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Items: 43

1.

Pulchinenosides from Pulsatilla Chinensis Increase P-Glycoprotein Activity and Induce P-Glycoprotein Expression.

Liu Y, Zhang L, Wei S, Cai J, Zang Z, Wang M, Su D, Gerk PM.

Evid Based Complement Alternat Med. 2020 Feb 18;2020:4861719. doi: 10.1155/2020/4861719. eCollection 2020.

2.

Pharmacological characterization of 17-cyclopropylmethyl-3,14-dihydroxy-4,5-epoxy-6-[(3'-fluoro-4'-pyridyl)acetamido]morphinan (NFP) as a dual selective MOR/KOR ligand with potential applications in treating opioid use disorder.

Zheng Y, Obeng S, Reinecke BA, Chen C, Phansalkar PS, Walentiny DM, Gerk PM, Liu-Chen LY, Selley DE, Beardsley PM, Zhang Y.

Eur J Pharmacol. 2019 Dec 15;865:172812. doi: 10.1016/j.ejphar.2019.172812. Epub 2019 Nov 16.

PMID:
31743739
3.

Selectivity of Dietary Phenolics for Inhibition of Human Monoamine Oxidases A and B.

Zhang Z, Hamada H, Gerk PM.

Biomed Res Int. 2019 Jan 23;2019:8361858. doi: 10.1155/2019/8361858. eCollection 2019.

4.

Peroxynitrite and 4-Hydroxynonenal Inactivate Breast Cancer Resistance Protein/ABCG2.

Verenich S, Gerk PM.

Biomed Res Int. 2019 Jan 21;2019:3891535. doi: 10.1155/2019/3891535. eCollection 2019.

5.

Use of generally recognized as safe or dietary compounds to inhibit buprenorphine metabolism: potential to improve buprenorphine oral bioavailability.

Maharao N, Venitz J, Gerk PM.

Biopharm Drug Dispos. 2019 Jan;40(1):18-31. doi: 10.1002/bdd.2166. Epub 2019 Jan 1.

PMID:
30520057
6.

Preparation of phenylephrine 3-O-sulfate as the major in vivo metabolite of phenylephrine to facilitate its pharmacokinetic and metabolism studies.

Zhang Z, Zhang Y, Gerk PM.

J Pharmacol Toxicol Methods. 2019 Jan - Feb;95:66-69. doi: 10.1016/j.vascn.2018.11.009. Epub 2018 Nov 28.

PMID:
30502391
7.

Effects of generally recognized as safe (GRAS) and dietary compounds on phenylephrine metabolism in LS180 human intestinal cells.

Zhang Z, Gerk PM.

Biopharm Drug Dispos. 2018 Nov;39(9):443-447. doi: 10.1002/bdd.2162. Epub 2018 Nov 18.

PMID:
30368855
8.

Inhibition of glucuronidation and oxidative metabolism of buprenorphine using GRAS compounds or dietary constituents/supplements: in vitro proof of concept.

Maharao NV, Joshi AA, Gerk PM.

Biopharm Drug Dispos. 2017 Mar;38(2):139-154. doi: 10.1002/bdd.2050. Epub 2017 Jan 24.

PMID:
27925249
9.

Direct detection of phenylephrine 3-O-sulfate in LS180 human intestinal cells using a novel hydrophilic interaction liquid chromatography (HILIC) assay.

Shah HN, Halquist MT, Gerk PM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1;1040:67-72. doi: 10.1016/j.jchromb.2016.11.018. Epub 2016 Nov 13.

PMID:
27912158
10.

Placental ABC Transporters: Biological Impact and Pharmaceutical Significance.

Joshi AA, Vaidya SS, St-Pierre MV, Mikheev AM, Desino KE, Nyandege AN, Audus KL, Unadkat JD, Gerk PM.

Pharm Res. 2016 Dec;33(12):2847-2878. Epub 2016 Sep 19. Review.

11.

Improving the oral bioavailability of buprenorphine: an in-vivo proof of concept.

Joshi A, Halquist M, Konsoula Z, Liu Y, Jones JP 3rd, Heidbreder C, Gerk PM.

J Pharm Pharmacol. 2017 Jan;69(1):23-31. doi: 10.1111/jphp.12652. Epub 2016 Oct 26.

PMID:
27781278
12.

Quantitative determination of buprenorphine, naloxone and their metabolites in rat plasma using hydrophilic interaction liquid chromatography coupled with tandem mass spectrometry.

Joshi A, Parris B, Liu Y, Heidbreder C, Gerk PM, Halquist M.

Biomed Chromatogr. 2017 Feb;31(2). doi: 10.1002/bmc.3785. Epub 2016 Aug 22.

PMID:
27390058
13.

The Role of Megalin in the Transport of Gentamicin Across BeWo Cells, an In Vitro Model of the Human Placenta.

Akour AA, Kennedy MJ, Gerk PM.

AAPS J. 2015 Sep;17(5):1193-9. doi: 10.1208/s12248-015-9778-9. Epub 2015 May 19.

14.

Simultaneous determination of lopinavir and three ester prodrugs by LC-MS/MS in lysates of BeWo cells.

Wang M, Halquist MS, Zhang Y, Gerk PM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jan 15;975:84-90. doi: 10.1016/j.jchromb.2014.10.032. Epub 2014 Nov 3.

PMID:
25481295
15.

2-Methoxyestradiol in the human corpus luteum throughout the luteal phase and its influence on lutein cell steroidogenesis and angiogenic activity.

Kohen P, Henríquez S, Rojas C, Gerk PM, Palomino WA, Strauss JF 3rd, Devoto L.

Fertil Steril. 2013 Nov;100(5):1397-404. doi: 10.1016/j.fertnstert.2013.07.1980. Epub 2013 Aug 15.

PMID:
23954354
16.

Inhibition of P-glycoprotein by HIV protease inhibitors increases intracellular accumulation of berberine in murine and human macrophages.

Zha W, Wang G, Xu W, Liu X, Wang Y, Zha BS, Shi J, Zhao Q, Gerk PM, Studer E, Hylemon PB, Pandak WM Jr, Zhou H.

PLoS One. 2013;8(1):e54349. doi: 10.1371/journal.pone.0054349. Epub 2013 Jan 23.

17.

Design, synthesis, and biological evaluation of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)carboxamido]morphinan derivatives as peripheral selective μ opioid receptor Agents.

Yuan Y, Elbegdorj O, Chen J, Akubathini SK, Zhang F, Stevens DL, Beletskaya IO, Scoggins KL, Zhang Z, Gerk PM, Selley DE, Akbarali HI, Dewey WL, Zhang Y.

J Med Chem. 2012 Nov 26;55(22):10118-29. doi: 10.1021/jm301247n. Epub 2012 Nov 9.

18.

Characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives as novel leads to development of mu opioid receptor selective antagonists.

Yuan Y, Li G, He H, Stevens DL, Kozak P, Scoggins KL, Mitra P, Gerk PM, Selley DE, Dewey WL, Zhang Y.

ACS Chem Neurosci. 2011 Jul 20;2(7):346-51. doi: 10.1021/cn2000348. Epub 2011 May 6.

19.

Monitoring cellular accumulation of 3'-deoxy-3'-fluorothymidine (FLT) and its monophosphate metabolite (FLT-MP) by LC-MS/MS as a measure of cell proliferation in vitro.

Li W, Araya M, Elliott M, Kang X, Gerk PM, Halquist MS, Karnes HT, Zhang C, O'Brien PJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Oct 15;879(28):2963-70. doi: 10.1016/j.jchromb.2011.08.024. Epub 2011 Aug 31.

PMID:
21925976
20.

Postpartum pharmacokinetics of peramivir in the treatment of 2009 H1N1 influenza.

Clay PG, Adiga RB, Taylor TA, Alsup R, Gerk PM, McRae M.

Obstet Gynecol. 2011 Aug;118(2 Pt 2):463-7. doi: 10.1097/AOG.0b013e31821b1b3e.

21.

Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2).

Megaraj V, Zhao T, Paumi CM, Gerk PM, Kim RB, Vore M.

Pharmacogenet Genomics. 2011 Aug;21(8):506-15. doi: 10.1097/FPC.0b013e328348c786.

22.

Preclinical disposition (in vitro) of novel μ-opioid receptor selective antagonists.

Mitra P, Venitz J, Yuan Y, Zhang Y, Gerk PM.

Drug Metab Dispos. 2011 Sep;39(9):1589-96. doi: 10.1124/dmd.111.038588. Epub 2011 Jun 17.

23.

Monitoring rFVIIa 90 μg kg⁻¹ dosing in haemophiliacs: comparing laboratory response using various whole blood assays over 6 h.

Brophy DF, Martin EJ, Christian Barrett J, Nolte ME, Kuhn JG, Gerk PM, Carr ME, Pelzer H, Agersø H, Ezban M, Hedner U.

Haemophilia. 2011 Sep;17(5):e949-57. doi: 10.1111/j.1365-2516.2011.02492.x. Epub 2011 Mar 1.

PMID:
21362113
24.
25.

Quantitative immunofluorescent blotting of the multidrug resistance-associated protein 2 (MRP2).

Gerk PM.

J Pharmacol Toxicol Methods. 2011 May-Jun;63(3):279-82. doi: 10.1016/j.vascn.2011.01.003. Epub 2011 Jan 26.

26.

Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges.

Verenich S, Gerk PM.

Mol Pharm. 2010 Dec 6;7(6):2030-9. doi: 10.1021/mp100190f. Epub 2010 Oct 21. Review.

27.

"Clicked" bivalent ligands containing curcumin and cholesterol as multifunctional abeta oligomerization inhibitors: design, synthesis, and biological characterization.

Lenhart JA, Ling X, Gandhi R, Guo TL, Gerk PM, Brunzell DH, Zhang S.

J Med Chem. 2010 Aug 26;53(16):6198-209. doi: 10.1021/jm100601q.

PMID:
20666513
28.

Binding of lopinavir to human alpha1-acid glycoprotein and serum albumin.

Gulati A, Boudinot FD, Gerk PM.

Drug Metab Dispos. 2009 Aug;37(8):1572-5. doi: 10.1124/dmd.109.026708. Epub 2009 May 13.

29.
30.

Role of placental ATP-binding cassette (ABC) transporters in antiretroviral therapy during pregnancy.

Gulati A, Gerk PM.

J Pharm Sci. 2009 Jul;98(7):2317-35. doi: 10.1002/jps.21623. Review.

31.
32.

Human multidrug resistance protein 2 transports the therapeutic bile salt tauroursodeoxycholate.

Gerk PM, Li W, Megaraj V, Vore M.

J Pharmacol Exp Ther. 2007 Feb;320(2):893-9. Epub 2006 Nov 15.

PMID:
17108237
33.
34.

The role of protein synthesis and degradation in the post-transcriptional regulation of rat multidrug resistance-associated protein 2 (Mrp2, Abcc2).

Jones BR, Li W, Cao J, Hoffman TA, Gerk PM, Vore M.

Mol Pharmacol. 2005 Sep;68(3):701-10. Epub 2005 May 25.

PMID:
15917434
36.
37.

Basolateral active uptake of nitrofurantoin in the CIT3 cell culture model of lactation.

Gerk PM, Moscow JA, McNamara PJ.

Drug Metab Dispos. 2003 Jun;31(6):691-3.

PMID:
12756197
38.
39.
40.

Influence of lysine on cimetidine uptake and on excretion of cimetidine by the rat mammary gland.

Gerk PM, Paxton EW, Bandyopadhyay AM, McNamara PJ.

Adv Exp Med Biol. 2001;501:553-8.

PMID:
11787728
41.

Active transport of nitrofurantoin into human milk.

Gerk PM, Kuhn RJ, Desai NS, McNamara PJ.

Pharmacotherapy. 2001 Jun;21(6):669-75.

PMID:
11401180
42.

Interactions between cimetidine, nitrofurantoin, and probenecid active transport into rat milk.

Gerk PM, Oo CY, Paxton EW, Moscow JA, McNamara PJ.

J Pharmacol Exp Ther. 2001 Jan;296(1):175-80.

PMID:
11123378
43.

Effects of naltrexone pellet implantation on morphine tolerance and physical dependence in the rat.

Bhargava HN, Matwyshyn GA, Gerk PM, Bozek PS, Bailey MD, Ko KH, Simko RJ, Thorat SN.

Gen Pharmacol. 1994 Jan;25(1):149-55.

PMID:
8026700

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