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Asking the right questions about secondhand smoke.

Klein JD, Chamberlin ME, Kress EA, Geraci MW, Rosenblatt S, Boykan R, Jenssen B, Rosenblatt SM, Milberger S, Adams WG, Goldstein AO, Rigotti NA, Hovell MF, Holm AL, Vandivier RW, Croxton TL, Young PL, Blissard L, Jewell K, Richardson L, Ostrow J, Resnick EA.

Nicotine Tob Res. 2019 Aug 13. pii: ntz125. doi: 10.1093/ntr/ntz125. [Epub ahead of print]


Collagen type-V is a danger signal associated with primary graft dysfunction in lung transplantation.

Zaffiri L, Shah RJ, Stearman RS, Rothhaar K, Emtiazjoo AM, Yoshimoto M, Fisher AJ, Mickler EA, Gartenhaus MD, Cohort LTOG, Diamond JM, Geraci MW, Christie JD, Wilkes DS.

Transpl Immunol. 2019 Oct;56:101224. doi: 10.1016/j.trim.2019.101224. Epub 2019 Jul 17.


A Randomized Phase II Trial of Pioglitazone for Lung Cancer Chemoprevention in High-Risk Current and Former Smokers.

Keith RL, Blatchford PJ, Merrick DT, Bunn PA Jr, Bagwell B, Dwyer-Nield LD, Jackson MK, Geraci MW, Miller YE.

Cancer Prev Res (Phila). 2019 Oct;12(10):721-730. doi: 10.1158/1940-6207.CAPR-19-0006. Epub 2019 Jul 15.


Familial Pulmonary Fibrosis and Hermansky-Pudlak Syndrome Rare Missense Mutations in Context.

Stearman RS, Cornelius AR, Young LR, Conklin DS, Mickler EA, Lu X, Hara N, Fettig LM, Phang TL, Geraci MW.

Am J Respir Crit Care Med. 2019 Jul 15;200(2):253-256. doi: 10.1164/rccm.201902-0457LE. No abstract available.


Carbonic Anhydrase Inhibition Ameliorates Inflammation and Experimental Pulmonary Hypertension.

Hudalla H, Michael Z, Christodoulou N, Willis GR, Fernandez-Gonzalez A, Filatava EJ, Dieffenbach P, Fredenburgh LE, Stearman RS, Geraci MW, Kourembanas S, Christou H.

Am J Respir Cell Mol Biol. 2019 Oct;61(4):512-524. doi: 10.1165/rcmb.2018-0232OC.


Systems Analysis of the Human Pulmonary Arterial Hypertension Lung Transcriptome.

Stearman RS, Bui QM, Speyer G, Handen A, Cornelius AR, Graham BB, Kim S, Mickler EA, Tuder RM, Chan SY, Geraci MW.

Am J Respir Cell Mol Biol. 2019 Jun;60(6):637-649. doi: 10.1165/rcmb.2018-0368OC.


Best Practices for Physician-Scientist Training Programs: Recommendations from the Alliance for Academic Internal Medicine.

Blanchard M, Burton MC, Geraci MW, Madaio MP, Marsh JD, Proweller A, Rockey DC, Salata RA, Tan W, Williams CS, Zaidi M, Todd RF 3rd.

Am J Med. 2018 May;131(5):578-584. doi: 10.1016/j.amjmed.2018.01.015. Epub 2018 Feb 2. No abstract available.


U.S. Physician-Scientist Workforce in the 21st Century: Recommendations to Attract and Sustain the Pipeline.

Salata RA, Geraci MW, Rockey DC, Blanchard M, Brown NJ, Cardinal LJ, Garcia M, Madaio MP, Marsh JD, Todd RF 3rd.

Acad Med. 2018 Apr;93(4):565-573. doi: 10.1097/ACM.0000000000001950.


PTTG1 Levels Are Predictive of Saracatinib Sensitivity in Ovarian Cancer Cell Lines.

Nakachi I, Helfrich BA, Spillman MA, Mickler EA, Olson CJ, Rice JL, Coldren CD, Heasley LE, Geraci MW, Stearman RS.

Clin Transl Sci. 2016 Dec;9(6):293-301. doi: 10.1111/cts.12413. Epub 2016 Oct 20.


Extremes of Interferon-Stimulated Gene Expression Associate with Worse Outcomes in the Acute Respiratory Distress Syndrome.

Nick JA, Caceres SM, Kret JE, Poch KR, Strand M, Faino AV, Nichols DP, Saavedra MT, Taylor-Cousar JL, Geraci MW, Burnham EL, Fessler MB, Suratt BT, Abraham E, Moss M, Malcolm KC.

PLoS One. 2016 Sep 8;11(9):e0162490. doi: 10.1371/journal.pone.0162490. eCollection 2016.


Histone deacetylation contributes to low extracellular superoxide dismutase expression in human idiopathic pulmonary arterial hypertension.

Nozik-Grayck E, Woods C, Stearman RS, Venkataraman S, Ferguson BS, Swain K, Bowler RP, Geraci MW, Ihida-Stansbury K, Stenmark KR, McKinsey TA, Domann FE.

Am J Physiol Lung Cell Mol Physiol. 2016 Jul 1;311(1):L124-34. doi: 10.1152/ajplung.00263.2015. Epub 2016 May 27.


Speckle Tracking Echocardiography to Evaluate for Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease.

Rice JL, Stream AR, Fox DL, Geraci MW, Vandivier RW, Dorosz JL, Bull TM.

COPD. 2016 Oct;13(5):595-600. doi: 10.3109/15412555.2015.1134468. Epub 2016 Feb 1.


Blood Transcriptional Biomarkers for Active Tuberculosis among Patients in the United States: a Case-Control Study with Systematic Cross-Classifier Evaluation.

Walter ND, Miller MA, Vasquez J, Weiner M, Chapman A, Engle M, Higgins M, Quinones AM, Rosselli V, Canono E, Yoon C, Cattamanchi A, Davis JL, Phang T, Stearman RS, Datta G, Garcia BJ, Daley CL, Strong M, Kechris K, Fingerlin TE, Reves R, Geraci MW.

J Clin Microbiol. 2016 Feb;54(2):274-82. doi: 10.1128/JCM.01990-15. Epub 2015 Nov 18.


Transcriptional Impact of Rare and Private Copy Number Variants in Hypoplastic Left Heart Syndrome.

Glidewell SC, Miyamoto SD, Grossfeld PD, Clouthier DE, Coldren CD, Stearman RS, Geraci MW.

Clin Transl Sci. 2015 Dec;8(6):682-9. doi: 10.1111/cts.12340. Epub 2015 Nov 4.


Signatures of accelerated somatic evolution in gene promoters in multiple cancer types.

Smith KS, Yadav VK, Pedersen BS, Shaknovich R, Geraci MW, Pollard KS, De S.

Nucleic Acids Res. 2015 Jun 23;43(11):5307-17. doi: 10.1093/nar/gkv419. Epub 2015 May 1.


MODMatcher: multi-omics data matcher for integrative genomic analysis.

Yoo S, Huang T, Campbell JD, Lee E, Tu Z, Geraci MW, Powell CA, Schadt EE, Spira A, Zhu J.

PLoS Comput Biol. 2014 Aug 14;10(8):e1003790. doi: 10.1371/journal.pcbi.1003790. eCollection 2014 Aug.


Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension.

Stearman RS, Cornelius AR, Lu X, Conklin DS, Del Rosario MJ, Lowe AM, Elos MT, Fettig LM, Wong RE, Hara N, Cogan JD, Phillips JA 3rd, Taylor MR, Graham BB, Tuder RM, Loyd JE, Geraci MW.

Am J Respir Crit Care Med. 2014 May 1;189(9):1110-20. doi: 10.1164/rccm.201309-1697OC.


Application of SNP microarrays to the genome-wide analysis of chromosomal instability in premalignant airway lesions.

Nakachi I, Rice JL, Coldren CD, Edwards MG, Stearman RS, Glidewell SC, Varella-Garcia M, Franklin WA, Keith RL, Lewis MT, Gao B, Merrick DT, Miller YE, Geraci MW.

Cancer Prev Res (Phila). 2014 Feb;7(2):255-65. doi: 10.1158/1940-6207.CAPR-12-0485. Epub 2013 Dec 17.


Integrating molecular genetics and systems approaches to pulmonary vascular diseases.

Geraci MW.

Pulm Circ. 2013 Jan;3(1):171-5. doi: 10.4103/2045-8932.109959.


The pulmonary endothelial glycocalyx regulates neutrophil adhesion and lung injury during experimental sepsis.

Schmidt EP, Yang Y, Janssen WJ, Gandjeva A, Perez MJ, Barthel L, Zemans RL, Bowman JC, Koyanagi DE, Yunt ZX, Smith LP, Cheng SS, Overdier KH, Thompson KR, Geraci MW, Douglas IS, Pearse DB, Tuder RM.

Nat Med. 2012 Aug;18(8):1217-23. doi: 10.1038/nm.2843. Epub 2012 Jul 22.


Increased lymphatic vessel length is associated with the fibroblast reticulum and disease severity in usual interstitial pneumonia and nonspecific interstitial pneumonia.

Lara AR, Cosgrove GP, Janssen WJ, Huie TJ, Burnham EL, Heinz DE, Curran-Everett D, Sahin H, Schwarz MI, Cool CD, Groshong SD, Geraci MW, Tuder RM, Hyde DM, Henson PM.

Chest. 2012 Dec;142(6):1569-1576. doi: 10.1378/chest.12-0029.


Promoter G-quadruplex sequences are targets for base oxidation and strand cleavage during hypoxia-induced transcription.

Clark DW, Phang T, Edwards MG, Geraci MW, Gillespie MN.

Free Radic Biol Med. 2012 Jul 1;53(1):51-9. doi: 10.1016/j.freeradbiomed.2012.04.024. Epub 2012 May 1.


Con: the case for expanded lung cancer research support.

Geraci MW, Keith RL.

Am J Respir Crit Care Med. 2011 Dec 1;184(11):1234-6. doi: 10.1164/rccm.201104-0697ED. No abstract available.


PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression.

Zhou W, Dowell DR, Geraci MW, Blackwell TS, Collins RD, Polosukhin VV, Lawson WE, Wu P, Sussan T, Biswal S, Goleniewska K, O'Neal J, Newcomb DC, Toki S, Morrow JD, Peebles RS Jr.

Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L615-22. doi: 10.1152/ajplung.00224.2010. Epub 2011 Jul 15.


Oral iloprost improves endobronchial dysplasia in former smokers.

Keith RL, Blatchford PJ, Kittelson J, Minna JD, Kelly K, Massion PP, Franklin WA, Mao J, Wilson DO, Merrick DT, Hirsch FR, Kennedy TC, Bunn PA Jr, Geraci MW, Miller YE.

Cancer Prev Res (Phila). 2011 Jun;4(6):793-802. doi: 10.1158/1940-6207.CAPR-11-0057.


Significant downregulation of platelet gene expression in metastatic lung cancer.

Calverley DC, Phang TL, Choudhury QG, Gao B, Oton AB, Weyant MJ, Geraci MW.

Clin Transl Sci. 2010 Oct;3(5):227-32.


Altered immune phenotype in peripheral blood cells of patients with scleroderma-associated pulmonary hypertension.

Risbano MG, Meadows CA, Coldren CD, Jenkins TJ, Edwards MG, Collier D, Huber W, Mack DG, Fontenot AP, Geraci MW, Bull TM.

Clin Transl Sci. 2010 Oct;3(5):210-8. doi: 10.1111/j.1752-8062.2010.00218.x. Erratum in: Clin Transl Sci. 2010 Dec;3(6):340. Hunt, James [added].


Increased expression of growth differentiation factor-15 in systemic sclerosis-associated pulmonary arterial hypertension.

Meadows CA, Risbano MG, Zhang L, Geraci MW, Tuder RM, Collier DH, Bull TM.

Chest. 2011 May;139(5):994-1002. doi: 10.1378/chest.10-0302. Epub 2010 Sep 9.


Somatic chromosome abnormalities in the lungs of patients with pulmonary arterial hypertension.

Aldred MA, Comhair SA, Varella-Garcia M, Asosingh K, Xu W, Noon GP, Thistlethwaite PA, Tuder RM, Erzurum SC, Geraci MW, Coldren CD.

Am J Respir Crit Care Med. 2010 Nov 1;182(9):1153-60. doi: 10.1164/rccm.201003-0491OC. Epub 2010 Jun 25.


The case for 24/7 in-house intensivist coverage.

Burnham EL, Moss M, Geraci MW.

Am J Respir Crit Care Med. 2010 Jun 1;181(11):1159-60. doi: 10.1164/rccm.201004-0651ED. No abstract available.


Genomics of pulmonary arterial hypertension: implications for therapy.

Geraci MW, Bull TM, Tuder RM.

Heart Fail Clin. 2010 Jan;6(1):101-14. doi: 10.1016/j.hfc.2009.08.001. Review.


Prostacyclin inhibits IFN-gamma-stimulated cytokine expression by reduced recruitment of CBP/p300 to STAT1 in a SOCS-1-independent manner.

Strassheim D, Riddle SR, Burke DL, Geraci MW, Stenmark KR.

J Immunol. 2009 Dec 1;183(11):6981-8. doi: 10.4049/jimmunol.0901045. Epub 2009 Nov 13.


Genetics and genomics of pulmonary arterial hypertension.

Machado RD, Eickelberg O, Elliott CG, Geraci MW, Hanaoka M, Loyd JE, Newman JH, Phillips JA 3rd, Soubrier F, Trembath RC, Chung WK.

J Am Coll Cardiol. 2009 Jun 30;54(1 Suppl):S32-42. doi: 10.1016/j.jacc.2009.04.015. Review.


Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis.

Weiser-Evans MC, Wang XQ, Amin J, Van Putten V, Choudhary R, Winn RA, Scheinman R, Simpson P, Geraci MW, Nemenoff RA.

Cancer Res. 2009 Mar 1;69(5):1733-8. doi: 10.1158/0008-5472.CAN-08-3766. Epub 2009 Feb 10.


Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of peroxisomal proliferator--activated receptor gamma.

Nemenoff R, Meyer AM, Hudish TM, Mozer AB, Snee A, Narumiya S, Stearman RS, Winn RA, Weiser-Evans M, Geraci MW, Keith RL.

Cancer Prev Res (Phila). 2008 Oct;1(5):349-56. doi: 10.1158/1940-6207.CAPR-08-0145.


Circulating RNA transcripts identify therapeutic response in cystic fibrosis lung disease.

Saavedra MT, Hughes GJ, Sanders LA, Carr M, Rodman DM, Coldren CD, Geraci MW, Sagel SD, Accurso FJ, West J, Nick JA.

Am J Respir Crit Care Med. 2008 Nov 1;178(9):929-38. doi: 10.1164/rccm.200803-387OC. Epub 2008 Aug 21.


Human herpesvirus-8 infection of primary pulmonary microvascular endothelial cells.

Bull TM, Meadows CA, Coldren CD, Moore M, Sotto-Santiago SM, Nana-Sinkam SP, Campbell TB, Geraci MW.

Am J Respir Cell Mol Biol. 2008 Dec;39(6):706-16. doi: 10.1165/rcmb.2007-0368OC. Epub 2008 Jun 27.


A macrophage gene expression signature defines a field effect in the lung tumor microenvironment.

Stearman RS, Dwyer-Nield L, Grady MC, Malkinson AM, Geraci MW.

Cancer Res. 2008 Jan 1;68(1):34-43. doi: 10.1158/0008-5472.CAN-07-0988.


MicroRNA in lung cancer.

Nana-Sinkam SP, Geraci MW.

J Thorac Oncol. 2006 Nov;1(9):929-31. Review. No abstract available.


Prostacyclin in lung cancer.

Keith RL, Geraci MW.

J Thorac Oncol. 2006 Jul;1(6):503-5. Review. No abstract available.


Genetic and epigenetic regulation of the human prostacyclin synthase promoter in lung cancer cell lines.

Stearman RS, Grady MC, Nana-Sinkam P, Varella-Garcia M, Geraci MW.

Mol Cancer Res. 2007 Mar;5(3):295-308.


Prostacyclin prevents pulmonary endothelial cell apoptosis induced by cigarette smoke.

Nana-Sinkam SP, Lee JD, Sotto-Santiago S, Stearman RS, Keith RL, Choudhury Q, Cool C, Parr J, Moore MD, Bull TM, Voelkel NF, Geraci MW.

Am J Respir Crit Care Med. 2007 Apr 1;175(7):676-85. Epub 2007 Jan 25.


Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells.

Zhou W, Hashimoto K, Goleniewska K, O'Neal JF, Ji S, Blackwell TS, Fitzgerald GA, Egan KM, Geraci MW, Peebles RS Jr.

J Immunol. 2007 Jan 15;178(2):702-10.


Gene expression profiling in pulmonary hypertension.

Bull TM, Coldren CD, Geraci MW, Voelkel NF.

Proc Am Thorac Soc. 2007 Jan;4(1):117-20. Review.


Lung tissue banks for gene expression studies.

Cool CD, Geraci MW.

COPD. 2004;1(2):153. No abstract available.


Prostacyclin synthase in smoking-related lung disease.

Nana-Sinkam SP, Lee JD, Stearman R, Sakao S, Sotto-Santiago S, Voelkel NF, Geraci MW.

Proc Am Thorac Soc. 2006 Aug;3(6):517. No abstract available.


Prostaglandin E2 receptor subtype 2 (EP2) null mice are protected against murine lung tumorigenesis.

Keith RL, Geraci MW, Nana-Sinkam SP, Breyer RM, Hudish TM, Meyer AM, Malkinson AM, Dwyer-Nield LD.

Anticancer Res. 2006 Jul-Aug;26(4B):2857-61.


Baseline gene expression predicts sensitivity to gefitinib in non-small cell lung cancer cell lines.

Coldren CD, Helfrich BA, Witta SE, Sugita M, Lapadat R, Zeng C, BarĂ³n A, Franklin WA, Hirsch FR, Geraci MW, Bunn PA Jr.

Mol Cancer Res. 2006 Aug;4(8):521-8.


Functional and genomic changes induced by alveolar transmigration in human neutrophils.

Coldren CD, Nick JA, Poch KR, Woolum MD, Fouty BW, O'Brien JM, Gruber MP, Zamora MR, Svetkauskaite D, Richter DA, He Q, Park JS, Overdier KH, Abraham E, Geraci MW.

Am J Physiol Lung Cell Mol Physiol. 2006 Dec;291(6):L1267-76. Epub 2006 Jul 21.

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