Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 48

1.

Sex dictates the constitutive expression of hepatic cytochrome P450 isoforms in Göttingen minipigs.

Rasmussen MK, Scavenius C, Gerbal-Chaloin S, Enghild J.

Toxicol Lett. 2019 Oct 10;314:181-186. doi: 10.1016/j.toxlet.2019.08.008. Epub 2019 Aug 9.

PMID:
31404594
2.

Mitochondrial Complex I activity signals antioxidant response through ERK5.

Khan AUH, Allende-Vega N, Gitenay D, Garaude J, Vo DN, Belkhala S, Gerbal-Chaloin S, Gondeau C, Daujat-Chavanieu M, Delettre C, Orecchioni S, Talarico G, Bertolini F, Anel A, Cuezva JM, Enriquez JA, Cartron G, Lecellier CH, Hernandez J, Villalba M.

Sci Rep. 2018 May 9;8(1):7420. doi: 10.1038/s41598-018-23884-4.

3.

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes.

Abderrahmani A, Yengo L, Caiazzo R, Canouil M, Cauchi S, Raverdy V, Plaisance V, Pawlowski V, Lobbens S, Maillet J, Rolland L, Boutry R, Queniat G, Kwapich M, Tenenbaum M, Bricambert J, Saussenthaler S, Anthony E, Jha P, Derop J, Sand O, Rabearivelo I, Leloire A, Pigeyre M, Daujat-Chavanieu M, Gerbal-Chaloin S, Dayeh T, Lassailly G, Mathurin P, Staels B, Auwerx J, Schürmann A, Postic C, Schafmayer C, Hampe J, Bonnefond A, Pattou F, Froguel P.

Diabetes. 2018 Jul;67(7):1310-1321. doi: 10.2337/db17-1539. Epub 2018 May 4.

4.

Improving Prediction of Metabolic Clearance Using Quantitative Extrapolation of Results Obtained From Human Hepatic Micropatterned Cocultures Model and by Considering the Impact of Albumin Binding.

Da-Silva F, Boulenc X, Vermet H, Compigne P, Gerbal-Chaloin S, Daujat-Chavanieu M, Klieber S, Poulin P.

J Pharm Sci. 2018 Jul;107(7):1957-1972. doi: 10.1016/j.xphs.2018.03.001. Epub 2018 Mar 7.

PMID:
29524447
5.

Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor.

de Boussac H, Gondeau C, Briolotti P, Duret C, Treindl F, Römer M, Fabre JM, Herrero A, Ramos J, Maurel P, Templin M, Gerbal-Chaloin S, Daujat-Chavanieu M.

Drug Metab Dispos. 2018 Mar;46(3):223-236. doi: 10.1124/dmd.117.078683. Epub 2017 Dec 21.

PMID:
29269410
6.

Skeletal Muscle Interleukin-6 Regulates Hepatic Cytochrome P450 Expression: Effects of 16-Week High-Fat Diet and Exercise.

Knudsen JG, Bertholdt L, Gudiksen A, Gerbal-Chaloin S, Rasmussen MK.

Toxicol Sci. 2018 Mar 1;162(1):309-317. doi: 10.1093/toxsci/kfx258.

PMID:
29177473
7.

The PDK1 Inhibitor Dichloroacetate Controls Cholesterol Homeostasis Through the ERK5/MEF2 Pathway.

Khan AUH, Allende-Vega N, Gitenay D, Gerbal-Chaloin S, Gondeau C, Vo DN, Belkahla S, Orecchioni S, Talarico G, Bertolini F, Bozic M, Valdivielso JM, Bejjani F, Jariel I, Lopez-Mejia IC, Fajas L, Lecellier CH, Hernandez J, Daujat M, Villalba M.

Sci Rep. 2017 Sep 6;7(1):10654. doi: 10.1038/s41598-017-10339-5.

8.

Activation of the aryl hydrocarbon receptor decreases rifampicin-induced CYP3A4 expression in primary human hepatocytes and HepaRG.

Rasmussen MK, Daujat-Chavanieu M, Gerbal-Chaloin S.

Toxicol Lett. 2017 Aug 5;277:1-8. doi: 10.1016/j.toxlet.2017.05.029. Epub 2017 May 29.

PMID:
28571685
9.

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells.

Nzigou Mombo B, Gerbal-Chaloin S, Bokus A, Daujat-Chavanieu M, Jorgensen C, Hugnot JP, Vignais ML.

J Vis Exp. 2017 Feb 22;(120). doi: 10.3791/55245.

10.

Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.

Marmugi A, Lukowicz C, Lasserre F, Montagner A, Polizzi A, Ducheix S, Goron A, Gamet-Payrastre L, Gerbal-Chaloin S, Pascussi JM, Moldes M, Pineau T, Guillou H, Mselli-Lakhal L.

Toxicol Appl Pharmacol. 2016 Jul 15;303:90-100. doi: 10.1016/j.taap.2016.05.006. Epub 2016 May 11.

PMID:
27180240
11.

Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes.

Rasmussen MK, Balaguer P, Ekstrand B, Daujat-Chavanieu M, Gerbal-Chaloin S.

PLoS One. 2016 May 3;11(5):e0154629. doi: 10.1371/journal.pone.0154629. eCollection 2016.

12.

The pregnane X receptor down-regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for ("squelching") SRC-1 coactivator.

Hyrsova L, Smutny T, Carazo A, Moravcik S, Mandikova J, Trejtnar F, Gerbal-Chaloin S, Pavek P.

Br J Pharmacol. 2016 May;173(10):1703-15. doi: 10.1111/bph.13472. Epub 2016 Apr 8.

13.

Synergistic activation of human pregnane X receptor by binary cocktails of pharmaceutical and environmental compounds.

Delfosse V, Dendele B, Huet T, Grimaldi M, Boulahtouf A, Gerbal-Chaloin S, Beucher B, Roecklin D, Muller C, Rahmani R, Cavaillès V, Daujat-Chavanieu M, Vivat V, Pascussi JM, Balaguer P, Bourguet W.

Nat Commun. 2015 Sep 3;6:8089. doi: 10.1038/ncomms9089.

14.

Analysis of Glycogen Synthase Kinase Inhibitors That Regulate Cytochrome P450 Expression in Primary Human Hepatocytes by Activation of β-Catenin, Aryl Hydrocarbon Receptor and Pregnane X Receptor Signaling.

Briolotti P, Chaloin L, Balaguer P, Da Silva F, Tománková V, Pascussi JM, Duret C, Fabre JM, Ramos J, Klieber S, Maurel P, Daujat-Chavanieu M, Gerbal-Chaloin S.

Toxicol Sci. 2015 Nov;148(1):261-75. doi: 10.1093/toxsci/kfv177. Epub 2015 Aug 10.

PMID:
26259606
15.

PBPK modeling of irbesartan: incorporation of hepatic uptake.

Chapy H, Klieber S, Brun P, Gerbal-Chaloin S, Boulenc X, Nicolas O.

Biopharm Drug Dispos. 2015 Nov;36(8):491-506. doi: 10.1002/bdd.1961. Epub 2015 Aug 3.

PMID:
26037524
16.

Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking.

Marmier S, Dentin R, Daujat-Chavanieu M, Guillou H, Bertrand-Michel J, Gerbal-Chaloin S, Girard J, Lotersztajn S, Postic C.

Hepatology. 2015 Oct;62(4):1086-100. doi: 10.1002/hep.27778. Epub 2015 May 6.

PMID:
25761756
17.

Cold Preservation of Human Adult Hepatocytes for Liver Cell Therapy.

Duret C, Moreno D, Balasiddaiah A, Roux S, Briolotti P, Raulet E, Herrero A, Ramet H, Biron-Andreani C, Gerbal-Chaloin S, Ramos J, Navarro F, Hardwigsen J, Maurel P, Aldabe R, Daujat-Chavanieu M.

Cell Transplant. 2015;24(12):2541-55. doi: 10.3727/096368915X687020. Epub 2015 Jan 23.

PMID:
25622096
18.

The WNT/β-catenin pathway is a transcriptional regulator of CYP2E1, CYP1A2, and aryl hydrocarbon receptor gene expression in primary human hepatocytes.

Gerbal-Chaloin S, Dumé AS, Briolotti P, Klieber S, Raulet E, Duret C, Fabre JM, Ramos J, Maurel P, Daujat-Chavanieu M.

Mol Pharmacol. 2014 Dec;86(6):624-34. doi: 10.1124/mol.114.094797. Epub 2014 Sep 16.

PMID:
25228302
19.

Human induced pluripotent stem cells in hepatology: beyond the proof of concept.

Gerbal-Chaloin S, Funakoshi N, Caillaud A, Gondeau C, Champon B, Si-Tayeb K.

Am J Pathol. 2014 Feb;184(2):332-47. doi: 10.1016/j.ajpath.2013.09.026. Epub 2013 Nov 21. Review.

20.

The sodium/iodide symporter NIS is a transcriptional target of the p53-family members in liver cancer cells.

Guerrieri F, Piconese S, Lacoste C, Schinzari V, Testoni B, Valogne Y, Gerbal-Chaloin S, Samuel D, Bréchot C, Faivre J, Levrero M.

Cell Death Dis. 2013 Sep 19;4:e807. doi: 10.1038/cddis.2013.302.

21.

Nuclear receptors in the cross-talk of drug metabolism and inflammation.

Gerbal-Chaloin S, Iankova I, Maurel P, Daujat-Chavanieu M.

Drug Metab Rev. 2013 Feb;45(1):122-44. doi: 10.3109/03602532.2012.756011. Review.

PMID:
23330545
22.

Dissecting the first transcriptional divergence during human embryonic development.

Bai Q, Assou S, Haouzi D, Ramirez JM, Monzo C, Becker F, Gerbal-Chaloin S, Hamamah S, De Vos J.

Stem Cell Rev Rep. 2012 Mar;8(1):150-62. doi: 10.1007/s12015-011-9301-3.

23.

Brief report: benchmarking human pluripotent stem cell markers during differentiation into the three germ layers unveils a striking heterogeneity: all markers are not equal.

Ramirez JM, Gerbal-Chaloin S, Milhavet O, Qiang B, Becker F, Assou S, Lemaître JM, Hamamah S, De Vos J.

Stem Cells. 2011 Sep;29(9):1469-74. doi: 10.1002/stem.681.

24.

Human pluripotent stem cells: from biology to cell therapy.

Ramirez JM, Bai Q, Dijon-Grinand M, Assou S, Gerbal-Chaloin S, Hamamah S, De Vos J.

World J Stem Cells. 2010 Apr 26;2(2):24-33. doi: 10.4252/wjsc.v2.i2.24.

25.

Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2.

Testoni B, Völlenkle C, Guerrieri F, Gerbal-Chaloin S, Blandino G, Levrero M.

J Biol Chem. 2011 Jun 10;286(23):20217-27. doi: 10.1074/jbc.M111.231068. Epub 2011 Apr 15.

26.

p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor.

Testoni B, Schinzari V, Guerrieri F, Gerbal-Chaloin S, Blandino G, Levrero M.

Oncogene. 2011 Jun 9;30(23):2670-8. doi: 10.1038/onc.2010.635. Epub 2011 Mar 14.

27.

Modular bioreactor for primary human hepatocyte culture: medium flow stimulates expression and activity of detoxification genes.

Vinci B, Duret C, Klieber S, Gerbal-Chaloin S, Sa-Cunha A, Laporte S, Suc B, Maurel P, Ahluwalia A, Daujat-Chavanieu M.

Biotechnol J. 2011 May;6(5):554-64. doi: 10.1002/biot.201000326. Epub 2011 Jan 21.

28.

Comparison of hepatic-like cell production from human embryonic stem cells and adult liver progenitor cells: CAR transduction activates a battery of detoxification genes.

Funakoshi N, Duret C, Pascussi JM, Blanc P, Maurel P, Daujat-Chavanieu M, Gerbal-Chaloin S.

Stem Cell Rev Rep. 2011 Sep;7(3):518-31. doi: 10.1007/s12015-010-9225-3.

29.

Isolation and culture of adult human liver progenitor cells: in vitro differentiation to hepatocyte-like cells.

Gerbal-Chaloin S, Duret C, Raulet E, Navarro F, Blanc P, Ramos J, Maurel P, Daujat-Chavanieu M.

Methods Mol Biol. 2010;640:247-60. doi: 10.1007/978-1-60761-688-7_12.

PMID:
20645055
30.

Comparative effects of microtubules disruption on glucocorticoid receptor functions in proliferating and quiescent cells.

Vrzal R, Gerbal-Chaloin S, Maurel P, Dvorák Z.

Int J Toxicol. 2010 May-Jun;29(3):326-35. doi: 10.1177/1091581810366486.

PMID:
20448266
31.

The tangle of nuclear receptors that controls xenobiotic metabolism and transport: crosstalk and consequences.

Pascussi JM, Gerbal-Chaloin S, Duret C, Daujat-Chavanieu M, Vilarem MJ, Maurel P.

Annu Rev Pharmacol Toxicol. 2008;48:1-32. Review.

PMID:
17608617
32.

Isolation, characterization, and differentiation to hepatocyte-like cells of nonparenchymal epithelial cells from adult human liver.

Duret C, Gerbal-Chaloin S, Ramos J, Fabre JM, Jacquet E, Navarro F, Blanc P, Sa-Cunha A, Maurel P, Daujat-Chavanieu M.

Stem Cells. 2007 Jul;25(7):1779-90. Epub 2007 Apr 5.

33.

First step of the cell-penetrating peptide mechanism involves Rac1 GTPase-dependent actin-network remodelling.

Gerbal-Chaloin S, Gondeau C, Aldrian-Herrada G, Heitz F, Gauthier-Rouvière C, Divita G.

Biol Cell. 2007 Apr;99(4):223-38.

PMID:
17233629
34.

Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor.

Duret C, Daujat-Chavanieu M, Pascussi JM, Pichard-Garcia L, Balaguer P, Fabre JM, Vilarem MJ, Maurel P, Gerbal-Chaloin S.

Mol Pharmacol. 2006 Jul;70(1):329-39. Epub 2006 Apr 11.

PMID:
16608920
35.

Is nuclear factor kappa-B the missing link between inflammation, cancer and alteration in hepatic drug metabolism in patients with cancer?

Assenat E, Gerbal-chaloin S, Maurel P, Vilarem MJ, Pascussi JM.

Eur J Cancer. 2006 Apr;42(6):785-92. Epub 2006 Feb 28. Review.

PMID:
16510279
36.

Role of CYP3A4 in the regulation of the aryl hydrocarbon receptor by omeprazole sulphide.

Gerbal-Chaloin S, Pichard-Garcia L, Fabre JM, Sa-Cunha A, Poellinger L, Maurel P, Daujat-Chavanieu M.

Cell Signal. 2006 May;18(5):740-50. Epub 2005 Aug 16.

PMID:
16109480
37.

Cross-talk between xenobiotic detoxication and other signalling pathways: clinical and toxicological consequences.

Pascussi JM, Gerbal-Chaloin S, Drocourt L, Assénat E, Larrey D, Pichard-Garcia L, Vilarem MJ, Maurel P.

Xenobiotica. 2004 Jul;34(7):633-64. Review.

PMID:
15672753
38.

Design of a novel class of peptide inhibitors of cyclin-dependent kinase/cyclin activation.

Gondeau C, Gerbal-Chaloin S, Bello P, Aldrian-Herrada G, Morris MC, Divita G.

J Biol Chem. 2005 Apr 8;280(14):13793-800. Epub 2005 Jan 13.

39.

On the mechanism of non-endosomial peptide-mediated cellular delivery of nucleic acids.

Deshayes S, Gerbal-Chaloin S, Morris MC, Aldrian-Herrada G, Charnet P, Divita G, Heitz F.

Biochim Biophys Acta. 2004 Dec 15;1667(2):141-7.

40.

Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance.

Assenat E, Gerbal-Chaloin S, Larrey D, Saric J, Fabre JM, Maurel P, Vilarem MJ, Pascussi JM.

Hepatology. 2004 Oct;40(4):951-60.

PMID:
15382119
41.

Pathophysiological factors affecting CAR gene expression.

Pascussi JM, Dvorák Z, Gerbal-Chaloin S, Assenat E, Maurel P, Vilarem MJ.

Drug Metab Rev. 2003 Nov;35(4):255-68. Review.

PMID:
14705859
42.

The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.

Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ.

Biochim Biophys Acta. 2003 Feb 17;1619(3):243-53. Review.

PMID:
12573484
43.

Use of long-term cultures of human hepatocytes to study cytochrome P450 gene expression.

Pichard-Garcia L, Gerbal-Chaloin S, Ferrini JB, Fabre JM, Maurel P.

Methods Enzymol. 2002;357:311-21. No abstract available.

PMID:
12424921
44.

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.

Pascussi JM, Drocourt L, Gerbal-Chaloin S, Fabre JM, Maurel P, Vilarem MJ.

Eur J Biochem. 2001 Dec;268(24):6346-58.

45.

Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor.

Gerbal-Chaloin S, Daujat M, Pascussi JM, Pichard-Garcia L, Vilarem MJ, Maurel P.

J Biol Chem. 2002 Jan 4;277(1):209-17. Epub 2001 Oct 25.

46.

Induction of CYP2C genes in human hepatocytes in primary culture.

Gerbal-Chaloin S, Pascussi JM, Pichard-Garcia L, Daujat M, Waechter F, Fabre JM, Carrère N, Maurel P.

Drug Metab Dispos. 2001 Mar;29(3):242-51.

PMID:
11181490
47.

Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation.

Pascussi JM, Gerbal-Chaloin S, Fabre JM, Maurel P, Vilarem MJ.

Mol Pharmacol. 2000 Dec;58(6):1441-50.

PMID:
11093784
48.

Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes.

Pascussi JM, Gerbal-Chaloin S, Pichard-Garcia L, Daujat M, Fabre JM, Maurel P, Vilarem MJ.

Biochem Biophys Res Commun. 2000 Aug 11;274(3):707-13.

PMID:
10924340

Supplemental Content

Loading ...
Support Center