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Items: 1 to 50 of 356

1.

Negligible-Cost and Weekend-Free Chemically Defined Human iPSC Culture.

Kuo HH, Gao X, DeKeyser JM, Fetterman KA, Pinheiro EA, Weddle CJ, Fonoudi H, Orman MV, Romero-Tejeda M, Jouni M, Blancard M, Magdy T, Epting CL, George AL Jr, Burridge PW.

Stem Cell Reports. 2020 Jan 9. pii: S2213-6711(19)30446-1. doi: 10.1016/j.stemcr.2019.12.007. [Epub ahead of print]

2.

Reply: Familial Hypercholesterolemia Causes Sudden Death.

Webster G, Olson R, Balmert LC, Cherny S, George AL Jr.

J Am Coll Cardiol. 2019 Dec 10;74(23):2952-2953. doi: 10.1016/j.jacc.2019.09.061. No abstract available.

PMID:
31806143
3.

Spectrum of KV 2.1 Dysfunction in KCNB1-Associated Neurodevelopmental Disorders.

Kang SK, Vanoye CG, Misra SN, Echevarria DM, Calhoun JD, O'Connor JB, Fabre KL, McKnight D, Demmer L, Goldenberg P, Grote LE, Thiffault I, Saunders C, Strauss KA, Torkamani A, van der Smagt J, van Gassen K, Carson RP, Diaz J, Leon E, Jacher JE, Hannibal MC, Litwin J, Friedman NR, Schreiber A, Lynch B, Poduri A, Marsh ED, Goldberg EM, Millichap JJ, George AL Jr, Kearney JA.

Ann Neurol. 2019 Dec;86(6):899-912. doi: 10.1002/ana.25607. Epub 2019 Oct 24.

PMID:
31600826
4.

Decoding KCNH2 variants of unknown significance.

Vanoye CG, George AL Jr.

Heart Rhythm. 2019 Oct 5. pii: S1547-5271(19)30915-4. doi: 10.1016/j.hrthm.2019.10.009. [Epub ahead of print] No abstract available.

PMID:
31593778
5.

Functional consequences of a KCNT1 variant associated with status dystonicus and early-onset infantile encephalopathy.

Gertler TS, Thompson CH, Vanoye CG, Millichap JJ, George AL Jr.

Ann Clin Transl Neurol. 2019 Sep;6(9):1606-1615. doi: 10.1002/acn3.50847. Epub 2019 Jul 15.

6.

Upgraded molecular models of the human KCNQ1 potassium channel.

Kuenze G, Duran AM, Woods H, Brewer KR, McDonald EF, Vanoye CG, George AL Jr, Sanders CR, Meiler J.

PLoS One. 2019 Sep 13;14(9):e0220415. doi: 10.1371/journal.pone.0220415. eCollection 2019.

7.

Genetic Mosaicism in Calmodulinopathy.

Wren LM, Jiménez-Jáimez J, Al-Ghamdi S, Al-Aama JY, Bdeir A, Al-Hassnan ZN, Kuan JL, Foo RY, Potet F, Johnson CN, Aziz MC, Carvill GL, Kaski JP, Crotti L, Perin F, Monserrat L, Burridge PW, Schwartz PJ, Chazin WJ, Bhuiyan ZA, George AL Jr.

Circ Genom Precis Med. 2019 Sep;12(9):375-385. doi: 10.1161/CIRCGEN.119.002581. Epub 2019 Aug 27.

PMID:
31454269
8.

The CaMKII inhibitor KN93-calmodulin interaction and implications for calmodulin tuning of NaV1.5 and RyR2 function.

Johnson CN, Pattanayek R, Potet F, Rebbeck RT, Blackwell DJ, Nikolaienko R, Sequeira V, Le Meur R, Radwański PB, Davis JP, Zima AV, Cornea RL, Damo SM, Györke S, George AL Jr, Knollmann BC.

Cell Calcium. 2019 Sep;82:102063. doi: 10.1016/j.ceca.2019.102063. Epub 2019 Jul 30.

PMID:
31401388
9.

Cardiac Evaluation of Children With a Family History of Sudden Death.

Webster G, Olson R, Schoppen ZJ, Giancola N, Balmert LC, Cherny S, George AL Jr.

J Am Coll Cardiol. 2019 Aug 13;74(6):759-770. doi: 10.1016/j.jacc.2019.05.062.

PMID:
31395126
10.

Molecular Mechanisms of p63-Mediated Squamous Cancer Pathogenesis.

Moses MA, George AL, Sakakibara N, Mahmood K, Ponnamperuma RM, King KE, Weinberg WC.

Int J Mol Sci. 2019 Jul 23;20(14). pii: E3590. doi: 10.3390/ijms20143590. Review.

11.

Intersection of the p63 and NF-κB pathways in epithelial homeostasis and disease.

King KE, George AL, Sakakibara N, Mahmood K, Moses MA, Weinberg WC.

Mol Carcinog. 2019 Sep;58(9):1571-1580. doi: 10.1002/mc.23081. Epub 2019 Jul 8. Review.

PMID:
31286584
12.

Immunotherapy in Oral Cancer.

Mohan SP, Bhaskaran MK, George AL, Thirutheri A, Somasundaran M, Pavithran A.

J Pharm Bioallied Sci. 2019 May;11(Suppl 2):S107-S111. doi: 10.4103/JPBS.JPBS_31_19. Review.

13.

Calmodulin mutations and life-threatening cardiac arrhythmias: insights from the International Calmodulinopathy Registry.

Crotti L, Spazzolini C, Tester DJ, Ghidoni A, Baruteau AE, Beckmann BM, Behr ER, Bennett JS, Bezzina CR, Bhuiyan ZA, Celiker A, Cerrone M, Dagradi F, De Ferrari GM, Etheridge SP, Fatah M, Garcia-Pavia P, Al-Ghamdi S, Hamilton RM, Al-Hassnan ZN, Horie M, Jimenez-Jaimez J, Kanter RJ, Kaski JP, Kotta MC, Lahrouchi N, Makita N, Norrish G, Odland HH, Ohno S, Papagiannis J, Parati G, Sekarski N, Tveten K, Vatta M, Webster G, Wilde AAM, Wojciak J, George AL, Ackerman MJ, Schwartz PJ.

Eur Heart J. 2019 Sep 14;40(35):2964-2975. doi: 10.1093/eurheartj/ehz311.

PMID:
31170290
14.

Potentiating α2 subunit containing perisomatic GABAA receptors protects against seizures in a mouse model of Dravet syndrome.

Nomura T, Hawkins NA, Kearney JA, George AL Jr, Contractor A.

J Physiol. 2019 Aug;597(16):4293-4307. doi: 10.1113/JP277651. Epub 2019 May 20.

PMID:
31045243
15.

Protein structure aids predicting functional perturbation of missense variants in SCN5A and KCNQ1.

Kroncke BM, Mendenhall J, Smith DK, Sanders CR, Capra JA, George AL, Blume JD, Meiler J, Roden DM.

Comput Struct Biotechnol J. 2019 Feb 1;17:206-214. doi: 10.1016/j.csbj.2019.01.008. eCollection 2019.

16.

High-Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance.

Vanoye CG, Desai RR, Fabre KL, Gallagher SL, Potet F, DeKeyser JM, Macaya D, Meiler J, Sanders CR, George AL Jr.

Circ Genom Precis Med. 2018 Nov;11(11):e002345. doi: 10.1161/CIRCGEN.118.002345.

17.

The importance of being selective.

George AL Jr.

Heart Rhythm. 2019 Feb;16(2):279-280. doi: 10.1016/j.hrthm.2018.09.022. Epub 2018 Sep 25. No abstract available.

PMID:
30266689
18.

Modifier genes for sudden cardiac death.

Schwartz PJ, Crotti L, George AL Jr.

Eur Heart J. 2018 Nov 21;39(44):3925-3931. doi: 10.1093/eurheartj/ehy502. Review.

19.

Long QT syndrome KCNH2 mutation with sequential fetal and maternal sudden death.

Tuveng JM, Berling BM, Bunford G, Vanoye CG, Welch RC, Leren TP, George AL Jr, Rognum TO.

Forensic Sci Med Pathol. 2018 Sep;14(3):367-371. doi: 10.1007/s12024-018-9989-3. Epub 2018 Jun 8.

PMID:
29881912
20.

The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy.

Baker EM, Thompson CH, Hawkins NA, Wagnon JL, Wengert ER, Patel MK, George AL Jr, Meisler MH, Kearney JA.

Epilepsia. 2018 Jun;59(6):1166-1176. doi: 10.1111/epi.14196. Epub 2018 May 21.

21.

Progress in Understanding and Treating SCN2A-Mediated Disorders.

Sanders SJ, Campbell AJ, Cottrell JR, Moller RS, Wagner FF, Auldridge AL, Bernier RA, Catterall WA, Chung WK, Empfield JR, George AL Jr, Hipp JF, Khwaja O, Kiskinis E, Lal D, Malhotra D, Millichap JJ, Otis TS, Petrou S, Pitt G, Schust LF, Taylor CM, Tjernagel J, Spiro JE, Bender KJ.

Trends Neurosci. 2018 Jul;41(7):442-456. doi: 10.1016/j.tins.2018.03.011. Epub 2018 Apr 23. Review.

22.

A Mechanism of Calmodulin Modulation of the Human Cardiac Sodium Channel.

Johnson CN, Potet F, Thompson MK, Kroncke BM, Glazer AM, Voehler MW, Knollmann BC, George AL Jr, Chazin WJ.

Structure. 2018 May 1;26(5):683-694.e3. doi: 10.1016/j.str.2018.03.005. Epub 2018 Apr 5.

23.

SCN1A variants associated with sudden infant death syndrome.

Brownstein CA, Goldstein RD, Thompson CH, Haynes RL, Giles E, Sheidley B, Bainbridge M, Haas EA, Mena OJ, Lucas J, Schaber B, Holm IA, George AL, Kinney HC, Poduri AH.

Epilepsia. 2018 Apr;59(4):e56-e62. doi: 10.1111/epi.14055. Epub 2018 Mar 30.

24.

Direct evidence of impaired neuronal Na/K-ATPase pump function in alternating hemiplegia of childhood.

Simmons CQ, Thompson CH, Cawthon BE, Westlake G, Swoboda KJ, Kiskinis E, Ess KC, George AL Jr.

Neurobiol Dis. 2018 Jul;115:29-38. doi: 10.1016/j.nbd.2018.03.009. Epub 2018 Mar 19.

PMID:
29567111
25.

Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations.

Huang H, Kuenze G, Smith JA, Taylor KC, Duran AM, Hadziselimovic A, Meiler J, Vanoye CG, George AL Jr, Sanders CR.

Sci Adv. 2018 Mar 7;4(3):eaar2631. doi: 10.1126/sciadv.aar2631. eCollection 2018 Mar.

26.

Physiological genomics identifies genetic modifiers of long QT syndrome type 2 severity.

Chai S, Wan X, Ramirez-Navarro A, Tesar PJ, Kaufman ES, Ficker E, George AL Jr, Deschênes I.

J Clin Invest. 2018 Mar 1;128(3):1043-1056. doi: 10.1172/JCI94996. Epub 2018 Feb 12.

27.

Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update.

Phillips EJ, Sukasem C, Whirl-Carrillo M, Müller DJ, Dunnenberger HM, Chantratita W, Goldspiel B, Chen YT, Carleton BC, George AL Jr, Mushiroda T, Klein T, Gammal RS, Pirmohamed M.

Clin Pharmacol Ther. 2018 Apr;103(4):574-581. doi: 10.1002/cpt.1004. Epub 2018 Feb 2.

28.

Characterization of a KCNB1 variant associated with autism, intellectual disability, and epilepsy.

Calhoun JD, Vanoye CG, Kok F, George AL Jr, Kearney JA.

Neurol Genet. 2017 Dec 11;3(6):e198. doi: 10.1212/NXG.0000000000000198. eCollection 2017 Dec.

29.

Predicting the Functional Impact of KCNQ1 Variants of Unknown Significance.

Li B, Mendenhall JL, Kroncke BM, Taylor KC, Huang H, Smith DK, Vanoye CG, Blume JD, George AL Jr, Sanders CR, Meiler J.

Circ Cardiovasc Genet. 2017 Oct;10(5). pii: e001754. doi: 10.1161/CIRCGENETICS.117.001754.

30.

Comparative evaluation of the efficacy of lignocaine containing topical anesthetic agents during extraction of deciduous anterior teeth.

Sarpangala M, Devasya A, George AL, Kumara A, Panicker P, Mathew M.

Minerva Stomatol. 2018 Feb;67(1):26-31. doi: 10.23736/S0026-4970.17.04052-3. Epub 2017 Oct 9.

PMID:
29017289
31.

Natural genetic variation of the cardiac transcriptome in non-diseased donors and patients with dilated cardiomyopathy.

Heinig M, Adriaens ME, Schafer S, van Deutekom HWM, Lodder EM, Ware JS, Schneider V, Felkin LE, Creemers EE, Meder B, Katus HA, Rühle F, Stoll M, Cambien F, Villard E, Charron P, Varro A, Bishopric NH, George AL Jr, Dos Remedios C, Moreno-Moral A, Pesce F, Bauerfeind A, Rüschendorf F, Rintisch C, Petretto E, Barton PJ, Cook SA, Pinto YM, Bezzina CR, Hubner N.

Genome Biol. 2017 Sep 14;18(1):170. doi: 10.1186/s13059-017-1286-z.

32.

Treatment of calmodulinopathy with verapamil.

Webster G, Schoppen ZJ, George AL Jr.

BMJ Case Rep. 2017 Aug 7;2017. pii: bcr-2017-220568. doi: 10.1136/bcr-2017-220568.

33.

Allelic Complexity in Long QT Syndrome: A Family-Case Study.

Zullo A, Frisso G, Detta N, Sarubbi B, Romeo E, Cordella A, Vanoye CG, Calabrò R, George AL, Salvatore F.

Int J Mol Sci. 2017 Jul 27;18(8). pii: E1633. doi: 10.3390/ijms18081633.

34.

Sodium channel NaV1.9 mutations associated with insensitivity to pain dampen neuronal excitability.

Huang J, Vanoye CG, Cutts A, Goldberg YP, Dib-Hajj SD, Cohen CJ, Waxman SG, George AL Jr.

J Clin Invest. 2017 Jun 30;127(7):2805-2814. doi: 10.1172/JCI92373. Epub 2017 May 22.

35.

Screening of conventional anticonvulsants in a genetic mouse model of epilepsy.

Hawkins NA, Anderson LL, Gertler TS, Laux L, George AL Jr, Kearney JA.

Ann Clin Transl Neurol. 2017 Apr 26;4(5):326-339. doi: 10.1002/acn3.413. eCollection 2017 May.

36.

Unexpected Efficacy of a Novel Sodium Channel Modulator in Dravet Syndrome.

Anderson LL, Hawkins NA, Thompson CH, Kearney JA, George AL Jr.

Sci Rep. 2017 May 10;7(1):1682. doi: 10.1038/s41598-017-01851-9.

37.

In vivo reprogramming of non-mammary cells to an epithelial cell fate is independent of amphiregulin signaling.

George AL, Boulanger CA, Anderson LH, Cagnet S, Brisken C, Smith GH.

J Cell Sci. 2017 Jun 15;130(12):2018-2025. doi: 10.1242/jcs.200030. Epub 2017 Apr 28.

38.

Azithromycin Causes a Novel Proarrhythmic Syndrome.

Yang Z, Prinsen JK, Bersell KR, Shen W, Yermalitskaya L, Sidorova T, Luis PB, Hall L, Zhang W, Du L, Milne G, Tucker P, George AL Jr, Campbell CM, Pickett RA, Shaffer CM, Chopra N, Yang T, Knollmann BC, Roden DM, Murray KT.

Circ Arrhythm Electrophysiol. 2017 Apr;10(4). pii: e003560. doi: 10.1161/CIRCEP.115.003560.

39.

Research conference summary from the 2014 International Task Force on ATP1A3-Related Disorders.

Rosewich H, Sweney MT, DeBrosse S, Ess K, Ozelius L, Andermann E, Andermann F, Andrasco G, Belgrade A, Brashear A, Ciccodicola S, Egan L, George AL Jr, Lewelt A, Magelby J, Merida M, Newcomb T, Platt V, Poncelin D, Reyna S, Sasaki M, Sotero de Menezes M, Sweadner K, Viollet L, Zupanc M, Silver K, Swoboda K.

Neurol Genet. 2017 Mar 2;3(2):e139. doi: 10.1212/NXG.0000000000000139. eCollection 2017 Apr.

40.

Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes.

Rocchetti M, Sala L, Dreizehnter L, Crotti L, Sinnecker D, Mura M, Pane LS, Altomare C, Torre E, Mostacciuolo G, Severi S, Porta A, De Ferrari GM, George AL Jr, Schwartz PJ, Gnecchi M, Moretti A, Zaza A.

Cardiovasc Res. 2017 Apr 1;113(5):531-541. doi: 10.1093/cvr/cvx006.

PMID:
28158429
41.

CaMKII modulates sodium current in neurons from epileptic Scn2a mutant mice.

Thompson CH, Hawkins NA, Kearney JA, George AL Jr.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1696-1701. doi: 10.1073/pnas.1615774114. Epub 2017 Jan 30.

42.

Mammary extracellular matrix directs differentiation of testicular and embryonic stem cells to form functional mammary glands in vivo.

Bruno RD, Fleming JM, George AL, Boulanger CA, Schedin P, Smith GH.

Sci Rep. 2017 Jan 10;7:40196. doi: 10.1038/srep40196.

43.

Structural basis for KCNE3 modulation of potassium recycling in epithelia.

Kroncke BM, Van Horn WD, Smith J, Kang C, Welch RC, Song Y, Nannemann DP, Taylor KC, Sisco NJ, George AL Jr, Meiler J, Vanoye CG, Sanders CR.

Sci Adv. 2016 Sep 9;2(9):e1501228. doi: 10.1126/sciadv.1501228. eCollection 2016 Sep.

44.

Measuring Drug Metabolism Kinetics and Drug-Drug Interactions Using Self-Assembled Monolayers for Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry.

Anderson LL, Berns EJ, Bugga P, George AL Jr, Mrksich M.

Anal Chem. 2016 Sep 6;88(17):8604-9. doi: 10.1021/acs.analchem.6b01750. Epub 2016 Aug 12.

PMID:
27467208
45.

Mammary Epithelial Cell Lineage Analysis via the Lyon's Hypothesis.

George AL, Smith GH.

Int J Stem Cell Res Ther. 2016;3(1). pii: 018. Epub 2016 Jan 3.

46.

Novel calmodulin mutations associated with congenital long QT syndrome affect calcium current in human cardiomyocytes.

Pipilas DC, Johnson CN, Webster G, Schlaepfer J, Fellmann F, Sekarski N, Wren LM, Ogorodnik KV, Chazin DM, Chazin WJ, Crotti L, Bhuiyan ZA, George AL Jr.

Heart Rhythm. 2016 Oct;13(10):2012-9. doi: 10.1016/j.hrthm.2016.06.038. Epub 2016 Jul 1.

47.
48.

Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current.

Yu CC, Ko JS, Ai T, Tsai WC, Chen Z, Rubart M, Vatta M, Everett TH 4th, George AL Jr, Chen PS.

Heart Rhythm. 2016 Aug;13(8):1716-23. doi: 10.1016/j.hrthm.2016.05.009. Epub 2016 May 7.

49.

Use-Dependent Block of Human Cardiac Sodium Channels by GS967.

Potet F, Vanoye CG, George AL Jr.

Mol Pharmacol. 2016 Jul;90(1):52-60. doi: 10.1124/mol.116.103358. Epub 2016 May 2.

PMID:
27136942
50.

Rationale and design for an investigation to optimize selective serotonin reuptake inhibitor treatment for pregnant women with depression.

Avram MJ, Stika CS, Rasmussen-Torvik LJ, Ciolino JD, Pinheiro E, George AL Jr, Wisner KL.

Clin Pharmacol Ther. 2016 Jul;100(1):31-3. doi: 10.1002/cpt.375. Epub 2016 May 9.

PMID:
27037844

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