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Items: 1 to 50 of 365

1.

Pixantrone plus rituximab versus gemcitabine plus rituximab in patients with relapsed aggressive B-cell non-Hodgkin lymphoma not eligible for stem cell transplantation: a phase 3, randomized, multicentre trial (PIX306).

Pettengell R, Długosz-Danecka M, Andorsky D, Belada D, Georgiev P, Quick D, Singer JW, Singh SB, Pallis A, Egorov A, Salles G.

Br J Haematol. 2020 Jan;188(2):240-248. doi: 10.1111/bjh.16255. Epub 2019 Dec 27.

PMID:
31879945
2.

HIPP1 stabilizes the interaction between CP190 and Su(Hw) in the Drosophila insulator complex.

Melnikova L, Molodina V, Erokhin M, Georgiev P, Golovnin A.

Sci Rep. 2019 Dec 13;9(1):19102. doi: 10.1038/s41598-019-55617-6.

3.

Activation of Su(Hw)-Controlled Genes Is Associated with Increase in GAF Binding.

Elizar'ev PV, Chetverina DA, Melnikova LS, Srivastava A, Mishra RK, Golovnin AK, Georgiev PG, Erokhin MM.

Dokl Biochem Biophys. 2019 Sep;488(1):293-295. doi: 10.1134/S1607672919050016. Epub 2019 Nov 25.

PMID:
31768843
4.

Small Drosophila zinc finger C2H2 protein with an N-terminal zinc finger-associated domain demonstrates the architecture functions.

Maksimenko O, Kyrchanova O, Klimenko N, Zolotarev N, Elizarova A, Bonchuk A, Georgiev P.

Biochim Biophys Acta Gene Regul Mech. 2020 Jan;1863(1):194446. doi: 10.1016/j.bbagrm.2019.194446. Epub 2019 Nov 6.

PMID:
31706027
5.

Grandmaster level in StarCraft II using multi-agent reinforcement learning.

Vinyals O, Babuschkin I, Czarnecki WM, Mathieu M, Dudzik A, Chung J, Choi DH, Powell R, Ewalds T, Georgiev P, Oh J, Horgan D, Kroiss M, Danihelka I, Huang A, Sifre L, Cai T, Agapiou JP, Jaderberg M, Vezhnevets AS, Leblond R, Pohlen T, Dalibard V, Budden D, Sulsky Y, Molloy J, Paine TL, Gulcehre C, Wang Z, Pfaff T, Wu Y, Ring R, Yogatama D, Wünsch D, McKinney K, Smith O, Schaul T, Lillicrap T, Kavukcuoglu K, Hassabis D, Apps C, Silver D.

Nature. 2019 Nov;575(7782):350-354. doi: 10.1038/s41586-019-1724-z. Epub 2019 Oct 30.

PMID:
31666705
6.

Distinct Elements Confer the Blocking and Bypass Functions of the Bithorax Fab-8 Boundary.

Kyrchanova O, Wolle D, Sabirov M, Kurbidaeva A, Aoki T, Maksimenko O, Kyrchanova M, Georgiev P, Schedl P.

Genetics. 2019 Nov;213(3):865-876. doi: 10.1534/genetics.119.302694. Epub 2019 Sep 24.

PMID:
31551239
7.

Regulatory T Cells: the Many Faces of Foxp3.

Georgiev P, Charbonnier LM, Chatila TA.

J Clin Immunol. 2019 Oct;39(7):623-640. doi: 10.1007/s10875-019-00684-7. Epub 2019 Sep 2. Review.

PMID:
31478130
8.

Functional Comparison of Short and Long Isoforms of the TRF2 Protein in Drosophila melanogaster.

Osadchiy IS, Georgiev PG, Maksimenko OG.

Dokl Biochem Biophys. 2019 May;486(1):224-228. doi: 10.1134/S1607672919030165. Epub 2019 Jul 31.

PMID:
31367827
9.

Study of dCTCF Insulator Activity in Drosophilamelanogaster Model Systems.

Postika NE, Ivlieva TA, Georgiev PG, Kyrchanova OV.

Dokl Biochem Biophys. 2019 May;486(1):187-191. doi: 10.1134/S1607672919030074. Epub 2019 Jul 31.

PMID:
31367818
10.

BET Bromodomain Inhibition Suppresses Human T Cell Function.

Georgiev P, Wang Y, Muise ES, Bandi ML, Blumenschein W, Sathe M, Pinheiro EM, Shumway SD.

Immunohorizons. 2019 Jul 11;3(7):294-305. doi: 10.4049/immunohorizons.1900037.

PMID:
31356159
11.

The simultaneous interaction of MSL2 with CLAMP and DNA provides redundancy in the initiation of dosage compensation in Drosophila males.

Tikhonova E, Fedotova A, Bonchuk A, Mogila V, Larschan EN, Georgiev P, Maksimenko O.

Development. 2019 Aug 23;146(19). pii: dev179663. doi: 10.1242/dev.179663.

PMID:
31320325
12.

Complete reconstitution of bypass and blocking functions in a minimal artificial Fab-7 insulator from Drosophila bithorax complex.

Kyrchanova O, Sabirov M, Mogila V, Kurbidaeva A, Postika N, Maksimenko O, Schedl P, Georgiev P.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13462-13467. doi: 10.1073/pnas.1907190116. Epub 2019 Jun 17.

13.

The Development of Reporter System for the Investigation of Molecular Mechanisms of Ecdysone Response.

Mazina MY, Krasnov AN, Georgiev PG, Vorobyeva NE.

Dokl Biochem Biophys. 2019 Mar;485(1):138-140. doi: 10.1134/S1607672919020170. Epub 2019 Jun 14.

PMID:
31201635
14.

Effect of Transcription on the white Gene Enhancer Integrated into the Intron.

Erokhin MM, Mikhailova AV, Georgiev PG, Chetverina DA.

Dokl Biochem Biophys. 2019 May;484(1):45-47. doi: 10.1134/S1607672919010125. Epub 2019 Apr 22.

PMID:
31012011
15.

A Novel PRE-Element from Drosophila virilis Genome as a Useful Model Silencer.

Chetverina DA, Mikhailova AV, Georgiev PG, Erokhin MM.

Dokl Biochem Biophys. 2019 May;484(1):33-36. doi: 10.1134/S1607672919010095. Epub 2019 Apr 22.

PMID:
31012008
16.

Removal of extra sequences with I-SceI in combination with CRISPR/Cas9 technique for precise gene editing in Drosophila.

Zolotarev N, Georgiev P, Maksimenko O.

Biotechniques. 2019 Apr;66(4):198-201. doi: 10.2144/btn-2018-0147.

17.

The same domain of Su(Hw) is required for enhancer blocking and direct promoter repression.

Melnikova L, Elizar'ev P, Erokhin M, Molodina V, Chetverina D, Kostyuchenko M, Georgiev P, Golovnin A.

Sci Rep. 2019 Mar 29;9(1):5314. doi: 10.1038/s41598-019-41761-6.

18.

Transcription termination sequences support the expression of transgene product secreted with milk.

Deykin A, Tikhonov M, Kalmykov V, Korobko I, Georgiev P, Maksimenko O.

Transgenic Res. 2019 Aug;28(3-4):401-410. doi: 10.1007/s11248-019-00122-9. Epub 2019 Mar 28.

PMID:
30919251
19.

The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise.

Lam KC, Chung HR, Semplicio G, Iyer SS, Gaub A, Bhardwaj V, Holz H, Georgiev P, Akhtar A.

Genes Dev. 2019 Apr 1;33(7-8):452-465. doi: 10.1101/gad.321489.118. Epub 2019 Feb 28.

20.

Functional dissection of the developmentally restricted BEN domain chromatin boundary factor Insensitive.

Fedotova A, Clendinen C, Bonchuk A, Mogila V, Aoki T, Georgiev P, Schedl P.

Epigenetics Chromatin. 2019 Jan 3;12(1):2. doi: 10.1186/s13072-018-0249-2.

21.

Boundaries mediate long-distance interactions between enhancers and promoters in the Drosophila Bithorax complex.

Postika N, Metzler M, Affolter M, Müller M, Schedl P, Georgiev P, Kyrchanova O.

PLoS Genet. 2018 Dec 12;14(12):e1007702. doi: 10.1371/journal.pgen.1007702. eCollection 2018 Dec.

22.

The Role of GC-Rich Sequences from the Promoter Region of the Drosophila melanogaster yellow Gene in the Enhancer- Dependent Activation of Transcription.

Kostyuchenko MV, Golovnin AK, Georgiev PG, Melnikova LS.

Dokl Biochem Biophys. 2018 Sep;482(1):255-260. doi: 10.1134/S1607672918050071. Epub 2018 Nov 5.

PMID:
30397887
23.

Facultative dosage compensation of developmental genes on autosomes in Drosophila and mouse embryonic stem cells.

Valsecchi CIK, Basilicata MF, Semplicio G, Georgiev P, Gutierrez NM, Akhtar A.

Nat Commun. 2018 Sep 7;9(1):3626. doi: 10.1038/s41467-018-05642-2.

24.

The bithorax complex iab-7 Polycomb response element has a novel role in the functioning of the Fab-7 chromatin boundary.

Kyrchanova O, Kurbidaeva A, Sabirov M, Postika N, Wolle D, Aoki T, Maksimenko O, Mogila V, Schedl P, Georgiev P.

PLoS Genet. 2018 Aug 15;14(8):e1007442. doi: 10.1371/journal.pgen.1007442. eCollection 2018 Aug.

25.

Conserved sequences in the Drosophila mod(mdg4) intron promote poly(A)-independent transcription termination and trans-splicing.

Tikhonov M, Utkina M, Maksimenko O, Georgiev P.

Nucleic Acids Res. 2018 Nov 16;46(20):10608-10618. doi: 10.1093/nar/gky716.

26.

The BEN Domain Protein Insensitive Binds to the Fab-7 Chromatin Boundary To Establish Proper Segmental Identity in Drosophila.

Fedotova A, Aoki T, Rossier M, Mishra RK, Clendinen C, Kyrchanova O, Wolle D, Bonchuk A, Maeda RK, Mutero A, Cleard F, Mogila V, Karch F, Georgiev P, Schedl P.

Genetics. 2018 Oct;210(2):573-585. doi: 10.1534/genetics.118.301259. Epub 2018 Aug 6.

27.

Study of the Ability of the gypsy Insulator to Stabilize Amplification of the chorion Replication Origin of Drosophila melanogaster.

Maksimenko OG, Belova EV, Georgiev PG.

Dokl Biochem Biophys. 2018 May;480(1):166-168. doi: 10.1134/S1607672918030110. Epub 2018 Jul 14.

PMID:
30008102
28.

Identification of the ORC Complex Subunits That Can Interact with the ENY2 Protein of Drosophila melanogaster.

Maksimenko OG, Belova EV, Georgiev PG.

Dokl Biochem Biophys. 2018 May;480(1):155-157. doi: 10.1134/S1607672918030080. Epub 2018 Jul 14.

PMID:
30008099
29.

Individual thrombin generation and spontaneous bleeding rate during personalized prophylaxis with Nuwiq® (human-cl rhFVIII) in previously treated patients with severe haemophilia A.

Dargaud Y, Negrier C, Rusen L, Windyga J, Georgiev P, Bichler J, Solomon C, Knaub S, Lissitchkov T, Klamroth R.

Haemophilia. 2018 Jul;24(4):619-627. doi: 10.1111/hae.13493. Epub 2018 May 31.

PMID:
29855112
30.

Structure and Functions of the Mediator Complex.

Putlyaev EV, Ibragimov AN, Lebedeva LA, Georgiev PG, Shidlovskii YV.

Biochemistry (Mosc). 2018 Apr;83(4):423-436. doi: 10.1134/S0006297918040132. Review.

31.

Role of Su(Hw) zinc finger 10 and interaction with CP190 and Mod(mdg4) proteins in recruiting the Su(Hw) complex to chromatin sites in Drosophila.

Melnikova L, Kostyuchenko M, Parshikov A, Georgiev P, Golovnin A.

PLoS One. 2018 Feb 23;13(2):e0193497. doi: 10.1371/journal.pone.0193497. eCollection 2018.

32.

[Control of the gene activity by polycomb and trithorax group proteins in Drosophila].

Chetverina DA, Elizar’ev PV, Lomaev DV, Georgiev PG, Erokhin MM.

Genetika. 2017 Feb;53(2):133-54. Review. Russian.

PMID:
29372960
33.

RDGBα localization and function at membrane contact sites is regulated by FFAT-VAP interactions.

Yadav S, Thakur R, Georgiev P, Deivasigamani S, Krishnan H, Ratnaparkhi G, Raghu P.

J Cell Sci. 2018 Jan 8;131(1). pii: jcs207985. doi: 10.1242/jcs.207985.

34.

A mutually exclusive stem-loop arrangement in roX2 RNA is essential for X-chromosome regulation in Drosophila.

Ilik IA, Maticzka D, Georgiev P, Gutierrez NM, Backofen R, Akhtar A.

Genes Dev. 2017 Oct 1;31(19):1973-1987. doi: 10.1101/gad.304600.117. Epub 2017 Oct 24.

35.

Opbp is a new architectural/insulator protein required for ribosomal gene expression.

Zolotarev N, Maksimenko O, Kyrchanova O, Sokolinskaya E, Osadchiy I, Girardot C, Bonchuk A, Ciglar L, Furlong EEM, Georgiev P.

Nucleic Acids Res. 2017 Dec 1;45(21):12285-12300. doi: 10.1093/nar/gkx840.

36.

Multiple interactions are involved in a highly specific association of the Mod(mdg4)-67.2 isoform with the Su(Hw) sites in Drosophila.

Melnikova L, Kostyuchenko M, Molodina V, Parshikov A, Georgiev P, Golovnin A.

Open Biol. 2017 Oct;7(10). pii: 170150. doi: 10.1098/rsob.170150.

37.

Interactions between BTB domain of CP190 and two adjacent regions in Su(Hw) are required for the insulator complex formation.

Melnikova L, Kostyuchenko M, Molodina V, Parshikov A, Georgiev P, Golovnin A.

Chromosoma. 2018 Mar;127(1):59-71. doi: 10.1007/s00412-017-0645-6. Epub 2017 Sep 22.

PMID:
28939920
38.

On the elusive nature of oxygen binding at coordinatively unsaturated 3d transition metal centers in metal-organic frameworks.

Rosnes MH, Sheptyakov D, Franz A, Frontzek M, Dietzel PDC, Georgiev PA.

Phys Chem Chem Phys. 2017 Oct 4;19(38):26346-26357. doi: 10.1039/c7cp05119k.

PMID:
28936514
39.

[Optimal Artificial Mini-Introns for Transgenic Expression in the Cells of Mice and Hamsters].

Tikhonov MV, Maksimenko OG, Georgiev PG, Korobko IV.

Mol Biol (Mosk). 2017 Jul-Aug;51(4):671-676. doi: 10.7868/S0026898417040176. Russian.

40.

C2H2 Zinc Finger Proteins: The Largest but Poorly Explored Family of Higher Eukaryotic Transcription Factors.

Fedotova AA, Bonchuk AN, Mogila VA, Georgiev PG.

Acta Naturae. 2017 Apr-Jun;9(2):47-58.

41.

Presenilin-1 Delta E9 Mutant Induces STIM1-Driven Store-Operated Calcium Channel Hyperactivation in Hippocampal Neurons.

Ryazantseva M, Goncharova A, Skobeleva K, Erokhin M, Methner A, Georgiev P, Kaznacheyeva E.

Mol Neurobiol. 2018 Jun;55(6):4667-4680. doi: 10.1007/s12035-017-0674-4. Epub 2017 Jul 13.

PMID:
28707074
42.

Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy.

Pasi KJ, Rangarajan S, Georgiev P, Mant T, Creagh MD, Lissitchkov T, Bevan D, Austin S, Hay CR, Hegemann I, Kazmi R, Chowdary P, Gercheva-Kyuchukova L, Mamonov V, Timofeeva M, Soh CH, Garg P, Vaishnaw A, Akinc A, Sørensen B, Ragni MV.

N Engl J Med. 2017 Aug 31;377(9):819-828. doi: 10.1056/NEJMoa1616569. Epub 2017 Jul 10.

43.

Architectural protein Pita cooperates with dCTCF in organization of functional boundaries in Bithorax complex.

Kyrchanova O, Zolotarev N, Mogila V, Maksimenko O, Schedl P, Georgiev P.

Development. 2017 Jul 15;144(14):2663-2672. doi: 10.1242/dev.149815. Epub 2017 Jun 15.

44.

Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells.

Sukumar S, Wilson DC, Yu Y, Wong J, Naravula S, Ermakov G, Riener R, Bhagwat B, Necheva AS, Grein J, Churakova T, Mangadu R, Georgiev P, Manfra D, Pinheiro EM, Sriram V, Bailey WJ, Herzyk D, McClanahan TK, Willingham A, Beebe AM, Sadekova S.

Cancer Res. 2017 Aug 15;77(16):4378-4388. doi: 10.1158/0008-5472.CAN-16-1439. Epub 2017 Jun 13.

45.

LTR sequence of the MDG4 retrotransposon contains the MAD protein binding site that affects the east-dependent repression.

Golovnin AK, Molodina VV, Shapovalov IS, Georgiev PG, Melnikova LS.

Dokl Biochem Biophys. 2017 Mar;473(1):106-110. doi: 10.1134/S1607672917020053. Epub 2017 May 17.

PMID:
28510129
46.
47.

PK-guided personalized prophylaxis with Nuwiq® (human-cl rhFVIII) in adults with severe haemophilia A.

Lissitchkov T, Rusen L, Georgiev P, Windyga J, Klamroth R, Gercheva L, Nemes L, Tiede A, Bichler J, Knaub S, Belyanskaya L, Walter O, Pasi KJ.

Haemophilia. 2017 Sep;23(5):697-704. doi: 10.1111/hae.13251. Epub 2017 Apr 27. Erratum in: Haemophilia. 2018 Jan;24(1):162.

PMID:
28452151
48.

The bxdPRE/TRE element terminates passing through transcription.

Erokhin MM, Elizar'ev PV, Georgiev PG, Chetverina DA.

Dokl Biochem Biophys. 2017 Jan;472(1):49-51. doi: 10.1134/S1607672917010112. Epub 2017 Apr 19.

PMID:
28421448
49.

PRE/TRE elements act as transcription activators in Drosophila S2 Cells.

Chetverina DA, Mikhailova AV, Georgiev PG, Erokhin MM.

Dokl Biochem Biophys. 2017 Jan;472(1):68-70. doi: 10.1134/S1607672917010161. Epub 2017 Apr 19.

PMID:
28421446
50.

The GAGA factor regulatory network: Identification of GAGA factor associated proteins.

Lomaev D, Mikhailova A, Erokhin M, Shaposhnikov AV, Moresco JJ, Blokhina T, Wolle D, Aoki T, Ryabykh V, Yates JR 3rd, Shidlovskii YV, Georgiev P, Schedl P, Chetverina D.

PLoS One. 2017 Mar 15;12(3):e0173602. doi: 10.1371/journal.pone.0173602. eCollection 2017.

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