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Items: 1 to 50 of 128

1.

CFTR regulates B cell activation and lymphoid follicle development.

Polverino F, Lu B, Quintero JR, Vargas SO, Patel AS, Owen CA, Gerard NP, Gerard C, Cernadas M.

Respir Res. 2019 Jul 1;20(1):133. doi: 10.1186/s12931-019-1103-1.

2.

Apelin protects against abdominal aortic aneurysm and the therapeutic role of neutral endopeptidase resistant apelin analogs.

Wang W, Shen M, Fischer C, Basu R, Hazra S, Couvineau P, Paul M, Wang F, Toth S, Mix DS, Poglitsch M, Gerard NP, Bouvier M, Vederas JC, Penninger JM, Kassiri Z, Oudit GY.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13006-13015. doi: 10.1073/pnas.1900152116. Epub 2019 Jun 12.

3.

Observational Pain Assessment Instruments for Use With Nonverbal Patients at the End-of-life: A Systematic Review.

Tapp D, Chenacher S, Gérard NPA, Bérubé-Mercier P, Gelinas C, Douville F, Desbiens JF.

J Palliat Care. 2019 Jan 13:825859718816073. doi: 10.1177/0825859718816073. [Epub ahead of print]

PMID:
30638134
4.

Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration.

Natarajan N, Abbas Y, Bryant DM, Gonzalez-Rosa JM, Sharpe M, Uygur A, Cocco-Delgado LH, Ho NN, Gerard NP, Gerard CJ, MacRae CA, Burns CE, Burns CG, Whited JL, Lee RT.

Circulation. 2018 May 15;137(20):2152-2165. doi: 10.1161/CIRCULATIONAHA.117.030801. Epub 2018 Jan 18.

5.

The Epithelial Sodium Channel Is a Modifier of the Long-Term Nonprogressive Phenotype Associated with F508del CFTR Mutations.

Agrawal PB, Wang R, Li HL, Schmitz-Abe K, Simone-Roach C, Chen J, Shi J, Louie T, Sheng S, Towne MC, Brainson CF, Matthay MA, Kim CF, Bamshad M, Emond MJ, Gerard NP, Kleyman TR, Gerard C.

Am J Respir Cell Mol Biol. 2017 Dec;57(6):711-720. doi: 10.1165/rcmb.2017-0166OC.

6.

Loss of Neurokinin-1 Receptor Alters Ocular Surface Homeostasis and Promotes an Early Development of Herpes Stromal Keratitis.

Gaddipati S, Rao P, Jerome AD, Burugula BB, Gerard NP, Suvas S.

J Immunol. 2016 Nov 15;197(10):4021-4033. Epub 2016 Oct 17.

7.

C5L2, the Second C5a Anaphylatoxin Receptor, Suppresses LPS-Induced Acute Lung Injury.

Wang R, Lu B, Gerard C, Gerard NP.

Am J Respir Cell Mol Biol. 2016 Nov;55(5):657-666.

8.

Cloning of the Human C5a Anaphylatoxin Receptor, and More.

Gerard NP, Gerard C.

Front Immunol. 2015 Sep 1;6:445. doi: 10.3389/fimmu.2015.00445. eCollection 2015. Review. No abstract available.

9.

Differential Interaction of the Staphylococcal Toxins Panton-Valentine Leukocidin and γ-Hemolysin CB with Human C5a Receptors.

Spaan AN, Schiepers A, de Haas CJ, van Hooijdonk DD, Badiou C, Contamin H, Vandenesch F, Lina G, Gerard NP, Gerard C, van Kessel KP, Henry T, van Strijp JA.

J Immunol. 2015 Aug 1;195(3):1034-43. doi: 10.4049/jimmunol.1500604. Epub 2015 Jun 19.

10.

C5a receptor (CD88) blockade protects against MPO-ANCA GN.

Xiao H, Dairaghi DJ, Powers JP, Ertl LS, Baumgart T, Wang Y, Seitz LC, Penfold ME, Gan L, Hu P, Lu B, Gerard NP, Gerard C, Schall TJ, Jaen JC, Falk RJ, Jennette JC.

J Am Soc Nephrol. 2014 Feb;25(2):225-31. doi: 10.1681/ASN.2013020143. Epub 2013 Oct 31.

11.

Biased agonism as a mechanism for differential signaling by chemokine receptors.

Rajagopal S, Bassoni DL, Campbell JJ, Gerard NP, Gerard C, Wehrman TS.

J Biol Chem. 2013 Dec 6;288(49):35039-48. doi: 10.1074/jbc.M113.479113. Epub 2013 Oct 21.

12.

Disruption of the complement anaphylatoxin receptor C5L2 exacerbates inflammation in allergic contact dermatitis.

Wang R, Lu B, Gerard C, Gerard NP.

J Immunol. 2013 Oct 15;191(8):4001-9. doi: 10.4049/jimmunol.1301626. Epub 2013 Sep 16.

13.

Intrarectal immunization and IgA antibody-secreting cell homing to the small intestine.

Agnello D, Denimal D, Lavaux A, Blondeau-Germe L, Lu B, Gerard NP, Gerard C, Pothier P.

J Immunol. 2013 May 1;190(9):4836-47. doi: 10.4049/jimmunol.1202979. Epub 2013 Apr 1.

14.

Neurokinin-1 receptor signalling impacts bone marrow repopulation efficiency.

Berger A, Frelin C, Shah DK, Benveniste P, Herrington R, Gerard NP, Zúñiga-Pflücker JC, Iscove NN, Paige CJ.

PLoS One. 2013;8(3):e58787. doi: 10.1371/journal.pone.0058787. Epub 2013 Mar 14.

15.

Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice.

Schäfer B, Piliponsky AM, Oka T, Song CH, Gerard NP, Gerard C, Tsai M, Kalesnikoff J, Galli SJ.

J Allergy Clin Immunol. 2013 Feb;131(2):541-8.e1-9. doi: 10.1016/j.jaci.2012.05.009. Epub 2012 Jun 22.

16.

Diminished pheromone-induced sexual behavior in neurokinin-1 receptor deficient (TACR1(-/-)) mice.

Berger A, Tran AH, Dida J, Minkin S, Gerard NP, Yeomans J, Paige CJ.

Genes Brain Behav. 2012 Jul;11(5):568-76. doi: 10.1111/j.1601-183X.2012.00787.x. Epub 2012 Apr 26.

17.

Th17 cytokines are critical for respiratory syncytial virus-associated airway hyperreponsiveness through regulation by complement C3a and tachykinins.

Bera MM, Lu B, Martin TR, Cui S, Rhein LM, Gerard C, Gerard NP.

J Immunol. 2011 Oct 15;187(8):4245-55. doi: 10.4049/jimmunol.1101789. Epub 2011 Sep 14.

18.

Substance P signaling mediates BMP-dependent heterotopic ossification.

Kan L, Lounev VY, Pignolo RJ, Duan L, Liu Y, Stock SR, McGuire TL, Lu B, Gerard NP, Shore EM, Kaplan FS, Kessler JA.

J Cell Biochem. 2011 Oct;112(10):2759-72. doi: 10.1002/jcb.23259.

19.

Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action.

Karagiannides I, Stavrakis D, Bakirtzi K, Kokkotou E, Pirtskhalava T, Nayeb-Hashemi H, Bowe C, Bugni JM, Nuño M, Lu B, Gerard NP, Leeman SE, Kirkland JL, Pothoulakis C.

Endocrinology. 2011 Jun;152(6):2197-205. doi: 10.1210/en.2010-1345. Epub 2011 Apr 5.

20.

A critical role for C5L2 in the pathogenesis of experimental allergic asthma.

Zhang X, Schmudde I, Laumonnier Y, Pandey MK, Clark JR, König P, Gerard NP, Gerard C, Wills-Karp M, Köhl J.

J Immunol. 2010 Dec 1;185(11):6741-52. doi: 10.4049/jimmunol.1000892. Epub 2010 Oct 25.

21.

The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction.

Bamberg CE, Mackay CR, Lee H, Zahra D, Jackson J, Lim YS, Whitfeld PL, Craig S, Corsini E, Lu B, Gerard C, Gerard NP.

J Biol Chem. 2010 Mar 5;285(10):7633-44. doi: 10.1074/jbc.M109.092106. Epub 2009 Dec 31.

22.

Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7.

Rajagopal S, Kim J, Ahn S, Craig S, Lam CM, Gerard NP, Gerard C, Lefkowitz RJ.

Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):628-32. doi: 10.1073/pnas.0912852107. Epub 2009 Dec 17.

23.

A paradoxical protective role for the proinflammatory peptide substance P receptor (NK1R) in acute hyperoxic lung injury.

Dib M, Zsengeller Z, Mitsialis A, Lu B, Craig S, Gerard C, Gerard NP.

Am J Physiol Lung Cell Mol Physiol. 2009 Oct;297(4):L687-97. doi: 10.1152/ajplung.90509.2008. Epub 2009 Jul 24.

24.

Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia.

Dempsey EC, Wick MJ, Karoor V, Barr EJ, Tallman DW, Wehling CA, Walchak SJ, Laudi S, Le M, Oka M, Majka S, Cool CD, Fagan KA, Klemm DJ, Hersh LB, Gerard NP, Gerard C, Miller YE.

Am J Pathol. 2009 Mar;174(3):782-96. doi: 10.2353/ajpath.2009.080345.

25.

Functional roles for C5a receptors in sepsis.

Rittirsch D, Flierl MA, Nadeau BA, Day DE, Huber-Lang M, Mackay CR, Zetoune FS, Gerard NP, Cianflone K, Köhl J, Gerard C, Sarma JV, Ward PA.

Nat Med. 2008 May;14(5):551-7. doi: 10.1038/nm1753. Epub 2008 May 4.

26.

FcgammaRIII is protective against Pseudomonas aeruginosa pneumonia.

Rhein LM, Perkins M, Gerard NP, Gerard C.

Am J Respir Cell Mol Biol. 2008 Apr;38(4):401-6. Epub 2007 Nov 1.

27.

Ventilatory responses to acute hypoxia in neurokinin-1 receptor deficient mice.

Grasemann H, Gerard NP, De Sanctis GT.

Respir Physiol Neurobiol. 2007 Nov 15;159(2):227-31. Epub 2007 Aug 6.

PMID:
17869190
28.

Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity.

Mukhopadhyay P, Bátkai S, Rajesh M, Czifra N, Harvey-White J, Haskó G, Zsengeller Z, Gerard NP, Liaudet L, Kunos G, Pacher P.

J Am Coll Cardiol. 2007 Aug 7;50(6):528-36. Epub 2007 Jul 23.

29.

Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury.

Gazzieri D, Trevisani M, Springer J, Harrison S, Cottrell GS, Andre E, Nicoletti P, Massi D, Zecchi S, Nosi D, Santucci M, Gerard NP, Lucattelli M, Lungarella G, Fischer A, Grady EF, Bunnett NW, Geppetti P.

Free Radic Biol Med. 2007 Aug 15;43(4):581-9. Epub 2007 May 18. Erratum in: Free Radic Biol Med. 2007 Dec 15;43(12):1670.

PMID:
17640568
30.

Neurokinin-1 enables measles virus trans-synaptic spread in neurons.

Makhortova NR, Askovich P, Patterson CE, Gechman LA, Gerard NP, Rall GF.

Virology. 2007 May 25;362(1):235-44. Epub 2007 Apr 16.

31.

C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression.

Melendi GA, Hoffman SJ, Karron RA, Irusta PM, Laham FR, Humbles A, Schofield B, Pan CH, Rabold R, Thumar B, Thumar A, Gerard NP, Mitzner W, Barnum SR, Gerard C, Kleeberger SR, Polack FP.

J Virol. 2007 Jan;81(2):991-9. Epub 2006 Nov 1.

32.

Neurokinin-1 receptor blockade and murine lung tumorigenesis.

Lucattelli M, Fineschi S, Geppetti P, Gerard NP, Lungarella G.

Am J Respir Crit Care Med. 2006 Sep 15;174(6):674-83. Epub 2006 Jun 23.

PMID:
16799078
33.

An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2.

Gerard NP, Lu B, Liu P, Craig S, Fujiwara Y, Okinaga S, Gerard C.

J Biol Chem. 2005 Dec 2;280(48):39677-80. Epub 2005 Oct 4.

34.

C5L2 receptor is not involved in C3a / C3a-desArg-mediated enhancement of bone marrow hematopoietic cell migration to CXCL12.

Honczarenko M, Lu B, Nicholson-Weller A, Gerard NP, Silberstein LE, Gerard C.

Leukemia. 2005 Sep;19(9):1682-3; author reply 1684-5. No abstract available.

PMID:
15990859
35.

Lack of neurokinin-1 receptor expression affects tissue mast cell numbers but not their spatial relationship with nerves.

D'Andrea MR, Saban MR, Gerard NP, Wershil BK, Saban R.

Am J Physiol Regul Integr Comp Physiol. 2005 Feb;288(2):R491-500. Epub 2004 Sep 30.

36.

A critical role for eosinophils in allergic airways remodeling.

Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, Ghiran S, Gerard NP, Yu C, Orkin SH, Gerard C.

Science. 2004 Sep 17;305(5691):1776-9.

37.

Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain.

Iwata N, Mizukami H, Shirotani K, Takaki Y, Muramatsu S, Lu B, Gerard NP, Gerard C, Ozawa K, Saido TC.

J Neurosci. 2004 Jan 28;24(4):991-8.

38.

Basal and activity-induced release of substance P from primary afferent fibres in NK1 receptor knockout mice: evidence for negative feedback.

Lever IJ, Grant AD, Pezet S, Gerard NP, Brain SD, Malcangio M.

Neuropharmacology. 2003 Dec;45(8):1101-10.

PMID:
14614953
39.

Early granuloma formation after aerosol Mycobacterium tuberculosis infection is regulated by neutrophils via CXCR3-signaling chemokines.

Seiler P, Aichele P, Bandermann S, Hauser AE, Lu B, Gerard NP, Gerard C, Ehlers S, Mollenkopf HJ, Kaufmann SH.

Eur J Immunol. 2003 Oct;33(10):2676-86.

40.

The tachykinin NK1 receptor is crucial for the development of non-atopic airway inflammation and hyperresponsiveness.

van der Kleij HP, Kraneveld AD, Redegeld FA, Gerard NP, Morteau O, Nijkamp FP.

Eur J Pharmacol. 2003 Aug 29;476(3):249-55.

PMID:
12969772
41.

C5L2, a nonsignaling C5A binding protein.

Okinaga S, Slattery D, Humbles A, Zsengeller Z, Morteau O, Kinrade MB, Brodbeck RM, Krause JE, Choe HR, Gerard NP, Gerard C.

Biochemistry. 2003 Aug 12;42(31):9406-15.

PMID:
12899627
42.

Sulfation of tyrosine 174 in the human C3a receptor is essential for binding of C3a anaphylatoxin.

Gao J, Choe H, Bota D, Wright PL, Gerard C, Gerard NP.

J Biol Chem. 2003 Sep 26;278(39):37902-8. Epub 2003 Jul 18.

43.

Neurokinin 1 receptors and neprilysin modulation of mouse bladder gene regulation.

Dozmorov I, Saban MR, Gerard NP, Lu B, Nguyen NB, Centola M, Saban R.

Physiol Genomics. 2003 Feb 6;12(3):239-50.

PMID:
12499446
44.

Complement in allergy and asthma.

Gerard NP, Gerard C.

Curr Opin Immunol. 2002 Dec;14(6):705-8. Review.

PMID:
12413519
45.

Neurokinin B induces oedema formation in mouse lung via tachykinin receptor-independent mechanisms.

Grant AD, Akhtar R, Gerard NP, Brain SD.

J Physiol. 2002 Sep 15;543(Pt 3):1007-14.

46.

Mast cells mediate substance P-induced bladder inflammation through an NK(1) receptor-independent mechanism.

Saban R, Gerard NP, Saban MR, Nguyen NB, DeBoer DJ, Wershil BK.

Am J Physiol Renal Physiol. 2002 Oct;283(4):F616-29.

47.

Tyrosine-sulfated peptides functionally reconstitute a CCR5 variant lacking a critical amino-terminal region.

Farzan M, Chung S, Li W, Vasilieva N, Wright PL, Schnitzler CE, Marchione RJ, Gerard C, Gerard NP, Sodroski J, Choe H.

J Biol Chem. 2002 Oct 25;277(43):40397-402. Epub 2002 Aug 14.

48.

Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology.

Fukami S, Watanabe K, Iwata N, Haraoka J, Lu B, Gerard NP, Gerard C, Fraser P, Westaway D, St George-Hyslop P, Saido TC.

Neurosci Res. 2002 May;43(1):39-56.

PMID:
12074840
49.

Protective effects of neurokinin-1 receptor during colitis in mice: role of the epidermal growth factor receptor.

Castagliuolo I, Morteau O, Keates AC, Valenick L, Wang CC, Zacks J, Lu B, Gerard NP, Pothoulakis C.

Br J Pharmacol. 2002 May;136(2):271-9.

50.

Secondary lymphoid tissue chemokine (CCL21) activates CXCR3 to trigger a Cl- current and chemotaxis in murine microglia.

Rappert A, Biber K, Nolte C, Lipp M, Schubel A, Lu B, Gerard NP, Gerard C, Boddeke HW, Kettenmann H.

J Immunol. 2002 Apr 1;168(7):3221-6.

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