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Items: 1 to 50 of 85

1.

Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction.

Aarts SABM, Reiche ME, den Toom M, Beckers L, Gijbels MJJ, Gerdes N, de Winther MPJ, Lutgens E.

PLoS One. 2018 Aug 10;13(8):e0202150. doi: 10.1371/journal.pone.0202150. eCollection 2018.

2.

Mif-deficiency favors an atheroprotective autoantibody phenotype in atherosclerosis.

Schmitz C, Noels H, El Bounkari O, Straussfeld E, Megens RTA, Sternkopf M, Alampour-Rajabi S, Krammer C, Tilstam PV, Gerdes N, Bürger C, Kapurniotu A, Bucala R, Jankowski J, Weber C, Bernhagen J.

FASEB J. 2018 Aug;32(8):4428-4443. doi: 10.1096/fj.201800058R. Epub 2018 Mar 15.

PMID:
29543531
3.

CD40L Deficiency Protects Against Aneurysm Formation.

Kusters PJH, Seijkens TTP, Beckers L, Lievens D, Winkels H, de Waard V, Duijvestijn A, Lindquist Liljeqvist M, Roy J, Daugherty A, Newby A, Gerdes N, Lutgens E.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):1076-1085. doi: 10.1161/ATVBAHA.117.310640. Epub 2018 Mar 8.

PMID:
29519940
4.

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis.

Seijkens TTP, van Tiel CM, Kusters PJH, Atzler D, Soehnlein O, Zarzycka B, Aarts SABM, Lameijer M, Gijbels MJ, Beckers L, den Toom M, Slütter B, Kuiper J, Duchene J, Aslani M, Megens RTA, van 't Veer C, Kooij G, Schrijver R, Hoeksema MA, Boon L, Fay F, Tang J, Baxter S, Jongejan A, Moerland PD, Vriend G, Bleijlevens B, Fisher EA, Duivenvoorden R, Gerdes N, de Winther MPJ, Nicolaes GA, Mulder WJM, Weber C, Lutgens E.

J Am Coll Cardiol. 2018 Feb 6;71(5):527-542. doi: 10.1016/j.jacc.2017.11.055.

5.

Atherosclerosis: cell biology and lipoproteins - focus on anti-inflammatory therapies.

Pfeiler S, Gerdes N.

Curr Opin Lipidol. 2018 Feb;29(1):53-55. doi: 10.1097/MOL.0000000000000481. No abstract available.

PMID:
29298275
6.

IL-1 family cytokines in cardiovascular disease.

Pfeiler S, Winkels H, Kelm M, Gerdes N.

Cytokine. 2017 Nov 30. pii: S1043-4666(17)30351-4. doi: 10.1016/j.cyto.2017.11.009. [Epub ahead of print]

PMID:
29198612
7.

CD27 co-stimulation increases the abundance of regulatory T cells and reduces atherosclerosis in hyperlipidaemic mice.

Winkels H, Meiler S, Lievens D, Engel D, Spitz C, Bürger C, Beckers L, Dandl A, Reim S, Ahmadsei M, Hartwig H, Holdt LM, Hristov M, Megens RTA, Schmitt MM, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E, Gerdes N.

Eur Heart J. 2017 Dec 21;38(48):3590-3599. doi: 10.1093/eurheartj/ehx517.

PMID:
29045618
8.

Constitutive CD40 Signaling in Dendritic Cells Limits Atherosclerosis by Provoking Inflammatory Bowel Disease and Ensuing Cholesterol Malabsorption.

Kusters P, Seijkens T, Bürger C, Legein B, Winkels H, Gijbels M, Barthels C, Bennett R, Beckers L, Atzler D, Biessen E, Brocker T, Weber C, Gerdes N, Lutgens E.

Am J Pathol. 2017 Dec;187(12):2912-2919. doi: 10.1016/j.ajpath.2017.08.016. Epub 2017 Sep 19.

PMID:
28935569
9.

Unique properties of thymic antigen-presenting cells promote epigenetic imprinting of alloantigen-specific regulatory T cells.

Garg G, Nikolouli E, Hardtke-Wolenski M, Toker A, Ohkura N, Beckstette M, Miyao T, Geffers R, Floess S, Gerdes N, Lutgens E, Osterloh A, Hori S, Sakaguchi S, Jaeckel E, Huehn J.

Oncotarget. 2017 May 30;8(22):35542-35557. doi: 10.18632/oncotarget.16221.

10.

ATVB Distinguished Scientist Award: How Costimulatory and Coinhibitory Pathways Shape Atherosclerosis.

Ley K, Gerdes N, Winkels H.

Arterioscler Thromb Vasc Biol. 2017 May;37(5):764-777. doi: 10.1161/ATVBAHA.117.308611. Epub 2017 Mar 30. Review.

11.

Atherosclerosis: cell biology and lipoproteins focus on epigenetic modification and macrophage biology.

Ferrari E, Lutgens E, Weber C, Gerdes N.

Curr Opin Lipidol. 2017 Apr;28(2):220-221. doi: 10.1097/MOL.0000000000000405. No abstract available.

PMID:
28272157
12.

CD70 limits atherosclerosis and promotes macrophage function.

Winkels H, Meiler S, Smeets E, Lievens D, Engel D, Spitz C, Bürger C, Rinne P, Beckers L, Dandl A, Reim S, Ahmadsei M, Van den Bossche J, Holdt LM, Megens RT, Schmitt M, de Winther M, Biessen EA, Borst J, Faussner A, Weber C, Lutgens E, Gerdes N.

Thromb Haemost. 2017 Jan 5;117(1):164-175. doi: 10.1160/TH16-04-0318. Epub 2016 Oct 27.

PMID:
27786334
13.

[Burdens at Admission, Short-term Effects and Predictors of Health Status at Discharge among 1 803 Patients with Fibromyalgia Syndrome].

Gerdes N, Farin E.

Rehabilitation (Stuttg). 2016 Oct;55(5):305-311. Epub 2016 Oct 11. German.

PMID:
27728937
14.

Alterations in systemic levels of Th1, Th2, and Th17 cytokines in overweight adolescents and obese mice.

Jung C, Lichtenauer M, Strodthoff D, Winkels H, Wernly B, Bürger C, Kamchybekov U, Lutgens E, Figulla HR, Gerdes N.

Pediatr Diabetes. 2017 Dec;18(8):714-721. doi: 10.1111/pedi.12435. Epub 2016 Sep 6.

PMID:
27597513
15.

Constitutive GITR Activation Reduces Atherosclerosis by Promoting Regulatory CD4+ T-Cell Responses-Brief Report.

Meiler S, Smeets E, Winkels H, Shami A, Pascutti MF, Nolte MA, Beckers L, Weber C, Gerdes N, Lutgens E.

Arterioscler Thromb Vasc Biol. 2016 Sep;36(9):1748-52. doi: 10.1161/ATVBAHA.116.307354. Epub 2016 Jul 21.

PMID:
27444204
16.

Atherosclerosis: cell biology and lipoproteins-focus on interleukin-18 signaling, chemotactic heteromers, and microRNAs.

Meiler S, Lutgens E, Weber C, Gerdes N.

Curr Opin Lipidol. 2016 Jun;27(3):308-9. doi: 10.1097/MOL.0000000000000305. No abstract available.

PMID:
27145104
17.

Platelet CD40 Exacerbates Atherosclerosis by Transcellular Activation of Endothelial Cells and Leukocytes.

Gerdes N, Seijkens T, Lievens D, Kuijpers MJ, Winkels H, Projahn D, Hartwig H, Beckers L, Megens RT, Boon L, Noelle RJ, Soehnlein O, Heemskerk JW, Weber C, Lutgens E.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):482-90. doi: 10.1161/ATVBAHA.115.307074. Epub 2016 Jan 28.

PMID:
26821950
18.

Regulatory T cells in atherosclerosis: critical immune regulatory function and therapeutic potential.

Spitz C, Winkels H, Bürger C, Weber C, Lutgens E, Hansson GK, Gerdes N.

Cell Mol Life Sci. 2016 Mar;73(5):901-22. doi: 10.1007/s00018-015-2080-2. Epub 2015 Oct 30. Review.

PMID:
26518635
19.

Immune-mediated and lipid-mediated platelet function in atherosclerosis.

Ahmadsei M, Lievens D, Weber C, von Hundelshausen P, Gerdes N.

Curr Opin Lipidol. 2015 Oct;26(5):438-48. doi: 10.1097/MOL.0000000000000212. Review.

PMID:
26270811
20.

Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter.

Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, Zhou Y, Sukhova GK, Chen H, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, Jiang M, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, Jarolim P, Libby P, Shi GP.

Nat Med. 2015 Jul;21(7):820-6. doi: 10.1038/nm.3890. Epub 2015 Jun 22.

21.

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction.

Yamano T, Nedjic J, Hinterberger M, Steinert M, Koser S, Pinto S, Gerdes N, Lutgens E, Ishimaru N, Busslinger M, Brors B, Kyewski B, Klein L.

Immunity. 2015 Jun 16;42(6):1048-61. doi: 10.1016/j.immuni.2015.05.013. Epub 2015 Jun 9.

22.

Atherosclerosis: cell biology and lipoproteins-focus on CD40 signaling, PCSK9, and novel animal models.

Bürger C, Weber C, Lutgens E, Gerdes N.

Curr Opin Lipidol. 2015 Jun;26(3):245-6. doi: 10.1097/MOL.0000000000000185. No abstract available.

PMID:
25950709
23.

Platelet CD40L Modulates Thrombus Growth Via Phosphatidylinositol 3-Kinase β, and Not Via CD40 and IκB Kinase α.

Kuijpers MJ, Mattheij NJ, Cipolla L, van Geffen JP, Lawrence T, Donners MM, Boon L, Lievens D, Torti M, Noels H, Gerdes N, Cosemans JM, Lutgens E, Heemskerk JW.

Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1374-81. doi: 10.1161/ATVBAHA.114.305127. Epub 2015 Apr 23.

PMID:
25908768
24.

Elevated plasma levels of interleukin-12p40 and interleukin-16 in overweight adolescents.

Lichtenauer M, Franz M, Fritzenwanger M, Figulla HR, Gerdes N, Jung C.

Biomed Res Int. 2015;2015:940910. doi: 10.1155/2015/940910. Epub 2015 Feb 2.

25.

[Suitability of the SINGER as a tool for assessment in outpatient neurological rehabilitation].

Pöppl D, Deck R, Gerdes N, Funke UN, Kringler W, Friedrich N, Kohlmann T, Reuther P.

Rehabilitation (Stuttg). 2015 Feb;54(1):22-9. doi: 10.1055/s-0034-1394451. Epub 2015 Feb 12. German.

PMID:
25675320
26.

Case reports of fatal or metastasizing melanoma in children and adolescents: a systematic analysis of the literature.

Neuhold JC, Friesenhahn J, Gerdes N, Krengel S.

Pediatr Dermatol. 2015 Jan-Feb;32(1):13-22. doi: 10.1111/pde.12400. Epub 2014 Dec 9. Review.

PMID:
25487565
27.

Deficiency of the stroke relevant HDAC9 gene attenuates atherosclerosis in accord with allele-specific effects at 7p21.1.

Azghandi S, Prell C, van der Laan SW, Schneider M, Malik R, Berer K, Gerdes N, Pasterkamp G, Weber C, Haffner C, Dichgans M.

Stroke. 2015 Jan;46(1):197-202. doi: 10.1161/STROKEAHA.114.007213. Epub 2014 Nov 11.

PMID:
25388417
28.

Mast cells control the expansion and differentiation of IL-10-competent B cells.

Mion F, D'Incà F, Danelli L, Toffoletto B, Guarnotta C, Frossi B, Burocchi A, Rigoni A, Gerdes N, Lutgens E, Tripodo C, Colombo MP, Rivera J, Vitale G, Pucillo CE.

J Immunol. 2014 Nov 1;193(9):4568-79. doi: 10.4049/jimmunol.1302593. Epub 2014 Sep 29.

29.

Atherosclerosis: cell biology and lipoproteins focus on iNKT cells and CD40/CD40L in atherosclerosis and metabolic disorders.

Winkels H, Weber C, Lutgens E, Gerdes N.

Curr Opin Lipidol. 2014 Oct;25(5):408-9. doi: 10.1097/MOL.0000000000000120. No abstract available.

PMID:
25186203
30.

Artery tertiary lymphoid organs contribute to innate and adaptive immune responses in advanced mouse atherosclerosis.

Mohanta SK, Yin C, Peng L, Srikakulapu P, Bontha V, Hu D, Weih F, Weber C, Gerdes N, Habenicht AJ.

Circ Res. 2014 May 23;114(11):1772-87. doi: 10.1161/CIRCRESAHA.114.301137. Review.

PMID:
24855201
31.

Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance.

Chatzigeorgiou A, Seijkens T, Zarzycka B, Engel D, Poggi M, van den Berg S, van den Berg S, Soehnlein O, Winkels H, Beckers L, Lievens D, Driessen A, Kusters P, Biessen E, Garcia-Martin R, Klotzsche-von Ameln A, Gijbels M, Noelle R, Boon L, Hackeng T, Schulte KM, Xu A, Vriend G, Nabuurs S, Chung KJ, Willems van Dijk K, Rensen PC, Gerdes N, de Winther M, Block NL, Schally AV, Weber C, Bornstein SR, Nicolaes G, Chavakis T, Lutgens E.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2686-91. doi: 10.1073/pnas.1400419111. Epub 2014 Feb 3. Erratum in: Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4644. Schulte, Klaus [corrected to Schulte, Klaus-Martin].

32.

Lack of invariant natural killer T cells affects lipid metabolism in adipose tissue of diet-induced obese mice.

Strodthoff D, Lundberg AM, Agardh HE, Ketelhuth DF, Paulsson-Berne G, Arner P, Hansson GK, Gerdes N.

Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1189-96. doi: 10.1161/ATVBAHA.112.301105. Epub 2013 Mar 21.

PMID:
23520162
33.

Atherosclerosis: cell biology and lipoproteins-focus on anti-inflammatory mechanisms as therapeutic options.

Gerdes N, Winkels H, Weber C.

Curr Opin Lipidol. 2013 Apr;24(2):187-8. doi: 10.1097/MOL.0b013e32835ec608. No abstract available.

PMID:
23481233
34.

Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis.

Klingenberg R, Gerdes N, Badeau RM, Gisterå A, Strodthoff D, Ketelhuth DF, Lundberg AM, Rudling M, Nilsson SK, Olivecrona G, Zoller S, Lohmann C, Lüscher TF, Jauhiainen M, Sparwasser T, Hansson GK.

J Clin Invest. 2013 Mar;123(3):1323-34. doi: 10.1172/JCI63891. Epub 2013 Feb 15.

35.

Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis.

Lundberg AM, Ketelhuth DF, Johansson ME, Gerdes N, Liu S, Yamamoto M, Akira S, Hansson GK.

Cardiovasc Res. 2013 Jul 15;99(2):364-73. doi: 10.1093/cvr/cvt033. Epub 2013 Feb 14.

PMID:
23417039
36.

Altered red blood cell distribution width in overweight adolescents and its association with markers of inflammation.

Fujita B, Strodthoff D, Fritzenwanger M, Pfeil A, Ferrari M, Goebel B, Figulla HR, Gerdes N, Jung C.

Pediatr Obes. 2013 Oct;8(5):385-91. doi: 10.1111/j.2047-6310.2012.00111.x. Epub 2012 Dec 13.

PMID:
23239558
37.

[Empirically derived recommendations for measuring patient-reported change in rehabilitation studies].

Mittag O, Kohlmann T, Meyer T, Meyer-Moock S, Meffert C, Farin E, Gerdes N, Pohontsch N, Moock J, Jelitte M, Löschmann C, Bitzer EM, Raspe H.

Rehabilitation (Stuttg). 2013 Apr;52(2):119-25. doi: 10.1055/s-0032-1314876. Epub 2012 Jul 4. German.

PMID:
22763791
38.

[Use of trajectories for measuring change in medical rehabilitation: a contribution toward comparison of different methods of outcome measurement].

Meffert C, Kohlmann T, Raspe H, Gerdes N, Mittag O.

Rehabilitation (Stuttg). 2012 Jun;51(3):151-9. doi: 10.1055/s-0032-1312660. Epub 2012 Jun 11. German.

PMID:
22689308
39.

Macrophage migration inhibitory factor is elevated in obese adolescents.

Kamchybekov U, Figulla HR, Gerdes N, Jung C.

Arch Physiol Biochem. 2012 Oct;118(4):204-9. doi: 10.3109/13813455.2012.693089. Epub 2012 Jun 7.

PMID:
22676646
40.

Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis.

Lievens D, Habets KL, Robertson AK, Laouar Y, Winkels H, Rademakers T, Beckers L, Wijnands E, Boon L, Mosaheb M, Ait-Oufella H, Mallat Z, Flavell RA, Rudling M, Binder CJ, Gerdes N, Biessen EA, Weber C, Daemen MJ, Kuiper J, Lutgens E.

Eur Heart J. 2013 Dec;34(48):3717-27. doi: 10.1093/eurheartj/ehs106. Epub 2012 May 21.

41.

["Scores of Independence for Neurologic and Geriatric Rehabilitation (SINGER)" - development and validation of a new assessment instrument].

Gerdes N, Funke UN, Schüwer U, Themann P, Pfeiffer G, Meffert C.

Rehabilitation (Stuttg). 2012 Oct;51(5):289-99. doi: 10.1055/s-0031-1287805. Epub 2012 Apr 2. German.

PMID:
22473480
42.

Co-stimulatory molecules in and beyond co-stimulation - tipping the balance in atherosclerosis?

Gerdes N, Zirlik A.

Thromb Haemost. 2011 Nov;106(5):804-13. doi: 10.1160/TH11-09-0605. Epub 2011 Oct 6. Review.

PMID:
21979444
43.

CD40L deficiency ameliorates adipose tissue inflammation and metabolic manifestations of obesity in mice.

Poggi M, Engel D, Christ A, Beckers L, Wijnands E, Boon L, Driessen A, Cleutjens J, Weber C, Gerdes N, Lutgens E.

Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2251-60. doi: 10.1161/ATVBAHA.111.231357. Epub 2011 Aug 4.

PMID:
21817098
44.

Caveolin-1 deficiency decreases atherosclerosis by hampering leukocyte influx into the arterial wall and generating a regulatory T-cell response.

Engel D, Beckers L, Wijnands E, Seijkens T, Lievens D, Drechsler M, Gerdes N, Soehnlein O, Daemen MJ, Stan RV, Biessen EA, Lutgens E.

FASEB J. 2011 Nov;25(11):3838-48. doi: 10.1096/fj.11-183350. Epub 2011 Jul 27. Erratum in: FASEB J. 2013 Aug;27(8):3408.

45.

Platelets regulate CD4⁺ T-cell differentiation via multiple chemokines in humans.

Gerdes N, Zhu L, Ersoy M, Hermansson A, Hjemdahl P, Hu H, Hansson GK, Li N.

Thromb Haemost. 2011 Aug;106(2):353-62. doi: 10.1160/TH11-01-0020. Epub 2011 Jun 9.

PMID:
21655676
46.

Program adherence and effectiveness of a commercial nutrition program: the metabolic balance study.

Meffert C, Gerdes N.

J Nutr Metab. 2010;2010:197656. doi: 10.1155/2010/197656. Epub 2010 Dec 21.

47.

Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis.

Lievens D, Zernecke A, Seijkens T, Soehnlein O, Beckers L, Munnix IC, Wijnands E, Goossens P, van Kruchten R, Thevissen L, Boon L, Flavell RA, Noelle RJ, Gerdes N, Biessen EA, Daemen MJ, Heemskerk JW, Weber C, Lutgens E.

Blood. 2010 Nov 18;116(20):4317-27. doi: 10.1182/blood-2010-01-261206. Epub 2010 Aug 12.

48.

Atherosclerosis: cell biology and lipoproteins.

Lievens D, Gerdes N, Schober A, Weber C.

Curr Opin Lipidol. 2010 Jun;21(3):284-5. doi: 10.1097/MOL.0b013e3283395093. No abstract available.

PMID:
20463476
49.

Circulating levels of interleukin-1 family cytokines in overweight adolescents.

Jung C, Gerdes N, Fritzenwanger M, Figulla HR.

Mediators Inflamm. 2010;2010:958403. doi: 10.1155/2010/958403. Epub 2010 Feb 9.

50.

Intranasal immunization with an apolipoprotein B-100 fusion protein induces antigen-specific regulatory T cells and reduces atherosclerosis.

Klingenberg R, Lebens M, Hermansson A, Fredrikson GN, Strodthoff D, Rudling M, Ketelhuth DF, Gerdes N, Holmgren J, Nilsson J, Hansson GK.

Arterioscler Thromb Vasc Biol. 2010 May;30(5):946-52. doi: 10.1161/ATVBAHA.109.202671. Epub 2010 Feb 18.

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