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Items: 1 to 50 of 428


A three-year study of epidemiological trends of gastrointestinal cancers in a Haitian cancer program.

Bernard J, Gilbert D, Germain R, Alexis L, DeGennaro V.

Ann Oncol. 2019 Jul;30 Suppl 4:iv20. doi: 10.1093/annonc/mdz155.073. Epub 2019 Dec 4. No abstract available.


Evolution of an inferior competitor increases resistance to biological invasion.

Germain RM, Srivastava D, Angert AL.

Nat Ecol Evol. 2020 Feb 17. doi: 10.1038/s41559-020-1105-x. [Epub ahead of print]


Cancer prognosis with shallow tumor RNA sequencing.

Milanez-Almeida P, Martins AJ, Germain RN, Tsang JS.

Nat Med. 2020 Feb;26(2):188-192. doi: 10.1038/s41591-019-0729-3. Epub 2020 Feb 10.


Scaling-up biodiversity-ecosystem functioning research.

Gonzalez A, Germain RM, Srivastava DS, Filotas E, Dee LE, Gravel D, Thompson PL, Isbell F, Wang S, Kéfi S, Montoya J, Zelnik YR, Loreau M.

Ecol Lett. 2020 Jan 29. doi: 10.1111/ele.13456. [Epub ahead of print]


Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance.

Freeman SA, Uderhardt S, Saric A, Collins RF, Buckley CM, Mylvaganam S, Boroumand P, Plumb J, Germain RN, Ren D, Grinstein S.

Science. 2020 Jan 17;367(6475):301-305. doi: 10.1126/science.aaw9544. Epub 2019 Dec 5.


The Cellular Determinants of Adaptive Immunity.

Germain RN.

N Engl J Med. 2019 Sep 12;381(11):1083-1085. doi: 10.1056/NEJMcibr1909387. Epub 2019 Sep 10. No abstract available.


Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells.

Lee PH, Yamamoto TN, Gurusamy D, Sukumar M, Yu Z, Hu-Li J, Kawabe T, Gangaplara A, Kishton RJ, Henning AN, Vodnala SK, Germain RN, Paul WE, Restifo NP.

J Exp Med. 2019 Nov 4;216(11):2619-2634. doi: 10.1084/jem.20181218. Epub 2019 Aug 12.


IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses.

Gottschalk RA, Dorrington MG, Dutta B, Krauss KS, Martins AJ, Uderhardt S, Chan W, Tsang JS, Torabi-Parizi P, Fraser ID, Germain RN.

Elife. 2019 Aug 6;8. pii: e46836. doi: 10.7554/eLife.46836.


Cryptic dispersal networks shape biodiversity in an invaded landscape.

Germain RM, Jones NT, Grainger TN.

Ecology. 2019 Aug;100(8):e02738. doi: 10.1002/ecy.2738. Epub 2019 Jun 3.


The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity.

Baptista AP, Gola A, Huang Y, Milanez-Almeida P, Torabi-Parizi P, Urban JF Jr, Shapiro VS, Gerner MY, Germain RN.

Immunity. 2019 May 21;50(5):1188-1201.e6. doi: 10.1016/j.immuni.2019.04.001. Epub 2019 Apr 30.


High-dimensional cell-level analysis of tissues with Ce3D multiplex volume imaging.

Li W, Germain RN, Gerner MY.

Nat Protoc. 2019 Jun;14(6):1708-1733. doi: 10.1038/s41596-019-0156-4. Epub 2019 Apr 26.


Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage.

Uderhardt S, Martins AJ, Tsang JS, Lämmermann T, Germain RN.

Cell. 2019 Apr 18;177(3):541-555.e17. doi: 10.1016/j.cell.2019.02.028. Epub 2019 Apr 4.


Tissue clonality of dendritic cell subsets and emergency DCpoiesis revealed by multicolor fate mapping of DC progenitors.

Cabeza-Cabrerizo M, van Blijswijk J, Wienert S, Heim D, Jenkins RP, Chakravarty P, Rogers N, Frederico B, Acton S, Beerling E, van Rheenen J, Clevers H, Schraml BU, Bajénoff M, Gerner M, Germain RN, Sahai E, Klauschen F, Reis E Sousa C.

Sci Immunol. 2019 Mar 1;4(33). pii: eaaw1941. doi: 10.1126/sciimmunol.aaw1941.


Quantifying in situ adaptive immune cell cognate interactions in humans.

Liarski VM, Sibley A, van Panhuys N, Ai J, Chang A, Kennedy D, Merolle M, Germain RN, Giger ML, Clark MR.

Nat Immunol. 2019 Apr;20(4):503-513. doi: 10.1038/s41590-019-0315-3. Epub 2019 Feb 18.


Commensal Microbiota Promote Lung Cancer Development via γδ T Cells.

Jin C, Lagoudas GK, Zhao C, Bullman S, Bhutkar A, Hu B, Ameh S, Sandel D, Liang XS, Mazzilli S, Whary MT, Meyerson M, Germain R, Blainey PC, Fox JG, Jacks T.

Cell. 2019 Feb 21;176(5):998-1013.e16. doi: 10.1016/j.cell.2018.12.040. Epub 2019 Jan 31.


Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses.

Franco LM, Gadkari M, Howe KN, Sun J, Kardava L, Kumar P, Kumari S, Hu Z, Fraser IDC, Moir S, Tsang JS, Germain RN.

J Exp Med. 2019 Feb 4;216(2):384-406. doi: 10.1084/jem.20180595. Epub 2019 Jan 23.


ILC2s - resident lymphocytes pre-adapted to a specific tissue or migratory effectors that adapt to where they move?

Germain RN, Huang Y.

Curr Opin Immunol. 2019 Feb;56:76-81. doi: 10.1016/j.coi.2018.11.001. Epub 2018 Nov 23. Review.


Towards a multi-trophic extension of metacommunity ecology.

Guzman LM, Germain RM, Forbes C, Straus S, O'Connor MI, Gravel D, Srivastava DS, Thompson PL.

Ecol Lett. 2019 Jan;22(1):19-33. doi: 10.1111/ele.13162. Epub 2018 Oct 28.


AS03-adjuvanted H5N1 vaccine promotes antibody diversity and affinity maturation, NAI titers, cross-clade H5N1 neutralization, but not H1N1 cross-subtype neutralization.

Khurana S, Coyle EM, Manischewitz J, King LR, Gao J, Germain RN, Schwartzberg PL, Tsang JS, Golding H; and the CHI Consortium.

NPJ Vaccines. 2018 Oct 1;3:40. doi: 10.1038/s41541-018-0076-2. eCollection 2018.


Thinking differently about ILCs-Not just tissue resident and not just the same as CD4+ T-cell effectors.

Huang Y, Mao K, Germain RN.

Immunol Rev. 2018 Nov;286(1):160-171. doi: 10.1111/imr.12704. Review.


Prime and target immunization protects against liver-stage malaria in mice.

Gola A, Silman D, Walters AA, Sridhar S, Uderhardt S, Salman AM, Halbroth BR, Bellamy D, Bowyer G, Powlson J, Baker M, Venkatraman N, Poulton I, Berrie E, Roberts R, Lawrie AM, Angus B, Khan SM, Janse CJ, Ewer KJ, Germain RN, Spencer AJ, Hill AVS.

Sci Transl Med. 2018 Sep 26;10(460). pii: eaap9128. doi: 10.1126/scitranslmed.aap9128.


The 'filtering' metaphor revisited: competition and environment jointly structure invasibility and coexistence.

Germain RM, Mayfield MM, Gilbert B.

Biol Lett. 2018 Aug;14(8). pii: 20180460. doi: 10.1098/rsbl.2018.0460.


Hyperactivated PI3Kδ promotes self and commensal reactivity at the expense of optimal humoral immunity.

Preite S, Cannons JL, Radtke AJ, Vujkovic-Cvijin I, Gomez-Rodriguez J, Volpi S, Huang B, Cheng J, Collins N, Reilley J, Handon R, Dobbs K, Huq L, Raman I, Zhu C, Li QZ, Li MO, Pittaluga S, Uzel G, Notarangelo LD, Belkaid Y, Germain RN, Schwartzberg PL.

Nat Immunol. 2018 Sep;19(9):986-1000. doi: 10.1038/s41590-018-0182-3. Epub 2018 Aug 20.


In Vivo Intradermal Delivery of Bacteria by Using Microneedle Arrays.

Chandler CE, Harberts EM, Laemmermann T, Zeng Q, Opene BN, Germain RN, Jewell CM, Scott AJ, Ernst RK.

Infect Immun. 2018 Aug 22;86(9). pii: e00406-18. doi: 10.1128/IAI.00406-18. Print 2018 Sep.


Individual repeatability and heritability of divorce in a wild population.

Germain RR, Wolak ME, Reid JM.

Biol Lett. 2018 Jun;14(6). pii: 20180061. doi: 10.1098/rsbl.2018.0061.


Purifying Selection in the Toll-Like Receptors of Song Sparrows Melospiza melodia.

Nelson-Flower MJ, Germain RR, MacDougall-Shackleton EA, Taylor SS, Arcese P.

J Hered. 2018 Jun 27;109(5):501-509. doi: 10.1093/jhered/esy027.


Spatial distribution and function of T follicular regulatory cells in human lymph nodes.

Sayin I, Radtke AJ, Vella LA, Jin W, Wherry EJ, Buggert M, Betts MR, Herati RS, Germain RN, Canaday DH.

J Exp Med. 2018 Jun 4;215(6):1531-1542. doi: 10.1084/jem.20171940. Epub 2018 May 16.


The Consequences of Polyandry for Sibship Structures, Distributions of Relationships and Relatedness, and Potential for Inbreeding in a Wild Population.

Germain RR, Arcese P, Reid JM.

Am Nat. 2018 May;191(5):638-657. doi: 10.1086/696855. Epub 2018 Feb 28.


Demographic consequences of invasion by a native, controphic competitor to an insular bird population.

Johnson KM, Germain RR, Tarwater CE, Reid JM, Arcese P.

Oecologia. 2018 May;187(1):155-165. doi: 10.1007/s00442-018-4101-y. Epub 2018 Mar 2.


No evidence of inbreeding depression in sperm performance traits in wild song sparrows.

Losdat S, Germain RR, Nietlisbach P, Arcese P, Reid JM.

Ecol Evol. 2018 Jan 12;8(3):1842-1852. doi: 10.1002/ece3.3721. eCollection 2018 Feb.


Innate and adaptive lymphocytes sequentially shape the gut microbiota and lipid metabolism.

Mao K, Baptista AP, Tamoutounour S, Zhuang L, Bouladoux N, Martins AJ, Huang Y, Gerner MY, Belkaid Y, Germain RN.

Nature. 2018 Feb 8;554(7691):255-259. doi: 10.1038/nature25437. Epub 2018 Jan 22.


S1P-dependent interorgan trafficking of group 2 innate lymphoid cells supports host defense.

Huang Y, Mao K, Chen X, Sun MA, Kawabe T, Li W, Usher N, Zhu J, Urban JF Jr, Paul WE, Germain RN.

Science. 2018 Jan 5;359(6371):114-119. doi: 10.1126/science.aam5809.


Robust control of the adaptive immune system.

Wong HS, Germain RN.

Semin Immunol. 2018 Apr;36:17-27. doi: 10.1016/j.smim.2017.12.009. Epub 2017 Dec 29. Review.


Moving Character Displacement beyond Characters Using Contemporary Coexistence Theory.

Germain RM, Williams JL, Schluter D, Angert AL.

Trends Ecol Evol. 2018 Feb;33(2):74-84. doi: 10.1016/j.tree.2017.11.002. Epub 2017 Nov 25.


Migrating Myeloid Cells Sense Temporal Dynamics of Chemoattractant Concentrations.

Petrie Aronin CE, Zhao YM, Yoon JS, Morgan NY, Prüstel T, Germain RN, Meier-Schellersheim M.

Immunity. 2017 Nov 21;47(5):862-874.e3. doi: 10.1016/j.immuni.2017.10.020.


Evolution of precopulatory and post-copulatory strategies of inbreeding avoidance and associated polyandry.

Duthie AB, Bocedi G, Germain RR, Reid JM.

J Evol Biol. 2018 Jan;31(1):31-45. doi: 10.1111/jeb.13189. Epub 2017 Nov 3.


Dendritic cell and antigen dispersal landscapes regulate T cell immunity.

Gerner MY, Casey KA, Kastenmuller W, Germain RN.

J Exp Med. 2017 Oct 2;214(10):3105-3122. doi: 10.1084/jem.20170335. Epub 2017 Aug 28.


Immune Modulation Therapy and Imaging: Workshop Report.

Shields AF, Jacobs PM, Sznol M, Graham MM, Germain RN, Lum LG, Jaffee EM, de Vries EGE, Nimmagadda S, Van den Abbeele AD, Leung DK, Wu AM, Sharon E, Shankar LK.

J Nucl Med. 2018 Mar;59(3):410-417. doi: 10.2967/jnumed.117.195610. Epub 2017 Aug 17.


Multiplex, quantitative cellular analysis in large tissue volumes with clearing-enhanced 3D microscopy (Ce3D).

Li W, Germain RN, Gerner MY.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7321-E7330. doi: 10.1073/pnas.1708981114. Epub 2017 Aug 14.


Memory-phenotype CD4+ T cells spontaneously generated under steady-state conditions exert innate TH1-like effector function.

Kawabe T, Jankovic D, Kawabe S, Huang Y, Lee PH, Yamane H, Zhu J, Sher A, Germain RN, Paul WE.

Sci Immunol. 2017 Jun 16;2(12). pii: eaam9304. doi: 10.1126/sciimmunol.aam9304.


Co-stimulatory function in primary germinal center responses: CD40 and B7 are required on distinct antigen-presenting cells.

Watanabe M, Fujihara C, Radtke AJ, Chiang YJ, Bhatia S, Germain RN, Hodes RJ.

J Exp Med. 2017 Sep 4;214(9):2795-2810. doi: 10.1084/jem.20161955. Epub 2017 Aug 2.


Experimental dispersal reveals characteristic scales of biodiversity in a natural landscape.

Germain RM, Strauss SY, Gilbert B.

Proc Natl Acad Sci U S A. 2017 Apr 25;114(17):4447-4452. doi: 10.1073/pnas.1615338114. Epub 2017 Apr 17.


A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System.

Oyler-Yaniv A, Oyler-Yaniv J, Whitlock BM, Liu Z, Germain RN, Huse M, Altan-Bonnet G, Krichevsky O.

Immunity. 2017 Apr 18;46(4):609-620. doi: 10.1016/j.immuni.2017.03.011. Epub 2017 Apr 4.


Intubation-free in vivo imaging of the tracheal mucosa using two-photon microscopy.

Veres TZ, Kopcsányi T, Tirri M, Braun A, Miyasaka M, Germain RN, Jalkanen S, Salmi M.

Sci Rep. 2017 Apr 6;7(1):694. doi: 10.1038/s41598-017-00769-6.


CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming.

Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W.

Immunity. 2017 Feb 21;46(2):205-219. doi: 10.1016/j.immuni.2017.01.003. Epub 2017 Feb 9.


Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity.

Levine AG, Hemmers S, Baptista AP, Schizas M, Faire MB, Moltedo B, Konopacki C, Schmidt-Supprian M, Germain RN, Treuting PM, Rudensky AY.

J Exp Med. 2017 Mar 6;214(3):609-622. doi: 10.1084/jem.20161318. Epub 2017 Jan 27.


Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies.

Petrovas C, Ferrando-Martinez S, Gerner MY, Casazza JP, Pegu A, Deleage C, Cooper A, Hataye J, Andrews S, Ambrozak D, Del Río Estrada PM, Boritz E, Paris R, Moysi E, Boswell KL, Ruiz-Mateos E, Vagios I, Leal M, Ablanedo-Terrazas Y, Rivero A, Gonzalez-Hernandez LA, McDermott AB, Moir S, Reyes-Terán G, Docobo F, Pantaleo G, Douek DC, Betts MR, Estes JD, Germain RN, Mascola JR, Koup RA.

Sci Transl Med. 2017 Jan 18;9(373). pii: eaag2285. doi: 10.1126/scitranslmed.aag2285.


Adjuvant and carrier protein-dependent T-cell priming promotes a robust antibody response against the Plasmodium falciparum Pfs25 vaccine candidate.

Radtke AJ, Anderson CF, Riteau N, Rausch K, Scaria P, Kelnhofer ER, Howard RF, Sher A, Germain RN, Duffy P.

Sci Rep. 2017 Jan 16;7:40312. doi: 10.1038/srep40312.


Predators modify biogeographic constraints on species distributions in an insect metacommunity.

Grainger TN, Germain RM, Jones NT, Gilbert B.

Ecology. 2017 Mar;98(3):851-860. doi: 10.1002/ecy.1712.


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