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Establishing a Cell-Free Vibrio natriegens Expression System.
Wiegand DJ, Lee HH, Ostrov N, Church GM.
ACS Synth Biol. 2018 Sep 12. doi: 10.1021/acssynbio.8b00222. [Epub ahead of print]
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Developmental barcoding of whole mouse via homing CRISPR.
Kalhor R, Kalhor K, Mejia L, Leeper K, Graveline A, Mali P, Church GM.
Science. 2018 Aug 31;361(6405). pii: eaat9804. doi: 10.1126/science.aat9804. Epub 2018 Aug 9.
Inter-homologue repair in fertilized human eggs?
Egli D, Zuccaro MV, Kosicki M, Church GM, Bradley A, Jasin M.
Nature. 2018 Aug;560(7717):E5-E7. doi: 10.1038/s41586-018-0379-5. Epub 2018 Aug 8. No abstract available.
Biosensor libraries harness large classes of binding domains for construction of allosteric transcriptional regulators.
Juárez JF, Lecube-Azpeitia B, Brown SL, Johnston CD, Church GM.
Nat Commun. 2018 Aug 6;9(1):3101. doi: 10.1038/s41467-018-05525-6.
An enhanced CRISPR repressor for targeted mammalian gene regulation.
Yeo NC, Chavez A, Lance-Byrne A, Chan Y, Menn D, Milanova D, Kuo CC, Guo X, Sharma S, Tung A, Cecchi RJ, Tuttle M, Pradhan S, Lim ET, Davidsohn N, Ebrahimkhani MR, Collins JJ, Lewis NE, Kiani S, Church GM.
Nat Methods. 2018 Aug;15(8):611-616. doi: 10.1038/s41592-018-0048-5. Epub 2018 Jul 16.
Directed differentiation of human induced pluripotent stem cells into mature kidney podocytes and establishment of a Glomerulus Chip.
Musah S, Dimitrakakis N, Camacho DM, Church GM, Ingber DE.
Nat Protoc. 2018 Jul;13(7):1662-1685. doi: 10.1038/s41596-018-0007-8.
Enhanced Bacterial Immunity and Mammalian Genome Editing via RNA-Polymerase-Mediated Dislodging of Cas9 from Double-Strand DNA Breaks.
Clarke R, Heler R, MacDougall MS, Yeo NC, Chavez A, Regan M, Hanakahi L, Church GM, Marraffini LA, Merrill BJ.
Mol Cell. 2018 Jul 5;71(1):42-55.e8. doi: 10.1016/j.molcel.2018.06.005.
Characterizing Protein Kinase Substrate Specificity Using the Proteomic Peptide Library (ProPeL) Approach.
Lubner JM, Balsbaugh JL, Church GM, Chou MF, Schwartz D.
Curr Protoc Chem Biol. 2018 Jun;10(2):e38. doi: 10.1002/cpch.38.
Current CRISPR gene drive systems are likely to be highly invasive in wild populations.
Noble C, Adlam B, Church GM, Esvelt KM, Nowak MA.
Elife. 2018 Jun 19;7. pii: e33423. doi: 10.7554/eLife.33423.
High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR-Cas9 in yeast.
Guo X, Chavez A, Tung A, Chan Y, Kaas C, Yin Y, Cecchi R, Garnier SL, Kelsic ED, Schubert M, DiCarlo JE, Collins JJ, Church GM.
Nat Biotechnol. 2018 Jul;36(6):540-546. doi: 10.1038/nbt.4147. Epub 2018 May 21.
Codon usage of highly expressed genes affects proteome-wide translation efficiency.
Frumkin I, Lajoie MJ, Gregg CJ, Hornung G, Church GM, Pilpel Y.
Proc Natl Acad Sci U S A. 2018 May 22;115(21):E4940-E4949. doi: 10.1073/pnas.1719375115. Epub 2018 May 7.
High-resolution mapping of DNA polymerase fidelity using nucleotide imbalances and next-generation sequencing.
de Paz AM, Cybulski TR, Marblestone AH, Zamft BM, Church GM, Boyden ES, Kording KP, Tyo KEJ.
Nucleic Acids Res. 2018 Jul 27;46(13):e78. doi: 10.1093/nar/gky296.
Simultaneous Discovery of Cell-Free DNA and the Nucleosome Ladder.
Henikoff S, Church GM.
Genetics. 2018 May;209(1):27-29. doi: 10.1534/genetics.118.300775. No abstract available.
The ethics of experimenting with human brain tissue.
Farahany NA, Greely HT, Hyman S, Koch C, Grady C, Pașca SP, Sestan N, Arlotta P, Bernat JL, Ting J, Lunshof JE, Iyer EPR, Hyun I, Capestany BH, Church GM, Huang H, Song H.
Nature. 2018 Apr;556(7702):429-432. doi: 10.1038/d41586-018-04813-x. No abstract available.
An Integrated Genome-wide CRISPRa Approach to Functionalize lncRNAs in Drug Resistance.
Bester AC, Lee JD, Chavez A, Lee YR, Nachmani D, Vora S, Victor J, Sauvageau M, Monteleone E, Rinn JL, Provero P, Church GM, Clohessy JG, Pandolfi PP.
Cell. 2018 Apr 19;173(3):649-664.e20. doi: 10.1016/j.cell.2018.03.052.
Enabling multiplexed testing of pooled donor cells through whole-genome sequencing.
Chan Y, Chan YK, Goodman DB, Guo X, Chavez A, Lim ET, Church GM.
Genome Med. 2018 Apr 19;10(1):31. doi: 10.1186/s13073-018-0541-6.
Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo".
Wilson CJ, Fennell T, Bothmer A, Maeder ML, Reyon D, Cotta-Ramusino C, Fernandez CA, Marco E, Barrera LA, Jayaram H, Albright CF, Cox GF, Church GM, Myer VE.
Nat Methods. 2018 Apr;15(4):236-237. doi: 10.1038/nmeth.4552. Epub 2018 Mar 30. No abstract available.
Precise Cas9 targeting enables genomic mutation prevention.
Chavez A, Pruitt BW, Tuttle M, Shapiro RS, Cecchi RJ, Winston J, Turczyk BM, Tung M, Collins JJ, Church GM.
Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3669-3673. doi: 10.1073/pnas.1718148115. Epub 2018 Mar 19.
Adaptive evolution of genomically recoded Escherichia coli.
Wannier TM, Kunjapur AM, Rice DP, McDonald MJ, Desai MM, Church GM.
Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):3090-3095. doi: 10.1073/pnas.1715530115. Epub 2018 Feb 13.
Spontaneous CRISPR loci generation in vivo by non-canonical spacer integration.
Nivala J, Shipman SL, Church GM.
Nat Microbiol. 2018 Mar;3(3):310-318. doi: 10.1038/s41564-017-0097-z. Epub 2018 Jan 29.
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