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Development and formative evaluation of patient research partner involvement in a multi-disciplinary European translational research project.

Birch R, Simons G, Wähämaa H, McGrath CM, Johansson EC, Skingle D, Bayliss K, Starling B, Gerlag DM, Buckley CD, Stack RJ, Raza K, Falahee M.

Res Involv Engagem. 2020 Feb 19;6:6. doi: 10.1186/s40900-020-0178-7. eCollection 2020.


Phenotypic Analysis of Human Lymph Nodes in Subjects With New-Onset Type 1 Diabetes and Healthy Individuals by Flow Cytometry.

Yang JHM, Khatri L, Mickunas M, Williams E, Tatovic D, Alhadj Ali M, Young P, Moyle P, Sahni V, Wang R, Kaur R, Tannahill GM, Beaton AR, Gerlag DM, Savage COS, Napolitano Rosen A, Waldron-Lynch F, Dayan CM, Tree TIM.

Front Immunol. 2019 Oct 31;10:2547. doi: 10.3389/fimmu.2019.02547. eCollection 2019.


Molecular Characterization of Human Lymph Node Stromal Cells During the Earliest Phases of Rheumatoid Arthritis.

Karouzakis E, Hähnlein J, Grasso C, Semmelink JF, Tak PP, Gerlag DM, Gay S, Ospelt C, van Baarsen LGM.

Front Immunol. 2019 Aug 20;10:1863. doi: 10.3389/fimmu.2019.01863. eCollection 2019.


Myeloid Dendritic Cells Are Enriched in Lymph Node Tissue of Early Rheumatoid Arthritis Patients but not in At Risk Individuals.

Ramwadhdoebe TH, Ramos MI, Maijer KI, van Lienden KP, Maas M, Gerlag DM, Tak PP, Lebre MC, van Baarsen LGM.

Cells. 2019 Jul 20;8(7). pii: E756. doi: 10.3390/cells8070756.


Non-response to rituximab therapy in rheumatoid arthritis is associated with incomplete disruption of the B cell receptor repertoire.

Pollastro S, Klarenbeek PL, Doorenspleet ME, van Schaik BDC, Esveldt REE, Thurlings RM, Boumans MJH, Gerlag DM, Tak PP, Vos K, Baas F, van Kampen AHC, de Vries N.

Ann Rheum Dis. 2019 Oct;78(10):1339-1345. doi: 10.1136/annrheumdis-2018-214898. Epub 2019 Jun 19.


Effect of rituximab treatment on T and B cell subsets in lymph node biopsies of patients with rheumatoid arthritis.

Ramwadhdoebe TH, van Baarsen LGM, Boumans MJH, Bruijnen STG, Safy M, Berger FH, Semmelink JF, van der Laken CJ, Gerlag DM, Thurlings RM, Tak PP.

Rheumatology (Oxford). 2019 Jun 1;58(6):1075-1085. doi: 10.1093/rheumatology/key428.


Effects of B-cell directed therapy on the preclinical stage of rheumatoid arthritis: the PRAIRI study.

Gerlag DM, Safy M, Maijer KI, Tang MW, Tas SW, Starmans-Kool MJF, van Tubergen A, Janssen M, de Hair M, Hansson M, de Vries N, Zwinderman AH, Tak PP.

Ann Rheum Dis. 2019 Feb;78(2):179-185. doi: 10.1136/annrheumdis-2017-212763. Epub 2018 Dec 1.


Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis.

Hähnlein JS, Nadafi R, de Jong T, Ramwadhdoebe TH, Semmelink JF, Maijer KI, Zijlstra IA, Maas M, Gerlag DM, Geijtenbeek TBH, Tak PP, Mebius RE, van Baarsen LGM.

Arthritis Res Ther. 2018 Feb 26;20(1):35. doi: 10.1186/s13075-018-1529-8.


Distinctive expression of T cell guiding molecules in human autoimmune lymph node stromal cells upon TLR3 triggering.

Hähnlein JS, Ramwadhdoebe TH, Semmelink JF, Choi IY, Berger FH, Maas M, Gerlag DM, Tak PP, Geijtenbeek TBH, van Baarsen LGM.

Sci Rep. 2018 Jan 29;8(1):1736. doi: 10.1038/s41598-018-19951-5.


Stromal cell markers are differentially expressed in the synovial tissue of patients with early arthritis.

Choi IY, Karpus ON, Turner JD, Hardie D, Marshall JL, de Hair MJH, Maijer KI, Tak PP, Raza K, Hamann J, Buckley CD, Gerlag DM, Filer A.

PLoS One. 2017 Aug 9;12(8):e0182751. doi: 10.1371/journal.pone.0182751. eCollection 2017.


Dominant B cell receptor clones in peripheral blood predict onset of arthritis in individuals at risk for rheumatoid arthritis.

Tak PP, Doorenspleet ME, de Hair MJH, Klarenbeek PL, van Beers-Tas MH, van Kampen AHC, van Schaardenburg D, Gerlag DM, Baas F, de Vries N.

Ann Rheum Dis. 2017 Nov;76(11):1924-1930. doi: 10.1136/annrheumdis-2017-211351. Epub 2017 Aug 8.


Insight into the Endocrine System and the Immune System: A Review of the Inflammatory Role of Prolactin in Rheumatoid Arthritis and Psoriatic Arthritis.

Tang MW, Garcia S, Gerlag DM, Tak PP, Reedquist KA.

Front Immunol. 2017 Jun 23;8:720. doi: 10.3389/fimmu.2017.00720. eCollection 2017. Review.


Rheumatoid arthritis and psoriatic arthritis synovial fluids stimulate prolactin production by macrophages.

Tang MW, Garcia S, Malvar Fernandez B, Gerlag DM, Tak PP, Reedquist KA.

J Leukoc Biol. 2017 Sep;102(3):897-904. doi: 10.1189/jlb.2A0317-115RR. Epub 2017 Jun 22.


Single vagus nerve stimulation reduces early postprandial C-peptide levels but not other hormones or postprandial metabolism.

Tang MW, van Nierop FS, Koopman FA, Eggink HM, Gerlag DM, Chan MW, Zitnik R, Vaz FM, Romijn JA, Tak PP, Soeters MR.

Clin Rheumatol. 2018 Feb;37(2):505-514. doi: 10.1007/s10067-017-3618-5. Epub 2017 Apr 8.


Hormone, metabolic peptide, and nutrient levels in the earliest phases of rheumatoid arthritis-contribution of free fatty acids to an increased cardiovascular risk during very early disease.

Tang MW, Koopman FA, Visscher JP, de Hair MJ, Gerlag DM, Tak PP.

Clin Rheumatol. 2017 Feb;36(2):269-278. doi: 10.1007/s10067-016-3456-x. Epub 2016 Nov 2.


Lymph node biopsy analysis reveals an altered immunoregulatory balance already during the at-risk phase of autoantibody positive rheumatoid arthritis.

Ramwadhdoebe TH, Hähnlein J, Maijer KI, van Boven LJ, Gerlag DM, Tak PP, van Baarsen LG.

Eur J Immunol. 2016 Dec;46(12):2812-2821. doi: 10.1002/eji.201646393. Epub 2016 Oct 12.


The prolactin receptor is expressed in rheumatoid arthritis and psoriatic arthritis synovial tissue and contributes to macrophage activation.

Tang MW, Reedquist KA, Garcia S, Fernandez BM, Codullo V, Vieira-Sousa E, Goffin V, Reuwer AQ, Twickler MT, Gerlag DM, Tak PP.

Rheumatology (Oxford). 2016 Dec;55(12):2248-2259. Epub 2016 Sep 10.


Brief Report: Altered Innate Lymphoid Cell Subsets in Human Lymph Node Biopsy Specimens Obtained During the At-Risk and Earliest Phases of Rheumatoid Arthritis.

Rodríguez-Carrio J, Hähnlein JS, Ramwadhdoebe TH, Semmelink JF, Choi IY, van Lienden KP, Maas M, Gerlag DM, Tak PP, Geijtenbeek TB, van Baarsen LG.

Arthritis Rheumatol. 2017 Jan;69(1):70-76. doi: 10.1002/art.39811.


Autonomic Dysfunction Precedes Development of Rheumatoid Arthritis: A Prospective Cohort Study.

Koopman FA, Tang MW, Vermeij J, de Hair MJ, Choi IY, Vervoordeldonk MJ, Gerlag DM, Karemaker JM, Tak PP.

EBioMedicine. 2016 Apr;6:231-237. doi: 10.1016/j.ebiom.2016.02.029. Epub 2016 Feb 19.


Human lymph-node CD8(+) T cells display an altered phenotype during systemic autoimmunity.

Ramwadhdoebe TH, Hähnlein J, van Kuijk BJ, Choi IY, van Boven LJ, Gerlag DM, Tak PP, van Baarsen LG.

Clin Transl Immunology. 2016 Apr 1;5(4):e67. doi: 10.1038/cti.2016.8. eCollection 2016 Apr.


Reduced CLEC9A expression in synovial tissue of psoriatic arthritis patients after adalimumab therapy.

Ramos MI, Teunissen MB, Helder B, Aarrass S, de Hair MJ, van Kuijk AW, Gerlag DM, Tak PP, Lebre MC.

Rheumatology (Oxford). 2016 Sep;55(9):1575-84. doi: 10.1093/rheumatology/kew204. Epub 2016 May 13.


A Personalized Approach to Biological Therapy Using Prediction of Clinical Response Based on MRP8/14 Serum Complex Levels in Rheumatoid Arthritis Patients.

Nair SC, Welsing PM, Choi IY, Roth J, Holzinger D, Bijlsma JW, van Laar JM, Gerlag DM, Lafeber FP, Tak PP.

PLoS One. 2016 Mar 30;11(3):e0152362. doi: 10.1371/journal.pone.0152362. eCollection 2016.


Neo-Epitopes--Fragments of Cartilage and Connective Tissue Degradation in Early Rheumatoid Arthritis and Unclassified Arthritis.

Maijer KI, Gudmann NS, Karsdal MA, Gerlag DM, Tak PP, Bay-Jensen AC.

PLoS One. 2016 Mar 28;11(3):e0149329. doi: 10.1371/journal.pone.0149329. eCollection 2016.


Smelling the Diagnosis: The Electronic Nose as Diagnostic Tool in Inflammatory Arthritis. A Case-Reference Study.

Brekelmans MP, Fens N, Brinkman P, Bos LD, Sterk PJ, Tak PP, Gerlag DM.

PLoS One. 2016 Mar 16;11(3):e0151715. doi: 10.1371/journal.pone.0151715. eCollection 2016.


Discovery of Innovative Therapies for Rare Immune-Mediated Inflammatory Diseases via Off-Label Prescription of Biologics: The Case of IL-6 Receptor Blockade in Castleman's Disease.

Musters A, Assaf A, Gerlag DM, Tak PP, Tas SW.

Front Immunol. 2015 Dec 11;6:625. doi: 10.3389/fimmu.2015.00625. eCollection 2015. Review.


Serum Vaspin Levels Are Associated with the Development of Clinically Manifest Arthritis in Autoantibody-Positive Individuals.

Maijer KI, Neumann E, Müller-Ladner U, Drop DA, Ramwadhdoebe TH, Choi IY, Gerlag DM, de Hair MJ, Tak PP.

PLoS One. 2015 Dec 15;10(12):e0144932. doi: 10.1371/journal.pone.0144932. eCollection 2015.


Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using Pharmacokinetic Modeling: Initial Experience in Patients With Early Arthritis.

Maijer KI, van der Leij C, de Hair MJ, Tas SW, Maas M, Gerlag DM, Tak PP, Lavini C.

Arthritis Rheumatol. 2016 Mar;68(3):587-96. doi: 10.1002/art.39469.


Towards prevention of autoantibody-positive rheumatoid arthritis: from lifestyle modification to preventive treatment.

Gerlag DM, Norris JM, Tak PP.

Rheumatology (Oxford). 2016 Apr;55(4):607-14. doi: 10.1093/rheumatology/kev347. Epub 2015 Sep 15. Review.


Does the multi-biomarker disease activity score have diagnostic value in early rheumatoid arthritis and unclassified arthritis?

Maijer KI, Li W, Sasso EH, Gerlag DM, Defranoux NA, Tak PP.

Ann Rheum Dis. 2015 Nov;74(11):2097-9. doi: 10.1136/annrheumdis-2015-207911. Epub 2015 Sep 2. No abstract available.


Prevalence of Anti-Citrullinated Protein Antibodies and IgM Rheumatoid Factor in First-Degree Relatives of Dutch Rheumatoid Arthritis Patients.

Maijer KI, Gerlag DM, Tak PP.

Arthritis Rheumatol. 2015 Dec;67(12):3324-6. doi: 10.1002/art.39412. No abstract available.


Expression of Prostaglandin E2 Enzymes in the Synovium of Arthralgia Patients at Risk of Developing Rheumatoid Arthritis and in Early Arthritis Patients.

de Hair MJ, Leclerc P, Newsum EC, Maijer KI, van de Sande MG, Ramwadhdoebe TH, van Schaardenburg D, van Baarsen LG, Korotkova M, Gerlag DM, Tak PP, Jakobsson PJ.

PLoS One. 2015 Jul 30;10(7):e0133669. doi: 10.1371/journal.pone.0133669. eCollection 2015.


Single-joint Assessment for the Evaluation of Intraarticular Treatment: Responsiveness and Discrimination of the Composite Change Index.

Aalbers CJ, Gerlag DM, Vervoordeldonk MJ, Tak PP, Landewé RB.

J Rheumatol. 2015 Sep;42(9):1672-6. doi: 10.3899/jrheum.140956. Epub 2015 Jul 15.


Nuclear Factor-κB-inducing Kinase Is Expressed in Synovial Endothelial Cells in Patients with Early Arthritis and Correlates with Markers of Inflammation: A Prospective Cohort Study.

Maijer KI, Noort AR, de Hair MJ, van der Leij C, van Zoest KP, Choi IY, Gerlag DM, Maas M, Tak PP, Tas SW.

J Rheumatol. 2015 Sep;42(9):1573-81. doi: 10.3899/jrheum.150245. Epub 2015 Jul 15.


A clinically based protein discovery strategy to identify potential biomarkers of response to anti-TNF-α treatment of psoriatic arthritis.

Collins ES, Butt AQ, Gibson DS, Dunn MJ, Fearon U, van Kuijk AW, Gerlag DM, Pontifex E, Veale DJ, Tak PP, FitzGerald O, Pennington SR.

Proteomics Clin Appl. 2016 Jun;10(6):645-62. doi: 10.1002/prca.201500051. Epub 2015 Sep 28.


DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis.

Ai R, Whitaker JW, Boyle DL, Tak PP, Gerlag DM, Wang W, Firestein GS.

Arthritis Rheumatol. 2015 Jul;67(7):1978-80. doi: 10.1002/art.39123. No abstract available.


Preclinical inflammatory rheumatic diseases: an overview and relevant nomenclature.

Raza K, Gerlag DM.

Rheum Dis Clin North Am. 2014 Nov;40(4):569-80. doi: 10.1016/j.rdc.2014.07.001. Epub 2014 Sep 2. Review.


Discovery and confirmation of a protein biomarker panel with potential to predict response to biological therapy in psoriatic arthritis.

Ademowo OS, Hernandez B, Collins E, Rooney C, Fearon U, van Kuijk AW, Tak PP, Gerlag DM, FitzGerald O, Pennington SR.

Ann Rheum Dis. 2016 Jan;75(1):234-41. doi: 10.1136/annrheumdis-2014-205417. Epub 2014 Sep 3.


From synovial tissue to peripheral blood: myeloid related protein 8/14 is a sensitive biomarker for effective treatment in early drug development in patients with rheumatoid arthritis.

Choi IY, Gerlag DM, Holzinger D, Roth J, Tak PP.

PLoS One. 2014 Aug 28;9(8):e106253. doi: 10.1371/journal.pone.0106253. eCollection 2014.


Heterogeneous expression pattern of interleukin 17A (IL-17A), IL-17F and their receptors in synovium of rheumatoid arthritis, psoriatic arthritis and osteoarthritis: possible explanation for nonresponse to anti-IL-17 therapy?

van Baarsen LG, Lebre MC, van der Coelen D, Aarrass S, Tang MW, Ramwadhdoebe TH, Gerlag DM, Tak PP.

Arthritis Res Ther. 2014 Aug 22;16(4):426. doi: 10.1186/s13075-014-0426-z.


Clock gene expression in different synovial cells of patients with rheumatoid arthritis and osteoarthritis.

Becker T, Tohidast-Akrad M, Humpeler S, Gerlag DM, Kiener HP, Zenz P, Steiner G, Ekmekcioglu C.

Acta Histochem. 2014 Sep;116(7):1199-207. doi: 10.1016/j.acthis.2014.07.001. Epub 2014 Aug 7.


Citrullination of epithelial neutrophil-activating peptide 78/CXCL5 results in conversion from a non-monocyte-recruiting chemokine to a monocyte-recruiting chemokine.

Yoshida K, Korchynskyi O, Tak PP, Isozaki T, Ruth JH, Campbell PL, Baeten DL, Gerlag DM, Amin MA, Koch AE.

Arthritis Rheumatol. 2014 Oct;66(10):2716-27. doi: 10.1002/art.38750.


Preclinical characterisation of the GM-CSF receptor as a therapeutic target in rheumatoid arthritis.

Greven DE, Cohen ES, Gerlag DM, Campbell J, Woods J, Davis N, van Nieuwenhuijze A, Lewis A, Heasmen S, McCourt M, Corkill D, Dodd A, Elvin J, Statache G, Wicks IP, Anderson IK, Nash A, Sleeman MA, Tak PP.

Ann Rheum Dis. 2015 Oct;74(10):1924-30. doi: 10.1136/annrheumdis-2014-205234. Epub 2014 Jun 16.


Reply: To PMID 24574210.

de Hair MJ, van de Sande MG, Ramwadhdoebe TH, van der Leij C, Maas M, Hansson M, Klareskog L, Landewé R, Serre G, van Schaardenburg D, Gerlag DM, van Baarsen LG, Tak PP.

Arthritis Rheumatol. 2014 Jun;66(6):1683-4. doi: 10.1002/art.38411. No abstract available.


Features of the synovium of individuals at risk of developing rheumatoid arthritis: implications for understanding preclinical rheumatoid arthritis.

de Hair MJ, van de Sande MG, Ramwadhdoebe TH, Hansson M, Landewé R, van der Leij C, Maas M, Serre G, van Schaardenburg D, Klareskog L, Gerlag DM, van Baarsen LG, Tak PP.

Arthritis Rheumatol. 2014 Mar;66(3):513-22. doi: 10.1002/art.38273.


FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis in rheumatoid arthritis.

Ramos MI, Perez SG, Aarrass S, Helder B, Broekstra P, Gerlag DM, Reedquist KA, Tak PP, Lebre MC.

Arthritis Res Ther. 2013;15(6):R209.


MRP8/14 serum levels as a strong predictor of response to biological treatments in patients with rheumatoid arthritis.

Choi IY, Gerlag DM, Herenius MJ, Thurlings RM, Wijbrandts CA, Foell D, Vogl T, Roth J, Tak PP, Holzinger D.

Ann Rheum Dis. 2015 Mar;74(3):499-505. doi: 10.1136/annrheumdis-2013-203923. Epub 2013 Dec 2.


Local synovial engagement of angiogenic TIE-2 is associated with the development of persistent erosive rheumatoid arthritis in patients with early arthritis.

van de Sande MG, de Launay D, de Hair MJ, García S, van de Sande GP, Wijbrandts CA, Gerlag DM, Reedquist KA, Tak PP.

Arthritis Rheum. 2013 Dec;65(12):3073-83. doi: 10.1002/art.38128.


Pro-atherogenic lipid changes and decreased hepatic LDL receptor expression by tocilizumab in rheumatoid arthritis.

Strang AC, Bisoendial RJ, Kootte RS, Schulte DM, Dallinga-Thie GM, Levels JH, Kok M, Vos K, Tas SW, Tietge UJ, Müller N, Laudes M, Gerlag DM, Stroes ES, Tak PP.

Atherosclerosis. 2013 Jul;229(1):174-81. doi: 10.1016/j.atherosclerosis.2013.04.031. Epub 2013 May 11.


How to perform and analyse synovial biopsies.

Gerlag DM, Tak PP.

Best Pract Res Clin Rheumatol. 2013 Apr;27(2):195-207. doi: 10.1016/j.berh.2013.03.006. Review.


The cellular composition of lymph nodes in the earliest phase of inflammatory arthritis.

van Baarsen LG, de Hair MJ, Ramwadhdoebe TH, Zijlstra IJ, Maas M, Gerlag DM, Tak PP.

Ann Rheum Dis. 2013 Aug;72(8):1420-4. doi: 10.1136/annrheumdis-2012-202990. Epub 2013 May 9.

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