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Items: 42

1.

Specificity of RNAi, LNA and CRISPRi as loss-of-function methods in transcriptional analysis.

Stojic L, Lun ATL, Mangei J, Mascalchi P, Quarantotti V, Barr AR, Bakal C, Marioni JC, Gergely F, Odom DT.

Nucleic Acids Res. 2018 Jul 6;46(12):5950-5966. doi: 10.1093/nar/gky437.

PMID:
29860520
2.

Disease-Associated Mutations in CEP120 Destabilize the Protein and Impair Ciliogenesis.

Joseph N, Al-Jassar C, Johnson CM, Andreeva A, Barnabas DD, Freund SMV, Gergely F, van Breugel M.

Cell Rep. 2018 May 29;23(9):2805-2818. doi: 10.1016/j.celrep.2018.04.100.

3.

Mitotic spindle association of TACC3 requires Aurora-A-dependent stabilization of a cryptic α-helix.

Burgess SG, Mukherjee M, Sabir S, Joseph N, Gutiérrez-Caballero C, Richards MW, Huguenin-Dezot N, Chin JW, Kennedy EJ, Pfuhl M, Royle SJ, Gergely F, Bayliss R.

EMBO J. 2018 Apr 13;37(8). pii: e97902. doi: 10.15252/embj.201797902. Epub 2018 Mar 6.

4.

Neurodevelopmental protein Musashi-1 interacts with the Zika genome and promotes viral replication.

Chavali PL, Stojic L, Meredith LW, Joseph N, Nahorski MS, Sanford TJ, Sweeney TR, Krishna BA, Hosmillo M, Firth AE, Bayliss R, Marcelis CL, Lindsay S, Goodfellow I, Woods CG, Gergely F.

Science. 2017 Jul 7;357(6346):83-88. doi: 10.1126/science.aam9243. Epub 2017 Jun 1.

5.

A CEP215-HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer.

Chavali PL, Chandrasekaran G, Barr AR, Tátrai P, Taylor C, Papachristou EK, Woods CG, Chavali S, Gergely F.

Nat Commun. 2016 Mar 18;7:11005. doi: 10.1038/ncomms11005.

6.

Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions.

Stojic L, Niemczyk M, Orjalo A, Ito Y, Ruijter AE, Uribe-Lewis S, Joseph N, Weston S, Menon S, Odom DT, Rinn J, Gergely F, Murrell A.

Nat Commun. 2016 Feb 2;7:10406. doi: 10.1038/ncomms10406.

7.

Hitting the brakes: targeting microtubule motors in cancer.

Chandrasekaran G, Tátrai P, Gergely F.

Br J Cancer. 2015 Sep 1;113(5):693-8. doi: 10.1038/bjc.2015.264. Epub 2015 Jul 16. Review.

8.

Tackling centrosome biology through gene targeting in chicken B cells.

Chavali PL, Gergely F.

Methods Cell Biol. 2015;129:83-102. doi: 10.1016/bs.mcb.2015.03.008. Epub 2015 May 27.

PMID:
26175435
9.

Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly.

Burgess SG, Peset I, Joseph N, Cavazza T, Vernos I, Pfuhl M, Gergely F, Bayliss R.

PLoS Genet. 2015 Jul 2;11(7):e1005345. doi: 10.1371/journal.pgen.1005345. eCollection 2015 Jul.

10.

Centrosomes and mitotic spindle poles: a recent liaison?

Chavali PL, Peset I, Gergely F.

Biochem Soc Trans. 2015 Feb;43(1):13-8. doi: 10.1042/BST20140269.

PMID:
25619241
11.

Small organelle, big responsibility: the role of centrosomes in development and disease.

Chavali PL, Pütz M, Gergely F.

Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). pii: 20130468. doi: 10.1098/rstb.2013.0468. Review.

12.

Loss of centrioles causes chromosomal instability in vertebrate somatic cells.

Sir JH, Pütz M, Daly O, Morrison CG, Dunning M, Kilmartin JV, Gergely F.

J Cell Biol. 2013 Dec 9;203(5):747-56. doi: 10.1083/jcb.201309038. Epub 2013 Dec 2.

13.

Design, synthesis, and biological evaluation of an allosteric inhibitor of HSET that targets cancer cells with supernumerary centrosomes.

Watts CA, Richards FM, Bender A, Bond PJ, Korb O, Kern O, Riddick M, Owen P, Myers RM, Raff J, Gergely F, Jodrell DI, Ley SV.

Chem Biol. 2013 Nov 21;20(11):1399-410. doi: 10.1016/j.chembiol.2013.09.012. Epub 2013 Oct 24.

14.

Cilia born out of shock and stress.

Chavali PL, Gergely F.

EMBO J. 2013 Nov 27;32(23):3011-3. doi: 10.1038/emboj.2013.241. Epub 2013 Nov 1. No abstract available.

15.

Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells.

Inanç B, Pütz M, Lalor P, Dockery P, Kuriyama R, Gergely F, Morrison CG.

Mol Biol Cell. 2013 Sep;24(17):2645-54. doi: 10.1091/mbc.E13-03-0149. Epub 2013 Jul 17.

16.

Disruption of mouse Cenpj, a regulator of centriole biogenesis, phenocopies Seckel syndrome.

McIntyre RE, Lakshminarasimhan Chavali P, Ismail O, Carragher DM, Sanchez-Andrade G, Forment JV, Fu B, Del Castillo Velasco-Herrera M, Edwards A, van der Weyden L, Yang F; Sanger Mouse Genetics Project, Ramirez-Solis R, Estabel J, Gallagher FA, Logan DW, Arends MJ, Tsang SH, Mahajan VB, Scudamore CL, White JK, Jackson SP, Gergely F, Adams DJ.

PLoS Genet. 2012;8(11):e1003022. doi: 10.1371/journal.pgen.1003022. Epub 2012 Nov 15.

17.

Casein kinase I delta controls centrosome positioning during T cell activation.

Zyss D, Ebrahimi H, Gergely F.

J Cell Biol. 2011 Nov 28;195(5):781-97. doi: 10.1083/jcb.201106025.

18.

A primary microcephaly protein complex forms a ring around parental centrioles.

Sir JH, Barr AR, Nicholas AK, Carvalho OP, Khurshid M, Sossick A, Reichelt S, D'Santos C, Woods CG, Gergely F.

Nat Genet. 2011 Oct 9;43(11):1147-53. doi: 10.1038/ng.971.

19.

The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis.

Bakircioglu M, Carvalho OP, Khurshid M, Cox JJ, Tuysuz B, Barak T, Yilmaz S, Caglayan O, Dincer A, Nicholas AK, Quarrell O, Springell K, Karbani G, Malik S, Gannon C, Sheridan E, Crosier M, Lisgo SN, Lindsay S, Bilguvar K, Gergely F, Gunel M, Woods CG.

Am J Hum Genet. 2011 May 13;88(5):523-35. doi: 10.1016/j.ajhg.2011.03.019. Epub 2011 Apr 28.

20.

WDR62 is associated with the spindle pole and is mutated in human microcephaly.

Nicholas AK, Khurshid M, Désir J, Carvalho OP, Cox JJ, Thornton G, Kausar R, Ansar M, Ahmad W, Verloes A, Passemard S, Misson JP, Lindsay S, Gergely F, Dobyns WB, Roberts E, Abramowicz M, Woods CG.

Nat Genet. 2010 Nov;42(11):1010-4. doi: 10.1038/ng.682. Epub 2010 Oct 3.

21.

CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response.

Barr AR, Kilmartin JV, Gergely F.

J Cell Biol. 2010 Apr 5;189(1):23-39. doi: 10.1083/jcb.200912163.

22.

Ana3 is a conserved protein required for the structural integrity of centrioles and basal bodies.

Stevens NR, Dobbelaere J, Wainman A, Gergely F, Raff JW.

J Cell Biol. 2009 Nov 2;187(3):355-63. doi: 10.1083/jcb.200905031. Epub 2009 Oct 26.

23.

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse.

Jacoby M, Cox JJ, Gayral S, Hampshire DJ, Ayub M, Blockmans M, Pernot E, Kisseleva MV, Compère P, Schiffmann SN, Gergely F, Riley JH, Pérez-Morga D, Woods CG, Schurmans S.

Nat Genet. 2009 Sep;41(9):1027-31. doi: 10.1038/ng.427. Epub 2009 Aug 9.

PMID:
19668215
24.

Centrosome function in cancer: guilty or innocent?

Zyss D, Gergely F.

Trends Cell Biol. 2009 Jul;19(7):334-46. doi: 10.1016/j.tcb.2009.04.001. Epub 2009 Jun 29. Review.

PMID:
19570677
25.

Knock-in and knock-out: the use of reverse genetics in somatic cells to dissect mitotic pathways.

Barr AR, Zyss D, Gergely F.

Methods Mol Biol. 2009;545:1-19. doi: 10.1007/978-1-60327-993-2_1.

PMID:
19475379
26.

Mitosis: Cdh1 clears the way for anaphase spindle assembly.

Gergely F.

Curr Biol. 2008 Nov 11;18(21):R1009-12. doi: 10.1016/j.cub.2008.08.037.

27.

MCAK-independent functions of ch-Tog/XMAP215 in microtubule plus-end dynamics.

Barr AR, Gergely F.

Mol Cell Biol. 2008 Dec;28(23):7199-211. doi: 10.1128/MCB.01040-08. Epub 2008 Sep 22.

28.

Multiple centrosomes: together they stand, divided they fall.

Gergely F, Basto R.

Genes Dev. 2008 Sep 1;22(17):2291-6. doi: 10.1101/gad.1715208.

29.

Loss of Rassf1a cooperates with Apc(Min) to accelerate intestinal tumourigenesis.

van der Weyden L, Arends MJ, Dovey OM, Harrison HL, Lefebvre G, Conte N, Gergely FV, Bradley A, Adams DJ.

Oncogene. 2008 Jul 24;27(32):4503-8. doi: 10.1038/onc.2008.94. Epub 2008 Apr 7.

30.

Aurora-A: the maker and breaker of spindle poles.

Barr AR, Gergely F.

J Cell Sci. 2007 Sep 1;120(Pt 17):2987-96. Review.

31.

Targeting and retention of type 1 ryanodine receptors to the endoplasmic reticulum.

Meur G, Parker AK, Gergely FV, Taylor CW.

J Biol Chem. 2007 Aug 10;282(32):23096-103. Epub 2007 May 25.

32.

Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans.

Basto R, Gergely F, Draviam VM, Ohkura H, Liley K, Raff JW.

J Cell Sci. 2007 Apr 1;120(Pt 7):1278-87.

33.

BRCTx is a novel, highly conserved RAD18-interacting protein.

Adams DJ, van der Weyden L, Gergely FV, Arends MJ, Ng BL, Tannahill D, Kanaar R, Markus A, Morris BJ, Bradley A.

Mol Cell Biol. 2005 Jan;25(2):779-88.

34.

Targeting of inositol 1,4,5-trisphosphate receptors to the endoplasmic reticulum by multiple signals within their transmembrane domains.

Parker AK, Gergely FV, Taylor CW.

J Biol Chem. 2004 May 28;279(22):23797-805. Epub 2004 Mar 19.

35.

BRCA1-independent ubiquitination of FANCD2.

Vandenberg CJ, Gergely F, Ong CY, Pace P, Mallery DL, Hiom K, Patel KJ.

Mol Cell. 2003 Jul;12(1):247-54.

36.
37.

Centrosomal TACCtics.

Gergely F.

Bioessays. 2002 Oct;24(10):915-25. Review.

PMID:
12325124
38.

FANCE: the link between Fanconi anaemia complex assembly and activity.

Pace P, Johnson M, Tan WM, Mosedale G, Sng C, Hoatlin M, de Winter J, Joenje H, Gergely F, Patel KJ.

EMBO J. 2002 Jul 1;21(13):3414-23.

39.

Msps/XMAP215 interacts with the centrosomal protein D-TACC to regulate microtubule behaviour.

Lee MJ, Gergely F, Jeffers K, Peak-Chew SY, Raff JW.

Nat Cell Biol. 2001 Jul;3(7):643-9.

PMID:
11433296
40.

The TACC domain identifies a family of centrosomal proteins that can interact with microtubules.

Gergely F, Karlsson C, Still I, Cowell J, Kilmartin J, Raff JW.

Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14352-7.

41.

D-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo.

Gergely F, Kidd D, Jeffers K, Wakefield JG, Raff JW.

EMBO J. 2000 Jan 17;19(2):241-52.

42.

The mago nashi gene is required for the polarisation of the oocyte and the formation of perpendicular axes in Drosophila.

Micklem DR, Dasgupta R, Elliott H, Gergely F, Davidson C, Brand A, González-Reyes A, St Johnston D.

Curr Biol. 1997 Jul 1;7(7):468-78.

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