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GALAD Score Detects Early Hepatocellular Carcinoma in an International Cohort of Patients With Nonalcoholic Steatohepatitis.

Best J, Bechmann LP, Sowa JP, Sydor S, Dechêne A, Pflanz K, Bedreli S, Schotten C, Geier A, Berg T, Fischer J, Vogel A, Bantel H, Weinmann A, Schattenberg JM, Huber Y, Wege H, von Felden J, Schulze K, Bettinger D, Thimme R, Sinner F, Schütte K, Weiss KH, Toyoda H, Yasuda S, Kumada T, Berhane S, Wichert M, Heider D, Gerken G, Johnson P, Canbay A.

Clin Gastroenterol Hepatol. 2019 Nov 8. pii: S1542-3565(19)31267-4. doi: 10.1016/j.cgh.2019.11.012. [Epub ahead of print]


The predictive performance of SAPS 2 and SAPS 3 in an intermediate care unit for internal medicine at a German university transplant center; A retrospective analysis.

Jahn M, Rekowski J, Gerken G, Kribben A, Canbay A, Katsounas A.

PLoS One. 2019 Sep 25;14(9):e0222164. doi: 10.1371/journal.pone.0222164. eCollection 2019.


Enzymatic liver function measured by LiMAx - a reliable diagnostic and prognostic tool in chronic liver disease.

Buechter M, Kersting S, Gerken G, Kahraman A.

Sci Rep. 2019 Sep 19;9(1):13577. doi: 10.1038/s41598-019-49746-1.


Health outcome of older hospitalized patients in internal medicine environments evaluated by Identification of Seniors at Risk (ISAR) screening and geriatric assessment.

Scharf AC, Gronewold J, Dahlmann C, Schlitzer J, Kribben A, Gerken G, Rassaf T, Kleinschnitz C, Dodel R, Frohnhofen H, Hermann DM.

BMC Geriatr. 2019 Aug 14;19(1):221. doi: 10.1186/s12877-019-1239-3.


Low Free Triiodothyronine Is Associated with Advanced Fibrosis in Patients at High Risk for Nonalcoholic Steatohepatitis.

Manka P, Bechmann L, Best J, Sydor S, Claridge LC, Coombes JD, Canbay A, Moeller L, Gerken G, Wedemeyer H, Syn WK.

Dig Dis Sci. 2019 Aug;64(8):2351-2358. doi: 10.1007/s10620-019-05687-3. Epub 2019 Jun 3.


Single-Center Retrospective Study of Clinical and Laboratory Features That Predict Survival of Patients With Budd-Chiari Syndrome After Liver Transplant.

Jeschke B, Gottlieb A, Sowa JP, Jeschke S, Treckmann JW, Gerken G, Canbay A.

Exp Clin Transplant. 2019 Oct;17(5):665-672. doi: 10.6002/ect.2018.0274. Epub 2019 May 2.


Immunoglobulin G4-Related Pancreatitis: Our Experience in a German Cohort of 59 Patients.

Buechter M, Gerken G, Kahraman A.

Pancreas. 2019 Mar;48(3):e17-e19. doi: 10.1097/MPA.0000000000001264. No abstract available.


Ramucirumab after sorafenib in patients with advanced hepatocellular carcinoma and increased α-fetoprotein concentrations (REACH-2): a randomised, double-blind, placebo-controlled, phase 3 trial.

Zhu AX, Kang YK, Yen CJ, Finn RS, Galle PR, Llovet JM, Assenat E, Brandi G, Pracht M, Lim HY, Rau KM, Motomura K, Ohno I, Merle P, Daniele B, Shin DB, Gerken G, Borg C, Hiriart JB, Okusaka T, Morimoto M, Hsu Y, Abada PB, Kudo M; REACH-2 study investigators.

Lancet Oncol. 2019 Feb;20(2):282-296. doi: 10.1016/S1470-2045(18)30937-9. Epub 2019 Jan 18.


Treatment With Grazoprevir/Elbasvir for Renal Transplant Recipients With Chronic Hepatitis C Virus Infection and Impaired Allograft Function.

Eisenberger U, Friebus-Kardash J, Guberina H, Kribben A, Witzke O, Willuweit K, Gerken G, Herzer K.

Transplant Direct. 2018 Dec 27;5(1):e419. doi: 10.1097/TXD.0000000000000860. eCollection 2019 Jan.


Long-term outcome of patients with advanced pancreatic cancer treated with sequential chemotherapies before the era of modern combination therapy protocols.

Abendroth A, Noureddine R, Abramczyk M, Paul A, Gerken G, Schmid KW, Markus P, Schumacher B, Wiesweg M, Köhler J, Markus M, Mende B, Dechêne A, Schuler M, Kasper S.

J Cancer Res Clin Oncol. 2019 Feb;145(2):445-455. doi: 10.1007/s00432-018-2789-z. Epub 2018 Nov 14.


Liver Maximum Capacity: A Novel Test to Accurately Diagnose Different Stages of Liver Fibrosis.

Buechter M, Thimm J, Baba HA, Bertram S, Willuweit K, Gerken G, Kahraman A.

Digestion. 2019;100(1):45-54. doi: 10.1159/000493573. Epub 2018 Oct 2.


Clinical Outcome and Viral Genome Variability of Hepatitis B Virus-Induced Acute Liver Failure.

Anastasiou OE, Widera M, Westhaus S, Timmer L, Korth J, Gerken G, Canbay A, Todt D, Steinmann E, Schwarz T, Timm J, Verheyen J, Ciesek S.

Hepatology. 2019 Mar;69(3):993-1003. doi: 10.1002/hep.30279. Epub 2019 Feb 11.


How to Define Acute Liver Failure Patients with Pre-Existing Liver Disease without Signs of Cirrhosis.

Gottlieb A, Kottmann M, Manka P, Bedreli S, Hadem J, Bechmann L, Sowa JP, Gerken G, Canbay A.

Dig Dis. 2019;37(2):147-154. doi: 10.1159/000492869. Epub 2018 Sep 18.


Impact of direct-acting antiviral therapy on the need for liver transplantation related to hepatitis C in Germany.

Herzer K, Gerken G, Kroy D, Tacke F, Plewe J, Eurich D, Spengler U, Strassburg CP, Welker MW, Pischke S, Sterneck M, Mehrabi A, Weiss KH, Herber A, Berg T, Zimmermann T, Galle PR, Heinzow H, Schmidt H, Markova A, Serfert Y, Manns MP, Zeuzem S, Wedemeyer H.

J Hepatol. 2018 Oct;69(4):982-984. doi: 10.1016/j.jhep.2018.07.001. Epub 2018 Aug 6. No abstract available.


Liver maximum capacity (LiMAx) test as a helpful prognostic tool in acute liver failure with sepsis: a case report.

Buechter M, Gerken G, Hoyer DP, Bertram S, Theysohn JM, Thodou V, Kahraman A.

BMC Anesthesiol. 2018 Jun 20;18(1):71. doi: 10.1186/s12871-018-0538-0.


Spleen Stiffness Differentiates Between Acute and Chronic Liver Damage and Predicts Hepatic Decompensation.

Meister P, Dechêne A, Büchter M, Kälsch J, Gerken G, Canbay A, Jochum C.

J Clin Gastroenterol. 2019 Jul;53(6):457-463. doi: 10.1097/MCG.0000000000001044.


Corticosteroid Therapy Improves the Outcome of Autoimmune Hepatitis-Induced Acute Liver Failure.

Anastasiou OE, Dogan-Cavus B, Kucukoglu O, Baba H, Kahraman A, Gerken G, Schramm C, Canbay A.

Digestion. 2018;98(2):104-111. doi: 10.1159/000487940. Epub 2018 Apr 26.


Liver Regeneration-Related Cytokine Profiles in Donors and Recipients Before and After Living-Donor Liver Transplant.

Fingas CD, Beste M, Penndorf V, Sydor S, Nadalin S, Bechmann L, Paul A, Gerken G, Canbay A, Jochum C.

Exp Clin Transplant. 2018 Oct;16(5):554-561. doi: 10.6002/ect.2017.0039. Epub 2018 Apr 9.


Potential triggering factors of acute liver failure as a first manifestation of autoimmune hepatitis-a single center experience of 52 adult patients.

Buechter M, Manka P, Heinemann FM, Lindemann M, Baba HA, Schlattjan M, Canbay A, Gerken G, Kahraman A.

World J Gastroenterol. 2018 Apr 7;24(13):1410-1418. doi: 10.3748/wjg.v24.i13.1410.


IgG4-Associated Inflammatory Pseudotumor with Bilobar Hepatic Foci.

Büchter M, Gerken G, Kahraman A.

Dtsch Arztebl Int. 2018 Mar 16;115(11):181. doi: 10.3238/arztebl.2018.0181. No abstract available.


HBV reactivation in allogeneic stem cell transplant recipients: Risk factors, outcome, and role of hepatitis B virus mutations.

Anastasiou OE, Almpani F, Herrmann A, Gerken G, Ditschkowski M, Ciesek S.

Hepatol Commun. 2017 Nov 6;1(10):1014-1023. doi: 10.1002/hep4.1118. eCollection 2017 Dec.


Course of hepatitis E infection in a patient with rheumatoid arthritis and autoimmune hepatitis: A case report.

Thodou V, Buechter M, Manka P, Gerken G, Kahraman A.

Medicine (Baltimore). 2017 Dec;96(51):e9407. doi: 10.1097/MD.0000000000009407.


SPARC expression is associated with hepatic injury in rodents and humans with non-alcoholic fatty liver disease.

Mazzolini G, Atorrasagasti C, Onorato A, Peixoto E, Schlattjan M, Sowa JP, Sydor S, Gerken G, Canbay A.

Sci Rep. 2018 Jan 15;8(1):725. doi: 10.1038/s41598-017-18981-9.


Transjugular Intrahepatic Portosystemic Shunt in Patients with Portal Hypertension: Patency Depends on Coverage and Interventionalist's Experience.

Buechter M, Manka P, Gerken G, Canbay A, Blomeyer S, Wetter A, Altenbernd J, Kahraman A, Theysohn JM.

Dig Dis. 2018;36(3):218-227. doi: 10.1159/000486030. Epub 2018 Jan 9.


Successful treatment of cerebral aspergillosis: case report of a patient with T-cell large granular lymphocytic leukemia (T-LGL).

Turki AT, Rashidi-Alavijeh J, Dürig J, Gerken G, Rath PM, Witzke O.

BMC Infect Dis. 2017 Dec 28;17(1):797. doi: 10.1186/s12879-017-2877-8.


The influence of immunosuppressants on direct-acting antiviral therapy is dependent on the hepatitis C virus genotype.

Frey A, Piras-Straub K, Walker A, Timm J, Gerken G, Herzer K.

Transpl Infect Dis. 2018 Feb;20(1). doi: 10.1111/tid.12803. Epub 2017 Dec 21.


Long-term follow-up of clinical trial patients treated for chronic HCV infection with daclatasvir-based regimens.

Reddy KR, Pol S, Thuluvath PJ, Kumada H, Toyota J, Chayama K, Levin J, Lawitz EJ, Gadano A, Ghesquiere W, Gerken G, Brunetto MR, Peng CY, Silva M, Strasser SI, Heo J, McPhee F, Liu Z, Yang R, Linaberry M, Noviello S.

Liver Int. 2018 May;38(5):821-833. doi: 10.1111/liv.13596. Epub 2017 Oct 12.


Effects of the Mammalian Target of Rapamycin Inhibitor Everolimus on Hepatitis C Virus Replication In Vitro and In Vivo.

Frey A, Ecker EM, Piras-Straub K, Walker A, Hofmann TG, Timm J, Singer BB, Gerken G, Herzer K.

Transplant Proc. 2017 Oct;49(8):1947-1955. doi: 10.1016/j.transproceed.2017.04.012.


Clinical patterns associated with the concurrent detection of anti-HBs and HBV DNA.

Anastasiou OE, Widera M, Korth J, Kefalakes H, Katsounas A, Hilgard G, Gerken G, Canbay A, Ciesek S, Verheyen J.

J Med Virol. 2018 Feb;90(2):282-290. doi: 10.1002/jmv.24942. Epub 2017 Sep 26.


Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury.

Sydor S, Manka P, Best J, Jafoui S, Sowa JP, Zoubek ME, Hernandez-Gea V, Cubero FJ, Kälsch J, Vetter D, Fiel MI, Hoshida Y, Bian CB, Nelson LJ, Moshage H, Faber KN, Paul A, Baba HA, Gerken G, Friedman SL, Canbay A, Bechmann LP.

Sci Rep. 2017 Aug 14;7(1):8119. doi: 10.1038/s41598-017-08680-w.


Sorafenib in Patients with Hepatocellular Carcinoma-Results of the Observational INSIGHT Study.

Ganten TM, Stauber RE, Schott E, Malfertheiner P, Buder R, Galle PR, Göhler T, Walther M, Koschny R, Gerken G.

Clin Cancer Res. 2017 Oct 1;23(19):5720-5728. doi: 10.1158/1078-0432.CCR-16-0919. Epub 2017 Jul 11.


Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells.

Sydor S, Jafoui S, Wingerter L, Swoboda S, Mertens JC, Gerken G, Canbay A, Paul A, Fingas CD.

World J Gastroenterol. 2017 Jun 14;23(22):4007-4015. doi: 10.3748/wjg.v23.i22.4007.


Clinical course and core variability in HBV infected patients without detectable anti-HBc antibodies.

Anastasiou OE, Widera M, Verheyen J, Korth J, Gerken G, Helfritz FA, Canbay A, Wedemeyer H, Ciesek S.

J Clin Virol. 2017 Aug;93:46-52. doi: 10.1016/j.jcv.2017.06.001. Epub 2017 Jun 8.


Impact of Liver Indicators on Clinical Outcome in Patients Undergoing Transcatheter Aortic Valve Implantation.

Wendt D, Kahlert P, Canbay A, Knipp S, Thoenes M, Cremer G, Al-Rashid F, Jánosi RA, El-Chilali K, Kamler M, El Gabry M, Marx P, Dohle DS, Tsagakis K, Benedik J, Gerken G, Rassaf T, Jakob H, Thielmann M.

Ann Thorac Surg. 2017 Oct;104(4):1357-1364. doi: 10.1016/j.athoracsur.2017.02.075. Epub 2017 Jun 1.


Partial spleen embolization reduces the risk of portal hypertension-induced upper gastrointestinal bleeding in patients not eligible for TIPS implantation.

Buechter M, Kahraman A, Manka P, Gerken G, Dechêne A, Canbay A, Wetter A, Umutlu L, Theysohn JM.

PLoS One. 2017 May 11;12(5):e0177401. doi: 10.1371/journal.pone.0177401. eCollection 2017.


Acid sphingomyelinase deficiency in Western diet-fed mice protects against adipocyte hypertrophy and diet-induced liver steatosis.

Sydor S, Sowa JP, Megger DA, Schlattjan M, Jafoui S, Wingerter L, Carpinteiro A, Baba HA, Bechmann LP, Sitek B, Gerken G, Gulbins E, Canbay A.

Mol Metab. 2017 Mar 12;6(5):416-427. doi: 10.1016/j.molmet.2017.03.002. eCollection 2017 May.


Hepatic expression of oncogenes Bmi1 and Dkk1 is up-regulated in hepatitis B virus surface antigen-transgenic mice and can be induced by treatment with HBV particles or lipopolysaccharides in vitro.

Zhang R, Real CI, Liu C, Baba HA, Gerken G, Lu M, Broering R.

Int J Cancer. 2017 Jul 15;141(2):354-363. doi: 10.1002/ijc.30742. Epub 2017 May 8.


Tivantinib for the treatment of hepatocellular carcinoma.

Best J, Schotten C, Lohmann G, Gerken G, Dechêne A.

Expert Opin Pharmacother. 2017 May;18(7):727-733. doi: 10.1080/14656566.2017.1316376. Epub 2017 Apr 17. Review.


Monitoring of endoscope reprocessing with an adenosine triphosphate (ATP) bioluminescence method.

Parohl N, Stiefenhöfer D, Heiligtag S, Reuter H, Dopadlik D, Mosel F, Gerken G, Dechêne A, Heintschel von Heinegg E, Jochum C, Buer J, Popp W.

GMS Hyg Infect Control. 2017 Mar 27;12:Doc04. doi: 10.3205/dgkh000289. eCollection 2017.


Outcome and Genetic Factors in IgG4-Associated Autoimmune Pancreatitis and Cholangitis: A Single Center Experience.

Buechter M, Manka P, Heinemann FM, Lindemann M, Juntermanns B, Canbay A, Gerken G, Kahraman A.

Gastroenterol Res Pract. 2017;2017:6126707. doi: 10.1155/2017/6126707. Epub 2017 Mar 2.


Immunosuppression with mTOR inhibitors prevents the development of donor-specific antibodies after liver transplant.

Willuweit K, Heinold A, Rashidi-Alavijeh J, Heinemann FM, Horn PA, Paul A, Gerken G, Herzer K.

Clin Transplant. 2017 Jun;31(6). doi: 10.1111/ctr.12974. Epub 2017 Apr 16.


Nucleic acid-based polymers effective against hepatitis B Virus infection in patients don't harbor immunostimulatory properties in primary isolated liver cells.

Real CI, Werner M, Paul A, Gerken G, Schlaak JF, Vaillant A, Broering R.

Sci Rep. 2017 Mar 8;7:43838. doi: 10.1038/srep43838.


Microarrays-Enabled Hypothesis Generation: The Suspect Role of FNBP-1 in Neuropsychiatric Pathogenesis Associated with HIV and/or HCV Infection.

Katsounas A, Wilting KR, Lempicki RA, Schlaak JF, Gerken G.

J AIDS Clin Res. 2016 Dec;7(12). pii: 641. doi: 10.4172/2155-6113.1000641. Epub 2016 Dec 7.


[Obeticholic acid in primary biliary cholangitis : PBC OCA international study of efficacy (POISE)].

Gerken G, Nitschmann S.

Internist (Berl). 2017 Feb;58(2):202-204. doi: 10.1007/s00108-016-0185-9. German. No abstract available.


Low transferrin and high ferritin concentrations are associated with worse outcome in acute liver failure.

Anastasiou OE, Kälsch J, Hakmouni M, Kucukoglu O, Heider D, Korth J, Manka P, Sowa JP, Bechmann L, Saner FH, Paul A, Gerken G, Baba HA, Canbay A.

Liver Int. 2017 Jul;37(7):1032-1041. doi: 10.1111/liv.13369. Epub 2017 Feb 12.


Performance and Utility of Transient Elastography and Non-Invasive Markers of Liver Fiibrosis in Patients with Autoimmune Hepatitis: A Single Centre Experience.

E Anastasiou O, Büchter M, A Baba H, Korth J, Canbay A, Gerken G, Kahraman A.

Hepat Mon. 2016 Oct 31;16(11):e40737. doi: 10.5812/hepatmon.40737. eCollection 2016 Nov.


Novel implications in the treatment of hepatocellular carcinoma.

Best J, Schotten C, Theysohn JM, Wetter A, Müller S, Radünz S, Schulze M, Canbay A, Dechêne A, Gerken G.

Ann Gastroenterol. 2017;30(1):23-32. doi: 10.20524/aog.2016.0092. Epub 2016 Sep 30. Review.


Ledipasvir plus sofosbuvir fixed-dose combination for 6 weeks in patients with acute hepatitis C virus genotype 1 monoinfection (HepNet Acute HCV IV): an open-label, single-arm, phase 2 study.

Deterding K, Spinner CD, Schott E, Welzel TM, Gerken G, Klinker H, Spengler U, Wiegand J, Schulze Zur Wiesch J, Pathil A, Cornberg M, Umgelter A, Zöllner C, Zeuzem S, Papkalla A, Weber K, Hardtke S, von der Leyen H, Koch A, von Witzendorff D, Manns MP, Wedemeyer H; HepNet Acute HCV IV Study Group.

Lancet Infect Dis. 2017 Feb;17(2):215-222. doi: 10.1016/S1473-3099(16)30408-X. Epub 2016 Oct 28.


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