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mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis.

Choe J, Lin S, Zhang W, Liu Q, Wang L, Ramirez-Moya J, Du P, Kim W, Tang S, Sliz P, Santisteban P, George RE, Richards WG, Wong KK, Locker N, Slack FJ, Gregory RI.

Nature. 2018 Sep;561(7724):556-560. doi: 10.1038/s41586-018-0538-8. Epub 2018 Sep 19.


Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK).

Powell CE, Gao Y, Tan L, Donovan KA, Nowak RP, Loehr A, Bahcall M, Fischer ES, Jänne PA, George RE, Gray NS.

J Med Chem. 2018 May 10;61(9):4249-4255. doi: 10.1021/acs.jmedchem.7b01655. Epub 2018 Apr 24.


Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors.

Gao Y, Zhang T, Terai H, Ficarro SB, Kwiatkowski N, Hao MF, Sharma B, Christensen CL, Chipumuro E, Wong KK, Marto JA, Hammerman PS, Gray NS, George RE.

Cell Chem Biol. 2018 Feb 15;25(2):135-142.e5. doi: 10.1016/j.chembiol.2017.11.007. Epub 2017 Dec 21.


Super-Enhancer-Driven Transcriptional Dependencies in Cancer.

Sengupta S, George RE.

Trends Cancer. 2017 Apr;3(4):269-281. doi: 10.1016/j.trecan.2017.03.006. Epub 2017 Apr 12. Review.


Rituximab-induced urticarial dermatitis during the treatment of membranous nephropathy.

Radhakrishnan RC, Basu G, George RE, Parmar H, Tamilarasi V.

Saudi J Kidney Dis Transpl. 2017 May-Jun;28(3):657-660. doi: 10.4103/1319-2442.206462.


Cbx3/HP1γ deficiency confers enhanced tumor-killing capacity on CD8+ T cells.

Sun M, Ha N, Pham DH, Frederick M, Sharma B, Naruse C, Asano M, Pipkin ME, George RE, Thai TH.

Sci Rep. 2017 Feb 21;7:42888. doi: 10.1038/srep42888.


Anonychia with absent phalanges and brachydactyly: A report of two unrelated cases.

Ramassamy S, Gibikote S, George RE.

Indian J Dermatol Venereol Leprol. 2016 Nov-Dec;82(6):693-695. doi: 10.4103/0378-6323.184198. No abstract available.


Erratum: Nanoelectronic primary thermometry below 4 mK.

Bradley DI, George RE, Gunnarsson D, Haley RP, Heikkinen H, Pashkin YA, Penttilä J, Prance JR, Prunnila M, Roschier L, Sarsby M.

Nat Commun. 2016 Jun 3;7:11678. doi: 10.1038/ncomms11678. No abstract available.


Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis.

Carter DR, Sutton SK, Pajic M, Murray J, Sekyere EO, Fletcher J, Beckers A, De Preter K, Speleman F, George RE, Haber M, Norris MD, Cheung BB, Marshall GM.

Mol Oncol. 2016 Jun;10(6):866-78. doi: 10.1016/j.molonc.2016.02.004. Epub 2016 Mar 2.


Nanoelectronic primary thermometry below 4 mK.

Bradley DI, George RE, Gunnarsson D, Haley RP, Heikkinen H, Pashkin YA, Penttilä J, Prance JR, Prunnila M, Roschier L, Sarsby M.

Nat Commun. 2016 Jan 27;7:10455. doi: 10.1038/ncomms10455. Erratum in: Nat Commun. 2016 Jun 03;7:11678.


Targeting ALK: The Ten Lives of a Tumor.

Versteeg R, George RE.

Cancer Discov. 2016 Jan;6(1):20-1. doi: 10.1158/2159-8290.CD-15-1411.


ALK inhibitor resistance in ALK(F1174L)-driven neuroblastoma is associated with AXL activation and induction of EMT.

Debruyne DN, Bhatnagar N, Sharma B, Luther W, Moore NF, Cheung NK, Gray NS, George RE.

Oncogene. 2016 Jul 14;35(28):3681-91. doi: 10.1038/onc.2015.434. Epub 2015 Nov 30.


TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors.

Valentijn LJ, Koster J, Zwijnenburg DA, Hasselt NE, van Sluis P, Volckmann R, van Noesel MM, George RE, Tytgat GA, Molenaar JJ, Versteeg R.

Nat Genet. 2015 Dec;47(12):1411-4. doi: 10.1038/ng.3438. Epub 2015 Nov 2.


Seek and Ye Shall Find: Subclonal Anaplastic Lymphoma Kinase Mutations.

George RE.

Clin Cancer Res. 2015 Nov 1;21(21):4747-9. doi: 10.1158/1078-0432.CCR-15-1397. Epub 2015 Sep 11.


A phase I trial combining decitabine/dendritic cell vaccine targeting MAGE-A1, MAGE-A3 and NY-ESO-1 for children with relapsed or therapy-refractory neuroblastoma and sarcoma.

Krishnadas DK, Shusterman S, Bai F, Diller L, Sullivan JE, Cheerva AC, George RE, Lucas KG.

Cancer Immunol Immunother. 2015 Oct;64(10):1251-60. doi: 10.1007/s00262-015-1731-3. Epub 2015 Jun 24.


Cytomegalovirus reactivation in drug induced hypersensitivity syndrome.

Mathuram AJ, George RE.

J Assoc Physicians India. 2014 Jun;62(6):533-5.


Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor.

Christensen CL, Kwiatkowski N, Abraham BJ, Carretero J, Al-Shahrour F, Zhang T, Chipumuro E, Herter-Sprie GS, Akbay EA, Altabef A, Zhang J, Shimamura T, Capelletti M, Reibel JB, Cavanaugh JD, Gao P, Liu Y, Michaelsen SR, Poulsen HS, Aref AR, Barbie DA, Bradner JE, George RE, Gray NS, Young RA, Wong KK.

Cancer Cell. 2014 Dec 8;26(6):909-922. doi: 10.1016/j.ccell.2014.10.019. Erratum in: Cancer Cell. 2015 Jan 12;27(1):149.


A review of newer treatment approaches for type-2 diabetes: Focusing safety and efficacy of incretin based therapy.

George RE, Joseph S.

Saudi Pharm J. 2014 Nov;22(5):403-10. doi: 10.1016/j.jsps.2013.05.005. Epub 2013 May 28. Review.


CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

Chipumuro E, Marco E, Christensen CL, Kwiatkowski N, Zhang T, Hatheway CM, Abraham BJ, Sharma B, Yeung C, Altabef A, Perez-Atayde A, Wong KK, Yuan GC, Gray NS, Young RA, George RE.

Cell. 2014 Nov 20;159(5):1126-1139. doi: 10.1016/j.cell.2014.10.024. Epub 2014 Nov 6.


Siblings with fucosidosis.

Muthusamy K, Thomas MM, George RE, Alexander M, Mani S, Benjamin RN.

J Pediatr Neurosci. 2014 May;9(2):156-8. doi: 10.4103/1817-1745.139331.


Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma.

Moore NF, Azarova AM, Bhatnagar N, Ross KN, Drake LE, Frumm S, Liu QS, Christie AL, Sanda T, Chesler L, Kung AL, Gray NS, Stegmaier K, George RE.

Oncotarget. 2014 Sep 30;5(18):8737-49.


Mutations that disrupt PHOXB interaction with the neuronal calcium sensor HPCAL1 impede cellular differentiation in neuroblastoma.

Wang W, Zhong Q, Teng L, Bhatnagar N, Sharma B, Zhang X, Luther W 2nd, Haynes LP, Burgoyne RD, Vidal M, Volchenboum S, Hill DE, George RE.

Oncogene. 2014 Jun 19;33(25):3316-24. doi: 10.1038/onc.2013.290. Epub 2013 Jul 22.


Atomic clock transitions in silicon-based spin qubits.

Wolfowicz G, Tyryshkin AM, George RE, Riemann H, Abrosimov NV, Becker P, Pohl HJ, Thewalt ML, Lyon SA, Morton JJ.

Nat Nanotechnol. 2013 Aug;8(8):561-4. doi: 10.1038/nnano.2013.117. Epub 2013 Jun 23. Erratum in: Nat Nanotechnol. 2013 Nov;8(11):881.


Distinct neuroblastoma-associated alterations of PHOX2B impair sympathetic neuronal differentiation in zebrafish models.

Pei D, Luther W, Wang W, Paw BH, Stewart RA, George RE.

PLoS Genet. 2013 Jun;9(6):e1003533. doi: 10.1371/journal.pgen.1003533. Epub 2013 Jun 6.


Opening up three quantum boxes causes classically undetectable wavefunction collapse.

George RE, Robledo LM, Maroney OJ, Blok MS, Bernien H, Markham ML, Twitchen DJ, Morton JJ, Briggs GA, Hanson R.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):3777-81. doi: 10.1073/pnas.1208374110. Epub 2013 Feb 14.


Coherent spin control by electrical manipulation of the magnetic anisotropy.

George RE, Edwards JP, Ardavan A.

Phys Rev Lett. 2013 Jan 11;110(2):027601. Epub 2013 Jan 7.


Immortalized functional endothelial progenitor cell lines from umbilical cord blood for vascular tissue engineering.

Sobhan PK, Seervi M, Joseph J, Varghese S, Pillai PR, Sivaraman DM, James J, George RE, Elizabeth KE, Santhoshkumar TR, Pillai MR.

Tissue Eng Part C Methods. 2012 Nov;18(11):890-902. doi: 10.1089/ten.TEC.2011.0482. Epub 2012 Oct 1.


The ALK(F1174L) mutation potentiates the oncogenic activity of MYCN in neuroblastoma.

Berry T, Luther W, Bhatnagar N, Jamin Y, Poon E, Sanda T, Pei D, Sharma B, Vetharoy WR, Hallsworth A, Ahmad Z, Barker K, Moreau L, Webber H, Wang W, Liu Q, Perez-Atayde A, Rodig S, Cheung NK, Raynaud F, Hallberg B, Robinson SP, Gray NS, Pearson AD, Eccles SA, Chesler L, George RE.

Cancer Cell. 2012 Jul 10;22(1):117-30. doi: 10.1016/j.ccr.2012.06.001.


Promising therapeutic targets in neuroblastoma.

Matthay KK, George RE, Yu AL.

Clin Cancer Res. 2012 May 15;18(10):2740-53. doi: 10.1158/1078-0432.CCR-11-1939. Review.


Chemical engineering of molecular qubits.

Wedge CJ, Timco GA, Spielberg ET, George RE, Tuna F, Rigby S, McInnes EJ, Winpenny RE, Blundell SJ, Ardavan A.

Phys Rev Lett. 2012 Mar 9;108(10):107204. Epub 2012 Mar 7.


Activated ALK collaborates with MYCN in neuroblastoma pathogenesis.

Zhu S, Lee JS, Guo F, Shin J, Perez-Atayde AR, Kutok JL, Rodig SJ, Neuberg DS, Helman D, Feng H, Stewart RA, Wang W, George RE, Kanki JP, Look AT.

Cancer Cell. 2012 Mar 20;21(3):362-73. doi: 10.1016/j.ccr.2012.02.010.


Tumor histology during induction therapy in patients with high-risk neuroblastoma.

George RE, Perez-Atayde AR, Yao X, London WB, Shamberger RC, Neuberg D, Diller L.

Pediatr Blood Cancer. 2012 Sep;59(3):506-10. doi: 10.1002/pbc.24013. Epub 2011 Dec 11.


Emerging importance of ALK in neuroblastoma.

Azarova AM, Gautam G, George RE.

Semin Cancer Biol. 2011 Oct;21(4):267-75. doi: 10.1016/j.semcancer.2011.09.005. Epub 2011 Sep 16. Review.


Electrically detected magnetic resonance of neutral donors interacting with a two-dimensional electron gas.

Lo CC, Lang V, George RE, Morton JJ, Tyryshkin AM, Lyon SA, Bokor J, Schenkel T.

Phys Rev Lett. 2011 May 20;106(20):207601. Epub 2011 May 20.


Discovery of 3,5-Diamino-1,2,4-triazole Ureas as Potent Anaplastic Lymphoma Kinase Inhibitors.

Deng X, Wang J, Zhang J, Sim T, Kim ND, Sasaki T, Luther W 2nd, George RE, Jänne PA, Gray NS.

ACS Med Chem Lett. 2011 May 12;2(5):379-384. Epub 2011 Mar 15.


Electrically detected magnetic resonance in a W-band microwave cavity.

Lang V, Lo CC, George RE, Lyon SA, Bokor J, Schenkel T, Ardavan A, Morton JJ.

Rev Sci Instrum. 2011 Mar;82(3):034704. doi: 10.1063/1.3557395.


Storage of multiple coherent microwave excitations in an electron spin ensemble.

Wu H, George RE, Wesenberg JH, Mølmer K, Schuster DI, Schoelkopf RJ, Itoh KM, Ardavan A, Morton JJ, Briggs GA.

Phys Rev Lett. 2010 Oct 1;105(14):140503. Epub 2010 Sep 27.


Use of combination therapy of topical mitomycin C and cyclosporine a as an adjunct to surgery for corneal and conjunctival intraepithelial neoplasia and invasive squamous cell carcinoma.

Sugandhi P, George RE.

Cornea. 2011 Apr;30(4):486; author reply 486-7. doi: 10.1097/ICO.0b013e3181e2cf72. No abstract available.


Expression of the neuron-specific protein CHD5 is an independent marker of outcome in neuroblastoma.

Garcia I, Mayol G, Rodríguez E, Suñol M, Gershon TR, Ríos J, Cheung NK, Kieran MW, George RE, Perez-Atayde AR, Casala C, Galván P, de Torres C, Mora J, Lavarino C.

Mol Cancer. 2010 Oct 15;9:277. doi: 10.1186/1476-4598-9-277.


Electron spin coherence and electron nuclear double resonance of Bi donors in natural Si.

George RE, Witzel W, Riemann H, Abrosimov NV, Nötzel N, Thewalt ML, Morton JJ.

Phys Rev Lett. 2010 Aug 6;105(6):067601. Epub 2010 Aug 6.


Phase I study of decitabine with doxorubicin and cyclophosphamide in children with neuroblastoma and other solid tumors: a Children's Oncology Group study.

George RE, Lahti JM, Adamson PC, Zhu K, Finkelstein D, Ingle AM, Reid JM, Krailo M, Neuberg D, Blaney SM, Diller L.

Pediatr Blood Cancer. 2010 Oct;55(4):629-38. doi: 10.1002/pbc.22607.


Pharmacotherapy of neuroblastoma.

George RE, Diller L, Bernstein ML.

Expert Opin Pharmacother. 2010 Jun;11(9):1467-78. doi: 10.1517/14656566.2010.482100. Review.


Comparison of primary neuroblastoma tumors and derivative early-passage cell lines using genome-wide single nucleotide polymorphism array analysis.

Volchenboum SL, Li C, Li S, Attiyeh EF, Reynolds CP, Maris JM, Look AT, George RE.

Cancer Res. 2009 May 15;69(10):4143-9. doi: 10.1158/0008-5472.CAN-08-3112. Epub 2009 May 12.


Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.

Webb TR, Slavish J, George RE, Look AT, Xue L, Jiang Q, Cui X, Rentrop WB, Morris SW.

Expert Rev Anticancer Ther. 2009 Mar;9(3):331-56. doi: 10.1586/14737140.9.3.331. Review.


Activating mutations in ALK provide a therapeutic target in neuroblastoma.

George RE, Sanda T, Hanna M, Fröhling S, Luther W 2nd, Zhang J, Ahn Y, Zhou W, London WB, McGrady P, Xue L, Zozulya S, Gregor VE, Webb TR, Gray NS, Gilliland DG, Diller L, Greulich H, Morris SW, Meyerson M, Look AT.

Nature. 2008 Oct 16;455(7215):975-8. doi: 10.1038/nature07397.


The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor.

Schlisio S, Kenchappa RS, Vredeveld LC, George RE, Stewart R, Greulich H, Shahriari K, Nguyen NV, Pigny P, Dahia PL, Pomeroy SL, Maris JM, Look AT, Meyerson M, Peeper DS, Carter BD, Kaelin WG Jr.

Genes Dev. 2008 Apr 1;22(7):884-93. doi: 10.1101/gad.1648608. Epub 2008 Mar 11.


Neuroblastoma cells isolated from bone marrow metastases contain a naturally enriched tumor-initiating cell.

Hansford LM, McKee AE, Zhang L, George RE, Gerstle JT, Thorner PS, Smith KM, Look AT, Yeger H, Miller FD, Irwin MS, Thiele CJ, Kaplan DR.

Cancer Res. 2007 Dec 1;67(23):11234-43.


Pharmacologic modulation of sebaceous gland activity: mechanisms and clinical applications.

Clarke SB, Nelson AM, George RE, Thiboutot DM.

Dermatol Clin. 2007 Apr;25(2):137-46, v. Review.


Genome-wide analysis of neuroblastomas using high-density single nucleotide polymorphism arrays.

George RE, Attiyeh EF, Li S, Moreau LA, Neuberg D, Li C, Fox EA, Meyerson M, Diller L, Fortina P, Look AT, Maris JM.

PLoS One. 2007 Feb 28;2(2):e255.


Does MYCN amplification manifested as homogeneously staining regions at diagnosis predict a worse outcome in children with neuroblastoma? A Children's Oncology Group study.

Moreau LA, McGrady P, London WB, Shimada H, Cohn SL, Maris JM, Diller L, Look AT, George RE.

Clin Cancer Res. 2006 Oct 1;12(19):5693-7.

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