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Items: 1 to 50 of 73

1.

Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein.

Pinho R, Paiva I, Jercic KG, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, Garcia-Esparcia P, Kerimoglu C, Pavlou MA, Villar-Piqué A, Szego É, Fonseca TL, Odoardi F, Soeroes S, Rego AC, Fischle W, Schwamborn JC, Meyer T, Kügler S, Ferrer I, Attems J, Fischer A, Becker S, Zweckstetter M, Borovecki F, Outeiro TF.

Hum Mol Genet. 2018 Sep 13. doi: 10.1093/hmg/ddy326. [Epub ahead of print]

PMID:
30219847
2.

Membrane binding, internalization, and sorting of alpha-synuclein in the cell.

Masaracchia C, Hnida M, Gerhardt E, Lopes da Fonseca T, Villar-Pique A, Branco T, Stahlberg MA, Dean C, Fernández CO, Milosevic I, Outeiro TF.

Acta Neuropathol Commun. 2018 Aug 14;6(1):79. doi: 10.1186/s40478-018-0578-1.

3.

Kinetics and structural features of dimeric glutamine-dependent bacterial NAD+ synthetases suggest evolutionary adaptation to available metabolites.

Santos ARS, Gerhardt ECM, Moure VR, Pedrosa FO, Souza EM, Diamanti R, Högbom M, Huergo LF.

J Biol Chem. 2018 May 11;293(19):7397-7407. doi: 10.1074/jbc.RA118.002241. Epub 2018 Mar 26.

PMID:
29581233
4.

Correction: Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles.

Pinho R, Guedes LC, Soreq L, Lobo PP, Mestre T, Coelho M, Rosa MM, Gonçalves N, Wales P, Mendes T, Gerhardt E, Fahlbusch C, Bonifati V, Bonin M, Miltenberger-Miltényi G, Borovecki F, Soreq H, Ferreira JJ, Outeiro TF.

PLoS One. 2017 Dec 28;12(12):e0190552. doi: 10.1371/journal.pone.0190552. eCollection 2017.

5.

Proteome analysis of an Escherichia coli ptsN-null strain under different nitrogen regimes.

Gravina F, Sanchuki HS, Rodrigues TE, Gerhardt ECM, Pedrosa FO, Souza EM, Valdameri G, de Souza GA, Huergo LF.

J Proteomics. 2018 Mar 1;174:28-35. doi: 10.1016/j.jprot.2017.12.006. Epub 2017 Dec 21.

PMID:
29274402
6.

Production, purification, and characterization of a novel serine-esterase from Aspergillus westerdijkiae.

Castro FF, Pinheiro ABP, Gerhardt ECM, Oliveira MAS, Barbosa-Tessmann IP.

J Basic Microbiol. 2018 Feb;58(2):131-143. doi: 10.1002/jobm.201700509. Epub 2017 Nov 28.

PMID:
29193163
7.

The Effectiveness of Trivalent Inactivated Influenza Vaccine in Children with Acute Leukemia.

Sykes A, Gerhardt E, Tang L, Adderson EE.

J Pediatr. 2017 Dec;191:218-224.e1. doi: 10.1016/j.jpeds.2017.08.071.

PMID:
29173310
8.

Epidemiological study of facial fractures at the Oral and Maxillofacial Surgery Service, Santa Casa de Misericordia Hospital Complex, Porto Alegre - RS - Brazil.

Zamboni RA, Wagner JCB, Volkweis MR, Gerhardt EL, Buchmann EM, Bavaresco CS.

Rev Col Bras Cir. 2017 Sep-Oct;44(5):491-497. doi: 10.1590/0100-69912017005011. English, Portuguese.

9.

Expression and purification of untagged GlnK proteins from actinobacteria.

Gerhardt ECM, Moure VR, Souza AW, Pedrosa FO, Souza EM, Diacovich L, Gramajo H, Huergo LF.

EXCLI J. 2017 Jun 27;16:949-958. doi: 10.17179/excli2017-394. eCollection 2017.

10.

Implications of fALS Mutations on Sod1 Function and Oligomerization in Cell Models.

Brasil AA, Magalhães RSS, De Carvalho MDC, Paiva I, Gerhardt E, Pereira MD, Outeiro TF, Eleutherio ECA.

Mol Neurobiol. 2018 Jun;55(6):5269-5281. doi: 10.1007/s12035-017-0755-4. Epub 2017 Sep 7.

11.

Tau deletion promotes brain insulin resistance.

Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E, Pagesy P, Vileno M, Bournonville C, Hamdane M, Bantubungi K, Lancel S, Demeyer D, Eddarkaoui S, Vallez E, Vieau D, Humez S, Faivre E, Grenier-Boley B, Outeiro TF, Staels B, Amouyel P, Balschun D, Buee L, Blum D.

J Exp Med. 2017 Aug 7;214(8):2257-2269. doi: 10.1084/jem.20161731. Epub 2017 Jun 26.

12.

Sirtuin 2 enhances dopaminergic differentiation via the AKT/GSK-3β/β-catenin pathway.

Szegő ÉM, Gerhardt E, Outeiro TF.

Neurobiol Aging. 2017 Aug;56:7-16. doi: 10.1016/j.neurobiolaging.2017.04.001. Epub 2017 Apr 10.

PMID:
28478325
13.

Correction: The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.

PLoS Biol. 2017 Apr 5;15(4):e1002601. doi: 10.1371/journal.pbio.1002601. eCollection 2017 Apr.

14.

Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage.

Paiva I, Pinho R, Pavlou MA, Hennion M, Wales P, Schütz AL, Rajput A, Szego ÉM, Kerimoglu C, Gerhardt E, Rego AC, Fischer A, Bonn S, Outeiro TF.

Hum Mol Genet. 2017 Jun 15;26(12):2231-2246. doi: 10.1093/hmg/ddx114.

PMID:
28369321
15.

The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.

de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF.

PLoS Biol. 2017 Mar 3;15(3):e2000374. doi: 10.1371/journal.pbio.2000374. eCollection 2017 Mar. Erratum in: PLoS Biol. 2017 Apr 5;15(4):e1002601.

16.

Dynamics of the Escherichia coli proteome in response to nitrogen starvation and entry into the stationary phase.

Sanchuki HB, Gravina F, Rodrigues TE, Gerhardt EC, Pedrosa FO, Souza EM, Raittz RT, Valdameri G, de Souza GA, Huergo LF.

Biochim Biophys Acta Proteins Proteom. 2017 Mar;1865(3):344-352. doi: 10.1016/j.bbapap.2016.12.002. Epub 2016 Dec 8.

PMID:
27939605
17.
18.

Environmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.

Villar-Piqué A, Lopes da Fonseca T, Sant'Anna R, Szegö ÉM, Fonseca-Ornelas L, Pinho R, Carija A, Gerhardt E, Masaracchia C, Abad Gonzalez E, Rossetti G, Carloni P, Fernández CO, Foguel D, Milosevic I, Zweckstetter M, Ventura S, Outeiro TF.

Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6506-E6515. Epub 2016 Oct 5.

19.

Gene Expression Differences in Peripheral Blood of Parkinson's Disease Patients with Distinct Progression Profiles.

Pinho R, Guedes LC, Soreq L, Lobo PP, Mestre T, Coelho M, Rosa MM, Gonçalves N, Wales P, Mendes T, Gerhardt E, Fahlbusch C, Bonifati V, Bonin M, Miltenberger-Miltényi G, Borovecki F, Soreq H, Ferreira JJ, F Outeiro T.

PLoS One. 2016 Jun 20;11(6):e0157852. doi: 10.1371/journal.pone.0157852. eCollection 2016. Erratum in: PLoS One. 2017 Dec 28;12 (12 ):e0190552.

20.

Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells.

Oliveira LM, Falomir-Lockhart LJ, Botelho MG, Lin KH, Wales P, Koch JC, Gerhardt E, Taschenberger H, Outeiro TF, Lingor P, Schüle B, Arndt-Jovin DJ, Jovin TM.

Cell Death Dis. 2015 Nov 26;6:e1994. doi: 10.1038/cddis.2015.318.

21.

Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity.

Tenreiro S, Rosado-Ramos R, Gerhardt E, Favretto F, Magalhães F, Popova B, Becker S, Zweckstetter M, Braus GH, Outeiro TF.

Hum Mol Genet. 2016 Jan 15;25(2):275-90. doi: 10.1093/hmg/ddv470. Epub 2015 Nov 18.

PMID:
26586132
22.

2-Oxoglutarate levels control adenosine nucleotide binding by Herbaspirillum seropedicae PII proteins.

Oliveira MA, Gerhardt EC, Huergo LF, Souza EM, Pedrosa FO, Chubatsu LS.

FEBS J. 2015 Dec;282(24):4797-809. doi: 10.1111/febs.13542. Epub 2015 Oct 24.

23.

HMGB1 and RAGE in skeletal muscle inflammation: Implications for protein accumulation in inclusion body myositis.

Muth IE, Zschüntzsch J, Kleinschnitz K, Wrede A, Gerhardt E, Balcarek P, Schreiber-Katz O, Zierz S, Dalakas MC, Voll RE, Schmidt J.

Exp Neurol. 2015 Sep;271:189-97. doi: 10.1016/j.expneurol.2015.05.023. Epub 2015 Jun 3.

PMID:
26048613
24.

Clade 8 and Clade 6 Strains of Escherichia coli O157:H7 from Cattle in Argentina have Hypervirulent-Like Phenotypes.

Amigo N, Mercado E, Bentancor A, Singh P, Vilte D, Gerhardt E, Zotta E, Ibarra C, Manning SD, Larzábal M, Cataldi A.

PLoS One. 2015 Jun 1;10(6):e0127710. doi: 10.1371/journal.pone.0127710. eCollection 2015.

25.

LRRK2 Promotes Tau Accumulation, Aggregation and Release.

Guerreiro PS, Gerhardt E, Lopes da Fonseca T, Bähr M, Outeiro TF, Eckermann K.

Mol Neurobiol. 2016 Jul;53(5):3124-3135. doi: 10.1007/s12035-015-9209-z. Epub 2015 May 27.

PMID:
26014385
26.

Inhibition of water absorption and selective damage to human colonic mucosa induced by Shiga toxin-2 are enhanced by Escherichia coli O157:H7 infection.

Albanese A, Gerhardt E, García H, Amigo N, Cataldi A, Zotta E, Ibarra C.

Int J Med Microbiol. 2015 May;305(3):348-54. doi: 10.1016/j.ijmm.2015.02.002. Epub 2015 Mar 5.

PMID:
25794836
27.

The bacterial signal transduction protein GlnB regulates the committed step in fatty acid biosynthesis by acting as a dissociable regulatory subunit of acetyl-CoA carboxylase.

Gerhardt EC, Rodrigues TE, Müller-Santos M, Pedrosa FO, Souza EM, Forchhammer K, Huergo LF.

Mol Microbiol. 2015 Mar;95(6):1025-35. doi: 10.1111/mmi.12912. Epub 2015 Jan 30.

28.

Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.

Lázaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Kröhnert K, Klucken J, Pereira MD, Popova B, Kruse N, Mollenhauer B, Rizzoli SO, Braus GH, Danzer KM, Outeiro TF.

PLoS Genet. 2014 Nov 13;10(11):e1004741. doi: 10.1371/journal.pgen.1004741. eCollection 2014 Nov.

29.

Mutant huntingtin alters Tau phosphorylation and subcellular distribution.

Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, Demeyer D, Sergeant N, Gerhardt E, Brouillet E, Buée L, Outeiro TF.

Hum Mol Genet. 2015 Jan 1;24(1):76-85. doi: 10.1093/hmg/ddu421. Epub 2014 Aug 20.

PMID:
25143394
30.

Search for novel targets of the PII signal transduction protein in Bacteria identifies the BCCP component of acetyl-CoA carboxylase as a PII binding partner.

Rodrigues TE, Gerhardt EC, Oliveira MA, Chubatsu LS, Pedrosa FO, Souza EM, Souza GA, Müller-Santos M, Huergo LF.

Mol Microbiol. 2014 Feb;91(4):751-61. doi: 10.1111/mmi.12493. Epub 2014 Jan 6.

31.

Inhibition of water absorption and selective damage to human colonic mucosa are induced by subtilase cytotoxin produced by Escherichia coli O113:H21.

Gerhardt E, Masso M, Paton AW, Paton JC, Zotta E, Ibarra C.

Infect Immun. 2013 Aug;81(8):2931-7. doi: 10.1128/IAI.00287-13. Epub 2013 Jun 3.

32.

The nitrogenase regulatory enzyme dinitrogenase reductase ADP-ribosyltransferase (DraT) is activated by direct interaction with the signal transduction protein GlnB.

Moure VR, Danyal K, Yang ZY, Wendroth S, Müller-Santos M, Pedrosa FO, Scarduelli M, Gerhardt EC, Huergo LF, Souza EM, Seefeldt LC.

J Bacteriol. 2013 Jan;195(2):279-86. doi: 10.1128/JB.01517-12. Epub 2012 Nov 9.

33.

Vaccination of pregnant cows with EspA, EspB, γ-intimin, and Shiga toxin 2 proteins from Escherichia coli O157:H7 induces high levels of specific colostral antibodies that are transferred to newborn calves.

Rabinovitz BC, Gerhardt E, Tironi Farinati C, Abdala A, Galarza R, Vilte DA, Ibarra C, Cataldi A, Mercado EC.

J Dairy Sci. 2012 Jun;95(6):3318-26. doi: 10.3168/jds.2011-5093.

PMID:
22612965
34.

Influence of the ADP/ATP ratio, 2-oxoglutarate and divalent ions on Azospirillum brasilense PII protein signalling.

Gerhardt EC, Araújo LM, Ribeiro RR, Chubatsu LS, Scarduelli M, Rodrigues TE, Monteiro RA, Pedrosa FO, Souza EM, Huergo LF.

Microbiology. 2012 Jun;158(Pt 6):1656-63. doi: 10.1099/mic.0.058446-0. Epub 2012 Mar 29.

PMID:
22461486
35.

Microalbuminuria and early renal response to lethal dose Shiga toxin type 2 in rats.

Ochoa F, Oltra G, Gerhardt E, Hermes R, Cohen L, Damiano AE, Ibarra C, Lago NR, Zotta E.

Int J Nephrol Renovasc Dis. 2012;5:29-36. doi: 10.2147/IJNRD.S27623. Epub 2012 Jan 19.

36.

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity.

Butler EK, Voigt A, Lutz AK, Toegel JP, Gerhardt E, Karsten P, Falkenburger B, Reinartz A, Winklhofer KF, Schulz JB.

PLoS Genet. 2012 Feb;8(2):e1002488. doi: 10.1371/journal.pgen.1002488. Epub 2012 Feb 2.

37.

Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice.

Gerhardt E, Gräber S, Szego EM, Moisoi N, Martins LM, Outeiro TF, Kermer P.

PLoS One. 2011;6(12):e28855. doi: 10.1371/journal.pone.0028855. Epub 2011 Dec 19.

38.

Profile of Shiga toxin-producing Escherichia coli strains isolated from dogs and cats and genetic relationships with isolates from cattle, meat and humans.

Bentancor A, Rumi MV, Carbonari C, Gerhardt E, Larzábal M, Vilte DA, Pistone-Creydt V, Chinen I, Ibarra C, Cataldi A, Mercado EC.

Vet Microbiol. 2012 May 4;156(3-4):336-42. doi: 10.1016/j.vetmic.2011.10.030. Epub 2011 Nov 6.

PMID:
22119188
39.

Crystal structure of the GlnZ-DraG complex reveals a different form of PII-target interaction.

Rajendran C, Gerhardt EC, Bjelic S, Gasperina A, Scarduelli M, Pedrosa FO, Chubatsu LS, Merrick M, Souza EM, Winkler FK, Huergo LF, Li XD.

Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):18972-6. doi: 10.1073/pnas.1108038108. Epub 2011 Nov 9.

40.

A30P α-synuclein impairs dopaminergic fiber regeneration and interacts with L-DOPA replacement in MPTP-treated mice.

Szego ÉM, Gerhardt E, Kermer P, Schulz JB.

Neurobiol Dis. 2012 Jan;45(1):591-600. doi: 10.1016/j.nbd.2011.09.017. Epub 2011 Oct 7.

PMID:
22001606
41.

Heat stability of Proteobacterial PII protein facilitate purification using a single chromatography step.

Moure VR, Razzera G, Araújo LM, Oliveira MAS, Gerhardt ECM, Müller-Santos M, Almeida F, Pedrosa FO, Valente AP, Souza EM, Huergo LF.

Protein Expr Purif. 2012 Jan;81(1):83-88. doi: 10.1016/j.pep.2011.09.008. Epub 2011 Sep 22.

42.

Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice.

Szego ÉM, Gerhardt E, Outeiro TF, Kermer P.

J Neurol Sci. 2011 Nov 15;310(1-2):90-5. doi: 10.1016/j.jns.2011.06.048. Epub 2011 Jul 19.

PMID:
21774947
43.

In vitro interaction between the ammonium transport protein AmtB and partially uridylylated forms of the P(II) protein GlnZ.

Rodrigues TE, Souza VE, Monteiro RA, Gerhardt EC, Araújo LM, Chubatsu LS, Souza EM, Pedrosa FO, Huergo LF.

Biochim Biophys Acta. 2011 Sep;1814(9):1203-9. doi: 10.1016/j.bbapap.2011.05.012. Epub 2011 May 27.

44.

Fas/CD95 regulatory protein Faim2 is neuroprotective after transient brain ischemia.

Reich A, Spering C, Gertz K, Harms C, Gerhardt E, Kronenberg G, Nave KA, Schwab M, Tauber SC, Drinkut A, Harms K, Beier CP, Voigt A, Göbbels S, Endres M, Schulz JB.

J Neurosci. 2011 Jan 5;31(1):225-33. doi: 10.1523/JNEUROSCI.2188-10.2011.

45.

Functional role of brain-derived neurotrophic factor in neuroprotective autoimmunity: therapeutic implications in a model of multiple sclerosis.

Linker RA, Lee DH, Demir S, Wiese S, Kruse N, Siglienti I, Gerhardt E, Neumann H, Sendtner M, Lühder F, Gold R.

Brain. 2010 Aug;133(Pt 8):2248-63. doi: 10.1093/brain/awq179.

PMID:
20826430
46.

Characterization of stx2 tubular response in a rat experimental model of hemolytic uremic syndrome.

Ochoa F, Lago NR, Gerhardt E, Ibarra C, Zotta E.

Am J Nephrol. 2010;32(4):340-6. doi: 10.1159/000319444. Epub 2010 Aug 20.

PMID:
20733289
47.

Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors.

Krenz A, Falkenburger BH, Gerhardt E, Drinkut A, Schulz JB.

J Neurochem. 2009 Jan;108(1):139-46. doi: 10.1111/j.1471-4159.2008.05755.x.

48.

Inhibition of water absorption in human proximal tubular epithelial cells in response to Shiga toxin-2.

Silberstein C, Pistone Creydt V, Gerhardt E, Núñez P, Ibarra C.

Pediatr Nephrol. 2008 Nov;23(11):1981-90. doi: 10.1007/s00467-008-0896-9. Epub 2008 Jul 8.

PMID:
18607643
49.

Emergence of brain-derived neurotrophic factor-induced postsynaptic potentiation of NMDA currents during the postnatal maturation of the Kolliker-Fuse nucleus of rat.

Kron M, Reuter J, Gerhardt E, Manzke T, Zhang W, Dutschmann M.

J Physiol. 2008 May 1;586(9):2331-43. doi: 10.1113/jphysiol.2007.148916. Epub 2008 Mar 13.

50.

Oxidative stress in vero cells infected with vesicular stomatitis virus.

Riva DA, de Molina MC, Rocchetta I, Gerhardt E, Coulombié FC, Mersich SE.

Intervirology. 2006;49(5):294-8. Epub 2006 Jun 29.

PMID:
16809935

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