Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 55

1.

Host-specialized fibrinogen-binding by a bacterial surface protein promotes biofilm formation and innate immune evasion.

Pickering AC, Vitry P, Prystopiuk V, Garcia B, Höök M, Schoenebeck J, Geoghegan JA, Dufrêne YF, Fitzgerald JR.

PLoS Pathog. 2019 Jun 19;15(6):e1007816. doi: 10.1371/journal.ppat.1007816. eCollection 2019 Jun.

2.

Clumping factor B is an important virulence factor during Staphylococcus aureus skin infection and a promising vaccine target.

Lacey KA, Mulcahy ME, Towell AM, Geoghegan JA, McLoughlin RM.

PLoS Pathog. 2019 Apr 22;15(4):e1007713. doi: 10.1371/journal.ppat.1007713. eCollection 2019 Apr.

3.

Fibronectin-binding protein B (FnBPB) from Staphylococcus aureus protects against the antimicrobial activity of histones.

Pietrocola G, Nobile G, Alfeo MJ, Foster TJ, Geoghegan JA, De Filippis V, Speziale P.

J Biol Chem. 2019 Mar 8;294(10):3588-3602. doi: 10.1074/jbc.RA118.005707. Epub 2019 Jan 8.

PMID:
30622139
4.

Mobile-Genetic-Element-Encoded Hypertolerance to Copper Protects Staphylococcus aureus from Killing by Host Phagocytes.

Zapotoczna M, Riboldi GP, Moustafa AM, Dickson E, Narechania A, Morrissey JA, Planet PJ, Holden MTG, Waldron KJ, Geoghegan JA.

MBio. 2018 Oct 16;9(5). pii: e00550-18. doi: 10.1128/mBio.00550-18.

5.

Adhesion of Staphylococcus aureus to Corneocytes from Atopic Dermatitis Patients Is Controlled by Natural Moisturizing Factor Levels.

Feuillie C, Vitry P, McAleer MA, Kezic S, Irvine AD, Geoghegan JA, Dufrêne YF.

MBio. 2018 Aug 14;9(4). pii: e01184-18. doi: 10.1128/mBio.01184-18.

6.

Mechanomicrobiology: How Mechanical Forces Activate Staphylococcus aureus Adhesion.

Geoghegan JA, Dufrêne YF.

Trends Microbiol. 2018 Aug;26(8):645-648. doi: 10.1016/j.tim.2018.05.004. Epub 2018 Jun 1.

PMID:
29866473
7.

Staphylococcus aureus clumping factor A is a force-sensitive molecular switch that activates bacterial adhesion.

Herman-Bausier P, Labate C, Towell AM, Derclaye S, Geoghegan JA, Dufrêne YF.

Proc Natl Acad Sci U S A. 2018 May 22;115(21):5564-5569. doi: 10.1073/pnas.1718104115. Epub 2018 May 7.

8.

The widespread use of topical antimicrobials enriches for resistance in Staphylococcus aureus isolated from patients with atopic dermatitis.

Harkins CP, McAleer MA, Bennett D, McHugh M, Fleury OM, Pettigrew KA, Oravcová K, Parkhill J, Proby CM, Dawe RS, Geoghegan JA, Irvine AD, Holden MTG.

Br J Dermatol. 2018 Oct;179(4):951-958. doi: 10.1111/bjd.16722. Epub 2018 Jul 24.

9.

A horizontally gene transferred copper resistance locus confers hyper-resistance to antibacterial copper toxicity and enables survival of community acquired methicillin resistant Staphylococcus aureus USA300 in macrophages.

Purves J, Thomas J, Riboldi GP, Zapotoczna M, Tarrant E, Andrew PW, Londoño A, Planet PJ, Geoghegan JA, Waldron KJ, Morrissey JA.

Environ Microbiol. 2018 Apr;20(4):1576-1589. doi: 10.1111/1462-2920.14088. Epub 2018 Mar 26.

10.

Staphylococcus aureus and Atopic Dermatitis: A Complex and Evolving Relationship.

Geoghegan JA, Irvine AD, Foster TJ.

Trends Microbiol. 2018 Jun;26(6):484-497. doi: 10.1016/j.tim.2017.11.008. Epub 2017 Dec 9. Review.

PMID:
29233606
11.

Force-Induced Strengthening of the Interaction between Staphylococcus aureus Clumping Factor B and Loricrin.

Vitry P, Valotteau C, Feuillie C, Bernard S, Alsteens D, Geoghegan JA, Dufrêne YF.

MBio. 2017 Dec 5;8(6). pii: e01748-17. doi: 10.1128/mBio.01748-17.

12.

The Staphylococcus aureus Cell Wall-Anchored Protein Clumping Factor A Is an Important T Cell Antigen.

Lacey KA, Leech JM, Lalor SJ, McCormack N, Geoghegan JA, McLoughlin RM.

Infect Immun. 2017 Nov 17;85(12). pii: e00549-17. doi: 10.1128/IAI.00549-17. Print 2017 Dec.

13.

Live-Cell Nanoscopy in Antiadhesion Therapy.

Geoghegan JA, Foster TJ, Speziale P, Dufrêne YF.

Trends Microbiol. 2017 Jul;25(7):512-514. doi: 10.1016/j.tim.2017.04.002. Epub 2017 May 8.

PMID:
28495024
14.

Conjugate of an IgG Binding Domain with Botulinum Neurotoxin A Lacking the Acceptor Moiety Targets Its SNARE Protease into TrkA-Expressing Cells When Coupled to Anti-TrkA IgG or Fc-βNGF.

Nugent M, Wang J, Lawrence G, Zurawski T, Geoghegan JA, Dolly JO.

Bioconjug Chem. 2017 Jun 21;28(6):1684-1692. doi: 10.1021/acs.bioconjchem.7b00157. Epub 2017 May 22.

PMID:
28489355
15.

Clumping Factor B Promotes Adherence of Staphylococcus aureus to Corneocytes in Atopic Dermatitis.

Fleury OM, McAleer MA, Feuillie C, Formosa-Dague C, Sansevere E, Bennett DE, Towell AM, McLean WHI, Kezic S, Robinson DA, Fallon PG, Foster TJ, Dufrêne YF, Irvine AD, Geoghegan JA.

Infect Immun. 2017 May 23;85(6). pii: e00994-16. doi: 10.1128/IAI.00994-16. Print 2017 Jun.

16.

Molecular interactions and inhibition of the staphylococcal biofilm-forming protein SdrC.

Feuillie C, Formosa-Dague C, Hays LM, Vervaeck O, Derclaye S, Brennan MP, Foster TJ, Geoghegan JA, Dufrêne YF.

Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3738-3743. doi: 10.1073/pnas.1616805114. Epub 2017 Mar 20.

17.

Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody.

Ganesh VK, Liang X, Geoghegan JA, Cohen ALV, Venugopalan N, Foster TJ, Hook M.

EBioMedicine. 2016 Nov;13:328-338. doi: 10.1016/j.ebiom.2016.09.027. Epub 2016 Oct 1.

18.

Molecular Interactions of Human Plasminogen with Fibronectin-binding Protein B (FnBPB), a Fibrinogen/Fibronectin-binding Protein from Staphylococcus aureus.

Pietrocola G, Nobile G, Gianotti V, Zapotoczna M, Foster TJ, Geoghegan JA, Speziale P.

J Biol Chem. 2016 Aug 26;291(35):18148-62. doi: 10.1074/jbc.M116.731125. Epub 2016 Jul 7.

19.

CRIg Functions as a Macrophage Pattern Recognition Receptor to Directly Bind and Capture Blood-Borne Gram-Positive Bacteria.

Zeng Z, Surewaard BG, Wong CH, Geoghegan JA, Jenne CN, Kubes P.

Cell Host Microbe. 2016 Jul 13;20(1):99-106. doi: 10.1016/j.chom.2016.06.002. Epub 2016 Jun 23.

20.

The Role of Staphylococcus aureus Virulence Factors in Skin Infection and Their Potential as Vaccine Antigens.

Lacey KA, Geoghegan JA, McLoughlin RM.

Pathogens. 2016 Feb 17;5(1). pii: E22. doi: 10.3390/pathogens5010022. Review.

21.

Zinc-dependent mechanical properties of Staphylococcus aureus biofilm-forming surface protein SasG.

Formosa-Dague C, Speziale P, Foster TJ, Geoghegan JA, Dufrêne YF.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):410-5. doi: 10.1073/pnas.1519265113. Epub 2015 Dec 29.

22.

Cell Wall-Anchored Surface Proteins of Staphylococcus aureus: Many Proteins, Multiple Functions.

Geoghegan JA, Foster TJ.

Curr Top Microbiol Immunol. 2017;409:95-120. doi: 10.1007/82_2015_5002.

PMID:
26667044
23.

Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection.

Brown AF, Murphy AG, Lalor SJ, Leech JM, O'Keeffe KM, Mac Aogáin M, O'Halloran DP, Lacey KA, Tavakol M, Hearnden CH, Fitzgerald-Hughes D, Humphreys H, Fennell JP, van Wamel WJ, Foster TJ, Geoghegan JA, Lavelle EC, Rogers TR, McLoughlin RM.

PLoS Pathog. 2015 Nov 5;11(11):e1005226. doi: 10.1371/journal.ppat.1005226. eCollection 2015.

24.

Fibronectin Binding Proteins SpsD and SpsL Both Support Invasion of Canine Epithelial Cells by Staphylococcus pseudintermedius.

Pietrocola G, Gianotti V, Richards A, Nobile G, Geoghegan JA, Rindi S, Monk IR, Bordt AS, Foster TJ, Fitzgerald JR, Speziale P.

Infect Immun. 2015 Oct;83(10):4093-102. doi: 10.1128/IAI.00542-15. Epub 2015 Aug 3.

25.

Staphylokinase Control of Staphylococcus aureus Biofilm Formation and Detachment Through Host Plasminogen Activation.

Kwiecinski J, Peetermans M, Liesenborghs L, Na M, Björnsdottir H, Zhu X, Jacobsson G, Johansson BR, Geoghegan JA, Foster TJ, Josefsson E, Bylund J, Verhamme P, Jin T.

J Infect Dis. 2016 Jan 1;213(1):139-48. doi: 10.1093/infdis/jiv360. Epub 2015 Jul 1.

PMID:
26136471
26.

Manipulation of Autophagy in Phagocytes Facilitates Staphylococcus aureus Bloodstream Infection.

O'Keeffe KM, Wilk MM, Leech JM, Murphy AG, Laabei M, Monk IR, Massey RC, Lindsay JA, Foster TJ, Geoghegan JA, McLoughlin RM.

Infect Immun. 2015 Sep;83(9):3445-57. doi: 10.1128/IAI.00358-15. Epub 2015 Jun 22.

27.

Staphylococcus aureus Fibronectin-Binding Protein A Mediates Cell-Cell Adhesion through Low-Affinity Homophilic Bonds.

Herman-Bausier P, El-Kirat-Chatel S, Foster TJ, Geoghegan JA, Dufrêne YF.

MBio. 2015 May 26;6(3):e00413-15. doi: 10.1128/mBio.00413-15.

28.

Biofilm formation by staphylococci and streptococci: structural, functional, and regulatory aspects and implications for pathogenesis.

Speziale P, Geoghegan JA.

Front Cell Infect Microbiol. 2015 Apr 8;5:31. doi: 10.3389/fcimb.2015.00031. eCollection 2015. No abstract available.

29.

Protein A is released into the Staphylococcus aureus culture supernatant with an unprocessed sorting signal.

O'Halloran DP, Wynne K, Geoghegan JA.

Infect Immun. 2015 Apr;83(4):1598-609. doi: 10.1128/IAI.03122-14. Epub 2015 Feb 2.

30.

Protein-based biofilm matrices in Staphylococci.

Speziale P, Pietrocola G, Foster TJ, Geoghegan JA.

Front Cell Infect Microbiol. 2014 Dec 10;4:171. doi: 10.3389/fcimb.2014.00171. eCollection 2014. Review.

31.

Role for the A domain of unprocessed accumulation-associated protein (Aap) in the attachment phase of the Staphylococcus epidermidis biofilm phenotype.

Conlon BP, Geoghegan JA, Waters EM, McCarthy H, Rowe SE, Davies JR, Schaeffer CR, Foster TJ, Fey PD, O'Gara JP.

J Bacteriol. 2014 Dec;196(24):4268-75. doi: 10.1128/JB.01946-14. Epub 2014 Sep 29.

32.

The binding force of the staphylococcal adhesin SdrG is remarkably strong.

Herman P, El-Kirat-Chatel S, Beaussart A, Geoghegan JA, Foster TJ, Dufrêne YF.

Mol Microbiol. 2014 Jul;93(2):356-68. doi: 10.1111/mmi.12663. Epub 2014 Jun 20.

33.

IsdC from Staphylococcus lugdunensis induces biofilm formation under low-iron growth conditions.

Missineo A, Di Poto A, Geoghegan JA, Rindi S, Heilbronner S, Gianotti V, Arciola CR, Foster TJ, Speziale P, Pietrocola G.

Infect Immun. 2014 Jun;82(6):2448-59. doi: 10.1128/IAI.01542-14. Epub 2014 Mar 31.

34.

Fibronectin-binding proteins are required for biofilm formation by community-associated methicillin-resistant Staphylococcus aureus strain LAC.

McCourt J, O'Halloran DP, McCarthy H, O'Gara JP, Geoghegan JA.

FEMS Microbiol Lett. 2014 Apr;353(2):157-64. doi: 10.1111/1574-6968.12424. Epub 2014 Apr 10.

35.

A short sequence within subdomain N1 of region A of the Staphylococcus aureus MSCRAMM clumping factor A is required for export and surface display.

McCormack N, Foster TJ, Geoghegan JA.

Microbiology. 2014 Apr;160(Pt 4):659-670. doi: 10.1099/mic.0.074724-0. Epub 2014 Jan 24.

PMID:
24464799
36.

Emergence of the epidemic methicillin-resistant Staphylococcus aureus strain USA300 coincides with horizontal transfer of the arginine catabolic mobile element and speG-mediated adaptations for survival on skin.

Planet PJ, LaRussa SJ, Dana A, Smith H, Xu A, Ryan C, Uhlemann AC, Boundy S, Goldberg J, Narechania A, Kulkarni R, Ratner AJ, Geoghegan JA, Kolokotronis SO, Prince A.

MBio. 2013 Dec 17;4(6):e00889-13. doi: 10.1128/mBio.00889-13.

37.

Adhesion, invasion and evasion: the many functions of the surface proteins of Staphylococcus aureus.

Foster TJ, Geoghegan JA, Ganesh VK, Höök M.

Nat Rev Microbiol. 2014 Jan;12(1):49-62. doi: 10.1038/nrmicro3161. Review.

38.

Targeted nasal vaccination provides antibody-independent protection against Staphylococcus aureus.

Misstear K, McNeela EA, Murphy AG, Geoghegan JA, O'Keeffe KM, Fox J, Chan K, Heuking S, Collin N, Foster TJ, McLoughlin RM, Lavelle EC.

J Infect Dis. 2014 May 1;209(9):1479-84. doi: 10.1093/infdis/jit636. Epub 2013 Nov 22.

39.

Forces driving the attachment of Staphylococcus epidermidis to fibrinogen-coated surfaces.

Herman P, El-Kirat-Chatel S, Beaussart A, Geoghegan JA, Vanzieleghem T, Foster TJ, Hols P, Mahillon J, Dufrêne YF.

Langmuir. 2013 Oct 22;29(42):13018-22. doi: 10.1021/la4029172. Epub 2013 Oct 10.

PMID:
24111821
40.

Nlrp-3-driven interleukin 17 production by γδT cells controls infection outcomes during Staphylococcus aureus surgical site infection.

Maher BM, Mulcahy ME, Murphy AG, Wilk M, O'Keeffe KM, Geoghegan JA, Lavelle EC, McLoughlin RM.

Infect Immun. 2013 Dec;81(12):4478-89. doi: 10.1128/IAI.01026-13. Epub 2013 Sep 30.

41.

Molecular Characterization of the Multiple Interactions of SpsD, a Surface Protein from Staphylococcus pseudintermedius, with Host Extracellular Matrix Proteins.

Pietrocola G, Geoghegan JA, Rindi S, Di Poto A, Missineo A, Consalvi V, Foster TJ, Speziale P.

PLoS One. 2013 Jun 21;8(6):e66901. doi: 10.1371/journal.pone.0066901. Print 2013.

42.

Subdomains N2N3 of fibronectin binding protein A mediate Staphylococcus aureus biofilm formation and adherence to fibrinogen using distinct mechanisms.

Geoghegan JA, Monk IR, O'Gara JP, Foster TJ.

J Bacteriol. 2013 Jun;195(11):2675-83. doi: 10.1128/JB.02128-12. Epub 2013 Apr 5.

43.

Nasal colonisation by Staphylococcus aureus depends upon clumping factor B binding to the squamous epithelial cell envelope protein loricrin.

Mulcahy ME, Geoghegan JA, Monk IR, O'Keeffe KM, Walsh EJ, Foster TJ, McLoughlin RM.

PLoS Pathog. 2012 Dec;8(12):e1003092. doi: 10.1371/journal.ppat.1003092. Epub 2012 Dec 27.

44.

Complement regulator C4BP binds to Staphylococcus aureus surface proteins SdrE and Bbp inhibiting bacterial opsonization and killing.

Hair PS, Foley CK, Krishna NK, Nyalwidhe JO, Geoghegan JA, Foster TJ, Cunnion KM.

Results Immunol. 2013 Nov 9;3:114-21. doi: 10.1016/j.rinim.2013.10.004. eCollection 2013.

45.

Socializing, networking and development: a report from the second 'Young Microbiologists Symposium on Microbe Signalling, Organization and Pathogenesis'.

Caly DL, Coulthurst SJ, Geoghegan JA, Malone JG, Ryan RP.

Mol Microbiol. 2012 Nov;86(3):501-12. doi: 10.1111/mmi.12016. Epub 2012 Sep 18.

46.

Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic.

Sharp JA, Echague CG, Hair PS, Ward MD, Nyalwidhe JO, Geoghegan JA, Foster TJ, Cunnion KM.

PLoS One. 2012;7(5):e38407. doi: 10.1371/journal.pone.0038407. Epub 2012 May 31.

47.

Staphylococcal biofilm-forming protein has a contiguous rod-like structure.

Gruszka DT, Wojdyla JA, Bingham RJ, Turkenburg JP, Manfield IW, Steward A, Leech AP, Geoghegan JA, Foster TJ, Clarke J, Potts JR.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):E1011-8. doi: 10.1073/pnas.1119456109. Epub 2012 Apr 9.

48.

The immune evasion protein Sbi of Staphylococcus aureus occurs both extracellularly and anchored to the cell envelope by binding lipoteichoic acid.

Smith EJ, Corrigan RM, van der Sluis T, Gründling A, Speziale P, Geoghegan JA, Foster TJ.

Mol Microbiol. 2012 Feb;83(4):789-804. doi: 10.1111/j.1365-2958.2011.07966.x. Epub 2012 Jan 18.

49.

Genome sequence of Staphylococcus lugdunensis N920143 allows identification of putative colonization and virulence factors.

Heilbronner S, Holden MT, van Tonder A, Geoghegan JA, Foster TJ, Parkhill J, Bentley SD.

FEMS Microbiol Lett. 2011 Sep;322(1):60-7. doi: 10.1111/j.1574-6968.2011.02339.x. Epub 2011 Jul 4.

50.

Functional analysis of a murine monoclonal antibody against the repetitive region of the fibronectin-binding adhesins fibronectin-binding protein A and fibronectin-binding protein B from Staphylococcus aureus.

Provenza G, Provenzano M, Visai L, Burke FM, Geoghegan JA, Stravalaci M, Gobbi M, Mazzini G, Arciola CR, Foster TJ, Speziale P.

FEBS J. 2010 Nov;277(21):4490-505. doi: 10.1111/j.1742-4658.2010.07835.x. Epub 2010 Sep 28.

Supplemental Content

Loading ...
Support Center