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Postoperative chemotherapy with single-agent fluoropyrimidines after resection of colorectal cancer liver metastases: a meta-analysis of randomised trials.

Mauri D, Zarkavelis G, Filis P, Tsali L, Zafeiri G, Papadaki A, Vassou A, Georgopoulos C, Pentheroudakis G.

ESMO Open. 2018 Jun 23;3(4):e000343. doi: 10.1136/esmoopen-2018-000343. eCollection 2018.


Incidence of and Risk Factors for Symptomatic Venous Thromboembolism After Shoulder Arthroplasty.

Tashjian RZ, Lilly DT, Isaacson AM, Georgopoulos CE, Bettwieser SP, Burks RT, Greis PE, Presson AP, Granger EK, Zhang Y.

Am J Orthop (Belle Mead NJ). 2016 Sep/Oct;45(6):E379-E385.


Ring Separation Highlights the Protein-Folding Mechanism Used by the Phage EL-Encoded Chaperonin.

Molugu SK, Hildenbrand ZL, Morgan DG, Sherman MB, He L, Georgopoulos C, Sernova NV, Kurochkina LP, Mesyanzhinov VV, Miroshnikov KA, Bernal RA.

Structure. 2016 Apr 5;24(4):537-546. doi: 10.1016/j.str.2016.02.006. Epub 2016 Mar 17.


How WWII and the old Turkish mass standard led a Greek to a scientific career.

Georgopoulos C.

Bacteriophage. 2015 Oct 27;6(1):e1093065. eCollection 2016 Jan-Mar. No abstract available.


Reporting of serious adverse events during cancer clinical trials to the institutional review board: an evaluation by the research on adverse drug events and reports (RADAR) project.

Belknap SM, Georgopoulos CH, Lagman J, Weitzman SA, Qualkenbush L, Yarnold PR, Edwards BJ, McKoy JM, Trifilio SM, West DP.

J Clin Pharmacol. 2013 Dec;53(12):1334-40. doi: 10.1002/jcph.177. Epub 2013 Sep 25.


Hsp33 controls elongation factor-Tu stability and allows Escherichia coli growth in the absence of the major DnaK and trigger factor chaperones.

Bruel N, Castanié-Cornet MP, Cirinesi AM, Koningstein G, Georgopoulos C, Luirink J, Genevaux P.

J Biol Chem. 2012 Dec 28;287(53):44435-46. doi: 10.1074/jbc.M112.418525. Epub 2012 Nov 12.


A bacteriophage-encoded J-domain protein interacts with the DnaK/Hsp70 chaperone and stabilizes the heat-shock factor σ32 of Escherichia coli.

Perrody E, Cirinesi AM, Desplats C, Keppel F, Schwager F, Tranier S, Georgopoulos C, Genevaux P.

PLoS Genet. 2012;8(11):e1003037. doi: 10.1371/journal.pgen.1003037. Epub 2012 Nov 1.


An ORFan no more: the bacteriophage T4 39.2 gene product, NwgI, modulates GroEL chaperone function.

Ang D, Georgopoulos C.

Genetics. 2012 Mar;190(3):989-1000. doi: 10.1534/genetics.111.135640. Epub 2012 Jan 10.


Quality of methods for assessing and reporting serious adverse events in clinical trials of cancer drugs.

Belknap SM, Georgopoulos CH, West DP, Yarnold PR, Kelly WN.

Clin Pharmacol Ther. 2010 Aug;88(2):231-6. doi: 10.1038/clpt.2010.79. Epub 2010 Jun 23.


Lon protease quality control of presecretory proteins in Escherichia coli and its dependence on the SecB and DnaJ (Hsp40) chaperones.

Sakr S, Cirinesi AM, Ullers RS, Schwager F, Georgopoulos C, Genevaux P.

J Biol Chem. 2010 Jul 23;285(30):23506-14. doi: 10.1074/jbc.M110.133058. Epub 2010 May 26.


The Hsp40 J-domain stimulates Hsp70 when tethered by the client to the ATPase domain.

Horne BE, Li T, Genevaux P, Georgopoulos C, Landry SJ.

J Biol Chem. 2010 Jul 9;285(28):21679-88. doi: 10.1074/jbc.M110.113118. Epub 2010 May 6.


Normochromic normocytic anemia in a postmenopausal woman with severe osteoporosis treated with intermittent parathyroid hormone.

Anastasilakis AD, Savvides M, Polyzos SA, Georgopoulos C, Delaroudis S.

J Bone Miner Metab. 2010;28(1):108-10. doi: 10.1007/s00774-009-0105-3. Epub 2009 Jul 4.


Quality of reporting of serious adverse drug events to an institutional review board: a case study with the novel cancer agent, imatinib mesylate.

Dorr DA, Burdon R, West DP, Lagman J, Georgopoulos C, Belknap SM, McKoy JM, Djulbegovic B, Edwards BJ, Weitzman SA, Boyle S, Tallman MS, Talpaz M, Sartor O, Bennett CL.

Clin Cancer Res. 2009 Jun 1;15(11):3850-5. doi: 10.1158/1078-0432.CCR-08-1811. Epub 2009 May 19.


Mitochondrial hsp60 chaperonopathy causes an autosomal-recessive neurodegenerative disorder linked to brain hypomyelination and leukodystrophy.

Magen D, Georgopoulos C, Bross P, Ang D, Segev Y, Goldsher D, Nemirovski A, Shahar E, Ravid S, Luder A, Heno B, Gershoni-Baruch R, Skorecki K, Mandel H.

Am J Hum Genet. 2008 Jul;83(1):30-42. doi: 10.1016/j.ajhg.2008.05.016. Epub 2008 Jun 19.


The Hsp60-(p.V98I) mutation associated with hereditary spastic paraplegia SPG13 compromises chaperonin function both in vitro and in vivo.

Bross P, Naundrup S, Hansen J, Nielsen MN, Christensen JH, Kruhøffer M, Palmfeldt J, Corydon TJ, Gregersen N, Ang D, Georgopoulos C, Nielsen KL.

J Biol Chem. 2008 Jun 6;283(23):15694-700. doi: 10.1074/jbc.M800548200. Epub 2008 Apr 8.


The Hsp70 chaperone machines of Escherichia coli: a paradigm for the repartition of chaperone functions.

Genevaux P, Georgopoulos C, Kelley WL.

Mol Microbiol. 2007 Nov;66(4):840-57. Epub 2007 Oct 4. Review.


A novel mutation in the HSPD1 gene in a patient with hereditary spastic paraplegia.

Hansen J, Svenstrup K, Ang D, Nielsen MN, Christensen JH, Gregersen N, Nielsen JE, Georgopoulos C, Bross P.

J Neurol. 2007 Jul;254(7):897-900. Epub 2007 Apr 10.


Trigger Factor can antagonize both SecB and DnaK/DnaJ chaperone functions in Escherichia coli.

Ullers RS, Ang D, Schwager F, Georgopoulos C, Genevaux P.

Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3101-6. Epub 2007 Feb 20.


Identification of nascent chain interaction sites on trigger factor.

Lakshmipathy SK, Tomic S, Kaiser CM, Chang HC, Genevaux P, Georgopoulos C, Barral JM, Johnson AE, Hartl FU, Etchells SA.

J Biol Chem. 2007 Apr 20;282(16):12186-93. Epub 2007 Feb 12.


Isolation and characterization of biofilm formation-defective mutants of Staphylococcus aureus.

Tu Quoc PH, Genevaux P, Pajunen M, Savilahti H, Georgopoulos C, Schrenzel J, Kelley WL.

Infect Immun. 2007 Mar;75(3):1079-88. Epub 2006 Dec 11.


Single-nucleotide variations in the genes encoding the mitochondrial Hsp60/Hsp10 chaperone system and their disease-causing potential.

Bross P, Li Z, Hansen J, Hansen JJ, Nielsen MN, Corydon TJ, Georgopoulos C, Ang D, Lundemose JB, Niezen-Koning K, Eiberg H, Yang H, Kølvraa S, Bolund L, Gregersen N.

J Hum Genet. 2007;52(1):56-65. Epub 2006 Oct 27.


The role of the DIF motif of the DnaJ (Hsp40) co-chaperone in the regulation of the DnaK (Hsp70) chaperone cycle.

Cajo GC, Horne BE, Kelley WL, Schwager F, Georgopoulos C, Genevaux P.

J Biol Chem. 2006 May 5;281(18):12436-44. Epub 2006 Mar 13.


Proteome-wide analysis of chaperonin-dependent protein folding in Escherichia coli.

Kerner MJ, Naylor DJ, Ishihama Y, Maier T, Chang HC, Stines AP, Georgopoulos C, Frishman D, Hayer-Hartl M, Mann M, Hartl FU.

Cell. 2005 Jul 29;122(2):209-20.


[Comparison of the genome for phylogenetically related bacteriophages phiKZ and EL of Pseudomonas aeruginosa: evolutionary aspects and minimal genome size].

Krylov VN, Pletneva EA, Lavigne R, Hertveldt K, Volkaert G, Sernova NV, Georgopoulos C, Korchevsliĭ RV, Kurochkina LP, Mesianzhinov VV.

Genetika. 2005 Apr;41(4):455-65. Russian.


The Escherichia coli DjlA and CbpA proteins can substitute for DnaJ in DnaK-mediated protein disaggregation.

Gur E, Biran D, Shechter N, Genevaux P, Georgopoulos C, Ron EZ.

J Bacteriol. 2004 Nov;186(21):7236-42.


A mobile loop order-disorder transition modulates the speed of chaperonin cycling.

Shewmaker F, Kerner MJ, Hayer-Hartl M, Klein G, Georgopoulos C, Landry SJ.

Protein Sci. 2004 Aug;13(8):2139-48. Epub 2004 Jul 6.


SecB is a bona fide generalized chaperone in Escherichia coli.

Ullers RS, Luirink J, Harms N, Schwager F, Georgopoulos C, Genevaux P.

Proc Natl Acad Sci U S A. 2004 May 18;101(20):7583-8. Epub 2004 May 5.


Function of trigger factor and DnaK in multidomain protein folding: increase in yield at the expense of folding speed.

Agashe VR, Guha S, Chang HC, Genevaux P, Hayer-Hartl M, Stemp M, Georgopoulos C, Hartl FU, Barral JM.

Cell. 2004 Apr 16;117(2):199-209.


In vivo analysis of the overlapping functions of DnaK and trigger factor.

Genevaux P, Keppel F, Schwager F, Langendijk-Genevaux PS, Hartl FU, Georgopoulos C.

EMBO Rep. 2004 Feb;5(2):195-200. Epub 2004 Jan 9.


Functional characterization of an archaeal GroEL/GroES chaperonin system: significance of substrate encapsulation.

Figueiredo L, Klunker D, Ang D, Naylor DJ, Kerner MJ, Georgopoulos C, Hartl FU, Hayer-Hartl M.

J Biol Chem. 2004 Jan 9;279(2):1090-9. Epub 2003 Oct 23.


Simian virus 40 T antigens and J domains: analysis of Hsp40 cochaperone functions in Escherichia coli.

Genevaux P, Lang F, Schwager F, Vartikar JV, Rundell K, Pipas JM, Georgopoulos C, Kelley WL.

J Virol. 2003 Oct;77(19):10706-13.


Intramedullary cervical chordoma. Case illustration.

Papanikolaou PG, Kotselas VT, Alamani MD, Atzemi-Moldow N, Foukas P, Hatzidakis GI, Georgopoulos CE.

J Neurosurg. 2003 Jul;99(1 Suppl):137. No abstract available.


The OmpL porin does not modulate redox potential in the periplasmic space of Escherichia coli.

Sardesai AA, Genevaux P, Schwager F, Ang D, Georgopoulos C.

EMBO J. 2003 Apr 1;22(7):1461-6.


Bacteriophage-encoded cochaperonins can substitute for Escherichia coli's essential GroES protein.

Keppel F, Rychner M, Georgopoulos C.

EMBO Rep. 2002 Sep;3(9):893-8. Epub 2002 Aug 16.


Hereditary spastic paraplegia SPG13 is associated with a mutation in the gene encoding the mitochondrial chaperonin Hsp60.

Hansen JJ, Dürr A, Cournu-Rebeix I, Georgopoulos C, Ang D, Nielsen MN, Davoine CS, Brice A, Fontaine B, Gregersen N, Bross P.

Am J Hum Genet. 2002 May;70(5):1328-32. Epub 2002 Mar 15.


The djlA gene acts synergistically with dnaJ in promoting Escherichia coli growth.

Genevaux P, Schwager F, Georgopoulos C, Kelley WL.

J Bacteriol. 2001 Oct;183(19):5747-50.


Structure-function analysis of the zinc-binding region of the Clpx molecular chaperone.

Banecki B, Wawrzynow A, Puzewicz J, Georgopoulos C, Zylicz M.

J Biol Chem. 2001 Jun 1;276(22):18843-8. Epub 2001 Mar 13.


Pseudo-T-even bacteriophage RB49 encodes CocO, a cochaperonin for GroEL, which can substitute for Escherichia coli's GroES and bacteriophage T4's Gp31.

Ang D, Richardson A, Mayer MP, Keppel F, Krisch H, Georgopoulos C.

J Biol Chem. 2001 Mar 23;276(12):8720-6. Epub 2000 Dec 4.


DjlA is a third DnaK co-chaperone of Escherichia coli, and DjlA-mediated induction of colanic acid capsule requires DjlA-DnaK interaction.

Genevaux P, Wawrzynow A, Zylicz M, Georgopoulos C, Kelley WL.

J Biol Chem. 2001 Mar 16;276(11):7906-12. Epub 2000 Dec 5.


Genetic analysis of bacteriophage-encoded cochaperonins.

Ang D, Keppel F, Klein G, Richardson A, Georgopoulos C.

Annu Rev Genet. 2000;34:439-456. Review.


The importance of a mobile loop in regulating chaperonin/ co-chaperonin interaction: humans versus Escherichia coli.

Richardson A, Schwager F, Landry SJ, Georgopoulos C.

J Biol Chem. 2001 Feb 16;276(7):4981-7. Epub 2000 Oct 24.


Ruptured aneurysm at the trunk of the accessory middle cerebral artery.

Georgopoulos CE, Papanikolaou PG, Vlachos KI, Atzemi-Moldow N, Hatzidakis GI.

Acta Neurochir (Wien). 1999;141(11):1233-5.


Genetic analysis of the bacteriophage T4-encoded cochaperonin Gp31.

Richardson A, Georgopoulos C.

Genetics. 1999 Aug;152(4):1449-57.


Polypeptide flux through bacterial Hsp70: DnaK cooperates with trigger factor in chaperoning nascent chains.

Teter SA, Houry WA, Ang D, Tradler T, Rockabrand D, Fischer G, Blum P, Georgopoulos C, Hartl FU.

Cell. 1999 Jun 11;97(6):755-65.


Recognition, targeting, and hydrolysis of the lambda O replication protein by the ClpP/ClpX protease.

Gonciarz-Swiatek M, Wawrzynow A, Um SJ, Learn BA, McMacken R, Kelley WL, Georgopoulos C, Sliekers O, Zylicz M.

J Biol Chem. 1999 May 14;274(20):13999-4005.


Compensatory changes in GroEL/Gp31 affinity as a mechanism for allele-specific genetic interaction.

Richardson A, van der Vies SM, Keppel F, Taher A, Landry SJ, Georgopoulos C.

J Biol Chem. 1999 Jan 1;274(1):52-8.

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