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Items: 43


Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins.

Romagnoli M, Cagnet S, Chiche A, Bresson L, Baulande S, de la Grange P, De Arcangelis A, Kreft M, Georges-Labouesse E, Sonnenberg A, Deugnier MA, Raymond K, Glukhova MA, Faraldo MM.

Stem Cell Reports. 2019 May 14;12(5):1178. doi: 10.1016/j.stemcr.2019.04.018. No abstract available.


Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins.

Romagnoli M, Cagnet S, Chiche A, Bresson L, Baulande S, de la Grange P, De Arcangelis A, Kreft M, Georges-Labouesse E, Sonnenberg A, Deugnier MA, Raymond K, Glukhova MA, Faraldo MM.

Stem Cell Reports. 2019 Apr 9;12(4):831-844. doi: 10.1016/j.stemcr.2019.02.008. Epub 2019 Mar 21. Erratum in: Stem Cell Reports. 2019 May 14;12(5):1178.


The laminin binding α3 and α6 integrins cooperate to promote epithelial cell adhesion and growth.

Yazlovitskaya EM, Viquez OM, Tu T, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Pozzi A, Zent R.

Matrix Biol. 2019 Apr;77:101-116. doi: 10.1016/j.matbio.2018.08.010. Epub 2018 Sep 4.


An Arf6- and caveolae-dependent pathway links hemidesmosome remodeling and mechanoresponse.

Osmani N, Pontabry J, Comelles J, Fekonja N, Goetz JG, Riveline D, Georges-Labouesse E, Labouesse M.

Mol Biol Cell. 2018 Feb 15;29(4):435-451. doi: 10.1091/mbc.E17-06-0356. Epub 2017 Dec 13.


Integrin alpha6 maintains the structural integrity of the kidney collecting system.

Viquez OM, Yazlovitskaya EM, Tu T, Mernaugh G, Secades P, McKee KK, Georges-Labouesse E, De Arcangelis A, Quaranta V, Yurchenco P, Gewin LC, Sonnenberg A, Pozzi A, Zent R.

Matrix Biol. 2017 Jan;57-58:244-257. doi: 10.1016/j.matbio.2016.12.003. Epub 2016 Dec 30.


Hemidesmosome integrity protects the colon against colitis and colorectal cancer.

De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, Méchine-Neuville A, Siebert S, Pfister V, Lepage P, Laquerriere P, Dembele D, Delanoye-Crespin A, Rodius S, Robine S, Kedinger M, Van Seuningen I, Simon-Assmann P, Chamaillard M, Labouesse M, Georges-Labouesse E.

Gut. 2017 Oct;66(10):1748-1760. doi: 10.1136/gutjnl-2015-310847. Epub 2016 Jul 1.


Tie2-dependent deletion of α6 integrin subunit in mice reduces tumor growth and angiogenesis.

Bouvard C, Segaoula Z, De Arcangelis A, Galy-Fauroux I, Mauge L, Fischer AM, Georges-Labouesse E, Helley D.

Int J Oncol. 2014 Nov;45(5):2058-64. doi: 10.3892/ijo.2014.2631. Epub 2014 Sep 1.


α6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation.

Basu S, Rajakaruna S, De Arcangelis A, Zhang L, Georges-Labouesse E, Menko AS.

J Biol Chem. 2014 Feb 14;289(7):3842-55. doi: 10.1074/jbc.M113.515254. Epub 2013 Dec 31.


α6β1 and α7β1 integrins are required in Schwann cells to sort axons.

Pellegatta M, De Arcangelis A, D'Urso A, Nodari A, Zambroni D, Ghidinelli M, Matafora V, Williamson C, Georges-Labouesse E, Kreidberg J, Mayer U, McKee KK, Yurchenco PD, Quattrini A, Wrabetz L, Feltri ML.

J Neurosci. 2013 Nov 13;33(46):17995-8007. doi: 10.1523/JNEUROSCI.3179-13.2013.


Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival.

Song J, Lokmic Z, Lämmermann T, Rolf J, Wu C, Zhang X, Hallmann R, Hannocks MJ, Horn N, Ruegg MA, Sonnenberg A, Georges-Labouesse E, Winkler TH, Kearney JF, Cardell S, Sorokin L.

Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):E2915-24. doi: 10.1073/pnas.1218131110. Epub 2013 Jul 11.


Integrin α6β1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis.

Schaff M, Tang C, Maurer E, Bourdon C, Receveur N, Eckly A, Hechler B, Arnold C, de Arcangelis A, Nieswandt B, Denis CV, Lefebvre O, Georges-Labouesse E, Gachet C, Lanza F, Mangin PH.

Circulation. 2013 Jul 30;128(5):541-52.


α6 integrin subunit regulates cerebellar development.

Marchetti G, De Arcangelis A, Pfister V, Georges-Labouesse E.

Cell Adh Migr. 2013 May-Jun;7(3):325-32. doi: 10.4161/cam.25140. Epub 2013 May 24.


Separation of distinct adhesion complexes and associated cytoskeleton by a micro-stencil-printing method.

Caballero D, Osmani N, Georges-Labouesse E, Labouesse M, Riveline D.

Cell Adh Migr. 2012 Nov-Dec;6(6):471-5. doi: 10.4161/cam.22198. Epub 2012 Oct 17.


Tie2-dependent knockout of α6 integrin subunit in mice reduces post-ischaemic angiogenesis.

Bouvard C, De Arcangelis A, Dizier B, Galy-Fauroux I, Fischer AM, Georges-Labouesse E, Helley D.

Cardiovasc Res. 2012 Jul 1;95(1):39-47. doi: 10.1093/cvr/cvs153. Epub 2012 Apr 19.


MIG-15 and ERM-1 promote growth cone directional migration in parallel to UNC-116 and WVE-1.

Teulière J, Gally C, Garriga G, Labouesse M, Georges-Labouesse E.

Development. 2011 Oct;138(20):4475-85. doi: 10.1242/dev.061952.


Conditional ablation of integrin alpha-6 in mouse epidermis leads to skin fragility and inflammation.

Niculescu C, Ganguli-Indra G, Pfister V, Dupé V, Messaddeq N, De Arcangelis A, Georges-Labouesse E.

Eur J Cell Biol. 2011 Feb-Mar;90(2-3):270-7. doi: 10.1016/j.ejcb.2010.09.003. Epub 2010 Oct 20.


Integrin alpha5beta1 is necessary for regulation of radial migration of cortical neurons during mouse brain development.

Marchetti G, Escuin S, van der Flier A, De Arcangelis A, Hynes RO, Georges-Labouesse E.

Eur J Neurosci. 2010 Feb;31(3):399-409. doi: 10.1111/j.1460-9568.2009.07072.x. Epub 2010 Jan 25.


Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis.

Germain M, De Arcangelis A, Robinson SD, Baker M, Tavora B, D'Amico G, Silva R, Kostourou V, Reynolds LE, Watson A, Jones JL, Georges-Labouesse E, Hodivala-Dilke K.

J Pathol. 2010 Feb;220(3):370-81. doi: 10.1002/path.2654.


Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain.

Wu C, Ivars F, Anderson P, Hallmann R, Vestweber D, Nilsson P, Robenek H, Tryggvason K, Song J, Korpos E, Loser K, Beissert S, Georges-Labouesse E, Sorokin LM.

Nat Med. 2009 May;15(5):519-27. doi: 10.1038/nm.1957. Epub 2009 Apr 26.


Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling.

Rebustini IT, Patel VN, Stewart JS, Layvey A, Georges-Labouesse E, Miner JH, Hoffman MP.

Dev Biol. 2007 Aug 1;308(1):15-29. Epub 2007 May 1.


Distinct roles of integrins alpha6 and alpha4 in homing of fetal liver hematopoietic stem and progenitor cells.

Qian H, Georges-Labouesse E, Nyström A, Domogatskaya A, Tryggvason K, Jacobsen SE, Ekblom M.

Blood. 2007 Oct 1;110(7):2399-407. Epub 2007 Jun 22.


Neuronal expression of muskelin in the rodent central nervous system.

Tagnaouti N, Loebrich S, Heisler F, Pechmann Y, Fehr S, De Arcangelis A, Georges-Labouesse E, Adams JC, Kneussel M.

BMC Neurosci. 2007 May 2;8:28.


Loss of alpha6 integrins in keratinocytes leads to an increase in TGFbeta and AP1 signaling and in expression of differentiation genes.

Rodius S, Indra G, Thibault C, Pfister V, Georges-Labouesse E.

J Cell Physiol. 2007 Aug;212(2):439-49.


Regulation of post-translational modifications of muskelin by protein kinase C.

Prag S, De Arcangelis A, Georges-Labouesse E, Adams JC.

Int J Biochem Cell Biol. 2007;39(2):366-78. Epub 2006 Sep 19.


Basement membrane attachment is dispensable for radial glial cell fate and for proliferation, but affects positioning of neuronal subtypes.

Haubst N, Georges-Labouesse E, De Arcangelis A, Mayer U, Götz M.

Development. 2006 Aug;133(16):3245-54.


The alpha6 integrin subunit in the developing mouse olfactory bulb.

Whitley M, Treloar H, De Arcangelis A, Georges Labouesse E, Greer CA.

J Neurocytol. 2005 Mar;34(1-2):81-96.


Expression of fascin-1, the gene encoding the actin-bundling protein fascin-1, during mouse embryogenesis.

De Arcangelis A, Georges-Labouesse E, Adams JC.

Gene Expr Patterns. 2004 Oct;4(6):637-43.


Cell adhesion: parallels between vertebrate and invertebrate focal adhesions.

Labouesse M, Georges-Labouesse E.

Curr Biol. 2003 Jul 1;13(13):R528-30. Review.


CNS integrins switch growth factor signalling to promote target-dependent survival.

Colognato H, Baron W, Avellana-Adalid V, Relvas JB, Baron-Van Evercooren A, Georges-Labouesse E, ffrench-Constant C.

Nat Cell Biol. 2002 Nov;4(11):833-41.


A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans.

Poinat P, De Arcangelis A, Sookhareea S, Zhu X, Hedgecock EM, Labouesse M, Georges-Labouesse E.

Curr Biol. 2002 Apr 16;12(8):622-31.


The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits.

El Mourabit H, Poinat P, Koster J, Sondermann H, Wixler V, Wegener E, Laplantine E, Geerts D, Georges-Labouesse E, Sonnenberg A, Aumailley M.

Matrix Biol. 2002 Mar;21(2):207-14.


Epithelial development and differentiation in the mammary gland is not dependent on alpha 3 or alpha 6 integrin subunits.

Klinowska TC, Alexander CM, Georges-Labouesse E, Van der Neut R, Kreidberg JA, Jones CJ, Sonnenberg A, Streuli CH.

Dev Biol. 2001 May 15;233(2):449-67.


Integrin and ECM functions: roles in vertebrate development.

De Arcangelis A, Georges-Labouesse E.

Trends Genet. 2000 Sep;16(9):389-95. Review.


alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development.

DiPersio CM, van der Neut R, Georges-Labouesse E, Kreidberg JA, Sonnenberg A, Hynes RO.

J Cell Sci. 2000 Sep;113 ( Pt 17):3051-62.


Normal fertilization occurs with eggs lacking the integrin alpha6beta1 and is CD9-dependent.

Miller BJ, Georges-Labouesse E, Primakoff P, Myles DG.

J Cell Biol. 2000 Jun 12;149(6):1289-96.


Synergistic activities of alpha3 and alpha6 integrins are required during apical ectodermal ridge formation and organogenesis in the mouse.

De Arcangelis A, Mark M, Kreidberg J, Sorokin L, Georges-Labouesse E.

Development. 1999 Sep;126(17):3957-68.


Mouse primordial germ cells lacking beta1 integrins enter the germline but fail to migrate normally to the gonads.

Anderson R, Fässler R, Georges-Labouesse E, Hynes RO, Bader BL, Kreidberg JA, Schaible K, Heasman J, Wylie C.

Development. 1999 Apr;126(8):1655-64.


Essential role of alpha 6 integrins in cortical and retinal lamination.

Georges-Labouesse E, Mark M, Messaddeq N, Gansmüller A.

Curr Biol. 1998 Aug 27;8(17):983-6.


Genetic analyses of integrin function in mice.

Fässler R, Georges-Labouesse E, Hirsch E.

Curr Opin Cell Biol. 1996 Oct;8(5):641-6. Review.


Mesodermal development in mouse embryos mutant for fibronectin.

Georges-Labouesse EN, George EL, Rayburn H, Hynes RO.

Dev Dyn. 1996 Oct;207(2):145-56.


Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice.

Georges-Labouesse E, Messaddeq N, Yehia G, Cadalbert L, Dierich A, Le Meur M.

Nat Genet. 1996 Jul;13(3):370-3.


Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin.

George EL, Georges-Labouesse EN, Patel-King RS, Rayburn H, Hynes RO.

Development. 1993 Dec;119(4):1079-91.

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