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Items: 1 to 50 of 370

1.

The Cellular Determinants of Adaptive Immunity.

Germain RN.

N Engl J Med. 2019 Sep 12;381(11):1083-1085. doi: 10.1056/NEJMcibr1909387. Epub 2019 Sep 10. No abstract available.

PMID:
31502768
2.

Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells.

Lee PH, Yamamoto TN, Gurusamy D, Sukumar M, Yu Z, Hu-Li J, Kawabe T, Gangaplara A, Kishton RJ, Henning AN, Vodnala SK, Germain RN, Paul WE, Restifo NP.

J Exp Med. 2019 Nov 4;216(11):2619-2634. doi: 10.1084/jem.20181218. Epub 2019 Aug 12.

3.

IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses.

Gottschalk RA, Dorrington MG, Dutta B, Krauss KS, Martins AJ, Uderhardt S, Chan W, Tsang JS, Torabi-Parizi P, Fraser ID, Germain RN.

Elife. 2019 Aug 6;8. pii: e46836. doi: 10.7554/eLife.46836.

4.

The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity.

Baptista AP, Gola A, Huang Y, Milanez-Almeida P, Torabi-Parizi P, Urban JF Jr, Shapiro VS, Gerner MY, Germain RN.

Immunity. 2019 May 21;50(5):1188-1201.e6. doi: 10.1016/j.immuni.2019.04.001. Epub 2019 Apr 30.

PMID:
31053504
5.

High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging.

Li W, Germain RN, Gerner MY.

Nat Protoc. 2019 Jun;14(6):1708-1733. doi: 10.1038/s41596-019-0156-4. Epub 2019 Apr 26.

PMID:
31028373
6.

Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.

Uderhardt S, Martins AJ, Tsang JS, Lämmermann T, Germain RN.

Cell. 2019 Apr 18;177(3):541-555.e17. doi: 10.1016/j.cell.2019.02.028. Epub 2019 Apr 4.

7.

Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors.

Cabeza-Cabrerizo M, van Blijswijk J, Wienert S, Heim D, Jenkins RP, Chakravarty P, Rogers N, Frederico B, Acton S, Beerling E, van Rheenen J, Clevers H, Schraml BU, Bajénoff M, Gerner M, Germain RN, Sahai E, Klauschen F, Reis E Sousa C.

Sci Immunol. 2019 Mar 1;4(33). pii: eaaw1941. doi: 10.1126/sciimmunol.aaw1941.

8.

Quantifying in situ adaptive immune cell cognate interactions in humans.

Liarski VM, Sibley A, van Panhuys N, Ai J, Chang A, Kennedy D, Merolle M, Germain RN, Giger ML, Clark MR.

Nat Immunol. 2019 Apr;20(4):503-513. doi: 10.1038/s41590-019-0315-3. Epub 2019 Feb 18.

9.

Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses.

Franco LM, Gadkari M, Howe KN, Sun J, Kardava L, Kumar P, Kumari S, Hu Z, Fraser IDC, Moir S, Tsang JS, Germain RN.

J Exp Med. 2019 Feb 4;216(2):384-406. doi: 10.1084/jem.20180595. Epub 2019 Jan 23.

10.

ILC2s - resident lymphocytes pre-adapted to a specific tissue or migratory effectors that adapt to where they move?

Germain RN, Huang Y.

Curr Opin Immunol. 2019 Feb;56:76-81. doi: 10.1016/j.coi.2018.11.001. Epub 2018 Nov 23. Review.

PMID:
30472437
11.

AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization.

Khurana S, Coyle EM, Manischewitz J, King LR, Gao J, Germain RN, Schwartzberg PL, Tsang JS, Golding H; and the CHI Consortium.

NPJ Vaccines. 2018 Oct 1;3:40. doi: 10.1038/s41541-018-0076-2. eCollection 2018.

12.

Thinking differently about ILCs-Not just tissue resident and not just the same as CD4+ T-cell effectors.

Huang Y, Mao K, Germain RN.

Immunol Rev. 2018 Nov;286(1):160-171. doi: 10.1111/imr.12704. Review.

PMID:
30294968
13.

Prime and target immunization protects against liver-stage malaria in mice.

Gola A, Silman D, Walters AA, Sridhar S, Uderhardt S, Salman AM, Halbroth BR, Bellamy D, Bowyer G, Powlson J, Baker M, Venkatraman N, Poulton I, Berrie E, Roberts R, Lawrie AM, Angus B, Khan SM, Janse CJ, Ewer KJ, Germain RN, Spencer AJ, Hill AVS.

Sci Transl Med. 2018 Sep 26;10(460). pii: eaap9128. doi: 10.1126/scitranslmed.aap9128.

PMID:
30257955
14.

Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.

Preite S, Cannons JL, Radtke AJ, Vujkovic-Cvijin I, Gomez-Rodriguez J, Volpi S, Huang B, Cheng J, Collins N, Reilley J, Handon R, Dobbs K, Huq L, Raman I, Zhu C, Li QZ, Li MO, Pittaluga S, Uzel G, Notarangelo LD, Belkaid Y, Germain RN, Schwartzberg PL.

Nat Immunol. 2018 Sep;19(9):986-1000. doi: 10.1038/s41590-018-0182-3. Epub 2018 Aug 20.

15.

In Vivo Intradermal Delivery of Bacteria by Using Microneedle Arrays.

Chandler CE, Harberts EM, Laemmermann T, Zeng Q, Opene BN, Germain RN, Jewell CM, Scott AJ, Ernst RK.

Infect Immun. 2018 Aug 22;86(9). pii: e00406-18. doi: 10.1128/IAI.00406-18. Print 2018 Sep.

16.

Spatial distribution and function of T follicular regulatory cells in human lymph nodes.

Sayin I, Radtke AJ, Vella LA, Jin W, Wherry EJ, Buggert M, Betts MR, Herati RS, Germain RN, Canaday DH.

J Exp Med. 2018 Jun 4;215(6):1531-1542. doi: 10.1084/jem.20171940. Epub 2018 May 16.

17.

Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism.

Mao K, Baptista AP, Tamoutounour S, Zhuang L, Bouladoux N, Martins AJ, Huang Y, Gerner MY, Belkaid Y, Germain RN.

Nature. 2018 Feb 8;554(7691):255-259. doi: 10.1038/nature25437. Epub 2018 Jan 22.

PMID:
29364878
18.

S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense.

Huang Y, Mao K, Chen X, Sun MA, Kawabe T, Li W, Usher N, Zhu J, Urban JF Jr, Paul WE, Germain RN.

Science. 2018 Jan 5;359(6371):114-119. doi: 10.1126/science.aam5809.

PMID:
29302015
19.

Robust control of the adaptive immune system.

Wong HS, Germain RN.

Semin Immunol. 2018 Apr;36:17-27. doi: 10.1016/j.smim.2017.12.009. Epub 2017 Dec 29. Review.

PMID:
29290544
20.

Migrating Myeloid Cells Sense Temporal Dynamics of Chemoattractant Concentrations.

Petrie Aronin CE, Zhao YM, Yoon JS, Morgan NY, Prüstel T, Germain RN, Meier-Schellersheim M.

Immunity. 2017 Nov 21;47(5):862-874.e3. doi: 10.1016/j.immuni.2017.10.020.

21.
22.

Dendritic cell and antigen dispersal landscapes regulate T cell immunity.

Gerner MY, Casey KA, Kastenmuller W, Germain RN.

J Exp Med. 2017 Oct 2;214(10):3105-3122. doi: 10.1084/jem.20170335. Epub 2017 Aug 28.

23.

Immune Modulation Therapy and Imaging: Workshop Report.

Shields AF, Jacobs PM, Sznol M, Graham MM, Germain RN, Lum LG, Jaffee EM, de Vries EGE, Nimmagadda S, Van den Abbeele AD, Leung DK, Wu AM, Sharon E, Shankar LK.

J Nucl Med. 2018 Mar;59(3):410-417. doi: 10.2967/jnumed.117.195610. Epub 2017 Aug 17.

24.

Multiplex, quantitative cellular analysis in large tissue volumes with clearing-enhanced 3D microscopy (Ce3D).

Li W, Germain RN, Gerner MY.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7321-E7330. doi: 10.1073/pnas.1708981114. Epub 2017 Aug 14.

25.

Memory-phenotype CD4+ T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function.

Kawabe T, Jankovic D, Kawabe S, Huang Y, Lee PH, Yamane H, Zhu J, Sher A, Germain RN, Paul WE.

Sci Immunol. 2017 Jun 16;2(12). pii: eaam9304. doi: 10.1126/sciimmunol.aam9304.

26.

Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells.

Watanabe M, Fujihara C, Radtke AJ, Chiang YJ, Bhatia S, Germain RN, Hodes RJ.

J Exp Med. 2017 Sep 4;214(9):2795-2810. doi: 10.1084/jem.20161955. Epub 2017 Aug 2.

27.

A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System.

Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, Liu Z, Germain RN, Huse M, Altan-Bonnet G, Krichevsky O.

Immunity. 2017 Apr 18;46(4):609-620. doi: 10.1016/j.immuni.2017.03.011. Epub 2017 Apr 4.

28.

Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy.

Veres TZ, Kopcsányi T, Tirri M, Braun A, Miyasaka M, Germain RN, Jalkanen S, Salmi M.

Sci Rep. 2017 Apr 6;7(1):694. doi: 10.1038/s41598-017-00769-6.

29.

CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming.

Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W.

Immunity. 2017 Feb 21;46(2):205-219. doi: 10.1016/j.immuni.2017.01.003. Epub 2017 Feb 9.

30.

Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity.

Levine AG, Hemmers S, Baptista AP, Schizas M, Faire MB, Moltedo B, Konopacki C, Schmidt-Supprian M, Germain RN, Treuting PM, Rudensky AY.

J Exp Med. 2017 Mar 6;214(3):609-622. doi: 10.1084/jem.20161318. Epub 2017 Jan 27.

31.

Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies.

Petrovas C, Ferrando-Martinez S, Gerner MY, Casazza JP, Pegu A, Deleage C, Cooper A, Hataye J, Andrews S, Ambrozak D, Del Río Estrada PM, Boritz E, Paris R, Moysi E, Boswell KL, Ruiz-Mateos E, Vagios I, Leal M, Ablanedo-Terrazas Y, Rivero A, Gonzalez-Hernandez LA, McDermott AB, Moir S, Reyes-Terán G, Docobo F, Pantaleo G, Douek DC, Betts MR, Estes JD, Germain RN, Mascola JR, Koup RA.

Sci Transl Med. 2017 Jan 18;9(373). pii: eaag2285. doi: 10.1126/scitranslmed.aag2285.

32.

Adjuvant and carrier protein-dependent T-cell priming promotes a robust antibody response against the Plasmodium falciparum Pfs25 vaccine candidate.

Radtke AJ, Anderson CF, Riteau N, Rausch K, Scaria P, Kelnhofer ER, Howard RF, Sher A, Germain RN, Duffy P.

Sci Rep. 2017 Jan 16;7:40312. doi: 10.1038/srep40312.

33.

Allergen-Induced CD4+ T Cell Cytokine Production within Airway Mucosal Dendritic Cell-T Cell Clusters Drives the Local Recruitment of Myeloid Effector Cells.

Veres TZ, Kopcsányi T, van Panhuys N, Gerner MY, Liu Z, Rantakari P, Dunkel J, Miyasaka M, Salmi M, Jalkanen S, Germain RN.

J Immunol. 2017 Jan 15;198(2):895-907. doi: 10.4049/jimmunol.1601448. Epub 2016 Nov 30.

34.

Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy.

Im SJ, Hashimoto M, Gerner MY, Lee J, Kissick HT, Burger MC, Shan Q, Hale JS, Lee J, Nasti TH, Sharpe AH, Freeman GJ, Germain RN, Nakaya HI, Xue HH, Ahmed R.

Nature. 2016 Sep 15;537(7620):417-421. doi: 10.1038/nature19330. Epub 2016 Aug 2.

35.

Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses.

Gottschalk RA, Martins AJ, Angermann BR, Dutta B, Ng CE, Uderhardt S, Tsang JS, Fraser ID, Meier-Schellersheim M, Germain RN.

Cell Syst. 2016 Jun 22;2(6):378-90. doi: 10.1016/j.cels.2016.04.016. Epub 2016 May 26.

36.

William E. Paul, MD (1936-2015).

Germain RN, Fowlkes BJ, Samelson LE, Leonard WJ.

Trends Immunol. 2015 Dec;36(12):751-3. No abstract available.

PMID:
27064162
37.

Corrigendum: An interactive web-based application for Comprehensive Analysis of RNAi-screen Data.

Dutta B, Azhir A, Merino LH, Guo Y, Revanur S, Madhamshettiwar PB, Germain RN, Smith JA, Simpson KJ, Martin SE, Buehler E, Fraser ID.

Nat Commun. 2016 Mar 21;7:11214. doi: 10.1038/ncomms11214. No abstract available.

38.

An interactive web-based application for Comprehensive Analysis of RNAi-screen Data.

Dutta B, Azhir A, Merino LH, Guo Y, Revanur S, Madhamshettiwar PB, Germain RN, Smith JA, Simpson KJ, Martin SE, Buehler E, Fraser ID.

Nat Commun. 2016 Feb 23;7:10578. doi: 10.1038/ncomms10578. Erratum in: Nat Commun. 2016;7:11214. Beuhler, Eugen [Corrected to Buehler, Eugen].

39.

William E. Paul, M.D. (1936–2015).

Germain RN, Fowlkes BJ, Samelson LE, Leonard WJ.

Immunity. 2015 Oct 20;43(4):617-9. No abstract available.

40.

William E. Paul, M.D. (1936-2015), President, The American Association of Immunologists, 1986-1987.

Germain RN.

J Immunol. 2015 Dec 15;195(12):5519-21. doi: 10.4049/jimmunol.1590025. No abstract available.

41.

Immune homeostasis enforced by co-localized effector and regulatory T cells.

Liu Z, Gerner MY, Van Panhuys N, Levine AG, Rudensky AY, Germain RN.

Nature. 2015 Dec 10;528(7581):225-30. doi: 10.1038/nature16169. Epub 2015 Nov 25.

42.

Tracking the T cell repertoire.

Germain RN.

Nat Rev Immunol. 2015 Dec;15(12):730. doi: 10.1038/nri3922. Epub 2015 Oct 30. No abstract available.

PMID:
26515079
43.

William E. Paul (1936-2015).

Germain RN.

Nature. 2015 Oct 15;526(7573):324. doi: 10.1038/526324a. No abstract available.

PMID:
26469035
44.

Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity.

Fonseca DM, Hand TW, Han SJ, Gerner MY, Glatman Zaretsky A, Byrd AL, Harrison OJ, Ortiz AM, Quinones M, Trinchieri G, Brenchley JM, Brodsky IE, Germain RN, Randolph GJ, Belkaid Y.

Cell. 2015 Oct 8;163(2):354-66. doi: 10.1016/j.cell.2015.08.030.

45.

NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ-IL-27 axis.

Chong WP, van Panhuys N, Chen J, Silver PB, Jittayasothorn Y, Mattapallil MJ, Germain RN, Caspi RR.

J Exp Med. 2015 Sep 21;212(10):1739-52. doi: 10.1084/jem.20141678. Epub 2015 Sep 7.

46.

Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions.

Eickhoff S, Brewitz A, Gerner MY, Klauschen F, Komander K, Hemmi H, Garbi N, Kaisho T, Germain RN, Kastenmüller W.

Cell. 2015 Sep 10;162(6):1322-37. doi: 10.1016/j.cell.2015.08.004. Epub 2015 Aug 18.

47.

Targeted Proteomics-Driven Computational Modeling of Macrophage S1P Chemosensing.

Manes NP, Angermann BR, Koppenol-Raab M, An E, Sjoelund VH, Sun J, Ishii M, Germain RN, Meier-Schellersheim M, Nita-Lazar A.

Mol Cell Proteomics. 2015 Oct;14(10):2661-81. doi: 10.1074/mcp.M115.048918. Epub 2015 Jul 21.

48.

Continuous volumetric imaging via an optical phase-locked ultrasound lens.

Kong L, Tang J, Little JP, Yu Y, Lämmermann T, Lin CP, Germain RN, Cui M.

Nat Methods. 2015 Aug;12(8):759-62. doi: 10.1038/nmeth.3476. Epub 2015 Jul 13.

49.

Healing the NIH-Funded Biomedical Research Enterprise.

Germain RN.

Cell. 2015 Jun 18;161(7):1485-91. doi: 10.1016/j.cell.2015.05.052.

50.

Antigen- and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice.

Kolodin D, van Panhuys N, Li C, Magnuson AM, Cipolletta D, Miller CM, Wagers A, Germain RN, Benoist C, Mathis D.

Cell Metab. 2015 Apr 7;21(4):543-57. doi: 10.1016/j.cmet.2015.03.005.

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