J Exp Med. 2017 Mar 6;214(3):609-622. doi: 10.1084/jem.20161318. Epub 2017 Jan 27.


Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies.

Petrovas C, Ferrando-Martinez S, Gerner MY, Casazza JP, Pegu A, Deleage C, Cooper A, Hataye J, Andrews S, Ambrozak D, Del Río Estrada PM, Boritz E, Paris R, Moysi E, Boswell KL, Ruiz-Mateos E, Vagios I, Leal M, Ablanedo-Terrazas Y, Rivero A, Gonzalez-Hernandez LA, McDermott AB, Moir S, Reyes-Terán G, Docobo F, Pantaleo G, Douek DC, Betts MR, Estes JD, Germain RN, Mascola JR, Koup RA.

Sci Transl Med. 2017 Jan 18;9(373). pii: eaag2285. doi: 10.1126/scitranslmed.aag2285.


Adjuvant and carrier protein-dependent T-cell priming promotes a robust antibody response against the Plasmodium falciparum Pfs25 vaccine candidate.

Radtke AJ, Anderson CF, Riteau N, Rausch K, Scaria P, Kelnhofer ER, Howard RF, Sher A, Germain RN, Duffy P.

Sci Rep. 2017 Jan 16;7:40312. doi: 10.1038/srep40312.


Allergen-Induced CD4+ T Cell Cytokine Production within Airway Mucosal Dendritic Cell-T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells.

Veres TZ, Kopcsányi T, van Panhuys N, Gerner MY, Liu Z, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN.

J Immunol. 2017 Jan 15;198(2):895-907. doi: 10.4049/jimmunol.1601448. Epub 2016 Nov 30.


Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy.

Im SJ, Hashimoto M, Gerner MY, Lee J, Kissick HT, Burger MC, Shan Q, Hale JS, Lee J, Nasti TH, Sharpe AH, Freeman GJ, Germain RN, Nakaya HI, Xue HH, Ahmed R.

Nature. 2016 Sep 15;537(7620):417-421. doi: 10.1038/nature19330. Epub 2016 Aug 2.


Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses.

Gottschalk RA, Martins AJ, Angermann BR, Dutta B, Ng CE, Uderhardt S, Tsang JS, Fraser ID, Meier-Schellersheim M, Germain RN.

Cell Syst. 2016 Jun 22;2(6):378-90. doi: 10.1016/j.cels.2016.04.016. Epub 2016 May 26.


William E. Paul, MD (1936-2015).

Germain RN, Fowlkes BJ, Samelson LE, Leonard WJ.

Trends Immunol. 2015 Dec;36(12):751-3. No abstract available.


Corrigendum: An interactive web-based application for Comprehensive Analysis of RNAi-screen Data.

Dutta B, Azhir A, Merino LH, Guo Y, Revanur S, Madhamshettiwar PB, Germain RN, Smith JA, Simpson KJ, Martin SE, Buehler E, Fraser ID.

Nat Commun. 2016 Mar 21;7:11214. doi: 10.1038/ncomms11214. No abstract available.


An interactive web-based application for Comprehensive Analysis of RNAi-screen Data.

Dutta B, Azhir A, Merino LH, Guo Y, Revanur S, Madhamshettiwar PB, Germain RN, Smith JA, Simpson KJ, Martin SE, Buehler E, Fraser ID.

Nat Commun. 2016 Feb 23;7:10578. doi: 10.1038/ncomms10578. Erratum in: Nat Commun. 2016;7:11214. Beuhler, Eugen [Corrected to Buehler, Eugen].


William E. Paul, M.D. (1936–2015).

Germain RN, Fowlkes BJ, Samelson LE, Leonard WJ.

Immunity. 2015 Oct 20;43(4):617-9. No abstract available.


William E. Paul, M.D. (1936-2015), President, The American Association of Immunologists, 1986-1987.

Germain RN.

J Immunol. 2015 Dec 15;195(12):5519-21. doi: 10.4049/jimmunol.1590025. No abstract available.


Immune homeostasis enforced by co-localized effector and regulatory T cells.

Liu Z, Gerner MY, Van Panhuys N, Levine AG, Rudensky AY, Germain RN.

Nature. 2015 Dec 10;528(7581):225-30. doi: 10.1038/nature16169. Epub 2015 Nov 25.


Tracking the T cell repertoire.

Germain RN.

Nat Rev Immunol. 2015 Dec;15(12):730. doi: 10.1038/nri3922. Epub 2015 Oct 30. No abstract available.


William E. Paul (1936-2015).

Germain RN.

Nature. 2015 Oct 15;526(7573):324. doi: 10.1038/526324a. No abstract available.


Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity.

Fonseca DM, Hand TW, Han SJ, Gerner MY, Glatman Zaretsky A, Byrd AL, Harrison OJ, Ortiz AM, Quinones M, Trinchieri G, Brenchley JM, Brodsky IE, Germain RN, Randolph GJ, Belkaid Y.

Cell. 2015 Oct 8;163(2):354-66. doi: 10.1016/j.cell.2015.08.030.


NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ-IL-27 axis.

Chong WP, van Panhuys N, Chen J, Silver PB, Jittayasothorn Y, Mattapallil MJ, Germain RN, Caspi RR.

J Exp Med. 2015 Sep 21;212(10):1739-52. doi: 10.1084/jem.20141678. Epub 2015 Sep 7.


Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions.

Eickhoff S, Brewitz A, Gerner MY, Klauschen F, Komander K, Hemmi H, Garbi N, Kaisho T, Germain RN, Kastenmüller W.

Cell. 2015 Sep 10;162(6):1322-37. doi: 10.1016/j.cell.2015.08.004. Epub 2015 Aug 18.


Targeted Proteomics-Driven Computational Modeling of Macrophage S1P Chemosensing.

Manes NP, Angermann BR, Koppenol-Raab M, An E, Sjoelund VH, Sun J, Ishii M, Germain RN, Meier-Schellersheim M, Nita-Lazar A.

Mol Cell Proteomics. 2015 Oct;14(10):2661-81. doi: 10.1074/mcp.M115.048918. Epub 2015 Jul 21.


Continuous volumetric imaging via an optical phase-locked ultrasound lens.

Kong L, Tang J, Little JP, Yu Y, Lämmermann T, Lin CP, Germain RN, Cui M.

Nat Methods. 2015 Aug;12(8):759-62. doi: 10.1038/nmeth.3476. Epub 2015 Jul 13.


Healing the NIH-Funded Biomedical Research Enterprise.

Germain RN.

Cell. 2015 Jun 18;161(7):1485-91. doi: 10.1016/j.cell.2015.05.052.


Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice.

Kolodin D, van Panhuys N, Li C, Magnuson AM, Cipolletta D, Miller CM, Wagers A, Germain RN, Benoist C, Mathis D.

Cell Metab. 2015 Apr 7;21(4):543-57. doi: 10.1016/j.cmet.2015.03.005.


Lymph-node resident CD8α+ dendritic cells capture antigens from migratory malaria sporozoites and induce CD8+ T cell responses.

Radtke AJ, Kastenmüller W, Espinosa DA, Gerner MY, Tse SW, Sinnis P, Germain RN, Zavala FP, Cockburn IA.

PLoS Pathog. 2015 Feb 6;11(2):e1004637. doi: 10.1371/journal.ppat.1004637. eCollection 2015 Feb.


Network representations of immune system complexity.

Subramanian N, Torabi-Parizi P, Gottschalk RA, Germain RN, Dutta B.

Wiley Interdiscip Rev Syst Biol Med. 2015 Jan-Feb;7(1):13-38. doi: 10.1002/wsbm.1288. Epub 2015 Jan 27. Review.


Strategically localized dendritic cells promote rapid T cell responses to lymph-borne particulate antigens.

Gerner MY, Torabi-Parizi P, Germain RN.

Immunity. 2015 Jan 20;42(1):172-85. doi: 10.1016/j.immuni.2014.12.024. Epub 2014 Dec 27.


DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity.

Zhang Q, Dove CG, Hor JL, Murdock HM, Strauss-Albee DM, Garcia JA, Mandl JN, Grodick RA, Jing H, Chandler-Brown DB, Lenardo TE, Crawford G, Matthews HF, Freeman AF, Cornall RJ, Germain RN, Mueller SN, Su HC.

J Exp Med. 2014 Dec 15;211(13):2549-66. doi: 10.1084/jem.20141307. Epub 2014 Nov 24.


Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes.

Clatworthy MR, Aronin CE, Mathews RJ, Morgan NY, Smith KG, Germain RN.

Nat Med. 2014 Dec;20(12):1458-63. doi: 10.1038/nm.3709. Epub 2014 Nov 10.


Spatiotemporal basis of innate and adaptive immunity in secondary lymphoid tissue.

Qi H, Kastenmüller W, Germain RN.

Annu Rev Cell Dev Biol. 2014;30:141-67. doi: 10.1146/annurev-cellbio-100913-013254. Epub 2014 Aug 8. Review.


Revisiting thymic positive selection and the mature T cell repertoire for antigen.

Vrisekoop N, Monteiro JP, Mandl JN, Germain RN.

Immunity. 2014 Aug 21;41(2):181-90. doi: 10.1016/j.immuni.2014.07.007.


T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization In Vivo.

van Panhuys N, Klauschen F, Germain RN.

Immunity. 2014 Jul 17;41(1):63-74. doi: 10.1016/j.immuni.2014.06.003. Epub 2014 Jun 26.


Focusing in on T cell cross-reactivity.

Mandl JN, Germain RN.

Cell. 2014 May 22;157(5):1006-8. doi: 10.1016/j.cell.2014.05.002.

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