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Items: 1 to 50 of 52

1.

Targeting a Pre-existing Anti-transgene T Cell Response for Effective Gene Therapy of MPS-I in the Mouse Model of the Disease.

Squeri G, Passerini L, Ferro F, Laudisa C, Tomasoni D, Deodato F, Donati MA, Gasperini S, Aiuti A, Bernardo ME, Gentner B, Naldini L, Annoni A, Biffi A, Gregori S.

Mol Ther. 2019 Jul 3;27(7):1215-1227. doi: 10.1016/j.ymthe.2019.04.014. Epub 2019 Apr 19.

2.

Acute myeloid leukaemia niche regulates response to L-asparaginase.

Michelozzi IM, Granata V, De Ponti G, Alberti G, Tomasoni C, Antolini L, Gambacorti-Passerini C, Gentner B, Dazzi F, Biondi A, Coliva T, Rizzari C, Pievani A, Serafini M.

Br J Haematol. 2019 Aug;186(3):420-430. doi: 10.1111/bjh.15920. Epub 2019 May 1.

PMID:
31044436
3.

Assessing the Impact of Cyclosporin A on Lentiviral Transduction and Preservation of Human Hematopoietic Stem Cells in Clinically Relevant Ex Vivo Gene Therapy Settings.

Petrillo C, Calabria A, Piras F, Capotondo A, Spinozzi G, Cuccovillo I, Benedicenti F, Naldini L, Montini E, Biffi A, Gentner B, Kajaste-Rudnitski A.

Hum Gene Ther. 2019 May 24. doi: 10.1089/hum.2019.016. [Epub ahead of print]

PMID:
31037976
4.

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation.

Toffalori C, Zito L, Gambacorta V, Riba M, Oliveira G, Bucci G, Barcella M, Spinelli O, Greco R, Crucitti L, Cieri N, Noviello M, Manfredi F, Montaldo E, Ostuni R, Naldini MM, Gentner B, Waterhouse M, Zeiser R, Finke J, Hanoun M, Beelen DW, Gojo I, Luznik L, Onozawa M, Teshima T, Devillier R, Blaise D, Halkes CJM, Griffioen M, Carrabba MG, Bernardi M, Peccatori J, Barlassina C, Stupka E, Lazarevic D, Tonon G, Rambaldi A, Cittaro D, Bonini C, Fleischhauer K, Ciceri F, Vago L.

Nat Med. 2019 Apr;25(4):603-611. doi: 10.1038/s41591-019-0400-z. Epub 2019 Mar 25.

PMID:
30911134
5.

MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation.

Crisafulli L, Muggeo S, Uva P, Wang Y, Iwasaki M, Locatelli S, Anselmo A, Colombo FS, Carlo-Stella C, Cleary ML, Villa A, Gentner B, Ficara F.

Haematologica. 2019 Sep;104(9):1744-1755. doi: 10.3324/haematol.2018.198499. Epub 2019 Feb 21.

6.

Gene therapy for mucopolysaccharidoses: in vivo and ex vivo approaches.

Fraldi A, Serafini M, Sorrentino NC, Gentner B, Aiuti A, Bernardo ME.

Ital J Pediatr. 2018 Nov 16;44(Suppl 2):130. doi: 10.1186/s13052-018-0565-y. Review.

7.

Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing In Human Hematopoietic Stem Cells.

Petrillo C, Thorne LG, Unali G, Schiroli G, Giordano AMS, Piras F, Cuccovillo I, Petit SJ, Ahsan F, Noursadeghi M, Clare S, Genovese P, Gentner B, Naldini L, Towers GJ, Kajaste-Rudnitski A.

Cell Stem Cell. 2018 Dec 6;23(6):820-832.e9. doi: 10.1016/j.stem.2018.10.008. Epub 2018 Nov 8.

8.

Interferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens.

Escobar G, Barbarossa L, Barbiera G, Norelli M, Genua M, Ranghetti A, Plati T, Camisa B, Brombin C, Cittaro D, Annoni A, Bondanza A, Ostuni R, Gentner B, Naldini L.

Nat Commun. 2018 Jul 24;9(1):2896. doi: 10.1038/s41467-018-05315-0.

9.

Impaired X-CGD T cell compartment is gp91phox-NADPH oxidase independent.

Chiriaco M, Casciano F, Di Matteo G, Gentner B, Claps A, Di Cesare S, Cotugno N, D'Argenio P, Rossi P, Aiuti A, Finocchi A.

Clin Immunol. 2018 Aug;193:52-59. doi: 10.1016/j.clim.2018.01.010. Epub 2018 Feb 3.

PMID:
29410324
10.

Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections.

Hetzel M, Mucci A, Blank P, Nguyen AHH, Schiller J, Halle O, Kühnel MP, Billig S, Meineke R, Brand D, Herder V, Baumgärtner W, Bange FC, Goethe R, Jonigk D, Förster R, Gentner B, Casanova JL, Bustamante J, Schambach A, Kalinke U, Lachmann N.

Blood. 2018 Feb 1;131(5):533-545. doi: 10.1182/blood-2017-10-812859. Epub 2017 Dec 12.

11.

Neonatal umbilical cord blood transplantation halts skeletal disease progression in the murine model of MPS-I.

Azario I, Pievani A, Del Priore F, Antolini L, Santi L, Corsi A, Cardinale L, Sawamoto K, Kubaski F, Gentner B, Bernardo ME, Valsecchi MG, Riminucci M, Tomatsu S, Aiuti A, Biondi A, Serafini M.

Sci Rep. 2017 Aug 25;7(1):9473. doi: 10.1038/s41598-017-09958-9.

12.

Lentiviral vectors escape innate sensing but trigger p53 in human hematopoietic stem and progenitor cells.

Piras F, Riba M, Petrillo C, Lazarevic D, Cuccovillo I, Bartolaccini S, Stupka E, Gentner B, Cittaro D, Naldini L, Kajaste-Rudnitski A.

EMBO Mol Med. 2017 Sep;9(9):1198-1211. doi: 10.15252/emmm.201707922.

13.

NY-ESO-1 TCR single edited stem and central memory T cells to treat multiple myeloma without graft-versus-host disease.

Mastaglio S, Genovese P, Magnani Z, Ruggiero E, Landoni E, Camisa B, Schiroli G, Provasi E, Lombardo A, Reik A, Cieri N, Rocchi M, Oliveira G, Escobar G, Casucci M, Gentner B, Spinelli A, Mondino A, Bondanza A, Vago L, Ponzoni M, Ciceri F, Holmes MC, Naldini L, Bonini C.

Blood. 2017 Aug 3;130(5):606-618. doi: 10.1182/blood-2016-08-732636. Epub 2017 Jun 21.

14.

Efficient Ex Vivo Engineering and Expansion of Highly Purified Human Hematopoietic Stem and Progenitor Cell Populations for Gene Therapy.

Zonari E, Desantis G, Petrillo C, Boccalatte FE, Lidonnici MR, Kajaste-Rudnitski A, Aiuti A, Ferrari G, Naldini L, Gentner B.

Stem Cell Reports. 2017 Apr 11;8(4):977-990. doi: 10.1016/j.stemcr.2017.02.010. Epub 2017 Mar 16.

15.

Plerixafor and G-CSF combination mobilizes hematopoietic stem and progenitors cells with a distinct transcriptional profile and a reduced in vivo homing capacity compared to plerixafor alone.

Lidonnici MR, Aprile A, Frittoli MC, Mandelli G, Paleari Y, Spinelli A, Gentner B, Zambelli M, Parisi C, Bellio L, Cassinerio E, Zanaboni L, Cappellini MD, Ciceri F, Marktel S, Ferrari G.

Haematologica. 2017 Apr;102(4):e120-e124. doi: 10.3324/haematol.2016.154740. Epub 2016 Dec 29. No abstract available.

16.

Lentiviral Vector Gene Therapy Protects XCGD Mice From Acute Staphylococcus aureus Pneumonia and Inflammatory Response.

Farinelli G, Jofra Hernandez R, Rossi A, Ranucci S, Sanvito F, Migliavacca M, Brombin C, Pramov A, Di Serio C, Bovolenta C, Gentner B, Bragonzi A, Aiuti A.

Mol Ther. 2016 Oct;24(10):1873-1880. doi: 10.1038/mt.2016.150. Epub 2016 Jul 26.

17.

miRNA-126 Orchestrates an Oncogenic Program in B Cell Precursor Acute Lymphoblastic Leukemia.

Nucera S, Giustacchini A, Boccalatte F, Calabria A, Fanciullo C, Plati T, Ranghetti A, Garcia-Manteiga J, Cittaro D, Benedicenti F, Lechman ER, Dick JE, Ponzoni M, Ciceri F, Montini E, Gentner B, Naldini L.

Cancer Cell. 2016 Jun 13;29(6):905-921. doi: 10.1016/j.ccell.2016.05.007.

18.

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.

Lechman ER, Gentner B, Ng SWK, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD, Zandstra PW, Golub TR, Ebert BL, Lu J, Minden M, Wang JCY, Naldini L, Dick JE.

Cancer Cell. 2016 Apr 11;29(4):602-606. doi: 10.1016/j.ccell.2016.03.015. No abstract available.

19.

Elderly patients > 65 years of age with acute myeloid leukemia and normal karyotype benefit from intensive therapeutic programs.

Bernardi M, Carrabba M, Messina C, Milani R, Sala E, Pavesi F, Gentner B, Peccatori J, Assanelli A, Marktel S, Corti C, Forcina A, Vago L, Ciceri F.

Am J Hematol. 2016 Jun;91(6):E302-3. doi: 10.1002/ajh.24345. Epub 2016 Apr 13. No abstract available.

20.

miR-126 Regulates Distinct Self-Renewal Outcomes in Normal and Malignant Hematopoietic Stem Cells.

Lechman ER, Gentner B, Ng SW, Schoof EM, van Galen P, Kennedy JA, Nucera S, Ciceri F, Kaufmann KB, Takayama N, Dobson SM, Trotman-Grant A, Krivdova G, Elzinga J, Mitchell A, Nilsson B, Hermans KG, Eppert K, Marke R, Isserlin R, Voisin V, Bader GD, Zandstra PW, Golub TR, Ebert BL, Lu J, Minden M, Wang JC, Naldini L, Dick JE.

Cancer Cell. 2016 Feb 8;29(2):214-28. doi: 10.1016/j.ccell.2015.12.011. Epub 2016 Jan 28. Erratum in: Cancer Cell. 2016 Apr 11;29(4):602-6.

21.

Design of a regulated lentiviral vector for hematopoietic stem cell gene therapy of globoid cell leukodystrophy.

Ungari S, Montepeloso A, Morena F, Cocchiarella F, Recchia A, Martino S, Gentner B, Naldini L, Biffi A.

Mol Ther Methods Clin Dev. 2015 Oct 14;2:15038. doi: 10.1038/mtm.2015.38. eCollection 2015.

22.

MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia.

Gentner B, Pochert N, Rouhi A, Boccalatte F, Plati T, Berg T, Sun SM, Mah SM, Mirkovic-Hösle M, Ruschmann J, Muranyi A, Leierseder S, Argiropoulos B, Starczynowski DT, Karsan A, Heuser M, Hogge D, Camargo FD, Engelhardt S, Döhner H, Buske C, Jongen-Lavrencic M, Naldini L, Humphries RK, Kuchenbauer F.

Exp Hematol. 2015 Oct;43(10):858-868.e7. doi: 10.1016/j.exphem.2015.05.018. Epub 2015 Jul 8.

23.
24.

Targeted genome editing in human repopulating haematopoietic stem cells.

Genovese P, Schiroli G, Escobar G, Tomaso TD, Firrito C, Calabria A, Moi D, Mazzieri R, Bonini C, Holmes MC, Gregory PD, van der Burg M, Gentner B, Montini E, Lombardo A, Naldini L.

Nature. 2014 Jun 12;510(7504):235-240. doi: 10.1038/nature13420. Epub 2014 May 28.

25.

Dual-regulated lentiviral vector for gene therapy of X-linked chronic granulomatosis.

Chiriaco M, Farinelli G, Capo V, Zonari E, Scaramuzza S, Di Matteo G, Sergi LS, Migliavacca M, Hernandez RJ, Bombelli F, Giorda E, Kajaste-Rudnitski A, Trono D, Grez M, Rossi P, Finocchi A, Naldini L, Gentner B, Aiuti A.

Mol Ther. 2014 Aug;22(8):1472-1483. doi: 10.1038/mt.2014.87. Epub 2014 May 29.

26.

microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons.

Akerblom M, Petri R, Sachdeva R, Klussendorf T, Mattsson B, Gentner B, Jakobsson J.

Development. 2014 Apr;141(7):1580-8. doi: 10.1242/dev.101659. Epub 2014 Mar 5.

27.

Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression.

Escobar G, Moi D, Ranghetti A, Ozkal-Baydin P, Squadrito ML, Kajaste-Rudnitski A, Bondanza A, Gentner B, De Palma M, Mazzieri R, Naldini L.

Sci Transl Med. 2014 Jan 1;6(217):217ra3. doi: 10.1126/scitranslmed.3006353.

28.

CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma.

Casucci M, Nicolis di Robilant B, Falcone L, Camisa B, Norelli M, Genovese P, Gentner B, Gullotta F, Ponzoni M, Bernardi M, Marcatti M, Saudemont A, Bordignon C, Savoldo B, Ciceri F, Naldini L, Dotti G, Bonini C, Bondanza A.

Blood. 2013 Nov 14;122(20):3461-72. doi: 10.1182/blood-2013-04-493361. Epub 2013 Sep 9.

29.

MicroRNA-126-mediated control of cell fate in B-cell myeloid progenitors as a potential alternative to transcriptional factors.

Okuyama K, Ikawa T, Gentner B, Hozumi K, Harnprasopwat R, Lu J, Yamashita R, Ha D, Toyoshima T, Chanda B, Kawamata T, Yokoyama K, Wang S, Ando K, Lodish HF, Tojo A, Kawamoto H, Kotani A.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13410-5. doi: 10.1073/pnas.1220710110. Epub 2013 Jul 26.

30.

Dynamic Activity of miR-125b and miR-93 during Murine Neural Stem Cell Differentiation In Vitro and in the Subventricular Zone Neurogenic Niche.

Lattanzi A, Gentner B, Corno D, Di Tomaso T, Mestdagh P, Speleman F, Naldini L, Gritti A.

PLoS One. 2013 Jun 27;8(6):e67411. doi: 10.1371/journal.pone.0067411. Print 2013.

31.

miR-142-3p prevents macrophage differentiation during cancer-induced myelopoiesis.

Sonda N, Simonato F, Peranzoni E, Calì B, Bortoluzzi S, Bisognin A, Wang E, Marincola FM, Naldini L, Gentner B, Trautwein C, Sackett SD, Zanovello P, Molon B, Bronte V.

Immunity. 2013 Jun 27;38(6):1236-49. doi: 10.1016/j.immuni.2013.06.004.

32.

A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice.

Zonari E, Pucci F, Saini M, Mazzieri R, Politi LS, Gentner B, Naldini L.

Blood. 2013 Jul 11;122(2):243-52. doi: 10.1182/blood-2012-08-449306. Epub 2013 Mar 13.

33.

A double-switch vector system positively regulates transgene expression by endogenous microRNA expression (miR-ON vector).

Amendola M, Giustacchini A, Gentner B, Naldini L.

Mol Ther. 2013 May;21(5):934-46. doi: 10.1038/mt.2013.12. Epub 2013 Feb 26.

34.

Attenuation of miR-126 activity expands HSC in vivo without exhaustion.

Lechman ER, Gentner B, van Galen P, Giustacchini A, Saini M, Boccalatte FE, Hiramatsu H, Restuccia U, Bachi A, Voisin V, Bader GD, Dick JE, Naldini L.

Cell Stem Cell. 2012 Dec 7;11(6):799-811. doi: 10.1016/j.stem.2012.09.001. Epub 2012 Nov 8.

35.

Exploiting microRNA regulation for genetic engineering.

Gentner B, Naldini L.

Tissue Antigens. 2012 Nov;80(5):393-403. doi: 10.1111/tan.12002. Review.

PMID:
23020307
36.

MicroRNA-124 is a subventricular zone neuronal fate determinant.

Åkerblom M, Sachdeva R, Barde I, Verp S, Gentner B, Trono D, Jakobsson J.

J Neurosci. 2012 Jun 27;32(26):8879-89. doi: 10.1523/JNEUROSCI.0558-12.2012.

37.

MicroRNA-150-regulated vectors allow lymphocyte-sparing transgene expression in hematopoietic gene therapy.

Lachmann N, Jagielska J, Heckl D, Brennig S, Pfaff N, Maetzig T, Modlich U, Cantz T, Gentner B, Schambach A, Moritz T.

Gene Ther. 2012 Sep;19(9):915-24. doi: 10.1038/gt.2011.148. Epub 2011 Oct 6.

PMID:
21975463
38.

A microRNA-based system for selecting and maintaining the pluripotent state in human induced pluripotent stem cells.

Di Stefano B, Maffioletti SM, Gentner B, Ungaro F, Schira G, Naldini L, Broccoli V.

Stem Cells. 2011 Nov;29(11):1684-95. doi: 10.1002/stem.726.

39.

Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.

Mazzieri R, Pucci F, Moi D, Zonari E, Ranghetti A, Berti A, Politi LS, Gentner B, Brown JL, Naldini L, De Palma M.

Cancer Cell. 2011 Apr 12;19(4):512-26. doi: 10.1016/j.ccr.2011.02.005.

40.

Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy.

Gentner B, Visigalli I, Hiramatsu H, Lechman E, Ungari S, Giustacchini A, Schira G, Amendola M, Quattrini A, Martino S, Orlacchio A, Dick JE, Biffi A, Naldini L.

Sci Transl Med. 2010 Nov 17;2(58):58ra84. doi: 10.1126/scitranslmed.3001522.

41.

Tracking differentiating neural progenitors in pluripotent cultures using microRNA-regulated lentiviral vectors.

Sachdeva R, Jönsson ME, Nelander J, Kirkeby A, Guibentif C, Gentner B, Naldini L, Björklund A, Parmar M, Jakobsson J.

Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11602-7. doi: 10.1073/pnas.1006568107. Epub 2010 Jun 7.

42.

The galactocerebrosidase enzyme contributes to the maintenance of a functional hematopoietic stem cell niche.

Visigalli I, Ungari S, Martino S, Park H, Cesani M, Gentner B, Sergi Sergi L, Orlacchio A, Naldini L, Biffi A.

Blood. 2010 Sep 16;116(11):1857-66. doi: 10.1182/blood-2009-12-256461. Epub 2010 May 28.

43.

Differences in the gene expression profile of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) in primary colorectal tumors and their synchronous liver metastases.

Gentner B, Wein A, Croner RS, Zeittraeger I, Wirtz RM, Roedel F, Dimmler A, Dorlaque L, Hohenberger W, Hahn EG, Brueckl WM.

Anticancer Res. 2009 Jan;29(1):67-74.

44.

Regulated and multiple miRNA and siRNA delivery into primary cells by a lentiviral platform.

Amendola M, Passerini L, Pucci F, Gentner B, Bacchetta R, Naldini L.

Mol Ther. 2009 Jun;17(6):1039-52. doi: 10.1038/mt.2009.48. Epub 2009 Mar 17.

45.

Stable knockdown of microRNA in vivo by lentiviral vectors.

Gentner B, Schira G, Giustacchini A, Amendola M, Brown BD, Ponzoni M, Naldini L.

Nat Methods. 2009 Jan;6(1):63-6. doi: 10.1038/nmeth.1277. Epub 2008 Nov 30.

PMID:
19043411
46.

Endogenous microRNA can be broadly exploited to regulate transgene expression according to tissue, lineage and differentiation state.

Brown BD, Gentner B, Cantore A, Colleoni S, Amendola M, Zingale A, Baccarini A, Lazzari G, Galli C, Naldini L.

Nat Biotechnol. 2007 Dec;25(12):1457-67. Epub 2007 Nov 16.

PMID:
18026085
47.

[A case of attenuated familial adenomatous polyposis coli (AFAP)].

Gentner B, Kraus C, Schwab D, Benninger J, Wein A, Hahn EG, Brueckl WM.

Z Gastroenterol. 2005 Jun;43(6):591-5. German.

PMID:
15986289
48.

Genetic testing for germline mutations of the APC gene in patients with apparently sporadic desmoid tumors but a family history of colorectal carcinoma.

Brueckl WM, Ballhausen WG, Förtsch T, Günther K, Fiedler W, Gentner B, Croner R, Boxberger F, Kirchner T, Hahn EG, Hohenberger W, Wein A.

Dis Colon Rectum. 2005 Jun;48(6):1275-81.

PMID:
15793634
49.

Clonal analysis of individual marrow-repopulating cells after experimental peripheral blood progenitor cell transplantation.

Nagy KZ, Laufs S, Gentner B, Naundorf S, Kuehlcke K, Topaly J, Buss EC, Zeller WJ, Fruehauf S.

Stem Cells. 2004;22(4):570-9.

50.

Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy.

Parikh AA, Gentner B, Wu TT, Curley SA, Ellis LM, Vauthey JN.

J Gastrointest Surg. 2003 Dec;7(8):1082-8.

PMID:
14675719

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