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Items: 1 to 50 of 100

1.

Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation.

Yoshida T, Hu Y, Zhang Z, Emmanuel AO, Galani K, Muhire B, Snippert HJ, Williams CJ, Tolstorukov MY, Gounari F, Georgopoulos K.

Genes Dev. 2019 Jul 1;33(13-14):763-781. doi: 10.1101/gad.321901.118. Epub 2019 May 23.

PMID:
31123064
2.

Hypomorphic mutation of the mouse Huntington's disease gene orthologue.

Murthy V, Tebaldi T, Yoshida T, Erdin S, Calzonetti T, Vijayvargia R, Tripathi T, Kerschbamer E, Seong IS, Quattrone A, Talkowski ME, Gusella JF, Georgopoulos K, MacDonald ME, Biagioli M.

PLoS Genet. 2019 Mar 21;15(3):e1007765. doi: 10.1371/journal.pgen.1007765. eCollection 2019 Mar.

3.

Actin' Up to Stop SNFin Out TEAD.

McClatchey AI, Georgopoulos K.

Dev Cell. 2018 Dec 17;47(6):693-695. doi: 10.1016/j.devcel.2018.11.037.

PMID:
30562513
4.

Transcriptional circuits in B cell transformation.

Hu Y, Yoshida T, Georgopoulos K.

Curr Opin Hematol. 2017 Jul;24(4):345-352. doi: 10.1097/MOH.0000000000000352. Review.

5.

The making of a lymphocyte: the choice among disparate cell fates and the IKAROS enigma.

Georgopoulos K.

Genes Dev. 2017 Mar 1;31(5):439-450. doi: 10.1101/gad.297002.117. Review.

6.

Calcium homeostasis in women with non-metastatic breast cancer with osteoporosis after a single dose of denosumab: a pilot study.

Toulis K, Iliadou P, Mandanas S, Kazila P, Margaritidou E, Georgopoulos K, Pazaitou-Panayiotou K.

Hormones (Athens). 2016 Oct;15(4):560-562. doi: 10.14310/horm.2002.1693. No abstract available.

7.

In search of the mechanism that shapes the neutrophil's nucleus.

Georgopoulos K.

Genes Dev. 2017 Jan 15;31(2):85-87. doi: 10.1101/gad.296228.117. Review.

8.

Direct control of regulatory T cells by keratinocytes.

Kashiwagi M, Hosoi J, Lai JF, Brissette J, Ziegler SF, Morgan BA, Georgopoulos K.

Nat Immunol. 2017 Mar;18(3):334-343. doi: 10.1038/ni.3661. Epub 2017 Jan 16.

9.

Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.

Hayakawa M, Hayakawa H, Petrova T, Ritprajak P, Sutavani RV, Jiménez-Andrade GY, Sano Y, Choo MK, Seavitt J, Venigalla RK, Otsu K, Georgopoulos K, Arthur JS, Park JM.

J Biol Chem. 2017 Feb 3;292(5):1762-1772. doi: 10.1074/jbc.M116.764548. Epub 2016 Dec 23.

10.

Superenhancer reprogramming drives a B-cell-epithelial transition and high-risk leukemia.

Hu Y, Zhang Z, Kashiwagi M, Yoshida T, Joshi I, Jena N, Somasundaram R, Emmanuel AO, Sigvardsson M, Fitamant J, El-Bardeesy N, Gounari F, Van Etten RA, Georgopoulos K.

Genes Dev. 2016 Sep 1;30(17):1971-90. doi: 10.1101/gad.283762.116.

11.

Protein-Based Graphene Biosensors: Optimizing Artificial Chemoreception in Bilayer Lipid Membranes.

Siontorou CG, Georgopoulos KN, Nikoleli GP, Nikolelis DP, Karapetis SK, Bratakou S.

Membranes (Basel). 2016 Sep 7;6(3). pii: E43. doi: 10.3390/membranes6030043.

12.

Induction of Bcl11b during T cell commitment through a tripartite mechanism.

Georgopoulos K.

Nat Immunol. 2016 Jul 19;17(8):903-4. doi: 10.1038/ni.3520. No abstract available.

PMID:
27434004
13.

The Chromatin Remodeling Complex Chd4/NuRD Controls Striated Muscle Identity and Metabolic Homeostasis.

Gómez-Del Arco P, Perdiguero E, Yunes-Leites PS, Acín-Pérez R, Zeini M, Garcia-Gomez A, Sreenivasan K, Jiménez-Alcázar M, Segalés J, López-Maderuelo D, Ornés B, Jiménez-Borreguero LJ, D'Amato G, Enshell-Seijffers D, Morgan B, Georgopoulos K, Islam AB, Braun T, de la Pompa JL, Kim J, Enriquez JA, Ballestar E, Muñoz-Cánoves P, Redondo JM.

Cell Metab. 2016 May 10;23(5):881-92. doi: 10.1016/j.cmet.2016.04.008.

14.

Treatment compliance and severe adverse events limit the use of tyrosine kinase inhibitors in refractory thyroid cancer.

Chrisoulidou A, Mandanas S, Margaritidou E, Mathiopoulou L, Boudina M, Georgopoulos K, Pazaitou-Panayiotou K.

Onco Targets Ther. 2015 Sep 3;8:2435-42. doi: 10.2147/OTT.S86322. eCollection 2015.

15.

Breast Metastasis from Medullary Thyroid Carcinoma in a Male Patient: Case Report and Review of the Literature.

Mandanas S, Margaritidou E, Christoforidou V, Karoglou E, Geranou C, Chrisoulidou A, Boudina M, Georgopoulos K, Pazaitou-Panayiotou K.

Rare Tumors. 2015 May 18;7(2):5765. doi: 10.4081/rt.2015.5765. eCollection 2015 May 5.

16.

An Ikaros Promoter Element with Dual Epigenetic and Transcriptional Activities.

Perotti EA, Georgopoulos K, Yoshida T.

PLoS One. 2015 Jul 2;10(7):e0131568. doi: 10.1371/journal.pone.0131568. eCollection 2015.

17.

Ebf1 in DNA repair and leukemogenesis.

Georgopoulos K.

Blood. 2015 Jun 25;125(26):3969-71. doi: 10.1182/blood-2015-05-639427.

18.

Ikaros fingers on lymphocyte differentiation.

Yoshida T, Georgopoulos K.

Int J Hematol. 2014 Sep;100(3):220-9. doi: 10.1007/s12185-014-1644-5. Epub 2014 Aug 2. Review.

19.

Promoter decommissioning by the NuRD chromatin remodeling complex triggers synaptic connectivity in the mammalian brain.

Yamada T, Yang Y, Hemberg M, Yoshida T, Cho HY, Murphy JP, Fioravante D, Regehr WG, Gygi SP, Georgopoulos K, Bonni A.

Neuron. 2014 Jul 2;83(1):122-34. doi: 10.1016/j.neuron.2014.05.039.

20.

Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia.

Joshi I, Yoshida T, Jena N, Qi X, Zhang J, Van Etten RA, Georgopoulos K.

Nat Immunol. 2014 Mar;15(3):294-304. doi: 10.1038/ni.2821. Epub 2014 Feb 9.

21.

β-Catenin induces T-cell transformation by promoting genomic instability.

Dose M, Emmanuel AO, Chaumeil J, Zhang J, Sun T, Germar K, Aghajani K, Davis EM, Keerthivasan S, Bredemeyer AL, Sleckman BP, Rosen ST, Skok JA, Le Beau MM, Georgopoulos K, Gounari F.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):391-6. doi: 10.1073/pnas.1315752111. Epub 2013 Dec 26.

22.

GATA-3 controls self-renewal in stressed HSCs.

Yoshida T, Georgopoulos K.

Nat Immunol. 2013 Oct;14(10):1032-3. doi: 10.1038/ni.2715. No abstract available.

PMID:
24048133
23.

Transcriptional regulation of the Ikzf1 locus.

Yoshida T, Landhuis E, Dose M, Hazan I, Zhang J, Naito T, Jackson AF, Wu J, Perotti EA, Kaufmann C, Gounari F, Morgan BA, Georgopoulos K.

Blood. 2013 Oct 31;122(18):3149-59. doi: 10.1182/blood-2013-01-474916. Epub 2013 Sep 3.

24.

Aiolos promotes TH17 differentiation by directly silencing Il2 expression.

Quintana FJ, Jin H, Burns EJ, Nadeau M, Yeste A, Kumar D, Rangachari M, Zhu C, Xiao S, Seavitt J, Georgopoulos K, Kuchroo VK.

Nat Immunol. 2012 Jul 1;13(8):770-7. doi: 10.1038/ni.2363. Erratum in: Nat Immunol. 2014 Jan;15(1):109.

25.

A pair of transmembrane receptors essential for the retention and pigmentation of hair.

Han R, Beppu H, Lee YK, Georgopoulos K, Larue L, Li E, Weiner L, Brissette JL.

Genesis. 2012 Nov;50(11):783-800. doi: 10.1002/dvg.22039. Epub 2012 Jun 19.

26.

Helios transcription factor expression depends on Gsx2 and Dlx1&2 function in developing striatal matrix neurons.

Martín-Ibáñez R, Crespo E, Esgleas M, Urban N, Wang B, Waclaw R, Georgopoulos K, Martínez S, Campbell K, Vicario-Abejón C, Alberch J, Chan S, Kastner P, Rubenstein JL, Canals JM.

Stem Cells Dev. 2012 Aug 10;21(12):2239-51. doi: 10.1089/scd.2011.0607. Epub 2012 Jan 26.

27.

Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis.

Zhang J, Jackson AF, Naito T, Dose M, Seavitt J, Liu F, Heller EJ, Kashiwagi M, Yoshida T, Gounari F, Petrie HT, Georgopoulos K.

Nat Immunol. 2011 Nov 13;13(1):86-94. doi: 10.1038/ni.2150.

28.

Pre-TCR signaling and CD8 gene bivalent chromatin resolution during thymocyte development.

Harker N, Garefalaki A, Menzel U, Ktistaki E, Naito T, Georgopoulos K, Kioussis D.

J Immunol. 2011 Jun 1;186(11):6368-77. doi: 10.4049/jimmunol.1003567. Epub 2011 Apr 22.

29.

Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis.

Gómez-del Arco P, Kashiwagi M, Jackson AF, Naito T, Zhang J, Liu F, Kee B, Vooijs M, Radtke F, Redondo JM, Georgopoulos K.

Immunity. 2010 Nov 24;33(5):685-98. doi: 10.1016/j.immuni.2010.11.008.

30.

Awakening lineage potential by Ikaros-mediated transcriptional priming.

Yoshida T, Ng SY, Georgopoulos K.

Curr Opin Immunol. 2010 Apr;22(2):154-60. doi: 10.1016/j.coi.2010.02.011. Epub 2010 Mar 17. Review.

31.

Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons.

Martín-Ibáñez R, Crespo E, Urbán N, Sergent-Tanguy S, Herranz C, Jaumot M, Valiente M, Long JE, Pineda JR, Andreu C, Rubenstein JL, Marín O, Georgopoulos K, Mengod G, Fariñas I, Bachs O, Alberch J, Canals JM.

J Comp Neurol. 2010 Feb 1;518(3):329-51. doi: 10.1002/cne.22215.

PMID:
19950118
32.

Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development.

Mandal M, Powers SE, Ochiai K, Georgopoulos K, Kee BL, Singh H, Clark MR.

Nat Immunol. 2009 Oct;10(10):1110-7. doi: 10.1038/ni.1785. Epub 2009 Sep 6.

33.

Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells.

Ng SY, Yoshida T, Zhang J, Georgopoulos K.

Immunity. 2009 Apr 17;30(4):493-507. doi: 10.1016/j.immuni.2009.01.014. Epub 2009 Apr 2.

34.

Acute lymphoblastic leukemia--on the wings of IKAROS.

Georgopoulos K.

N Engl J Med. 2009 Jan 29;360(5):524-6. doi: 10.1056/NEJMe0809819. Epub 2009 Jan 8. No abstract available.

PMID:
19131438
35.

From immunity to tolerance through HDAC.

Georgopoulos K.

Nat Immunol. 2009 Jan;10(1):13-4. doi: 10.1038/ni0109-13.

PMID:
19088734
36.

The role of the chromatin remodeler Mi-2beta in hematopoietic stem cell self-renewal and multilineage differentiation.

Yoshida T, Hazan I, Zhang J, Ng SY, Naito T, Snippert HJ, Heller EJ, Qi X, Lawton LN, Williams CJ, Georgopoulos K.

Genes Dev. 2008 May 1;22(9):1174-89. doi: 10.1101/gad.1642808.

37.

Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression.

Naito T, Gómez-Del Arco P, Williams CJ, Georgopoulos K.

Immunity. 2007 Nov;27(5):723-34. Epub 2007 Nov 1.

38.

Epigenetic flexibility underlying lineage choices in the adaptive immune system.

Kioussis D, Georgopoulos K.

Science. 2007 Aug 3;317(5838):620-2.

PMID:
17673651
39.

Ikaros is expressed in developing striatal neurons and involved in enkephalinergic differentiation.

Agoston DV, Szemes M, Dobi A, Palkovits M, Georgopoulos K, Gyorgy A, Ring MA.

J Neurochem. 2007 Sep;102(6):1805-1816. doi: 10.1111/j.1471-4159.2007.04653.x. Epub 2007 May 14.

40.

Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits.

Thompson EC, Cobb BS, Sabbattini P, Meixlsperger S, Parelho V, Liberg D, Taylor B, Dillon N, Georgopoulos K, Jumaa H, Smale ST, Fisher AG, Merkenschlager M.

Immunity. 2007 Mar;26(3):335-44. Erratum in: Immunity. 2007 Apr;26(4):533.

41.

The chromatin remodeler Mi-2beta is required for establishment of the basal epidermis and normal differentiation of its progeny.

Kashiwagi M, Morgan BA, Georgopoulos K.

Development. 2007 Apr;134(8):1571-82. Epub 2007 Mar 14.

42.

Ikaros and chromatin regulation in early hematopoiesis.

Ng SY, Yoshida T, Georgopoulos K.

Curr Opin Immunol. 2007 Apr;19(2):116-22. Epub 2007 Feb 20. Review.

PMID:
17307348
43.

Early hematopoietic lineage restrictions directed by Ikaros.

Yoshida T, Ng SY, Zuniga-Pflucker JC, Georgopoulos K.

Nat Immunol. 2006 Apr;7(4):382-91. Epub 2006 Mar 5.

44.

Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome.

Ueda Y, Okano M, Williams C, Chen T, Georgopoulos K, Li E.

Development. 2006 Mar;133(6):1183-92.

45.

Targeted deletion of integrin-linked kinase reveals a role in T-cell chemotaxis and survival.

Liu E, Sinha S, Williams C, Cyrille M, Heller E, Snapper SB, Georgopoulos K, St-Arnaud R, Force T, Dedhar S, Gerszten RE.

Mol Cell Biol. 2005 Dec;25(24):11145-55.

46.

Ikaros SUMOylation: switching out of repression.

Gómez-del Arco P, Koipally J, Georgopoulos K.

Mol Cell Biol. 2005 Apr;25(7):2688-97.

47.

The chromatin remodeler Mi-2beta is required for CD4 expression and T cell development.

Williams CJ, Naito T, Arco PG, Seavitt JR, Cashman SM, De Souza B, Qi X, Keables P, Von Andrian UH, Georgopoulos K.

Immunity. 2004 Jun;20(6):719-33.

48.

Phosphorylation controls Ikaros's ability to negatively regulate the G(1)-S transition.

Gómez-del Arco P, Maki K, Georgopoulos K.

Mol Cell Biol. 2004 Apr;24(7):2797-807.

49.
50.

A complex network of regulatory elements in Ikaros and their activity during hemo-lymphopoiesis.

Kaufmann C, Yoshida T, Perotti EA, Landhuis E, Wu P, Georgopoulos K.

EMBO J. 2003 May 1;22(9):2211-23.

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