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Items: 1 to 50 of 298

1.

Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1.

Zhao X, Nedvetsky P, Stanchi F, Vion AC, Popp O, Zühlke K, Dittmar G, Klussmann E, Gerhardt H.

Elife. 2019 Oct 3;8. pii: e46380. doi: 10.7554/eLife.46380.

2.

Artery-vein specification in the zebrafish trunk is pre-patterned by heterogeneous Notch activity and balanced by flow-mediated fine-tuning.

Geudens I, Coxam B, Alt S, Gebala V, Vion AC, Meier K, Rosa A, Gerhardt H.

Development. 2019 Aug 27;146(16). pii: dev181024. doi: 10.1242/dev.181024.

3.

ATTRACT.

Georgieva PB, Marchuk DA, Gerhardt H; Leducq ATTRACT Consortium*.

Circ Res. 2019 Jul 19;125(3):262-264. doi: 10.1161/CIRCRESAHA.119.315198. Epub 2019 Jul 18. No abstract available.

PMID:
31318652
4.

GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients.

Hu X, Matsumoto K, Jung RS, Weston TA, Heizer PJ, He C, Sandoval NP, Allan CM, Tu Y, Vinters HV, Liau LM, Ellison RM, Morales JE, Baufeld LJ, Bayley NA, He L, Betsholtz C, Beigneux AP, Nathanson DA, Gerhardt H, Young SG, Fong LG, Jiang H.

Elife. 2019 Jun 6;8. pii: e47178. doi: 10.7554/eLife.47178.

5.

Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2.

Hendrikx S, Coso S, Prat-Luri B, Wetterwald L, Sabine A, Franco CA, Nassiri S, Zangger N, Gerhardt H, Delorenzi M, Petrova TV.

Cell Rep. 2019 Jan 29;26(5):1227-1241.e6. doi: 10.1016/j.celrep.2019.01.016.

6.

Discovery of the Cyclic Lipopeptide Gacamide A by Genome Mining and Repair of the Defective GacA Regulator in Pseudomonas fluorescens Pf0-1.

Jahanshah G, Yan Q, Gerhardt H, Pataj Z, Lämmerhofer M, Pianet I, Josten M, Sahl HG, Silby MW, Loper JE, Gross H.

J Nat Prod. 2019 Feb 22;82(2):301-308. doi: 10.1021/acs.jnatprod.8b00747. Epub 2019 Jan 22.

PMID:
30666877
7.

Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility.

Angulo-Urarte A, Casado P, Castillo SD, Kobialka P, Kotini MP, Figueiredo AM, Castel P, Rajeeve V, Milà-Guasch M, Millan J, Wiesner C, Serra H, Muixi L, Casanovas O, Viñals F, Affolter M, Gerhardt H, Huveneers S, Belting HG, Cutillas PR, Graupera M.

Nat Commun. 2018 Nov 16;9(1):4826. doi: 10.1038/s41467-018-07172-3.

8.

Imaging Glioma Progression by Intravital Microscopy.

Stanchi F, Matsumoto K, Gerhardt H.

Methods Mol Biol. 2019;1862:227-243. doi: 10.1007/978-1-4939-8769-6_16.

PMID:
30315471
9.

Imaging of Endothelial Cell Dynamic Behavior in Zebrafish.

Coxam B, Gerhardt H.

Methods Mol Biol. 2018;1846:181-195. doi: 10.1007/978-1-4939-8712-2_12.

PMID:
30242760
10.

NanoSIMS imaging reveals unexpected heterogeneity in nutrient uptake by brown adipocytes.

He C, Hu X, Weston TA, Jung RS, Heizer P, Tu Y, Ellison R, Matsumoto K, Gerhardt H, Tontonoz P, Fong LG, Young SG, Jiang H.

Biochem Biophys Res Commun. 2018 Oct 12;504(4):899-902. doi: 10.1016/j.bbrc.2018.09.051. Epub 2018 Sep 15.

11.

Differences in healthcare costs in youths with conduct disorders in rural vs. urban regions: an analysis of German health insurance data.

Gerhardt H, Heinzel-Gutenbrunner M, Bachmann CJ.

BMC Health Serv Res. 2018 Sep 14;18(1):714. doi: 10.1186/s12913-018-3520-0.

12.

Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs.

Meyer K, Kirchner M, Uyar B, Cheng JY, Russo G, Hernandez-Miranda LR, Szymborska A, Zauber H, Rudolph IM, Willnow TE, Akalin A, Haucke V, Gerhardt H, Birchmeier C, Kühn R, Krauss M, Diecke S, Pascual JM, Selbach M.

Cell. 2018 Sep 20;175(1):239-253.e17. doi: 10.1016/j.cell.2018.08.019. Epub 2018 Sep 6.

13.

PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow.

Hikita T, Mirzapourshafiyi F, Barbacena P, Riddell M, Pasha A, Li M, Kawamura T, Brandes RP, Hirose T, Ohno S, Gerhardt H, Matsuda M, Franco CA, Nakayama M.

EMBO Rep. 2018 Sep;19(9). pii: e45253. doi: 10.15252/embr.201745253. Epub 2018 Jul 17.

14.

PolNet: A Tool to Quantify Network-Level Cell Polarity and Blood Flow in Vascular Remodeling.

Bernabeu MO, Jones ML, Nash RW, Pezzarossa A, Coveney PV, Gerhardt H, Franco CA.

Biophys J. 2018 May 8;114(9):2052-2058. doi: 10.1016/j.bpj.2018.03.032.

15.

Primary cilia sensitize endothelial cells to BMP and prevent excessive vascular regression.

Vion AC, Alt S, Klaus-Bergmann A, Szymborska A, Zheng T, Perovic T, Hammoutene A, Oliveira MB, Bartels-Klein E, Hollfinger I, Rautou PE, Bernabeu MO, Gerhardt H.

J Cell Biol. 2018 May 7;217(5):1651-1665. doi: 10.1083/jcb.201706151. Epub 2018 Mar 2.

16.

YAP and TAZ regulate adherens junction dynamics and endothelial cell distribution during vascular development.

Neto F, Klaus-Bergmann A, Ong YT, Alt S, Vion AC, Szymborska A, Carvalho JR, Hollfinger I, Bartels-Klein E, Franco CA, Potente M, Gerhardt H.

Elife. 2018 Feb 5;7. pii: e31037. doi: 10.7554/eLife.31037.

17.

Dynamic stroma reorganization drives blood vessel dysmorphia during glioma growth.

Mathivet T, Bouleti C, Van Woensel M, Stanchi F, Verschuere T, Phng LK, Dejaegher J, Balcer M, Matsumoto K, Georgieva PB, Belmans J, Sciot R, Stockmann C, Mazzone M, De Vleeschouwer S, Gerhardt H.

EMBO Mol Med. 2017 Dec;9(12):1629-1645. doi: 10.15252/emmm.201607445.

18.

Mouse Cutaneous Melanoma Induced by Mutant BRaf Arises from Expansion and Dedifferentiation of Mature Pigmented Melanocytes.

Köhler C, Nittner D, Rambow F, Radaelli E, Stanchi F, Vandamme N, Baggiolini A, Sommer L, Berx G, van den Oord JJ, Gerhardt H, Blanpain C, Marine JC.

Cell Stem Cell. 2017 Nov 2;21(5):679-693.e6. doi: 10.1016/j.stem.2017.08.003. Epub 2017 Oct 12.

19.

Leader preference in Neoconocephalus ensiger katydids: a female preference for a nonheritable male trait.

Murphy MA, Gerhardt HC, Schul J.

J Evol Biol. 2017 Dec;30(12):2222-2229. doi: 10.1111/jeb.13188. Epub 2017 Oct 16.

PMID:
28976614
20.

A reversible haploid mouse embryonic stem cell biobank resource for functional genomics.

Elling U, Wimmer RA, Leibbrandt A, Burkard T, Michlits G, Leopoldi A, Micheler T, Abdeen D, Zhuk S, Aspalter IM, Handl C, Liebergesell J, Hubmann M, Husa AM, Kinzer M, Schuller N, Wetzel E, van de Loo N, Martinez JAZ, Estoppey D, Riedl R, Yang F, Fu B, Dechat T, Ivics Z, Agu CA, Bell O, Blaas D, Gerhardt H, Hoepfner D, Stark A, Penninger JM.

Nature. 2017 Oct 5;550(7674):114-118. doi: 10.1038/nature24027. Epub 2017 Sep 27.

21.

Long-Lasting Enhancement of Visual Perception with Repetitive Noninvasive Transcranial Direct Current Stimulation.

Behrens JR, Kraft A, Irlbacher K, Gerhardt H, Olma MC, Brandt SA.

Front Cell Neurosci. 2017 Aug 15;11:238. doi: 10.3389/fncel.2017.00238. eCollection 2017.

22.

Hold Me, but Not Too Tight-Endothelial Cell-Cell Junctions in Angiogenesis.

Szymborska A, Gerhardt H.

Cold Spring Harb Perspect Biol. 2018 Aug 1;10(8). pii: a029223. doi: 10.1101/cshperspect.a029223. Review.

PMID:
28851748
23.

Oxytocin-enforced norm compliance reduces xenophobic outgroup rejection.

Marsh N, Scheele D, Feinstein JS, Gerhardt H, Strang S, Maier W, Hurlemann R.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9314-9319. doi: 10.1073/pnas.1705853114. Epub 2017 Aug 14.

24.

The endothelial transcription factor ERG mediates Angiopoietin-1-dependent control of Notch signalling and vascular stability.

Shah AV, Birdsey GM, Peghaire C, Pitulescu ME, Dufton NP, Yang Y, Weinberg I, Osuna Almagro L, Payne L, Mason JC, Gerhardt H, Adams RH, Randi AM.

Nat Commun. 2017 Jul 11;8:16002. doi: 10.1038/ncomms16002.

25.

Morph or Move? How Distinct Endothelial Cell Responses to Blood Flow Shape Vascular Networks.

Franco CA, Gerhardt H.

Dev Cell. 2017 Jun 19;41(6):574-576. doi: 10.1016/j.devcel.2017.06.008. Review.

26.

Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy.

Van Woensel M, Mathivet T, Wauthoz N, Rosière R, Garg AD, Agostinis P, Mathieu V, Kiss R, Lefranc F, Boon L, Belmans J, Van Gool SW, Gerhardt H, Amighi K, De Vleeschouwer S.

Sci Rep. 2017 Apr 27;7(1):1217. doi: 10.1038/s41598-017-01279-1.

27.

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.

Kammertoens T, Friese C, Arina A, Idel C, Briesemeister D, Rothe M, Ivanov A, Szymborska A, Patone G, Kunz S, Sommermeyer D, Engels B, Leisegang M, Textor A, Fehling HJ, Fruttiger M, Lohoff M, Herrmann A, Yu H, Weichselbaum R, Uckert W, Hübner N, Gerhardt H, Beule D, Schreiber H, Blankenstein T.

Nature. 2017 May 4;545(7652):98-102. doi: 10.1038/nature22311. Epub 2017 Apr 26.

28.

Pericytes or Mesenchymal Stem Cells: Is That the Question?

Cano E, Gebala V, Gerhardt H.

Cell Stem Cell. 2017 Mar 2;20(3):296-297. doi: 10.1016/j.stem.2017.02.005.

29.

A matter of distance-The effect of oxytocin on social discounting is empathy-dependent.

Strang S, Gerhardt H, Marsh N, Oroz Artigas S, Hu Y, Hurlemann R, Park SQ.

Psychoneuroendocrinology. 2017 Apr;78:229-232. doi: 10.1016/j.psyneuen.2017.01.031. Epub 2017 Feb 4.

PMID:
28219815
30.

cAMP-dependent protein kinase A (PKA) regulates angiogenesis by modulating tip cell behavior in a Notch-independent manner.

Nedvetsky PI, Zhao X, Mathivet T, Aspalter IM, Stanchi F, Metzger RJ, Mostov KE, Gerhardt H.

Development. 2016 Oct 1;143(19):3582-3590.

31.

Blood flow boosts BMP signaling to keep vessels in shape.

Franco CA, Gerhardt H.

J Cell Biol. 2016 Sep 26;214(7):793-5. doi: 10.1083/jcb.201609038.

32.

Glycolytic regulation of cell rearrangement in angiogenesis.

Cruys B, Wong BW, Kuchnio A, Verdegem D, Cantelmo AR, Conradi LC, Vandekeere S, Bouché A, Cornelissen I, Vinckier S, Merks RM, Dejana E, Gerhardt H, Dewerchin M, Bentley K, Carmeliet P.

Nat Commun. 2016 Jul 20;7:12240. doi: 10.1038/ncomms12240.

33.

Insect Adhesion Secretions: Similarities and Dissimilarities in Hydrocarbon Profiles of Tarsi and Corresponding Tibiae.

Gerhardt H, Betz O, Albert K, Lämmerhofer M.

J Chem Ecol. 2016 Aug;42(8):725-738. Epub 2016 Jul 5.

PMID:
27380036
34.

Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion.

Ubezio B, Blanco RA, Geudens I, Stanchi F, Mathivet T, Jones ML, Ragab A, Bentley K, Gerhardt H.

Elife. 2016 Apr 13;5. pii: e12167. doi: 10.7554/eLife.12167.

35.

Integrin signalling regulates YAP and TAZ to control skin homeostasis.

Elbediwy A, Vincent-Mistiaen ZI, Spencer-Dene B, Stone RK, Boeing S, Wculek SK, Cordero J, Tan EH, Ridgway R, Brunton VG, Sahai E, Gerhardt H, Behrens A, Malanchi I, Sansom OJ, Thompson BJ.

Development. 2016 May 15;143(10):1674-87. doi: 10.1242/dev.133728. Epub 2016 Mar 17.

36.

Blood flow drives lumen formation by inverse membrane blebbing during angiogenesis in vivo.

Gebala V, Collins R, Geudens I, Phng LK, Gerhardt H.

Nat Cell Biol. 2016 Apr;18(4):443-50. doi: 10.1038/ncb3320. Epub 2016 Feb 29.

37.

Development of siRNA-loaded chitosan nanoparticles targeting Galectin-1 for the treatment of glioblastoma multiforme via intranasal administration.

Van Woensel M, Wauthoz N, Rosière R, Mathieu V, Kiss R, Lefranc F, Steelant B, Dilissen E, Van Gool SW, Mathivet T, Gerhardt H, Amighi K, De Vleeschouwer S.

J Control Release. 2016 Apr 10;227:71-81. doi: 10.1016/j.jconrel.2016.02.032. Epub 2016 Feb 21.

PMID:
26902800
38.

Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling.

Franco CA, Jones ML, Bernabeu MO, Vion AC, Barbacena P, Fan J, Mathivet T, Fonseca CG, Ragab A, Yamaguchi TP, Coveney PV, Lang RA, Gerhardt H.

Elife. 2016 Feb 4;5:e07727. doi: 10.7554/eLife.07727.

39.

Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion.

Quétier I, Marshall JJT, Spencer-Dene B, Lachmann S, Casamassima A, Franco C, Escuin S, Worrall JT, Baskaran P, Rajeeve V, Howell M, Copp AJ, Stamp G, Rosewell I, Cutillas P, Gerhardt H, Parker PJ, Cameron AJM.

Cell Rep. 2016 Jan 26;14(3):440-448. doi: 10.1016/j.celrep.2015.12.049. Epub 2016 Jan 7.

40.

FOXO1 couples metabolic activity and growth state in the vascular endothelium.

Wilhelm K, Happel K, Eelen G, Schoors S, Oellerich MF, Lim R, Zimmermann B, Aspalter IM, Franco CA, Boettger T, Braun T, Fruttiger M, Rajewsky K, Keller C, Brüning JC, Gerhardt H, Carmeliet P, Potente M.

Nature. 2016 Jan 14;529(7585):216-20. doi: 10.1038/nature16498. Epub 2016 Jan 6.

41.

The Neuropeptide Oxytocin Induces a Social Altruism Bias.

Marsh N, Scheele D, Gerhardt H, Strang S, Enax L, Weber B, Maier W, Hurlemann R.

J Neurosci. 2015 Nov 25;35(47):15696-701. doi: 10.1523/JNEUROSCI.3199-15.2015.

42.

Incidental fear cues increase monetary loss aversion.

Schulreich S, Gerhardt H, Heekeren HR.

Emotion. 2016 Apr;16(3):402-12. doi: 10.1037/emo0000124. Epub 2015 Nov 23. Erratum in: Emotion. 2016 Dec;16(8):1185.

PMID:
26595436
43.

Corrigendum: Fatty acid carbon is essential for dNTP synthesis in endothelial cells.

Schoors S, Bruning U, Missiaen R, Queiroz KC, Borgers G, Elia I, Zecchin A, Cantelmo AR, Christen S, Goveia J, Heggermont W, Goddë L, Vinckier S, Van Veldhoven PP, Eelen G, Schoonjans L, Gerhardt H, Dewerchin M, Baes M, De Bock K, Ghesquière B, Lunt SY, Fendt SM, Carmeliet P.

Nature. 2015 Oct 1;526(7571):144. doi: 10.1038/nature14624. Epub 2015 Aug 5. No abstract available.

PMID:
26245368
44.

PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.

Serra H, Chivite I, Angulo-Urarte A, Soler A, Sutherland JD, Arruabarrena-Aristorena A, Ragab A, Lim R, Malumbres M, Fruttiger M, Potente M, Serrano M, Fabra À, Viñals F, Casanovas O, Pandolfi PP, Bigas A, Carracedo A, Gerhardt H, Graupera M.

Nat Commun. 2015 Jul 31;6:7935. doi: 10.1038/ncomms8935.

45.

Wiring the Vascular Network with Neural Cues: A CNS Perspective.

Wälchli T, Wacker A, Frei K, Regli L, Schwab ME, Hoerstrup SP, Gerhardt H, Engelhardt B.

Neuron. 2015 Jul 15;87(2):271-96. doi: 10.1016/j.neuron.2015.06.038. Review.

46.

Methods for the comprehensive structural elucidation of constitution and stereochemistry of lipopeptides.

Gerhardt H, Sievers-Engler A, Jahanshah G, Pataj Z, Ianni F, Gross H, Lindner W, Lämmerhofer M.

J Chromatogr A. 2016 Jan 8;1428:280-91. doi: 10.1016/j.chroma.2015.05.065. Epub 2015 Jun 5.

PMID:
26087965
47.

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch.

Aspalter IM, Gordon E, Dubrac A, Ragab A, Narloch J, Vizán P, Geudens I, Collins RT, Franco CA, Abrahams CL, Thurston G, Fruttiger M, Rosewell I, Eichmann A, Gerhardt H.

Nat Commun. 2015 Jun 17;6:7264. doi: 10.1038/ncomms8264.

48.

Correction: dynamic endothelial cell rearrangements drive developmental vessel regression.

Franco CA, Jones ML, Bernabeu MO, Geudens I, Mathivet T, Rosa A, Lopes FM, Lima AP, Ragab A, Collins RT, Phng LK, Coveney PV, Gerhardt H.

PLoS Biol. 2015 May 14;13(5):e1002163. doi: 10.1371/journal.pbio.1002163. eCollection 2015 May.

49.

Endothelial alpha-parvin controls integrity of developing vasculature and is required for maintenance of cell-cell junctions.

Fraccaroli A, Pitter B, Taha AA, Seebach J, Huveneers S, Kirsch J, Casaroli-Marano RP, Zahler S, Pohl U, Gerhardt H, Schnittler HJ, Montanez E.

Circ Res. 2015 Jun 19;117(1):29-40. doi: 10.1161/CIRCRESAHA.117.305818. Epub 2015 Apr 29.

50.

Dynamic endothelial cell rearrangements drive developmental vessel regression.

Franco CA, Jones ML, Bernabeu MO, Geudens I, Mathivet T, Rosa A, Lopes FM, Lima AP, Ragab A, Collins RT, Phng LK, Coveney PV, Gerhardt H.

PLoS Biol. 2015 Apr 17;13(4):e1002125. doi: 10.1371/journal.pbio.1002125. eCollection 2015 Apr. Erratum in: PLoS Biol. 2015 May;13(5):e1002163.

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