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Items: 41

1.

FRET-based assay using a three-way junction DNA substrate to identify inhibitors of human cytomegalovirus pUL89 endonuclease activity.

Wang Y, Geraghty RJ.

Eur J Pharm Sci. 2019 Jan 15;127:29-37. doi: 10.1016/j.ejps.2018.10.016. Epub 2018 Oct 17.

PMID:
30342172
2.

Hydroxypyridonecarboxylic Acids as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease.

Kankanala J, Wang Y, Geraghty RJ, Wang Z.

ChemMedChem. 2018 Aug 20;13(16):1658-1663. doi: 10.1002/cmdc.201800283. Epub 2018 Jul 20.

PMID:
29968426
3.

Nucleobases and corresponding nucleosides display potent antiviral activities against dengue virus possibly through viral lethal mutagenesis.

Qiu L, Patterson SE, Bonnac LF, Geraghty RJ.

PLoS Negl Trop Dis. 2018 Apr 19;12(4):e0006421. doi: 10.1371/journal.pntd.0006421. eCollection 2018 Apr.

4.

Metal-chelating 3-hydroxypyrimidine-2,4-diones inhibit human cytomegalovirus pUL89 endonuclease activity and virus replication.

Wang Y, Tang J, Wang Z, Geraghty RJ.

Antiviral Res. 2018 Apr;152:10-17. doi: 10.1016/j.antiviral.2018.01.015. Epub 2018 Feb 6.

PMID:
29425830
5.

A fluorescence-based high-throughput assay to identify inhibitors of tyrosylprotein sulfotransferase activity.

Zhou W, Wang Y, Xie J, Geraghty RJ.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):1207-1212. doi: 10.1016/j.bbrc.2016.12.013. Epub 2016 Dec 5.

PMID:
27923653
6.

Inhibition of Human Cytomegalovirus pUL89 Terminase Subunit Blocks Virus Replication and Genome Cleavage.

Wang Y, Mao L, Kankanala J, Wang Z, Geraghty RJ.

J Virol. 2017 Jan 18;91(3). pii: e02152-16. doi: 10.1128/JVI.02152-16. Print 2017 Feb 1.

7.

Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid.

Ai T, Qiu L, Xie J, Geraghty RJ, Chen L.

Bioorg Med Chem. 2016 Feb 15;24(4):686-92. doi: 10.1016/j.bmc.2015.12.035. Epub 2015 Dec 23.

PMID:
26753813
8.

5'-Silylated 3'-1,2,3-triazolyl Thymidine Analogues as Inhibitors of West Nile Virus and Dengue Virus.

Vernekar SK, Qiu L, Zhang J, Kankanala J, Li H, Geraghty RJ, Wang Z.

J Med Chem. 2015 May 14;58(9):4016-28. doi: 10.1021/acs.jmedchem.5b00327. Epub 2015 May 4.

9.

Hydroxamic acids block replication of hepatitis C virus.

Ai T, Xu Y, Qiu L, Geraghty RJ, Chen L.

J Med Chem. 2015 Jan 22;58(2):785-800. doi: 10.1021/jm501330g. Epub 2014 Dec 19.

PMID:
25490700
10.

Guidelines for the use of cell lines in biomedical research.

Geraghty RJ, Capes-Davis A, Davis JM, Downward J, Freshney RI, Knezevic I, Lovell-Badge R, Masters JR, Meredith J, Stacey GN, Thraves P, Vias M; Cancer Research UK.

Br J Cancer. 2014 Sep 9;111(6):1021-46. doi: 10.1038/bjc.2014.166. Epub 2014 Aug 12.

11.

Fluorescent peptide sensors for tyrosylprotein sulfotransferase activity.

Zhou W, Duckworth BP, Geraghty RJ.

Anal Biochem. 2014 Sep 15;461:1-6. doi: 10.1016/j.ab.2014.05.025. Epub 2014 Jun 5.

PMID:
24909447
12.

Mutations in the amino terminus of herpes simplex virus type 1 gL can reduce cell-cell fusion without affecting gH/gL trafficking.

Zhou W, Chen F, Klyachkin Y, Sham YY, Geraghty RJ.

J Virol. 2014 Jan;88(1):739-44. doi: 10.1128/JVI.02383-13. Epub 2013 Oct 23.

13.

C-6 aryl substituted 4-quinolone-3-carboxylic acids as inhibitors of hepatitis C virus.

Chen YL, Zacharias J, Vince R, Geraghty RJ, Wang Z.

Bioorg Med Chem. 2012 Aug 1;20(15):4790-800. doi: 10.1016/j.bmc.2012.05.066. Epub 2012 Jun 7.

PMID:
22748708
14.

Mechanisms of host receptor adaptation by severe acute respiratory syndrome coronavirus.

Wu K, Peng G, Wilken M, Geraghty RJ, Li F.

J Biol Chem. 2012 Mar 16;287(12):8904-11. doi: 10.1074/jbc.M111.325803. Epub 2012 Jan 30.

15.

The design, synthesis and biological evaluations of C-6 or C-7 substituted 2-hydroxyisoquinoline-1,3-diones as inhibitors of hepatitis C virus.

Chen YL, Tang J, Kesler MJ, Sham YY, Vince R, Geraghty RJ, Wang Z.

Bioorg Med Chem. 2012 Jan 1;20(1):467-79. doi: 10.1016/j.bmc.2011.10.058. Epub 2011 Oct 24.

PMID:
22100256
16.

A virus-binding hot spot on human angiotensin-converting enzyme 2 is critical for binding of two different coronaviruses.

Wu K, Chen L, Peng G, Zhou W, Pennell CA, Mansky LM, Geraghty RJ, Li F.

J Virol. 2011 Jun;85(11):5331-7. doi: 10.1128/JVI.02274-10. Epub 2011 Mar 16.

17.

Mutagenic analysis of herpes simplex virus type 1 glycoprotein L reveals the importance of an arginine-rich region for function.

Klyachkin YM, Geraghty RJ.

Virology. 2008 Apr 25;374(1):23-32. doi: 10.1016/j.virol.2007.11.014. Epub 2008 Jan 28.

18.

Herpes simplex virus type 1 mediates fusion through a hemifusion intermediate by sequential activity of glycoproteins D, H, L, and B.

Subramanian RP, Geraghty RJ.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2903-8. Epub 2007 Feb 13.

19.
21.

Testing for antibodies to equine arteritis virus.

Geraghty RJ, Newton JR, Nugent J, Hammond TA.

Vet Rec. 2005 Oct 22;157(17):527-8. No abstract available.

PMID:
16244241
22.
23.

Evidence that use of an inactivated equine herpesvirus vaccine induces serum cytotoxicity affecting the equine arteritis virus neutralisation test.

Newton JR, Geraghty RJ, Castillo-Olivares J, Cardwell JM, Mumford JA.

Vaccine. 2004 Sep 28;22(29-30):4117-23.

PMID:
15364465
24.
25.

Equine herpesvirus-1 abortion: atypical cases with lesions largely or wholly restricted to the placenta.

Smith KC, Whitwell KE, Blunden AS, Bestbier ME, Scase TJ, Geraghty RJ, Nugent J, Davis-Poynter NJ, Cardwell JM.

Equine Vet J. 2004 Jan;36(1):79-82. No abstract available.

PMID:
14756377
26.

Testing for equine arteritis virus.

Geraghty RJ, Newton JR, Castillo-Olivares J, Cardwell JM, Mumford JA.

Vet Rec. 2003 Jun 14;152(24):755. No abstract available.

PMID:
12833939
27.

Testing for equine arteritis virus.

Geraghty RJ, Newton JR, Castillo-Olivares J, Cardwell JM, Mumford JA.

Vet Rec. 2003 Apr 12;152(15):478-9. No abstract available.

PMID:
12723636
28.

Equine viral arteritis in the UK.

Cardwell JM, Wood JL, Mumford JA, Geraghty RJ, Hillyer LL, Pascoe RJ.

Vet Rec. 2002 Jun 29;150(26):819-20. No abstract available.

PMID:
12120929
29.

Use of chimeric nectin-1(HveC)-related receptors to demonstrate that ability to bind alphaherpesvirus gD is not necessarily sufficient for viral entry.

Geraghty RJ, Fridberg A, Krummenacher C, Cohen GH, Eisenberg RJ, Spear PG.

Virology. 2001 Jul 5;285(2):366-75.

30.

Organization of the rat Tage4 gene and herpesvirus entry activity of the encoded protein.

Baury B, Geraghty RJ, Masson D, Lustenberger P, Spear PG, Denis MG.

Gene. 2001 Mar 7;265(1-2):185-94.

PMID:
11255021
31.

Contributions of gD receptors and glycosaminoglycan sulfation to cell fusion mediated by herpes simplex virus 1.

Terry-Allison T, Montgomery RI, Warner MS, Geraghty RJ, Spear PG.

Virus Res. 2001 Apr;74(1-2):39-45.

PMID:
11226572
33.

The first immunoglobulin-like domain of HveC is sufficient to bind herpes simplex virus gD with full affinity, while the third domain is involved in oligomerization of HveC.

Krummenacher C, Rux AH, Whitbeck JC, Ponce-de-Leon M, Lou H, Baribaud I, Hou W, Zou C, Geraghty RJ, Spear PG, Eisenberg RJ, Cohen GH.

J Virol. 1999 Oct;73(10):8127-37.

34.

Herpes simplex virus glycoprotein D can bind to poliovirus receptor-related protein 1 or herpesvirus entry mediator, two structurally unrelated mediators of virus entry.

Krummenacher C, Nicola AV, Whitbeck JC, Lou H, Hou W, Lambris JD, Geraghty RJ, Spear PG, Cohen GH, Eisenberg RJ.

J Virol. 1998 Sep;72(9):7064-74.

35.

A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus.

Warner MS, Geraghty RJ, Martinez WM, Montgomery RI, Whitbeck JC, Xu R, Eisenberg RJ, Cohen GH, Spear PG.

Virology. 1998 Jun 20;246(1):179-89.

36.

Entry of alphaherpesviruses mediated by poliovirus receptor-related protein 1 and poliovirus receptor.

Geraghty RJ, Krummenacher C, Cohen GH, Eisenberg RJ, Spear PG.

Science. 1998 Jun 5;280(5369):1618-20.

37.

HIV-1 particle release mediated by Vpu is distinct from that mediated by p6.

Schwartz MD, Geraghty RJ, Panganiban AT.

Virology. 1996 Oct 1;224(1):302-9.

38.

Cell type-dependence for Vpu function.

Geraghty RJ, Talbot KJ, Callahan M, Harper W, Panganiban AT.

J Med Primatol. 1994 Feb-May;23(2-3):146-50.

PMID:
7966229
39.
41.

Autoimmune haemolytic anaemia associated with malignant peritoneal mesothelioma.

Selleslag DL, Geraghty RJ, Ganesan TS, Slevin ML, Wrigley PF, Brown R.

Acta Clin Belg. 1989;44(3):199-201.

PMID:
2816228

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