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Items: 1 to 50 of 184

1.

Hippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson's disease with cognitive decline.

Liu AKL, Chau TW, Lim EJ, Ahmed I, Chang RC, Kalaitzakis ME, Graeber MB, Gentleman SM, Pearce RKB.

Acta Neuropathol Commun. 2019 Apr 25;7(1):61. doi: 10.1186/s40478-019-0717-3.

2.

The dual roles of RPE65 S-palmitoylation in membrane association and visual cycle function.

Uppal S, Liu T, Poliakov E, Gentleman S, Redmond TM.

Sci Rep. 2019 Mar 26;9(1):5218. doi: 10.1038/s41598-019-41501-w.

3.

Primum non nocere: a call for balance when reporting on CTE.

Stewart W, Allinson K, Al-Sarraj S, Bachmeier C, Barlow K, Belli A, Burns MP, Carson A, Crawford F, Dams-O'Connor K, Diaz-Arrastia R, Dixon CE, Edlow BL, Ferguson S, Fischl B, Folkerth RD, Gentleman S, Giza CC, Grady MS, Helmy A, Herceg M, Holton JL, Howell D, Hutchinson PJ, Iacono D, Iglesias JE, Ikonomovic MD, Johnson VE, Keene CD, Kofler JK, Koliatsos VE, Lee EB, Levin H, Lifshitz J, Ling H, Loane DJ, Love S, Maas AI, Marklund N, Master CL, McElvenny DM, Meaney DF, Menon DK, Montine TJ, Mouzon B, Mufson EJ, Ojo JO, Prins M, Revesz T, Ritchie CW, Smith C, Sylvester R, Tang CY, Trojanowski JQ, Urankar K, Vink R, Wellington C, Wilde EA, Wilson L, Yeates K, Smith DH.

Lancet Neurol. 2019 Mar;18(3):231-233. doi: 10.1016/S1474-4422(19)30020-1. Epub 2019 Feb 12. No abstract available. Erratum in: Lancet Neurol. 2019 Apr;18(4):e3.

4.

Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines.

Woerman AL, Oehler A, Kazmi SA, Lee J, Halliday GM, Middleton LT, Gentleman SM, Mordes DA, Spina S, Grinberg LT, Olson SH, Prusiner SB.

Acta Neuropathol. 2019 Mar;137(3):437-454. doi: 10.1007/s00401-019-01959-4. Epub 2019 Jan 28.

PMID:
30690664
5.

The aftermath of boxing revisited: identifying chronic traumatic encephalopathy pathology in the original Corsellis boxer series.

Goldfinger MH, Ling H, Tilley BS, Liu AKL, Davey K, Holton JL, Revesz T, Gentleman SM.

Acta Neuropathol. 2018 Dec;136(6):973-974. doi: 10.1007/s00401-018-1926-8. Epub 2018 Oct 30. No abstract available.

6.

TauBI or not TauBI: what was the question?

Sastre M, Van Leuven F, Gentleman SM.

Brain. 2018 Sep 1;141(9):2536-2539. doi: 10.1093/brain/awy225. No abstract available.

PMID:
30169590
7.

Variation at the TRIM11 locus modifies progressive supranuclear palsy phenotype.

Jabbari E, Woodside J, Tan MMX, Shoai M, Pittman A, Ferrari R, Mok KY, Zhang D, Reynolds RH, de Silva R, Grimm MJ, Respondek G, Müller U, Al-Sarraj S, Gentleman SM, Lees AJ, Warner TT, Hardy J, Revesz T, Höglinger GU, Holton JL, Ryten M, Morris HR.

Ann Neurol. 2018 Oct;84(4):485-496. doi: 10.1002/ana.25308. Epub 2018 Sep 15.

8.

Review: Revisiting the human cholinergic nucleus of the diagonal band of Broca.

Liu AKL, Lim EJ, Ahmed I, Chang RC, Pearce RKB, Gentleman SM.

Neuropathol Appl Neurobiol. 2018 Dec;44(7):647-662. doi: 10.1111/nan.12513. Epub 2018 Aug 13. Review.

9.

Author Correction: Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues.

Lai HM, Liu AKL, Ng HHM, Goldfinger MH, Chau TW, DeFelice J, Tilley BS, Wong WM, Wu W, Gentleman SM.

Nat Commun. 2018 Jul 10;9(1):2726. doi: 10.1038/s41467-018-05089-5.

10.

Somatic copy number gains of α-synuclein (SNCA) in Parkinson's disease and multiple system atrophy brains.

Mokretar K, Pease D, Taanman JW, Soenmez A, Ejaz A, Lashley T, Ling H, Gentleman S, Houlden H, Holton JL, Schapira AHV, Nacheva E, Proukakis C.

Brain. 2018 Aug 1;141(8):2419-2431. doi: 10.1093/brain/awy157.

11.

Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues.

Lai HM, Liu AKL, Ng HHM, Goldfinger MH, Chau TW, DeFelice J, Tilley BS, Wong WM, Wu W, Gentleman SM.

Nat Commun. 2018 Mar 14;9(1):1066. doi: 10.1038/s41467-018-03359-w. Erratum in: Nat Commun. 2018 Jul 10;9(1):2726.

12.

Parametric mapping using spectral analysis for 11C-PBR28 PET reveals neuroinflammation in mild cognitive impairment subjects.

Fan Z, Dani M, Femminella GD, Wood M, Calsolaro V, Veronese M, Turkheimer F, Gentleman S, Brooks DJ, Hinz R, Edison P.

Eur J Nucl Med Mol Imaging. 2018 Jul;45(8):1432-1441. doi: 10.1007/s00259-018-3984-5. Epub 2018 Mar 9.

13.

A novel method to visualise the three-dimensional organisation of the human cerebral cortical vasculature.

Harrison CH, Buckland GR, Brooks SE, Johnston DA, Chatelet DS, Liu AKL, Gentleman SM, Boche D, Nicoll JAR.

J Anat. 2018 Jun;232(6):1025-1030. doi: 10.1111/joa.12805. Epub 2018 Mar 9.

14.

Neuropathological Assessment as an Endpoint in Clinical Trial Design.

Gentleman S, Liu AKL.

Methods Mol Biol. 2018;1750:271-279. doi: 10.1007/978-1-4939-7704-8_18.

PMID:
29512079
15.

Phylogenetic analysis of the metazoan carotenoid oxygenase superfamily: a new ancestral gene assemblage of BCO-like (BCOL) proteins.

Poliakov E, Soucy J, Gentleman S, Rogozin IB, Redmond TM.

Sci Rep. 2017 Oct 16;7(1):13192. doi: 10.1038/s41598-017-13521-x.

16.

MSA prions exhibit remarkable stability and resistance to inactivation.

Woerman AL, Kazmi SA, Patel S, Freyman Y, Oehler A, Aoyagi A, Mordes DA, Halliday GM, Middleton LT, Gentleman SM, Olson SH, Prusiner SB.

Acta Neuropathol. 2018 Jan;135(1):49-63. doi: 10.1007/s00401-017-1762-2. Epub 2017 Aug 28.

17.

Microglial Activation in Traumatic Brain Injury.

Donat CK, Scott G, Gentleman SM, Sastre M.

Front Aging Neurosci. 2017 Jun 28;9:208. doi: 10.3389/fnagi.2017.00208. eCollection 2017. Review.

18.

Chemical Probes for Visualizing Intact Animal and Human Brain Tissue.

Lai HM, Ng WL, Gentleman SM, Wu W.

Cell Chem Biol. 2017 Jun 22;24(6):659-672. doi: 10.1016/j.chembiol.2017.05.015. Review.

19.

Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG).

Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, Budka H, Dickson DW, Dugger BN, Duyckaerts C, Ferrer I, Forrest SL, Gelpi E, Gentleman SM, Giaccone G, Grinberg LT, Halliday GM, Hatanpaa KJ, Hof PR, Hofer M, Hortobágyi T, Ironside JW, King A, Kofler J, Kövari E, Kril JJ, Love S, Mackenzie IR, Mao Q, Matej R, McLean C, Munoz DG, Murray ME, Neltner J, Nelson PT, Ritchie D, Rodriguez RD, Rohan Z, Rozemuller A, Sakai K, Schultz C, Seilhean D, Smith V, Tacik P, Takahashi H, Takao M, Rudolf Thal D, Weis S, Wharton SB, White CL 3rd, Woulfe JM, Yamada M, Trojanowski JQ.

J Neuropathol Exp Neurol. 2017 Jul 1;76(7):605-619. doi: 10.1093/jnen/nlx041.

20.

On the characterization of the heterogeneous mechanical response of human brain tissue.

Forte AE, Gentleman SM, Dini D.

Biomech Model Mechanobiol. 2017 Jun;16(3):907-920. doi: 10.1007/s10237-016-0860-8. Epub 2016 Dec 8.

21.

Free of acrylamide sodium dodecyl sulphate (SDS)-based tissue clearing (FASTClear): a novel protocol of tissue clearing for three-dimensional visualization of human brain tissues.

Liu AKL, Lai HM, Chang RC, Gentleman SM.

Neuropathol Appl Neurobiol. 2017 Jun;43(4):346-351. doi: 10.1111/nan.12361. Epub 2017 Apr 19. No abstract available.

22.

The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide.

Ries M, Loiola R, Shah UN, Gentleman SM, Solito E, Sastre M.

J Neuroinflammation. 2016 Sep 2;13(1):234. doi: 10.1186/s12974-016-0692-6.

23.

Rationalisation and Validation of an Acrylamide-Free Procedure in Three-Dimensional Histological Imaging.

Lai HM, Liu AK, Ng WL, DeFelice J, Lee WS, Li H, Li W, Ng HM, Chang RC, Lin B, Wu W, Gentleman SM.

PLoS One. 2016 Jun 30;11(6):e0158628. doi: 10.1371/journal.pone.0158628. eCollection 2016.

24.

ARTAG in the basal forebrain: widening the constellation of astrocytic tau pathology.

Liu AK, Goldfinger MH, Questari HE, Pearce RK, Gentleman SM.

Acta Neuropathol Commun. 2016 Jun 13;4(1):59. doi: 10.1186/s40478-016-0330-7. No abstract available.

25.

Correction for Parr et al., Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-β Precursor Protein.

Parr C, Carzaniga R, Gentleman SM, Van Leuven F, Walter J, Sastre M.

Mol Cell Biol. 2016 Mar 18;36(7):1219. doi: 10.1128/MCB.00086-16. Print 2016 Apr. No abstract available.

26.

Amyloid pathology and axonal injury after brain trauma.

Scott G, Ramlackhansingh AF, Edison P, Hellyer P, Cole J, Veronese M, Leech R, Greenwood RJ, Turkheimer FE, Gentleman SM, Heckemann RA, Matthews PM, Brooks DJ, Sharp DJ.

Neurology. 2016 Mar 1;86(9):821-8. doi: 10.1212/WNL.0000000000002413. Epub 2016 Feb 3.

27.

Inhibition of RPE65 Retinol Isomerase Activity by Inhibitors of Lipid Metabolism.

Eroglu A, Gentleman S, Poliakov E, Redmond TM.

J Biol Chem. 2016 Mar 4;291(10):4966-73. doi: 10.1074/jbc.M115.685651. Epub 2015 Dec 30.

28.

Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy.

Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, Murray ME, Nelson PT, Takahashi H, Trojanowski JQ, Ansorge O, Arzberger T, Baborie A, Beach TG, Bieniek KF, Bigio EH, Bodi I, Dugger BN, Feany M, Gelpi E, Gentleman SM, Giaccone G, Hatanpaa KJ, Heale R, Hof PR, Hofer M, Hortobágyi T, Jellinger K, Jicha GA, Ince P, Kofler J, Kövari E, Kril JJ, Mann DM, Matej R, McKee AC, McLean C, Milenkovic I, Montine TJ, Murayama S, Lee EB, Rahimi J, Rodriguez RD, Rozemüller A, Schneider JA, Schultz C, Seeley W, Seilhean D, Smith C, Tagliavini F, Takao M, Thal DR, Toledo JB, Tolnay M, Troncoso JC, Vinters HV, Weis S, Wharton SB, White CL 3rd, Wisniewski T, Woulfe JM, Yamada M, Dickson DW.

Acta Neuropathol. 2016 Jan;131(1):87-102. doi: 10.1007/s00401-015-1509-x. Epub 2015 Dec 10. Review.

29.

Differential expression of galanin in the cholinergic basal forebrain of patients with Lewy body disorders.

Alexandris A, Liu AK, Chang RC, Pearce RK, Gentleman SM.

Acta Neuropathol Commun. 2015 Dec 1;3:77. doi: 10.1186/s40478-015-0249-4.

30.

Cortical Lewy bodies and Aβ burden are associated with prevalence and timing of dementia in Lewy body diseases.

Ruffmann C, Calboli FC, Bravi I, Gveric D, Curry LK, de Smith A, Pavlou S, Buxton JL, Blakemore AI, Takousis P, Molloy S, Piccini P, Dexter DT, Roncaroli F, Gentleman SM, Middleton LT.

Neuropathol Appl Neurobiol. 2016 Aug;42(5):436-50. doi: 10.1111/nan.12294. Epub 2015 Dec 2.

31.

Bringing CLARITY to the human brain: visualization of Lewy pathology in three dimensions.

Liu AK, Hurry ME, Ng OT, DeFelice J, Lai HM, Pearce RK, Wong GT, Chang RC, Gentleman SM.

Neuropathol Appl Neurobiol. 2016 Oct;42(6):573-87. doi: 10.1111/nan.12293. Epub 2015 Dec 7.

32.

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.

Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K.

Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5308-17. doi: 10.1073/pnas.1514475112. Epub 2015 Aug 31.

33.

Propagation of prions causing synucleinopathies in cultured cells.

Woerman AL, Stöhr J, Aoyagi A, Rampersaud R, Krejciova Z, Watts JC, Ohyama T, Patel S, Widjaja K, Oehler A, Sanders DW, Diamond MI, Seeley WW, Middleton LT, Gentleman SM, Mordes DA, Südhof TC, Giles K, Prusiner SB.

Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):E4949-58. doi: 10.1073/pnas.1513426112. Epub 2015 Aug 18.

34.

Altered Expression of Brain Proteinase-Activated Receptor-2, Trypsin-2 and Serpin Proteinase Inhibitors in Parkinson's Disease.

Hurley MJ, Durrenberger PF, Gentleman SM, Walls AF, Dexter DT.

J Mol Neurosci. 2015 Sep;57(1):48-62. doi: 10.1007/s12031-015-0576-8. Epub 2015 May 17.

35.
36.

Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer's and Parkinson's disease.

Liu AK, Chang RC, Pearce RK, Gentleman SM.

Acta Neuropathol. 2015 Apr;129(4):527-40. doi: 10.1007/s00401-015-1392-5. Epub 2015 Jan 30. Review.

37.

Deep-brain stimulation associates with improved microvascular integrity in the subthalamic nucleus in Parkinson's disease.

Pienaar IS, Lee CH, Elson JL, McGuinness L, Gentleman SM, Kalaria RN, Dexter DT.

Neurobiol Dis. 2015 Feb;74:392-405. doi: 10.1016/j.nbd.2014.12.006. Epub 2014 Dec 19.

38.

Extensive grey matter pathology in the cerebellum in multiple sclerosis is linked to inflammation in the subarachnoid space.

Howell OW, Schulz-Trieglaff EK, Carassiti D, Gentleman SM, Nicholas R, Roncaroli F, Reynolds R.

Neuropathol Appl Neurobiol. 2015 Oct;41(6):798-813. doi: 10.1111/nan.12199. Epub 2015 May 2.

PMID:
25421634
39.

Erratum to: Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium.

Alafuzoff I, Pikkarainen M, Neumann M, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Bugiani O, Ferrer I, Gelpi E, Gentleman S, Giaccone G, Graeber MB, Hortobagyi T, Ince PG, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Nilsson T, Parchi P, Patsouris E, Revesz T, Roggendorf W, Rozemuller A, Seilhean D, Streichenberger N, Thal DR, Wharton SB, Kretzschmar H.

J Neural Transm (Vienna). 2015 Jul;122(7):973-4. doi: 10.1007/s00702-014-1337-5. No abstract available.

PMID:
25418279
40.

LRRK2 exonic variants and risk of multiple system atrophy.

Heckman MG, Schottlaender L, Soto-Ortolaza AI, Diehl NN, Rayaprolu S, Ogaki K, Fujioka S, Murray ME, Cheshire WP, Uitti RJ, Wszolek ZK, Farrer MJ, Sailer A, Singleton AB, Chinnery PF, Keogh MJ, Gentleman SM, Holton JL, Aoife K, Mann DM, Al-Sarraj S, Troakes C, Dickson DW, Houlden H, Ross OA.

Neurology. 2014 Dec 9;83(24):2256-61. doi: 10.1212/WNL.0000000000001078. Epub 2014 Nov 5.

41.

Prenatal high-fat diet alters the cerebrovasculature and clearance of β-amyloid in adult offspring.

Hawkes CA, Gentleman SM, Nicoll JA, Carare RO.

J Pathol. 2015 Mar;235(4):619-31. doi: 10.1002/path.4468. Epub 2015 Jan 7.

PMID:
25345857
42.

Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium.

Alafuzoff I, Pikkarainen M, Neumann M, Arzberger T, Al-Sarraj S, Bodi I, Bogdanovic N, Bugiani O, Ferrer I, Gelpi E, Gentleman S, Giaccone G, Graeber MB, Hortobagyi T, Ince PG, Ironside JW, Kavantzas N, King A, Korkolopoulou P, Kovács GG, Meyronet D, Monoranu C, Nilsson T, Parchi P, Patsouris E, Revesz T, Roggendorf W, Rozemuller A, Seilhean D, Streichenberger N, Thal DR, Wharton SB, Kretzschmar H.

J Neural Transm (Vienna). 2015 Jul;122(7):957-72. doi: 10.1007/s00702-014-1304-1. Epub 2014 Sep 20. Erratum in: J Neural Transm (Vienna). 2015 Jul;122(7):973-4.

43.

Calcium CaV1 channel subtype mRNA expression in Parkinson's disease examined by in situ hybridization.

Hurley MJ, Gentleman SM, Dexter DT.

J Mol Neurosci. 2015 Mar;55(3):715-24. doi: 10.1007/s12031-014-0410-8. Epub 2014 Aug 31.

44.

Celastrol enhances cell viability and inhibits amyloid-β production induced by lipopolysaccharide in vitro.

Zhao Y, Zhao H, Lobo N, Guo X, Gentleman SM, Ma D.

J Alzheimers Dis. 2014;41(3):835-44. doi: 10.3233/JAD-131799.

PMID:
24685625
45.

Phenotypic profile of alternative activation marker CD163 is different in Alzheimer's and Parkinson's disease.

Pey P, Pearce RK, Kalaitzakis ME, Griffin WS, Gentleman SM.

Acta Neuropathol Commun. 2014 Feb 14;2:21. doi: 10.1186/2051-5960-2-21.

46.

Neuropathology of cigarette smoking.

Chang RC, Ho YS, Wong S, Gentleman SM, Ng HK.

Acta Neuropathol. 2014 Jan;127(1):53-69. doi: 10.1007/s00401-013-1210-x. Epub 2013 Nov 16. Review.

PMID:
24240736
47.

Transmission of multiple system atrophy prions to transgenic mice.

Watts JC, Giles K, Oehler A, Middleton L, Dexter DT, Gentleman SM, DeArmond SJ, Prusiner SB.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19555-60. doi: 10.1073/pnas.1318268110. Epub 2013 Nov 11.

48.

Parkinson's disease is associated with altered expression of CaV1 channels and calcium-binding proteins.

Hurley MJ, Brandon B, Gentleman SM, Dexter DT.

Brain. 2013 Jul;136(Pt 7):2077-97. doi: 10.1093/brain/awt134. Epub 2013 Jun 14.

PMID:
23771339
49.

Disturbed sleep in Parkinson's disease: anatomical and pathological correlates.

Kalaitzakis ME, Gentleman SM, Pearce RK.

Neuropathol Appl Neurobiol. 2013 Oct;39(6):644-53. doi: 10.1111/nan.12024.

PMID:
23363035
50.

Review: microglia in protein aggregation disorders: friend or foe?

Gentleman SM.

Neuropathol Appl Neurobiol. 2013 Feb;39(1):45-50. doi: 10.1111/nan.12017. Review.

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