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Items: 1 to 50 of 80

1.

Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3.

de Las Rivas M, Paul Daniel EJ, Narimatsu Y, Compañón I, Kato K, Hermosilla P, Thureau A, Ceballos-Laita L, Coelho H, Bernadó P, Marcelo F, Hansen L, Maeda R, Lostao A, Corzana F, Clausen H, Gerken TA, Hurtado-Guerrero R.

Nat Chem Biol. 2020 Jan 13. doi: 10.1038/s41589-019-0444-x. [Epub ahead of print]

PMID:
31932717
2.

The structure of the colorectal cancer-associated enzyme GalNAc-T12 reveals how nonconserved residues dictate its function.

Fernandez AJ, Daniel EJP, Mahajan SP, Gray JJ, Gerken TA, Tabak LA, Samara NL.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20404-20410. doi: 10.1073/pnas.1902211116. Epub 2019 Sep 23.

3.

Two Hands Grip Better Than One for Tight Binding and Specificity: How a Phage Endolysin Fits into the Cell Wall of Its Host.

Buck M, Gerken T.

Structure. 2019 Sep 3;27(9):1350-1352. doi: 10.1016/j.str.2019.08.006.

PMID:
31484048
4.

Maximum carbon uptake rate dominates the interannual variability of global net ecosystem exchange.

Fu Z, Stoy PC, Poulter B, Gerken T, Zhang Z, Wakbulcho G, Niu S.

Glob Chang Biol. 2019 Oct;25(10):3381-3394. doi: 10.1111/gcb.14731. Epub 2019 Jul 11.

PMID:
31197940
5.

Human red and green cone opsins are O-glycosylated at an N-terminal Ser/Thr-rich domain conserved in vertebrates.

Salom D, Jin H, Gerken TA, Yu C, Huang L, Palczewski K.

J Biol Chem. 2019 May 17;294(20):8123-8133. doi: 10.1074/jbc.RA118.006835. Epub 2019 Apr 4.

PMID:
30948514
6.

Polypeptide GalNAc-Ts: from redundancy to specificity.

de Las Rivas M, Lira-Navarrete E, Gerken TA, Hurtado-Guerrero R.

Curr Opin Struct Biol. 2019 Jun;56:87-96. doi: 10.1016/j.sbi.2018.12.007. Epub 2019 Jan 28. Review.

PMID:
30703750
7.

Comprehensive plasma and tissue profiling reveals systemic metabolic alterations in cardiac hypertrophy and failure.

Müller OJ, Heckmann MB, Ding L, Rapti K, Rangrez AY, Gerken T, Christiansen N, Rennefahrt UEE, Witt H, González Maldonado S, Ternes P, Schwab DM, Ruf T, Hille S, Remes A, Jungmann A, Weis TM, Kreußer JS, Gröne HJ, Backs J, Schatz P, Katus HA, Frey N.

Cardiovasc Res. 2019 Jul 1;115(8):1296-1305. doi: 10.1093/cvr/cvy274.

PMID:
30418544
8.

Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4.

de Las Rivas M, Paul Daniel EJ, Coelho H, Lira-Navarrete E, Raich L, Compañón I, Diniz A, Lagartera L, Jiménez-Barbero J, Clausen H, Rovira C, Marcelo F, Corzana F, Gerken TA, Hurtado-Guerrero R.

ACS Cent Sci. 2018 Sep 26;4(9):1274-1290. doi: 10.1021/acscentsci.8b00488. Epub 2018 Sep 14.

9.

The Kobresia pygmaea ecosystem of the Tibetan highlands - Origin, functioning and degradation of the world's largest pastoral alpine ecosystem: Kobresia pastures of Tibet.

Miehe G, Schleuss PM, Seeber E, Babel W, Biermann T, Braendle M, Chen F, Coners H, Foken T, Gerken T, Graf HF, Guggenberger G, Hafner S, Holzapfel M, Ingrisch J, Kuzyakov Y, Lai Z, Lehnert L, Leuschner C, Li X, Liu J, Liu S, Ma Y, Miehe S, Mosbrugger V, Noltie HJ, Schmidt J, Spielvogel S, Unteregelsbacher S, Wang Y, Willinghöfer S, Xu X, Yang Y, Zhang S, Opgenoorth L, Wesche K.

Sci Total Environ. 2019 Jan 15;648:754-771. doi: 10.1016/j.scitotenv.2018.08.164. Epub 2018 Aug 14. Review.

10.

Evidence for GALNT12 as a moderate penetrance gene for colorectal cancer.

Evans DR, Venkitachalam S, Revoredo L, Dohey AT, Clarke E, Pennell JJ, Powell AE, Quinn E, Ravi L, Gerken TA, Green JS, Woods MO, Guda K.

Hum Mutat. 2018 Aug;39(8):1092-1101. doi: 10.1002/humu.23549. Epub 2018 May 28.

11.

Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions.

Sletmoen M, Gerken TA, Stokke BT, Burchell J, Brewer CF.

Glycobiology. 2018 Jul 1;28(7):437-442. doi: 10.1093/glycob/cwy032. Review.

12.

The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences.

de Las Rivas M, Lira-Navarrete E, Daniel EJP, Compañón I, Coelho H, Diniz A, Jiménez-Barbero J, Peregrina JM, Clausen H, Corzana F, Marcelo F, Jiménez-Osés G, Gerken TA, Hurtado-Guerrero R.

Nat Commun. 2017 Dec 5;8(1):1959. doi: 10.1038/s41467-017-02006-0.

13.

Revisiting the human polypeptide GalNAc-T1 and T13 paralogs.

Festari MF, Trajtenberg F, Berois N, Pantano S, Revoredo L, Kong Y, Solari-Saquieres P, Narimatsu Y, Freire T, Bay S, Robello C, Bénard J, Gerken TA, Clausen H, Osinaga E.

Glycobiology. 2017 Jan;27(2):140-153. doi: 10.1093/glycob/cww111. Epub 2016 Nov 22.

14.

Interactions of mucins with the Tn or Sialyl Tn cancer antigens including MUC1 are due to GalNAc-GalNAc interactions.

Haugstad KE, Hadjialirezaei S, Stokke BT, Brewer CF, Gerken TA, Burchell J, Picco G, Sletmoen M.

Glycobiology. 2016 Dec;26(12):1338-1350. Epub 2016 Jun 9.

15.

Biochemical and functional characterization of glycosylation-associated mutational landscapes in colon cancer.

Venkitachalam S, Revoredo L, Varadan V, Fecteau RE, Ravi L, Lutterbaugh J, Markowitz SD, Willis JE, Gerken TA, Guda K.

Sci Rep. 2016 Mar 23;6:23642. doi: 10.1038/srep23642.

16.

Mucin-type O-glycosylation is controlled by short- and long-range glycopeptide substrate recognition that varies among members of the polypeptide GalNAc transferase family.

Revoredo L, Wang S, Bennett EP, Clausen H, Moremen KW, Jarvis DL, Ten Hagen KG, Tabak LA, Gerken TA.

Glycobiology. 2016 Apr;26(4):360-76. doi: 10.1093/glycob/cwv108. Epub 2015 Nov 26.

17.

Erratum: UDP-N-acetyl-α-D-galactosamine: polypeptide N-acetylgalactosaminyltransferases: completion of the family tree.

Raman J, Guan Y, Perrine CL, Gerken TA, Tabak LA.

Glycobiology. 2015 Apr;25(4):465. doi: 10.1093/glycob/cwv003. No abstract available.

18.

Single molecule study of heterotypic interactions between mucins possessing the Tn cancer antigen.

Haugstad KE, Stokke BT, Brewer CF, Gerken TA, Sletmoen M.

Glycobiology. 2015 May;25(5):524-34. doi: 10.1093/glycob/cwu183. Epub 2014 Dec 19.

19.

Probing polypeptide GalNAc-transferase isoform substrate specificities by in vitro analysis.

Kong Y, Joshi HJ, Schjoldager KT, Madsen TD, Gerken TA, Vester-Christensen MB, Wandall HH, Bennett EP, Levery SB, Vakhrushev SY, Clausen H.

Glycobiology. 2015 Jan;25(1):55-65. doi: 10.1093/glycob/cwu089. Epub 2014 Aug 25.

20.

Cloning and sequencing of the chaetocin biosynthetic gene cluster.

Gerken T, Walsh CT.

Chembiochem. 2013 Nov 25;14(17):2256-8. doi: 10.1002/cbic.201300513. Epub 2013 Oct 2.

PMID:
24123808
21.

The lectin domain of the polypeptide GalNAc transferase family of glycosyltransferases (ppGalNAc Ts) acts as a switch directing glycopeptide substrate glycosylation in an N- or C-terminal direction, further controlling mucin type O-glycosylation.

Gerken TA, Revoredo L, Thome JJ, Tabak LA, Vester-Christensen MB, Clausen H, Gahlay GK, Jarvis DL, Johnson RW, Moniz HA, Moremen K.

J Biol Chem. 2013 Jul 5;288(27):19900-14. doi: 10.1074/jbc.M113.477877. Epub 2013 May 20.

22.

Enhanced self-association of mucins possessing the T and Tn carbohydrate cancer antigens at the single-molecule level.

Haugstad KE, Gerken TA, Stokke BT, Dam TK, Brewer CF, Sletmoen M.

Biomacromolecules. 2012 May 14;13(5):1400-9. doi: 10.1021/bm300135h. Epub 2012 Apr 3.

23.

O-glycoprotein biosynthesis: site localization by Edman degradation and site prediction based on random peptide substrates.

Gerken TA.

Methods Mol Biol. 2012;842:81-108. doi: 10.1007/978-1-61779-513-8_5.

PMID:
22259131
24.

UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree.

Raman J, Guan Y, Perrine CL, Gerken TA, Tabak LA.

Glycobiology. 2012 Jun;22(6):768-77. doi: 10.1093/glycob/cwr183. Epub 2011 Dec 20. Erratum in: Glycobiology. 2015 Apr;25(4):465.

25.

Control of mucin-type O-glycosylation: a classification of the polypeptide GalNAc-transferase gene family.

Bennett EP, Mandel U, Clausen H, Gerken TA, Fritz TA, Tabak LA.

Glycobiology. 2012 Jun;22(6):736-56. doi: 10.1093/glycob/cwr182. Epub 2011 Dec 18. Review.

26.

Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferases.

Gerken TA, Jamison O, Perrine CL, Collette JC, Moinova H, Ravi L, Markowitz SD, Shen W, Patel H, Tabak LA.

J Biol Chem. 2011 Apr 22;286(16):14493-507. doi: 10.1074/jbc.M111.218701. Epub 2011 Feb 24.

27.

Isoform-specific O-glycosylation of osteopontin and bone sialoprotein by polypeptide N-acetylgalactosaminyltransferase-1.

Miwa HE, Gerken TA, Jamison O, Tabak LA.

J Biol Chem. 2010 Jan 8;285(2):1208-19. doi: 10.1074/jbc.M109.035436. Epub 2009 Oct 30.

28.

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.

Church C, Lee S, Bagg EA, McTaggart JS, Deacon R, Gerken T, Lee A, Moir L, Mecinović J, Quwailid MM, Schofield CJ, Ashcroft FM, Cox RD.

PLoS Genet. 2009 Aug;5(8):e1000599. doi: 10.1371/journal.pgen.1000599. Epub 2009 Aug 14.

29.

Inactivating germ-line and somatic mutations in polypeptide N-acetylgalactosaminyltransferase 12 in human colon cancers.

Guda K, Moinova H, He J, Jamison O, Ravi L, Natale L, Lutterbaugh J, Lawrence E, Lewis S, Willson JK, Lowe JB, Wiesner GL, Parmigiani G, Barnholtz-Sloan J, Dawson DW, Velculescu VE, Kinzler KW, Papadopoulos N, Vogelstein B, Willis J, Gerken TA, Markowitz SD.

Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12921-5. doi: 10.1073/pnas.0901454106. Epub 2009 Jul 17.

30.

Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2.

Perrine CL, Ganguli A, Wu P, Bertozzi CR, Fritz TA, Raman J, Tabak LA, Gerken TA.

J Biol Chem. 2009 Jul 24;284(30):20387-97. doi: 10.1074/jbc.M109.017236. Epub 2009 May 21.

31.

Single-molecule pair studies of the interactions of the alpha-GalNAc (Tn-antigen) form of porcine submaxillary mucin with soybean agglutinin.

Sletmoen M, Dam TK, Gerken TA, Stokke BT, Brewer CF.

Biopolymers. 2009 Sep;91(9):719-28. doi: 10.1002/bip.21213.

32.

Thermodynamics of multivalent carbohydrate-lectin cross-linking interactions: importance of entropy in the bind and jump mechanism.

Dam TK, Gerken TA, Brewer CF.

Biochemistry. 2009 May 12;48(18):3822-7. doi: 10.1021/bi9002919.

33.

Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5.

Miwa HE, Gerken TA, Huynh TD, Duesler LR, Cotter M, Hering TM.

Biochim Biophys Acta. 2009 Mar;1790(3):161-72. doi: 10.1016/j.bbagen.2008.11.008. Epub 2008 Dec 6.

34.

Systematic determination of the peptide acceptor preferences for the human UDP-Gal:glycoprotein-alpha-GalNAc beta 3 galactosyltransferase (T-synthase).

Perrine C, Ju T, Cummings RD, Gerken TA.

Glycobiology. 2009 Mar;19(3):321-8. doi: 10.1093/glycob/cwn143. Epub 2008 Dec 10.

35.

Conservation of peptide acceptor preferences between Drosophila and mammalian polypeptide-GalNAc transferase ortholog pairs.

Gerken TA, Ten Hagen KG, Jamison O.

Glycobiology. 2008 Nov;18(11):861-70. doi: 10.1093/glycob/cwn073. Epub 2008 Jul 31.

36.

The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selection.

Raman J, Fritz TA, Gerken TA, Jamison O, Live D, Liu M, Tabak LA.

J Biol Chem. 2008 Aug 22;283(34):22942-51. doi: 10.1074/jbc.M803387200. Epub 2008 Jun 18.

37.

The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase.

Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, Yeo GS, McDonough MA, Cunliffe S, McNeill LA, Galvanovskis J, Rorsman P, Robins P, Prieur X, Coll AP, Ma M, Jovanovic Z, Farooqi IS, Sedgwick B, Barroso I, Lindahl T, Ponting CP, Ashcroft FM, O'Rahilly S, Schofield CJ.

Science. 2007 Nov 30;318(5855):1469-72. Epub 2007 Nov 8.

38.

Yearling male great tits, Parus major, suffer more strongly from cuckoldry than older males.

Lubjuhn T, Gerken T, Brün J, Schmoll T.

Zoology (Jena). 2007;110(5):387-97. Epub 2007 Sep 20.

PMID:
17888642
39.

Binding studies of alpha-GalNAc-specific lectins to the alpha-GalNAc (Tn-antigen) form of porcine submaxillary mucin and its smaller fragments.

Dam TK, Gerken TA, Cavada BS, Nascimento KS, Moura TR, Brewer CF.

J Biol Chem. 2007 Sep 21;282(38):28256-63. Epub 2007 Jul 25.

40.

Quantification of human beta-defensin-2 and -3 in body fluids: application for studies of innate immunity.

Ghosh SK, Gerken TA, Schneider KM, Feng Z, McCormick TS, Weinberg A.

Clin Chem. 2007 Apr;53(4):757-65. Epub 2007 Feb 22.

41.

Effects of covalently attached chondroitin sulfate on aggrecan cleavage by ADAMTS-4 and MMP-13.

Miwa HE, Gerken TA, Hering TM.

Matrix Biol. 2006 Oct;25(8):534-45. Epub 2006 Jul 25.

PMID:
16945513
43.

Mammalian expression of full-length bovine aggrecan and link protein: formation of recombinant proteoglycan aggregates and analysis of proteolytic cleavage by ADAMTS-4 and MMP-13.

Miwa HE, Gerken TA, Huynh TD, Flory DM, Hering TM.

Biochim Biophys Acta. 2006 Mar;1760(3):472-86. Epub 2005 Dec 29.

PMID:
16427204
44.

Structure-activity relationships of different beta-lactam antibiotics against a soluble form of Enterococcus faecium PBP5, a type II bacterial transpeptidase.

Hujer AM, Kania M, Gerken T, Anderson VE, Buynak JD, Ge X, Caspers P, Page MG, Rice LB, Bonomo RA.

Antimicrob Agents Chemother. 2005 Feb;49(2):612-8.

46.

Deconvoluting the functions of polypeptide N-alpha-acetylgalactosaminyltransferase family members by glycopeptide substrate profiling.

Pratt MR, Hang HC, Ten Hagen KG, Rarick J, Gerken TA, Tabak LA, Bertozzi CR.

Chem Biol. 2004 Jul;11(7):1009-16.

48.

Functional characterization and expression analysis of members of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family from Drosophila melanogaster.

Ten Hagen KG, Tran DT, Gerken TA, Stein DS, Zhang Z.

J Biol Chem. 2003 Sep 12;278(37):35039-48. Epub 2003 Jun 26.

50.

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