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Validations of apomorphine-induced BOLD activation correlations in hemiparkinsonian rhesus macaques.

Quintero JE, Ai Y, Andersen AH, Hardy P, Grondin R, Guduru Z, Gash DM, Gerhardt GA, Zhang Z.

Neuroimage Clin. 2019 Feb 18;22:101724. doi: 10.1016/j.nicl.2019.101724. [Epub ahead of print]


GDNF revisited: A novel mammalian cell-derived variant form of GDNF increases dopamine turnover and improves brain biodistribution.

Grondin R, Littrell OM, Zhang Z, Ai Y, Huettl P, Pomerleau F, Quintero JE, Andersen AH, Stenslik MJ, Bradley LH, Lemmon J, O'Neill MJ, Gash DM, Gerhardt GA.

Neuropharmacology. 2019 Mar 15;147:28-36. doi: 10.1016/j.neuropharm.2018.05.014. Epub 2018 May 29. Review.


Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain.

Geyer ED, Shetty PA, Suozzi CJ, Allen DZ, Benavidez PP, Liu J, Hollis CN, Gerhardt GA, Quintero JE, Burmeister JJ, Whitaker EE.

J Vis Exp. 2018 May 12;(135). doi: 10.3791/57391.


Methodology and effects of repeated intranasal delivery of DNSP-11 in awake Rhesus macaques.

Stenslik MJ, Evans A, Pomerleau F, Weeks R, Huettl P, Foreman E, Turchan-Cholewo J, Andersen A, Cass WA, Zhang Z, Grondin RC, Gash DM, Gerhardt GA, Bradley LH.

J Neurosci Methods. 2018 Jun 1;303:30-40. doi: 10.1016/j.jneumeth.2018.03.006. Epub 2018 Mar 31.


Peripheral nerve grafts implanted into the substantia nigra in patients with Parkinson's disease during deep brain stimulation surgery: 1-year follow-up study of safety, feasibility, and clinical outcome.

van Horne CG, Quintero JE, Slevin JT, Anderson-Mooney A, Gurwell JA, Welleford AS, Lamm JR, Wagner RP, Gerhardt GA.

J Neurosurg. 2018 Dec 1;129(6):1550-1561. doi: 10.3171/2017.8.JNS163222.


Simultaneous measurements of ascorbate and glutamate in vivo in the rat brain using carbon fiber nanocomposite sensors and microbiosensor arrays.

Ferreira NR, Ledo A, Laranjinha J, Gerhardt GA, Barbosa RM.

Bioelectrochemistry. 2018 Jun;121:142-150. doi: 10.1016/j.bioelechem.2018.01.009. Epub 2018 Jan 31.


Chronic Methylphenidate Alters Tonic and Phasic Glutamate Signaling in the Frontal Cortex of a Freely-Moving Rat Model of ADHD.

Miller EM, Quintero JE, Pomerleau F, Huettl P, Gerhardt GA, Glaser PEA.

Neurochem Res. 2019 Jan;44(1):89-101. doi: 10.1007/s11064-018-2483-1. Epub 2018 Feb 3.


The role of glutamate signaling in incentive salience: second-by-second glutamate recordings in awake Sprague-Dawley rats.

Batten SR, Pomerleau F, Quintero J, Gerhardt GA, Beckmann JS.

J Neurochem. 2018 May;145(4):276-286. doi: 10.1111/jnc.14298. Epub 2018 May 15.


Combined in Vivo Amperometric Oximetry and Electrophysiology in a Single Sensor: A Tool for Epilepsy Research.

Ledo A, Lourenço CF, Laranjinha J, Gerhardt GA, Barbosa RM.

Anal Chem. 2017 Nov 21;89(22):12383-12390. doi: 10.1021/acs.analchem.7b03452. Epub 2017 Nov 7.


Linking kindling to increased glutamate release in the dentate gyrus of the hippocampus through the STXBP5/tomosyn-1 gene.

Batten SR, Matveeva EA, Whiteheart SW, Vanaman TC, Gerhardt GA, Slevin JT.

Brain Behav. 2017 Aug 13;7(9):e00795. doi: 10.1002/brb3.795. eCollection 2017 Sep.


Neurometabolic and electrophysiological changes during cortical spreading depolarization: multimodal approach based on a lactate-glucose dual microbiosensor arrays.

Lourenço CF, Ledo A, Gerhardt GA, Laranjinha J, Barbosa RM.

Sci Rep. 2017 Jul 28;7(1):6764. doi: 10.1038/s41598-017-07119-6.


Acute treatment with doxorubicin affects glutamate neurotransmission in the mouse frontal cortex and hippocampus.

Thomas TC, Beitchman JA, Pomerleau F, Noel T, Jungsuwadee P, Butterfield DA, Clair DKS, Vore M, Gerhardt GA.

Brain Res. 2017 Oct 1;1672:10-17. doi: 10.1016/j.brainres.2017.07.003. Epub 2017 Jul 11.


Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice.

Sompol P, Furman JL, Pleiss MM, Kraner SD, Artiushin IA, Batten SR, Quintero JE, Simmerman LA, Beckett TL, Lovell MA, Murphy MP, Gerhardt GA, Norris CM.

J Neurosci. 2017 Jun 21;37(25):6132-6148. doi: 10.1523/JNEUROSCI.0877-17.2017. Epub 2017 May 30.


Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models.

Hunsberger HC, Setti SE, Heslin RT, Quintero JE, Gerhardt GA, Reed MN.

J Vis Exp. 2017 May 3;(123). doi: 10.3791/55418.


Ceramic-Based Multisite Platinum Microelectrode Arrays: Morphological Characteristics and Electrochemical Performance for Extracellular Oxygen Measurements in Brain Tissue.

Ledo A, Lourenço CF, Laranjinha J, Brett CM, Gerhardt GA, Barbosa RM.

Anal Chem. 2017 Feb 7;89(3):1674-1683. doi: 10.1021/acs.analchem.6b03772. Epub 2017 Jan 25.


Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies.

Deeb W, Giordano JJ, Rossi PJ, Mogilner AY, Gunduz A, Judy JW, Klassen BT, Butson CR, Van Horne C, Deny D, Dougherty DD, Rowell D, Gerhardt GA, Smith GS, Ponce FA, Walker HC, Bronte-Stewart HM, Mayberg HS, Chizeck HJ, Langevin JP, Volkmann J, Ostrem JL, Shute JB, Jimenez-Shahed J, Foote KD, Wagle Shukla A, Rossi MA, Oh M, Pourfar M, Rosenberg PB, Silburn PA, de Hemptine C, Starr PA, Denison T, Akbar U, Grill WM, Okun MS.

Front Integr Neurosci. 2016 Nov 22;10:38. eCollection 2016.


Target-directed discovery and production of pharmaceuticals in transgenic mutant plant cells.

Brown DP, Rogers DT, Gunjan SK, Gerhardt GA, Littleton JM.

J Biotechnol. 2016 Nov 20;238:9-14. doi: 10.1016/j.jbiotec.2016.09.007. Epub 2016 Sep 13.


A cognitive prosthesis for memory facilitation by closed-loop functional ensemble stimulation of hippocampal neurons in primate brain.

Deadwyler SA, Hampson RE, Song D, Opris I, Gerhardt GA, Marmarelis VZ, Berger TW.

Exp Neurol. 2017 Jan;287(Pt 4):452-460. doi: 10.1016/j.expneurol.2016.05.031. Epub 2016 May 24.


Continuous intranigral infusion is not associated with observable behavioral deficits or marked pathology: a preclinical safety study.

Grondin R, Ai Y, Hardy PA, Butt MT, Nelson BD, Lemmon JD, Bumcrot D, Gash DM, Gerhardt GA, Zhang Z.

J Neurosurg. 2017 Apr;126(4):1253-1262. doi: 10.3171/2016.2.JNS152295. Epub 2016 May 27.


Implantation of autologous peripheral nerve grafts into the substantia nigra of subjects with idiopathic Parkinson's disease treated with bilateral STN DBS: a report of safety and feasibility.

van Horne CG, Quintero JE, Gurwell JA, Wagner RP, Slevin JT, Gerhardt GA.

J Neurosurg. 2017 Apr;126(4):1140-1147. doi: 10.3171/2016.2.JNS151988. Epub 2016 May 6.


Novel multifunctional pharmacology of lobinaline, the major alkaloid from Lobelia cardinalis.

Brown DP, Rogers DT, Pomerleau F, Siripurapu KB, Kulshrestha M, Gerhardt GA, Littleton JM.

Fitoterapia. 2016 Jun;111:109-23. doi: 10.1016/j.fitote.2016.04.013. Epub 2016 Apr 20.


Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies.

Rossi PJ, Gunduz A, Judy J, Wilson L, Machado A, Giordano JJ, Elias WJ, Rossi MA, Butson CL, Fox MD, McIntyre CC, Pouratian N, Swann NC, de Hemptinne C, Gross RE, Chizeck HJ, Tagliati M, Lozano AM, Goodman W, Langevin JP, Alterman RL, Akbar U, Gerhardt GA, Grill WM, Hallett M, Herrington T, Herron J, van Horne C, Kopell BH, Lang AE, Lungu C, Martinez-Ramirez D, Mogilner AY, Molina R, Opri E, Otto KJ, Oweiss KG, Pathak Y, Shukla A, Shute J, Sheth SA, Shih LC, Steinke GK, Tröster AI, Vanegas N, Zaghloul KA, Cendejas-Zaragoza L, Verhagen L, Foote KD, Okun MS.

Front Neurosci. 2016 Apr 6;10:119. doi: 10.3389/fnins.2016.00119. eCollection 2016. Review.


Distributed encoding of spatial and object categories in primate hippocampal microcircuits.

Opris I, Santos LM, Gerhardt GA, Song D, Berger TW, Hampson RE, Deadwyler SA.

Front Neurosci. 2015 Oct 6;9:317. doi: 10.3389/fnins.2015.00317. eCollection 2015.


Effect of cocaine on striatal dopamine clearance in a rat model of developmental stress and attention-deficit/hyperactivity disorder.

Womersley JS, Kellaway LA, Stein DJ, Gerhardt GA, Russell VA.

Stress. 2016;19(1):78-82. doi: 10.3109/10253890.2015.1096925. Epub 2015 Oct 20.


Real-time monitoring of extracellular adenosine using enzyme-linked microelectrode arrays.

Hinzman JM, Gibson JL, Tackla RD, Costello MS, Burmeister JJ, Quintero JE, Gerhardt GA, Hartings JA.

Biosens Bioelectron. 2015 Dec 15;74:512-7. doi: 10.1016/j.bios.2015.06.074. Epub 2015 Jul 7.


Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression.

Hunsberger HC, Weitzner DS, Rudy CC, Hickman JE, Libell EM, Speer RR, Gerhardt GA, Reed MN.

J Neurochem. 2015 Oct;135(2):381-94. doi: 10.1111/jnc.13230. Epub 2015 Aug 13.


Disruption of columnar and laminar cognitive processing in primate prefrontal cortex following cocaine exposure.

Opris I, Gerhardt GA, Hampson RE, Deadwyler SA.

Front Syst Neurosci. 2015 May 29;9:79. doi: 10.3389/fnsys.2015.00079. eCollection 2015.


Tribute to: Dr. Vivienne Russell, Ph.D. on Attention-Deficit/Hyperactivity Disorder (ADHD).

Gerhardt GA, Miller EM, Womersley J.

J Neurosci Methods. 2015 Aug 30;252:1. doi: 10.1016/j.jneumeth.2015.05.007. Epub 2015 May 18. No abstract available.


Methodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease.

Stenslik MJ, Potts LF, Sonne JW, Cass WA, Turchan-Cholewo J, Pomerleau F, Huettl P, Ai Y, Gash DM, Gerhardt GA, Bradley LH.

J Neurosci Methods. 2015 Aug 15;251:120-9. doi: 10.1016/j.jneumeth.2015.05.006. Epub 2015 May 18.


Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions.

Hinzman JM, DiNapoli VA, Mahoney EJ, Gerhardt GA, Hartings JA.

Exp Neurol. 2015 May;267:243-53. doi: 10.1016/j.expneurol.2015.03.014. Epub 2015 Mar 24.


Streamlining deep brain stimulation surgery by reversing the staging order.

van Horne CG, Vaughan SW, Massari C, Bennett M, Asfahani WS, Quintero JE, Gerhardt GA.

J Neurosurg. 2015 May;122(5):1042-7. doi: 10.3171/2014.9.JNS14619. Epub 2015 Mar 6.


Simultaneous glutamate recordings in the frontal cortex network with multisite biomorphic microelectrodes: New tools for ADHD research.

Miller EM, Quintero JE, Pomerleau F, Huettl P, Gerhardt GA, Glaser PE.

J Neurosci Methods. 2015 Aug 30;252:75-9. doi: 10.1016/j.jneumeth.2015.01.018. Epub 2015 Jan 19.


Pharmacologic MRI (phMRI) as a tool to differentiate Parkinson's disease-related from age-related changes in basal ganglia function.

Andersen AH, Hardy PA, Forman E, Gerhardt GA, Gash DM, Grondin RC, Zhang Z.

Neurobiol Aging. 2015 Feb;36(2):1174-82. doi: 10.1016/j.neurobiolaging.2014.10.014. Epub 2014 Oct 16.


P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway.

Hunsberger HC, Rudy CC, Batten SR, Gerhardt GA, Reed MN.

J Neurochem. 2015 Jan;132(2):169-82. doi: 10.1111/jnc.12967. Epub 2014 Oct 31.


Tonic glutamate in CA1 of aging rats correlates with phasic glutamate dysregulation during seizure.

Stephens ML, Williamson A, Deel ME, Bensalem-Owen M, Davis VA, Slevin J, Pomerleau F, Huettl P, Gerhardt GA.

Epilepsia. 2014 Nov;55(11):1817-25. doi: 10.1111/epi.12797. Epub 2014 Sep 29.


Prefrontal cortical recordings with biomorphic MEAs reveal complex columnar-laminar microcircuits for BCI/BMI implementation.

Opris I, Fuqua JL, Gerhardt GA, Hampson RE, Deadwyler SA.

J Neurosci Methods. 2015 Apr 15;244:104-13. doi: 10.1016/j.jneumeth.2014.05.029. Epub 2014 Jun 2.


Aberrant glutamate signaling in the prefrontal cortex and striatum of the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder.

Miller EM, Pomerleau F, Huettl P, Gerhardt GA, Glaser PE.

Psychopharmacology (Berl). 2014 Aug;231(15):3019-29. doi: 10.1007/s00213-014-3479-4. Epub 2014 Feb 28.


Donor/recipient enhancement of memory in rat hippocampus.

Deadwyler SA, Berger TW, Sweatt AJ, Song D, Chan RH, Opris I, Gerhardt GA, Marmarelis VZ, Hampson RE.

Front Syst Neurosci. 2013 Dec 26;7:120. doi: 10.3389/fnsys.2013.00120. eCollection 2013.


Dynamic changes in dopamine neuron function after DNSP-11 treatment: effects in vivo and increased ERK 1/2 phosphorylation in vitro.

Fuqua JL, Littrell OM, Lundblad M, Turchan-Cholewo J, Abdelmoti LG, Galperin E, Bradley LH, Cass WA, Gash DM, Gerhardt GA.

Peptides. 2014 Apr;54:1-8. doi: 10.1016/j.peptides.2013.12.007. Epub 2014 Jan 7.


Cortical glutamate levels decrease in a non-human primate model of dopamine deficiency.

Fan XT, Zhao F, Ai Y, Andersen A, Hardy P, Ling F, Gerhardt GA, Zhang Z, Quintero JE.

Brain Res. 2014 Mar 13;1552:34-40. doi: 10.1016/j.brainres.2013.12.035. Epub 2014 Jan 4.


Serotonergic nerve fibers in L-DOPA-derived dopamine release and dyskinesia.

Nevalainen N, Af Bjerkén S, Gerhardt GA, Strömberg I.

Neuroscience. 2014 Feb 28;260:73-86. doi: 10.1016/j.neuroscience.2013.12.029. Epub 2013 Dec 18.


Facilitation of memory encoding in primate hippocampus by a neuroprosthesis that promotes task-specific neural firing.

Hampson RE, Song D, Opris I, Santos LM, Shin DC, Gerhardt GA, Marmarelis VZ, Berger TW, Deadwyler SA.

J Neural Eng. 2013 Dec;10(6):066013. doi: 10.1088/1741-2560/10/6/066013. Epub 2013 Nov 12.


Conformal ceramic electrodes that record glutamate release and corresponding neural activity in primate prefrontal cortex.

Hampson RE, Fuqua JL, Huettl PF, Opris I, Song D, Shin D, Marmarelis VZ, Berger TW, Gerhardt GA, Deadwyler SA.

Conf Proc IEEE Eng Med Biol Soc. 2013;2013:5954-7. doi: 10.1109/EMBC.2013.6610908.


Prefrontal cortical microcircuits bind perception to executive control.

Opris I, Santos L, Gerhardt GA, Song D, Berger TW, Hampson RE, Deadwyler SA.

Sci Rep. 2013;3:2285. doi: 10.1038/srep02285.


Glutaraldehyde cross-linked glutamate oxidase coated microelectrode arrays: selectivity and resting levels of glutamate in the CNS.

Burmeister JJ, Davis VA, Quintero JE, Pomerleau F, Huettl P, Gerhardt GA.

ACS Chem Neurosci. 2013 May 15;4(5):721-8. doi: 10.1021/cn4000555. Epub 2013 May 9.


Striatal glutamate release in L-DOPA-induced dyskinetic animals.

Nevalainen N, Lundblad M, Gerhardt GA, Strömberg I.

PLoS One. 2013;8(2):e55706. doi: 10.1371/journal.pone.0055706. Epub 2013 Feb 4.


Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF.

Littrell OM, Granholm AC, Gerhardt GA, Boger HA.

Pharmacol Biochem Behav. 2013 Mar;104:10-9. doi: 10.1016/j.pbb.2012.12.022. Epub 2013 Jan 2.


Closing the loop in primate prefrontal cortex: inter-laminar processing.

Opris I, Fuqua JL, Huettl PF, Gerhardt GA, Berger TW, Hampson RE, Deadwyler SA.

Front Neural Circuits. 2012 Nov 22;6:88. doi: 10.3389/fncir.2012.00088. eCollection 2012.


Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11.

Eriksson TM, Alvarsson A, Stan TL, Zhang X, Hascup KN, Hascup ER, Kehr J, Gerhardt GA, Warner-Schmidt J, Arango-Lievano M, Kaplitt MG, Ogren SO, Greengard P, Svenningsson P.

Mol Psychiatry. 2013 Oct;18(10):1096-105. doi: 10.1038/mp.2012.130. Epub 2012 Oct 2.


Columnar processing in primate pFC: evidence for executive control microcircuits.

Opris I, Hampson RE, Gerhardt GA, Berger TW, Deadwyler SA.

J Cogn Neurosci. 2012 Dec;24(12):2334-47. doi: 10.1162/jocn_a_00307. Epub 2012 Sep 27.

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