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Items: 36


In vivo Firre and Dxz4 deletion elucidates roles for autosomal gene regulation.

Andergassen D, Smith ZD, Lewandowski JP, Gerhardinger C, Meissner A, Rinn JL.

Elife. 2019 Nov 18;8. pii: e47214. doi: 10.7554/eLife.47214.


The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis.

Lewandowski JP, Lee JC, Hwang T, Sunwoo H, Goldstein JM, Groff AF, Chang NP, Mallard W, Williams A, Henao-Meija J, Flavell RA, Lee JT, Gerhardinger C, Wagers AJ, Rinn JL.

Nat Commun. 2019 Nov 13;10(1):5137. doi: 10.1038/s41467-019-12970-4.


High-throughput functional analysis of lncRNA core promoters elucidates rules governing tissue specificity.

Mattioli K, Volders PJ, Gerhardinger C, Lee JC, Maass PG, Melé M, Rinn JL.

Genome Res. 2019 Mar;29(3):344-355. doi: 10.1101/gr.242222.118. Epub 2019 Jan 25.


Dynamic changes during the treatment of pancreatic cancer.

Wolff RA, Wang-Gillam A, Alvarez H, Tiriac H, Engle D, Hou S, Groff AF, San Lucas A, Bernard V, Allenson K, Castillo J, Kim D, Mulu F, Huang J, Stephens B, Wistuba II, Katz M, Varadhachary G, Park Y, Hicks J, Chinnaiyan A, Scampavia L, Spicer T, Gerhardinger C, Maitra A, Tuveson D, Rinn J, Lizee G, Yee C, Levine AJ.

Oncotarget. 2018 Feb 13;9(19):14764-14790. doi: 10.18632/oncotarget.24483. eCollection 2018 Mar 13.


High-throughput identification of RNA nuclear enrichment sequences.

Shukla CJ, McCorkindale AL, Gerhardinger C, Korthauer KD, Cabili MN, Shechner DM, Irizarry RA, Maass PG, Rinn JL.

EMBO J. 2018 Mar 15;37(6). pii: e98452. doi: 10.15252/embj.201798452. Epub 2018 Jan 15.


The Increased Transforming Growth Factor-β Signaling Induced by Diabetes Protects Retinal Vessels.

Dagher Z, Gerhardinger C, Vaz J, Goodridge M, Tecilazich F, Lorenzi M.

Am J Pathol. 2017 Mar;187(3):627-638. doi: 10.1016/j.ajpath.2016.11.007. Epub 2017 Feb 2.


Chromatin environment, transcriptional regulation, and splicing distinguish lincRNAs and mRNAs.

Melé M, Mattioli K, Mallard W, Shechner DM, Gerhardinger C, Rinn JL.

Genome Res. 2017 Jan;27(1):27-37. doi: 10.1101/gr.214205.116. Epub 2016 Dec 7.


In vivo Ebola virus infection leads to a strong innate response in circulating immune cells.

Caballero IS, Honko AN, Gire SK, Winnicki SM, Melé M, Gerhardinger C, Lin AE, Rinn JL, Sabeti PC, Hensley LE, Connor JH.

BMC Genomics. 2016 Sep 5;17:707. doi: 10.1186/s12864-016-3060-0.


In Vivo Characterization of Linc-p21 Reveals Functional cis-Regulatory DNA Elements.

Groff AF, Sanchez-Gomez DB, Soruco MML, Gerhardinger C, Barutcu AR, Li E, Elcavage L, Plana O, Sanchez LV, Lee JC, Sauvageau M, Rinn JL.

Cell Rep. 2016 Aug 23;16(8):2178-2186. doi: 10.1016/j.celrep.2016.07.050. Epub 2016 Aug 11.


Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain.

Goff LA, Groff AF, Sauvageau M, Trayes-Gibson Z, Sanchez-Gomez DB, Morse M, Martin RD, Elcavage LE, Liapis SC, Gonzalez-Celeiro M, Plana O, Li E, Gerhardinger C, Tomassy GS, Arlotta P, Rinn JL.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6855-62.


Multiple knockout mouse models reveal lincRNAs are required for life and brain development.

Sauvageau M, Goff LA, Lodato S, Bonev B, Groff AF, Gerhardinger C, Sanchez-Gomez DB, Hacisuleyman E, Li E, Spence M, Liapis SC, Mallard W, Morse M, Swerdel MR, D'Ecclessis MF, Moore JC, Lai V, Gong G, Yancopoulos GD, Frendewey D, Kellis M, Hart RP, Valenzuela DM, Arlotta P, Rinn JL.

Elife. 2013 Dec 31;2:e01749. doi: 10.7554/eLife.01749.


IL-1β is upregulated in the diabetic retina and retinal vessels: cell-specific effect of high glucose and IL-1β autostimulation.

Liu Y, Biarnés Costa M, Gerhardinger C.

PLoS One. 2012;7(5):e36949. doi: 10.1371/journal.pone.0036949. Epub 2012 May 16.


Endothelial progenitor cells carrying monocyte markers are selectively abnormal in type 1 diabetic patients with early retinopathy.

Zerbini G, Maestroni A, Palini A, Tremolada G, Lattanzio R, Maestroni S, Pastore MR, Secchi A, Bonfanti R, Gerhardinger C, Lorenzi M.

Diabetes. 2012 Apr;61(4):908-14. doi: 10.2337/db11-1197. Epub 2012 Feb 14.


Decreased cerebrovascular brain-derived neurotrophic factor-mediated neuroprotection in the diabetic brain.

Navaratna D, Guo SZ, Hayakawa K, Wang X, Gerhardinger C, Lo EH.

Diabetes. 2011 Jun;60(6):1789-96. doi: 10.2337/db10-1371. Epub 2011 May 11.


The transforming growth factor-beta pathway is a common target of drugs that prevent experimental diabetic retinopathy.

Gerhardinger C, Dagher Z, Sebastiani P, Park YS, Lorenzi M.

Diabetes. 2009 Jul;58(7):1659-67. doi: 10.2337/db08-1008. Epub 2009 Apr 28.


Expression of acute-phase response proteins in retinal Müller cells in diabetes.

Gerhardinger C, Costa MB, Coulombe MC, Toth I, Hoehn T, Grosu P.

Invest Ophthalmol Vis Sci. 2005 Jan;46(1):349-57.


Studies of rat and human retinas predict a role for the polyol pathway in human diabetic retinopathy.

Dagher Z, Park YS, Asnaghi V, Hoehn T, Gerhardinger C, Lorenzi M.

Diabetes. 2004 Sep;53(9):2404-11.


A role for the polyol pathway in the early neuroretinal apoptosis and glial changes induced by diabetes in the rat.

Asnaghi V, Gerhardinger C, Hoehn T, Adeboje A, Lorenzi M.

Diabetes. 2003 Feb;52(2):506-11.


Early cellular and molecular changes induced by diabetes in the retina.

Lorenzi M, Gerhardinger C.

Diabetologia. 2001 Jul;44(7):791-804. Review.


IGF-I mRNA and signaling in the diabetic retina.

Gerhardinger C, McClure KD, Romeo G, Podestà F, Lorenzi M.

Diabetes. 2001 Jan;50(1):175-83.


Bax is increased in the retina of diabetic subjects and is associated with pericyte apoptosis in vivo and in vitro.

Podestà F, Romeo G, Liu WH, Krajewski S, Reed JC, Gerhardinger C, Lorenzi M.

Am J Pathol. 2000 Mar;156(3):1025-32.


Expression of vascular endothelial growth factor in the human retina and in nonproliferative diabetic retinopathy.

Gerhardinger C, Brown LF, Roy S, Mizutani M, Zucker CL, Lorenzi M.

Am J Pathol. 1998 Jun;152(6):1453-62.


Müller cell changes in human diabetic retinopathy.

Mizutani M, Gerhardinger C, Lorenzi M.

Diabetes. 1998 Mar;47(3):445-9.


Novel degradation pathway of glycated amino acids into free fructosamine by a Pseudomonas sp. soil strain extract.

Gerhardinger C, Marion MS, Rovner A, Glomb M, Monnier VM.

J Biol Chem. 1995 Jan 6;270(1):218-24.


Isolation, purification, and characterization of an Amadori product binding protein from a Pseudomonas sp. soil strain.

Gerhardinger C, Taneda S, Marion MS, Monnier VM.

J Biol Chem. 1994 Nov 4;269(44):27297-302.


A study on in vitro glycation processes by matrix-assisted laser desorption ionization mass spectrometry.

Lapolla A, Gerhardinger C, Baldo L, Fedele D, Keane A, Seraglia R, Catinella S, Traldi P.

Biochim Biophys Acta. 1993 Nov 25;1225(1):33-8.


The lysine glycation 1. A preliminary investigation on the products arising from the reaction of protected lysine and D-glucose.

Lapolla A, Gerhardinger C, Baldo L, Fedele D, Bertani R, Facchin G, Rizzi E, Catinella S, Seraglia R, Traldi P.

Amino Acids. 1993 Oct;5(3):389-401. doi: 10.1007/BF00806957.


Investigation of products arising from enzymatic digestion of advanced glycated albumin by high-performance liquid chromatography/mass spectrometry.

Lapolla A, Gerhardinger C, Baldo L, Crepaldi G, Fedele D, Porter CJ, Seraglia R, Favretto D, Traldi P.

Rapid Commun Mass Spectrom. 1991 Dec;5(12):624-8.


Mass spectrometric approaches in structural identification of the reaction products arising from the interaction between glucose and lysine.

Lapolla A, Gerhardinger C, Crepaldi G, Fedele D, Palumbo M, Dalzoppo D, Porter CJ, Ghezzo E, Seraglia R, Traldi P.

Talanta. 1991 Apr;38(4):405-12.


Evidence of acid hydrolysis as responsible for 2-(2-furoyl)-4(5)-(2-furanyl)-1H-imidazole (FFI) production.

Gerhardinger C, Lapolla A, Crepaldi G, Fedele D, Ghezzo E, Seraglia R, Traldi P.

Clin Chim Acta. 1990 Aug 31;189(3):335-40. No abstract available.


Identification of furoyl-containing advanced glycation products in collagen samples from diabetic and healthy rats.

Lapolla A, Gerhardinger C, Ghezzo E, Seraglia R, Sturaro A, Crepaldi G, Fedele D, Traldi P.

Biochim Biophys Acta. 1990 Jan 29;1033(1):13-8.


Absence of brown product FFI in nondiabetic and diabetic rat collagen.

Lapolla A, Gerhardinger C, Pelli B, Sturaro A, Del Favero E, Traldi P, Crepaldi G, Fedele D.

Diabetes. 1990 Jan;39(1):57-61.


Red cell sorbitol concentration in relation to short- and medium-term variation of plasma glucose.

Lapolla A, Tessari P, Franchin A, Gerhardinger C, Valerio A, Proto N, Fedele D.

Acta Diabetol Lat. 1989 Jul-Sep;26(3):211-6.


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