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Items: 32

1.

Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling.

Thimmaiah KN, Easton JB, Germain GS, Morton CL, Kamath S, Buolamwini JK, Houghton PJ.

J Biol Chem. 2005 Sep 9;280(36):31924-35. Epub 2005 Jul 11.

2.

Gefitinib enhances the antitumor activity and oral bioavailability of irinotecan in mice.

Stewart CF, Leggas M, Schuetz JD, Panetta JC, Cheshire PJ, Peterson J, Daw N, Jenkins JJ 3rd, Gilbertson R, Germain GS, Harwood FC, Houghton PJ.

Cancer Res. 2004 Oct 15;64(20):7491-9.

3.

Inhibition of mammalian target of rapamycin activates apoptosis signal-regulating kinase 1 signaling by suppressing protein phosphatase 5 activity.

Huang S, Shu L, Easton J, Harwood FC, Germain GS, Ichijo H, Houghton PJ.

J Biol Chem. 2004 Aug 27;279(35):36490-6. Epub 2004 Jun 24.

4.

Imatinib mesylate is a potent inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to topotecan and SN-38 in vitro.

Houghton PJ, Germain GS, Harwood FC, Schuetz JD, Stewart CF, Buchdunger E, Traxler P.

Cancer Res. 2004 Apr 1;64(7):2333-7.

5.
6.

Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways.

Thimmaiah KN, Easton J, Huang S, Veverka KA, Germain GS, Harwood FC, Houghton PJ.

Cancer Res. 2003 Jan 15;63(2):364-74.

7.

4E-binding proteins, the suppressors of eukaryotic initiation factor 4E, are down-regulated in cells with acquired or intrinsic resistance to rapamycin.

Dilling MB, Germain GS, Dudkin L, Jayaraman AL, Zhang X, Harwood FC, Houghton PJ.

J Biol Chem. 2002 Apr 19;277(16):13907-17. Epub 2002 Feb 14.

8.

The influence of recombinant human insulin-like growth factor-I (rhIGF-I) on cell growth and cytotoxicity of drugs in childhood rhabdomyosarcoma cell lines and xenograft models.

Gidding CE, Germain GS, Dilling MB, Meeuwsen-de Boer TG, Ashmun RA, de Graaf SS, Veverka KA, Kamps WA, Houghton PJ.

Cancer Chemother Pharmacol. 2000;45(1):21-30.

PMID:
10647497
9.

Rapamycin causes poorly reversible inhibition of mTOR and induces p53-independent apoptosis in human rhabdomyosarcoma cells.

Hosoi H, Dilling MB, Shikata T, Liu LN, Shu L, Ashmun RA, Germain GS, Abraham RT, Houghton PJ.

Cancer Res. 1999 Feb 15;59(4):886-94.

10.

Characterization of 2-chloro-N10-substituted phenoxazines for reversing multidrug resistance in cancer cells.

Thimmaiah KN, Jayashree BS, Germain GS, Houghton PJ, Horton JK.

Oncol Res. 1998;10(1):29-41.

PMID:
9613455
11.

Characterization of a novel bisacridone and comparison with PSC 833 as a potent and poorly reversible modulator of P-glycoprotein.

Horton JK, Thimmaiah KN, Altenberg GA, Castro AF, Germain GS, Gowda GK, Houghton PJ.

Mol Pharmacol. 1997 Dec;52(6):948-57.

12.

Phytic acid stimulates the growth of a human rhabdomyosarcoma.

Germain GS, Houghton PJ.

In Vitro Cell Dev Biol Anim. 1997 Sep;33(8):581-3. No abstract available.

PMID:
9338134
13.
14.

Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor.

Dilling MB, Dias P, Shapiro DN, Germain GS, Johnson RK, Houghton PJ.

Cancer Res. 1994 Feb 15;54(4):903-7.

PMID:
7508822
15.

Proliferation-dependent and -independent cytotoxicity by antitumor diarylsulfonylureas. Indication of multiple mechanisms of drug action.

Sosinski J, Thakar JH, Germain GS, Harwood FC, Houghton PJ.

Biochem Pharmacol. 1993 May 25;45(10):2135-42.

PMID:
8512595
16.

Morphological and molecular characterization of spontaneous myogenic differentiation in a human rhabdomyosarcoma cell line.

Shapiro DN, Houghton PJ, Hazelton BJ, Germain GS, Murti KG, Rahman A, Houghton JA.

Cancer Res. 1990 Sep 15;50(18):6002-9.

17.

Studies on the cellular pharmacology of N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl)-urea.

Houghton PJ, Bailey FC, Germain GS, Grindey GB, Howbert JJ, Houghton JA.

Biochem Pharmacol. 1990 Apr 1;39(7):1187-92.

PMID:
2322303
18.

N-(5-indanylsulfonyl)-N'-(4-chlorophenyl)urea, a novel agent equally cytotoxic to nonproliferating human colon adenocarcinoma cells.

Houghton PJ, Bailey FC, Germain GS, Grindey GB, Witt BC, Houghton JA.

Cancer Res. 1990 Jan 15;50(2):318-22.

PMID:
2295071
19.

Mutants of human colon adenocarcinoma, selected for thymidylate synthase deficiency.

Houghton PJ, Germain GS, Hazelton BJ, Pennington JW, Houghton JA.

Proc Natl Acad Sci U S A. 1989 Feb;86(4):1377-81.

20.

Phosphorylation of nucleosides catalyzed by a mammalian enzyme other than uridine-cytidine kinase.

Ahmed NK, Germain GS, Welch AD, Paterson AR, Paran JH, Yang S.

Biochem Biophys Res Commun. 1980 Jul 16;95(1):440-5. No abstract available.

PMID:
6158318
21.
22.
23.

Selenium induced glutathione peroxidase activity in mouse neuroblastoma cells.

Germain GS, Arneson RM.

Biochem Biophys Res Commun. 1977 Nov 7;79(1):119-23. No abstract available.

PMID:
921790
24.

Endocrine-type antihypertensive function of renomedullary interstitial cells.

Muirhead EE, Germain GS, Armstrong FB, Brooks B, Leach BE, Byers LW, Pitcock JA, Brown P.

Kidney Int Suppl. 1975 Sep:S271-82. No abstract available.

PMID:
1059807
25.

A simple apparatus for retrieving density gradients by surface tension.

Germain GS.

Anal Biochem. 1974 Jan;57(1):89-92. No abstract available.

PMID:
4817513
26.

Renomedullary endocrine system: its antihypertensive action.

Muirhead EE, Germain GS, Armstrong FB, Brooks B, Leach BE, Byers LW, Pitcock JA, Brown P.

Trans Assoc Am Physicians. 1974;87:288-97. No abstract available.

PMID:
4376292
27.

Vasodepressor action of prostaglandins A 2 and E 2 in the spontaneously hypertensive rat (SH rat): evidence for an action mediated by the vagus.

Leach BE, Armstrong FB Jr, Germain GS, Muirhead EE.

J Pharmacol Exp Ther. 1973 Jun;185(3):479-85. No abstract available.

PMID:
4712646
28.

Renomedullary interstitial cells (RIC), prostaglandins (PG) and the antihypertensive function of the kidney.

Muirhead EE, Germain GS, Leach BE, Brooks B, Stephenson P.

Prostaglandins. 1973 May;3(5):581-94. Review. No abstract available.

PMID:
4354090
29.

Functional difference in transplantation of fragmented renal medulla and monolayer culture of renomedullary interstitial cells.

Muirhead EE, Germain GS, Brooks B, Pitcock JA, Armstrong FB.

Proc Clin Dial Transplant Forum. 1973;3:212-6. No abstract available.

PMID:
4619685
30.
31.

The renal medulla as an antihypertensive organ.

Muirhead EE, Brown GB, Germain GS, Leach BE.

J Lab Clin Med. 1970 Oct;76(4):641-51. No abstract available.

PMID:
4917704
32.

Multiple access diffusion chamber and the cultivation of liver cells.

Germain GS, Schneider H, Muirhead EE.

Exp Cell Res. 1966 Sep;43(2):493-505. No abstract available.

PMID:
5919905

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