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Items: 31

1.

Comparison of SLCO1B1 sequence variability among German, Turkish, and African populations.

Mwinyi J, Köpke K, Schaefer M, Roots I, Gerloff T.

Eur J Clin Pharmacol. 2008 Mar;64(3):257-66. doi: 10.1007/s00228-007-0409-y. Epub 2008 Jan 6.

PMID:
18185926
2.

Possible role of MDR1 two-locus genotypes for young-age onset ulcerative colitis but not Crohn's disease.

Fiedler T, Büning C, Reuter W, Pitre G, Gentz E, Schmidt HH, Büttner J, Ockenga J, Gerloff T, Meisel C, Lochs H, Roots I, Köpke K, Johne A.

Eur J Clin Pharmacol. 2007 Oct;63(10):917-25. Epub 2007 Jul 31.

PMID:
17665184
3.

Association of MDR1 genotypes with susceptibility to colorectal cancer in older non-smokers.

Osswald E, Johne A, Laschinski G, Arjomand-Nahad F, Malzahn U, Kirchheiner J, Gerloff T, Meisel C, Mrozikiewicz PM, Chernov J, Roots I, Köpke K.

Eur J Clin Pharmacol. 2007 Jan;63(1):9-16. Epub 2006 Dec 5.

PMID:
17146660
4.

Genotype and phenotype relationship in drug metabolism.

Roots I, Laschinski G, Arjomand-Nahad F, Kirchheiner J, Schwarz D, Brockmöller J, Cascorbi I, Gerloff T.

Ernst Schering Res Found Workshop. 2007;(59):81-100. Review.

PMID:
17117716
5.

In-vitro transport characteristics discriminate wild-type ABCB1 (MDR1) from ALA893SER and ALA893THR polymorphisms.

Schaefer M, Roots I, Gerloff T.

Pharmacogenet Genomics. 2006 Dec;16(12):855-61.

PMID:
17108809
6.

Influence of the SLCO1B1*1b and *5 haplotypes on pravastatin's cholesterol lowering capabilities and basal sterol serum levels.

Gerloff T, Schaefer M, Mwinyi J, Johne A, Sudhop T, Lütjohann D, Roots I, von Bergmann K.

Naunyn Schmiedebergs Arch Pharmacol. 2006 Apr;373(1):45-50. Epub 2006 Mar 28.

PMID:
16568260
7.

[Implications of pharmacogenetics in every-day practice].

Gerloff T, Roots I.

Internist (Berl). 2005 Nov;46(11):1270-7. Review. German.

PMID:
16170512
8.

[Clinical drug investigations. Definition of terms].

Johne A, Gerloff T, Mai I.

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2005 Apr;48(4):397-400. German.

PMID:
15830249
9.

Quantification of pravastatin in human plasma and urine after solid phase extraction using high performance liquid chromatography with ultraviolet detection.

Bauer S, Mwinyi J, Stoeckle A, Gerloff T, Roots I.

J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Apr 25;818(2):257-62.

PMID:
15734167
10.

Pharmacogenetics-based new therapeutic concepts.

Roots I, Gerloff T, Meisel C, Kirchheiner J, Goldammer M, Kaiser R, Laschinski G, Brockmöller J, Cascorbi I, Kleeberg U, Hildebrandt AG.

Drug Metab Rev. 2004 Oct;36(3-4):617-38. Review.

PMID:
15554239
11.

Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics.

Mwinyi J, Johne A, Bauer S, Roots I, Gerloff T.

Clin Pharmacol Ther. 2004 May;75(5):415-21.

PMID:
15116054
12.

[Pharmacogenetic implications of transmembrane transporters for the uptake, distribution and excretion of drugs].

Gerloff T, Roots I.

Dtsch Med Wochenschr. 2003 Nov 14;128(46):2431-6. Review. German. No abstract available.

PMID:
14614658
13.

Impact of genetic polymorphisms in transmembrane carrier-systems on drug and xenobiotic distribution.

Gerloff T.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Jan;369(1):69-77. Epub 2003 Nov 4. Review. Erratum in: Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):268.

PMID:
14598019
14.

Constitutive rat multidrug-resistance protein 2 gene transcription is down-regulated by Y-box protein 1.

Geier A, Mertens PR, Gerloff T, Dietrich CG, En-Nia A, Kullak-Ublick GA, Karpen SJ, Matern S, Gartung C.

Biochem Biophys Res Commun. 2003 Sep 26;309(3):612-8.

PMID:
12963034
15.

MDR1 polymorphisms G2677T in exon 21 and C3435T in exon 26 fail to affect rhodamine 123 efflux in peripheral blood lymphocytes.

Oselin K, Gerloff T, Mrozikiewicz PM, Pähkla R, Roots I.

Fundam Clin Pharmacol. 2003 Aug;17(4):463-9.

PMID:
12914549
16.

Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis.

Geier A, Dietrich CG, Voigt S, Kim SK, Gerloff T, Kullak-Ublick GA, Lorenzen J, Matern S, Gartung C.

Hepatology. 2003 Aug;38(2):345-54.

PMID:
12883478
17.

Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2 and of P-glycoprotein in a Russian population.

Gaikovitch EA, Cascorbi I, Mrozikiewicz PM, Brockmöller J, Frötschl R, Köpke K, Gerloff T, Chernov JN, Roots I.

Eur J Clin Pharmacol. 2003 Aug;59(4):303-12. Epub 2003 Jul 15.

PMID:
12879168
18.

Implications of pharmacogenetics for individualizing drug treatment and for study design.

Meisel C, Gerloff T, Kirchheiner J, Mrozikiewicz PM, Niewinski P, Brockmöller J, Roots I.

J Mol Med (Berl). 2003 Mar;81(3):154-67. Epub 2003 Mar 15. Review.

PMID:
12682724
19.

Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat.

Geier A, Dietrich CG, Gerloff T, Haendly J, Kullak-Ublick GA, Stieger B, Meier PJ, Matern S, Gartung C.

Biochim Biophys Acta. 2003 Jan 10;1609(1):87-94.

20.

MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males.

Gerloff T, Schaefer M, Johne A, Oselin K, Meisel C, Cascorbi I, Roots I.

Br J Clin Pharmacol. 2002 Dec;54(6):610-6.

21.

Modulation of steady-state kinetics of digoxin by haplotypes of the P-glycoprotein MDR1 gene.

Johne A, Köpke K, Gerloff T, Mai I, Rietbrock S, Meisel C, Hoffmeyer S, Kerb R, Fromm MF, Brinkmann U, Eichelbaum M, Brockmöller J, Cascorbi I, Roots I.

Clin Pharmacol Ther. 2002 Nov;72(5):584-94.

PMID:
12426522
22.

Functional analysis of the rat bile salt export pump gene promoter.

Gerloff T, Geier A, Roots I, Meier PJ, Gartung C.

Eur J Biochem. 2002 Jul;269(14):3495-503.

23.

Hepatobiliary organic anion transporters are differentially regulated in acute toxic liver injury induced by carbon tetrachloride.

Geier A, Kim SK, Gerloff T, Dietrich CG, Lammert F, Karpen SJ, Stieger B, Meier PJ, Matern S, Gartung C.

J Hepatol. 2002 Aug;37(2):198-205.

PMID:
12127424
24.

Identification of six methylenetetrahydrofolate reductase (MTHFR) genotypes resulting from common polymorphisms: impact on plasma homocysteine levels and development of coronary artery disease.

Meisel C, Cascorbi I, Gerloff T, Stangl V, Laule M, Müller JM, Wernecke KD, Baumann G, Roots I, Stangl K.

Atherosclerosis. 2001 Feb 15;154(3):651-8.

PMID:
11257266
25.

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects.

Cascorbi I, Gerloff T, Johne A, Meisel C, Hoffmeyer S, Schwab M, Schaeffeler E, Eichelbaum M, Brinkmann U, Roots I.

Clin Pharmacol Ther. 2001 Mar;69(3):169-74. Erratum in: Clin Pharmacol Ther. 2004 Jan;75(1):124.

PMID:
11240981
26.

Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo.

Hoffmeyer S, Burk O, von Richter O, Arnold HP, Brockmöller J, Johne A, Cascorbi I, Gerloff T, Roots I, Eichelbaum M, Brinkmann U.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3473-8.

27.

Differential expression of basolateral and canalicular organic anion transporters during regeneration of rat liver.

Gerloff T, Geier A, Stieger B, Hagenbuch B, Meier PJ, Matern S, Gartung C.

Gastroenterology. 1999 Dec;117(6):1408-15.

PMID:
10579982
28.
29.

The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver.

Gerloff T, Stieger B, Hagenbuch B, Madon J, Landmann L, Roth J, Hofmann AF, Meier PJ.

J Biol Chem. 1998 Apr 17;273(16):10046-50.

30.

Functional expression of the rat liver canalicular isoform of the multidrug resistance-associated protein.

Madon J, Eckhardt U, Gerloff T, Stieger B, Meier PJ.

FEBS Lett. 1997 Apr 7;406(1-2):75-8.

31.

Expression of a rat liver phosphatidylcholine translocator in Xenopus laevis oocytes.

Kullak-Ublick GA, Gerloff T, Hagenbuch B, Berr F, Meier PJ, Stieger B.

Hepatology. 1996 May;23(5):1254-9.

PMID:
8621161

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