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Items: 1 to 50 of 109


Factors associated with obesity alter matrix remodeling in breast cancer tissues.

Zhang Y, Baloglu FK, Ziemer LEH, Liu Z, Lyu B, Arendt LM, Georgakoudi I.

J Biomed Opt. 2020 Jan;25(1):1-14. doi: 10.1117/1.JBO.25.1.014513.


Optical changes in THP-1 macrophage metabolism in response to pro- and anti-inflammatory stimuli reported by label-free two-photon imaging.

Smokelin I, Mizzoni C, Erndt-Marino J, Kaplan D, Georgakoudi I.

J Biomed Opt. 2020 Jan;25(1):1-14. doi: 10.1117/1.JBO.25.1.014512.


Systemic Sclerosis Dermal Fibroblasts Induce Cutaneous Fibrosis Through LOXL4: New Evidence from 3D Skin-like Tissues.

Huang M, Cai G, Baugh LM, Liu Z, Smith A, Watson M, Popovich D, Zhang T, Stawski LS, Trojanowska M, Georgakoudi I, Black LD 3rd, Pioli PA, Whitfield ML, Garlick J.

Arthritis Rheumatol. 2019 Nov 9. doi: 10.1002/art.41163. [Epub ahead of print]


3D extracellular matrix microenvironment in bioengineered tissue models of primary pediatric and adult brain tumors.

Sood D, Tang-Schomer M, Pouli D, Mizzoni C, Raia N, Tai A, Arkun K, Wu J, Black LD 3rd, Scheffler B, Georgakoudi I, Steindler DA, Kaplan DL.

Nat Commun. 2019 Oct 4;10(1):4529. doi: 10.1038/s41467-019-12420-1.


Two-photon images reveal unique texture features for label-free identification of ovarian cancer peritoneal metastases.

Pouli D, Genega EM, Sullivan TB, Rieger-Christ KM, Wright V, Georgakoudi I, Schnelldorfer T.

Biomed Opt Express. 2019 Aug 6;10(9):4479-4488. doi: 10.1364/BOE.10.004479. eCollection 2019 Sep 1.


Lysyl oxidase enzymes mediate TGF-β1-induced fibrotic phenotypes in human skin-like tissues.

Huang M, Liu Z, Baugh L, DeFuria J, Maione A, Smith A, Kashpur O, Black Iii LD, Georgakoudi I, Whitfield ML, Garlick J.

Lab Invest. 2019 Apr;99(4):514-527. doi: 10.1038/s41374-018-0159-8. Epub 2018 Dec 19.


Human Corneal Tissue Model for Nociceptive Assessments.

Siran W, Ghezzi CE, Cairns DM, Pollard RE, Chen Y, Gomes R, McKay TB, Pouli D, Jamali A, Georgakoudi I, Funderburgh JL, Kenyon K, Hamrah P, Kaplan DL.

Adv Healthc Mater. 2018 Oct;7(19):e1800488. doi: 10.1002/adhm.201800488. Epub 2018 Aug 8.


3D organizational mapping of collagen fibers elucidates matrix remodeling in a hormone-sensitive 3D breast tissue model.

Liu Z, Speroni L, Quinn KP, Alonzo C, Pouli D, Zhang Y, Stuntz E, Sonnenschein C, Soto AM, Georgakoudi I.

Biomaterials. 2018 Oct;179:96-108. doi: 10.1016/j.biomaterials.2018.06.036. Epub 2018 Jun 26.


Bioluminescence and second harmonic generation imaging reveal dynamic changes in the inflammatory and collagen landscape in early osteoarthritis.

Hui Mingalone CK, Liu Z, Hollander JM, Garvey KD, Gibson AL, Banks RE, Zhang M, McAlindon TE, Nielsen HC, Georgakoudi I, Zeng L.

Lab Invest. 2018 May;98(5):656-669. doi: 10.1038/s41374-018-0040-9. Epub 2018 Mar 14.


Mapping metabolic changes by noninvasive, multiparametric, high-resolution imaging using endogenous contrast.

Liu Z, Pouli D, Alonzo CA, Varone A, Karaliota S, Quinn KP, Münger K, Karalis KP, Georgakoudi I.

Sci Adv. 2018 Mar 7;4(3):eaap9302. doi: 10.1126/sciadv.aap9302. eCollection 2018 Mar.


Non-destructive two-photon excited fluorescence imaging identifies early nodules in calcific aortic-valve disease.

Baugh LM, Liu Z, Quinn KP, Osseiran S, Evans CL, Huggins GS, Hinds PW, Black LD 3rd, Georgakoudi I.

Nat Biomed Eng. 2017 Nov;1(11):914-924. doi: 10.1038/s41551-017-0152-3. Epub 2017 Nov 6.


Conditional deletion of RB1 in the Tie2 lineage leads to aortic valve regurgitation.

Freytsis M, Baugh L, Liu Z, Georgakoudi I, Hinds PW, Black LD, Huggins GS.

PLoS One. 2018 Jan 5;13(1):e0190623. doi: 10.1371/journal.pone.0190623. eCollection 2018.


Label free monitoring of megakaryocytic development and proplatelet formation in vitro.

Pouli D, Tozzi L, Alonzo CA, Liu Z, Kaplan DL, Balduini A, Georgakoudi I.

Biomed Opt Express. 2017 Sep 27;8(10):4742-4755. doi: 10.1364/BOE.8.004742. eCollection 2017 Oct 1.


An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth.

Uchimura T, Hollander JM, Nakamura DS, Liu Z, Rosen CJ, Georgakoudi I, Zeng L.

Development. 2017 Oct 1;144(19):3533-3546. doi: 10.1242/dev.155598.


UV and NIR-Responsive Layer-by-Layer Films Containing 6-Bromo-7-hydroxycoumarin Photolabile Groups.

Feeney MJ, Hu X, Srinivasan R, Van N, Hunter M, Georgakoudi I, Thomas SW 3rd.

Langmuir. 2017 Oct 17;33(41):10877-10885. doi: 10.1021/acs.langmuir.7b01469. Epub 2017 Oct 2.


Variability in responses observed in human white adipose tissue models.

Abbott RD, Borowsky FE, Alonzo CA, Zieba A, Georgakoudi I, Kaplan DL.

J Tissue Eng Regen Med. 2018 Mar;12(3):840-847. doi: 10.1002/term.2572. Epub 2017 Nov 10.


Endogenous Two-Photon Excited Fluorescence Imaging Characterizes Neuron and Astrocyte Metabolic Responses to Manganese Toxicity.

Stuntz E, Gong Y, Sood D, Liaudanskaya V, Pouli D, Quinn KP, Alonzo C, Liu Z, Kaplan DL, Georgakoudi I.

Sci Rep. 2017 Apr 21;7(1):1041. doi: 10.1038/s41598-017-01015-9.


Hyaluronic acid modification of RNase A and its intracellular delivery using lipid-like nanoparticles.

Wang X, Li Y, Li Q, Neufeld CI, Pouli D, Sun S, Yang L, Deng P, Wang M, Georgakoudi I, Tang S, Xu Q.

J Control Release. 2017 Oct 10;263:39-45. doi: 10.1016/j.jconrel.2017.01.037. Epub 2017 Jan 31.


Skin regeneration with all accessory organs following ablation with irreversible electroporation.

Golberg A, Villiger M, Felix Broelsch G, Quinn KP, Albadawi H, Khan S, Watkins MT, Georgakoudi I, Austen WG Jr, Bei M, Bouma BE, Mihm MC Jr, Yarmush ML.

J Tissue Eng Regen Med. 2018 Jan;12(1):98-113. doi: 10.1002/term.2374. Epub 2017 May 23.


Automated quantification of three-dimensional organization of fiber-like structures in biological tissues.

Liu Z, Pouli D, Sood D, Sundarakrishnan A, Hui Mingalone CK, Arendt LM, Alonzo C, Quinn KP, Kuperwasser C, Zeng L, Schnelldorfer T, Kaplan DL, Georgakoudi I.

Biomaterials. 2017 Feb;116:34-47. doi: 10.1016/j.biomaterials.2016.11.041. Epub 2016 Nov 25.


Imaging mitochondrial dynamics in human skin reveals depth-dependent hypoxia and malignant potential for diagnosis.

Pouli D, Balu M, Alonzo CA, Liu Z, Quinn KP, Rius-Diaz F, Harris RM, Kelly KM, Tromberg BJ, Georgakoudi I.

Sci Transl Med. 2016 Nov 30;8(367):367ra169.


Optical metrics of the extracellular matrix predict compositional and mechanical changes after myocardial infarction.

Quinn KP, Sullivan KE, Liu Z, Ballard Z, Siokatas C, Georgakoudi I, Black LD.

Sci Rep. 2016 Nov 7;6:35823. doi: 10.1038/srep35823.


Two-photon excited fluorescence of intrinsic fluorophores enables label-free assessment of adipose tissue function.

Alonzo CA, Karaliota S, Pouli D, Liu Z, Karalis KP, Georgakoudi I.

Sci Rep. 2016 Aug 5;6:31012. doi: 10.1038/srep31012.


Endogenous light scattering as an optical signature of circulating tumor cell clusters.

Lyons J, Polmear M, Mineva ND, Romagnoli M, Sonenshein GE, Georgakoudi I.

Biomed Opt Express. 2016 Feb 25;7(3):1042-50. doi: 10.1364/BOE.7.001042. eCollection 2016 Mar 1.


Quantitative differentiation of normal and scarred tissues using second-harmonic generation microscopy.

Yildirim M, Quinn KP, Kobler JB, Zeitels SM, Georgakoudi I, Ben-Yakar A.

Scanning. 2016 Nov;38(6):684-693. doi: 10.1002/sca.21316. Epub 2016 Apr 25.


Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles.

Wang M, Zuris JA, Meng F, Rees H, Sun S, Deng P, Han Y, Gao X, Pouli D, Wu Q, Georgakoudi I, Liu DR, Xu Q.

Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):2868-73. doi: 10.1073/pnas.1520244113. Epub 2016 Feb 29.


Diabetic Wounds Exhibit Distinct Microstructural and Metabolic Heterogeneity through Label-Free Multiphoton Microscopy.

Quinn KP, Leal EC, Tellechea A, Kafanas A, Auster ME, Veves A, Georgakoudi I.

J Invest Dermatol. 2016 Jan;136(1):342-344. doi: 10.1038/JID.2015.371. No abstract available.


Fetal brain extracellular matrix boosts neuronal network formation in 3D bioengineered model of cortical brain tissue.

Sood D, Chwalek K, Stuntz E, Pouli D, Du C, Tang-Schomer M, Georgakoudi I, Black LD 3rd, Kaplan DL.

ACS Biomater Sci Eng. 2016;2(1):131-140. doi: 10.1021/acsbiomaterials.5b00446. Epub 2015 Dec 10.


Non-invasive Assessments of Adipose Tissue Metabolism In Vitro.

Abbott RD, Borowsky FE, Quinn KP, Bernstein DL, Georgakoudi I, Kaplan DL.

Ann Biomed Eng. 2016 Mar;44(3):725-32. doi: 10.1007/s10439-015-1438-9. Epub 2015 Sep 23. Review.


Rapid three-dimensional quantification of voxel-wise collagen fiber orientation.

Liu Z, Quinn KP, Speroni L, Arendt L, Kuperwasser C, Sonnenschein C, Soto AM, Georgakoudi I.

Biomed Opt Express. 2015 Jun 3;6(7):2294-310. doi: 10.1364/BOE.6.002294. eCollection 2015 Jul 1.


Laparoscopic narrow band imaging for detection of occult cancer metastases: a randomized feasibility trial.

Schnelldorfer T, Jenkins RL, Birkett DH, Wright VJ, Price LL, Georgakoudi I.

Surg Endosc. 2016 Apr;30(4):1656-61. doi: 10.1007/s00464-015-4401-9. Epub 2015 Jul 21.


Skin rejuvenation with non-invasive pulsed electric fields.

Golberg A, Khan S, Belov V, Quinn KP, Albadawi H, Felix Broelsch G, Watkins MT, Georgakoudi I, Papisov M, Mihm MC Jr, Austen WG Jr, Yarmush ML.

Sci Rep. 2015 May 12;5:10187. doi: 10.1038/srep10187.


Membrane potential depolarization causes alterations in neuron arrangement and connectivity in cocultures.

Özkucur N, Quinn KP, Pang JC, Du C, Georgakoudi I, Miller E, Levin M, Kaplan DL.

Brain Behav. 2015 Jan;5(1):24-38. doi: 10.1002/brb3.295. Epub 2014 Nov 5.


Cell-tethered ligands modulate bone remodeling by osteoblasts and osteoclasts.

Hayden RS, Fortin JP, Harwood B, Subramanian B, Quinn KP, Georgakoudi I, Kopin AS, Kaplan DL.

Adv Funct Mater. 2014 Jan 29;24(4):472-479.


Equine model for soft-tissue regeneration.

Bellas E, Rollins A, Moreau JE, Lo T, Quinn KP, Fourligas N, Georgakoudi I, Leisk GG, Mazan M, Thane KE, Taeymans O, Hoffman AM, Kaplan DL, Kirker-Head CA.

J Biomed Mater Res B Appl Biomater. 2015 Aug;103(6):1217-1227. doi: 10.1002/jbm.b.33299. Epub 2014 Oct 28.


An automated image processing method to quantify collagen fibre organization within cutaneous scar tissue.

Quinn KP, Golberg A, Broelsch GF, Khan S, Villiger M, Bouma B, Austen WG Jr, Sheridan RL, Mihm MC Jr, Yarmush ML, Georgakoudi I.

Exp Dermatol. 2015 Jan;24(1):78-80. doi: 10.1111/exd.12553. Epub 2014 Nov 11.


Bioengineered silk gene delivery system for nuclear targeting.

Yigit S, Tokareva O, Varone A, Georgakoudi I, Kaplan DL.

Macromol Biosci. 2014 Sep;14(9):1291-8. doi: 10.1002/mabi.201400113. Epub 2014 May 30.


Noninvasive assessment of mitochondrial organization in three-dimensional tissues reveals changes associated with cancer development.

Xylas J, Varone A, Quinn KP, Pouli D, McLaughlin-Drubin ME, Thieu HT, Garcia-Moliner ML, House M, Hunter M, Munger K, Georgakoudi I.

Int J Cancer. 2015 Jan 15;136(2):322-32. doi: 10.1002/ijc.28992. Epub 2014 Jun 5.


From shadow to light: visualization of extrahepatic bile ducts using image-enhanced laparoscopy.

Schnelldorfer T, Jenkins RL, Birkett DH, Georgakoudi I.

Surg Innov. 2015 Apr;22(2):194-200. doi: 10.1177/1553350614531661. Epub 2014 Apr 30. Review.


From single cells to tissues: interactions between the matrix and human breast cells in real time.

Barnes C, Speroni L, Quinn KP, Montevil M, Saetzler K, Bode-Animashaun G, McKerr G, Georgakoudi I, Downes CS, Sonnenschein C, Howard CV, Soto AM.

PLoS One. 2014 Apr 1;9(4):e93325. doi: 10.1371/journal.pone.0093325. eCollection 2014.


Endogenous two-photon fluorescence imaging elucidates metabolic changes related to enhanced glycolysis and glutamine consumption in precancerous epithelial tissues.

Varone A, Xylas J, Quinn KP, Pouli D, Sridharan G, McLaughlin-Drubin ME, Alonzo C, Lee K, Münger K, Georgakoudi I.

Cancer Res. 2014 Jun 1;74(11):3067-75. doi: 10.1158/0008-5472.CAN-13-2713. Epub 2014 Mar 31.


Introduction: feature issue on optical molecular probes, imaging, and drug delivery.

Campagnola P, French PM, Georgakoudi I, Mycek MA.

Biomed Opt Express. 2014 Jan 29;5(2):643-4. doi: 10.1364/BOE.5.000643. eCollection 2014 Feb 1.


Enhanced intracellular siRNA delivery using bioreducible lipid-like nanoparticles.

Wang M, Alberti K, Varone A, Pouli D, Georgakoudi I, Xu Q.

Adv Healthc Mater. 2014 Sep;3(9):1398-403. doi: 10.1002/adhm.201400039. Epub 2014 Feb 20.


Quantitative characterization of mineralized silk film remodeling during long-term osteoblast-osteoclast co-culture.

Hayden RS, Quinn KP, Alonzo CA, Georgakoudi I, Kaplan DL.

Biomaterials. 2014 Apr;35(12):3794-802. doi: 10.1016/j.biomaterials.2014.01.034. Epub 2014 Jan 29.


Extracellular matrix remodeling following myocardial infarction influences the therapeutic potential of mesenchymal stem cells.

Sullivan KE, Quinn KP, Tang KM, Georgakoudi I, Black LD 3rd.

Stem Cell Res Ther. 2014 Jan 24;5(1):14. doi: 10.1186/scrt403.


ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis.

Romagnoli M, Mineva ND, Polmear M, Conrad C, Srinivasan S, Loussouarn D, Barillé-Nion S, Georgakoudi I, Dagg Á, McDermott EW, Duffy MJ, McGowan PM, Schlomann U, Parsons M, Bartsch JW, Sonenshein GE.

EMBO Mol Med. 2014 Feb;6(2):278-94. doi: 10.1002/emmm.201303373. Epub 2013 Dec 27.


Lysyl oxidase-mediated collagen crosslinks may be assessed as markers of functional properties of tendon tissue formation.

Marturano JE, Xylas JF, Sridharan GV, Georgakoudi I, Kuo CK.

Acta Biomater. 2014 Mar;10(3):1370-9. doi: 10.1016/j.actbio.2013.11.024. Epub 2013 Dec 6.


Quantitative metabolic imaging using endogenous fluorescence to detect stem cell differentiation.

Quinn KP, Sridharan GV, Hayden RS, Kaplan DL, Lee K, Georgakoudi I.

Sci Rep. 2013 Dec 5;3:3432. doi: 10.1038/srep03432.


Autocorrelation method for fractal analysis in nonrectangular image domains.

MacDonald DH, Hunter M, Quinn KP, Georgakoudi I.

Opt Lett. 2013 Nov 1;38(21):4477-9. doi: 10.1364/OL.38.004477.


Young developmental age cardiac extracellular matrix promotes the expansion of neonatal cardiomyocytes in vitro.

Williams C, Quinn KP, Georgakoudi I, Black LD 3rd.

Acta Biomater. 2014 Jan;10(1):194-204. doi: 10.1016/j.actbio.2013.08.037. Epub 2013 Sep 6.

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