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Items: 45


Translation Approach for Dentine Regeneration Using GSK-3 Antagonists.

Zaugg LK, Banu A, Walther AR, Chandrasekaran D, Babb RC, Salzlechner C, Hedegaard MAB, Gentleman E, Sharpe PT.

J Dent Res. 2020 Mar 10:22034520908593. doi: 10.1177/0022034520908593. [Epub ahead of print]


Harnessing the secreted extracellular matrix to engineer tissues.

Blache U, Stevens MM, Gentleman E.

Nat Biomed Eng. 2020 Jan 23. doi: 10.1038/s41551-019-0500-6. [Epub ahead of print] No abstract available.


Adhesive Hydrogels for Maxillofacial Tissue Regeneration Using Minimally Invasive Procedures.

Salzlechner C, Haghighi T, Huebscher I, Walther AR, Schell S, Gardner A, Undt G, da Silva RMP, Dreiss CA, Fan K, Gentleman E.

Adv Healthc Mater. 2020 Feb;9(4):e1901134. doi: 10.1002/adhm.201901134. Epub 2020 Jan 14.


Hypoxia Inducible Factor-1α in Osteochondral Tissue Engineering.

Taheem DK, Jell G, Gentleman E.

Tissue Eng Part B Rev. 2020 Jan 9. doi: 10.1089/ten.TEB.2019.0283. [Epub ahead of print]


Multiscale analyses reveal native-like lamellar bone repair and near perfect bone-contact with porous strontium-loaded bioactive glass.

Autefage H, Allen F, Tang HM, Kallepitis C, Gentleman E, Reznikov N, Nitiputri K, Nommeots-Nomm A, O'Donnell MD, Lange C, Seidt BM, Kim TB, Solanki AK, Tallia F, Young G, Lee PD, Pierce BF, Wagermaier W, Fratzl P, Goodship A, Jones JR, Blunn G, Stevens MM.

Biomaterials. 2019 Jul;209:152-162. doi: 10.1016/j.biomaterials.2019.03.035. Epub 2019 Mar 25.


A comparison of lithium-substituted phosphate and borate bioactive glasses for mineralised tissue repair.

Zhang K, Alaohali A, Sawangboon N, Sharpe PT, Brauer DS, Gentleman E.

Dent Mater. 2019 Jun;35(6):919-927. doi: 10.1016/ Epub 2019 Apr 8.


Hypoxia impacts human MSC response to substrate stiffness during chondrogenic differentiation.

Foyt DA, Taheem DK, Ferreira SA, Norman MDA, Petzold J, Jell G, Grigoriadis AE, Gentleman E.

Acta Biomater. 2019 Apr 15;89:73-83. doi: 10.1016/j.actbio.2019.03.002. Epub 2019 Mar 4.


Author Correction: Bi-directional cell-pericellular matrix interactions direct stem cell fate.

Ferreira SA, Motwani MS, Faull PA, Seymour AJ, Yu TTL, Enayati M, Taheem DK, Salzlechner C, Haghighi T, Kania EM, Oommen OP, Ahmed T, Loaiza S, Parzych K, Dazzi F, Varghese OP, Festy F, Grigoriadis AE, Auner HW, Snijders AP, Bozec L, Gentleman E.

Nat Commun. 2018 Dec 18;9(1):5419. doi: 10.1038/s41467-018-07843-1.


Author Correction: Bi-directional cell-pericellular matrix interactions direct stem cell fate.

Ferreira SA, Motwani MS, Faull PA, Seymour AJ, Yu TTL, Enayati M, Taheem DK, Salzlechner C, Haghighi T, Kania EM, Oommen OP, Ahmed T, Loaiza S, Parzych K, Dazzi F, Varghese OP, Festy F, Grigoriadis AE, Auner HW, Snijders AP, Bozec L, Gentleman E.

Nat Commun. 2018 Nov 14;9(1):4851. doi: 10.1038/s41467-018-07398-1.


Bi-directional cell-pericellular matrix interactions direct stem cell fate.

Ferreira SA, Motwani MS, Faull PA, Seymour AJ, Yu TTL, Enayati M, Taheem DK, Salzlechner C, Haghighi T, Kania EM, Oommen OP, Ahmed T, Loaiza S, Parzych K, Dazzi F, Varghese OP, Festy F, Grigoriadis AE, Auner HW, Snijders AP, Bozec L, Gentleman E.

Nat Commun. 2018 Oct 3;9(1):4049. doi: 10.1038/s41467-018-06183-4. Erratum in: Nat Commun. 2018 Nov 14;9(1):4851. Nat Commun. 2018 Dec 18;9(1):5419.


An engineered, quantifiable in vitro model for analysing the effect of proteostasis-targeting drugs on tissue physical properties.

Loaiza S, Ferreira SA, Chinn TM, Kirby A, Tsolaki E, Dondi C, Parzych K, Strange AP, Bozec L, Bertazzo S, Hedegaard MAB, Gentleman E, Auner HW.

Biomaterials. 2018 Nov;183:102-113. doi: 10.1016/j.biomaterials.2018.08.041. Epub 2018 Aug 21.


Collective Cell Behavior in Mechanosensing of Substrate Thickness.

Tusan CG, Man YH, Zarkoob H, Johnston DA, Andriotis OG, Thurner PJ, Yang S, Sander EA, Gentleman E, Sengers BG, Evans ND.

Biophys J. 2018 Jun 5;114(11):2743-2755. doi: 10.1016/j.bpj.2018.03.037.


Neighboring cells override 3D hydrogel matrix cues to drive human MSC quiescence.

Ferreira SA, Faull PA, Seymour AJ, Yu TTL, Loaiza S, Auner HW, Snijders AP, Gentleman E.

Biomaterials. 2018 Sep;176:13-23. doi: 10.1016/j.biomaterials.2018.05.032. Epub 2018 May 22.


Differential Regulation of Human Bone Marrow Mesenchymal Stromal Cell Chondrogenesis by Hypoxia Inducible Factor-1α Hydroxylase Inhibitors.

Taheem DK, Foyt DA, Loaiza S, Ferreira SA, Ilic D, Auner HW, Grigoriadis AE, Jell G, Gentleman E.

Stem Cells. 2018 Sep;36(9):1380-1392. doi: 10.1002/stem.2844. Epub 2018 Jun 8.


Matrix-associated chondrocyte transplantation for reconstruction of articulating surfaces in the temporomandibular joint: a pilot study covering medium- and long-term outcomes of 6 patients.

Undt G, Jahl M, Pohl S, Marlovits S, Moser D, Yoon HH, Frank J, Lang S, Czerny C, Klima G, Gentleman E, Ewers R.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Aug;126(2):117-128. doi: 10.1016/j.oooo.2018.02.017. Epub 2018 Mar 9.


Exploiting Advanced Hydrogel Technologies to Address Key Challenges in Regenerative Medicine.

Foyt DA, Norman MDA, Yu TTL, Gentleman E.

Adv Healthc Mater. 2018 Apr;7(8):e1700939. doi: 10.1002/adhm.201700939. Epub 2018 Jan 9. Review.


Optimisation of lithium-substituted bioactive glasses to tailor cell response for hard tissue repair.

da Silva JG, Babb R, Salzlechner C, Sharpe PT, Brauer DS, Gentleman E.

J Mater Sci. 2017;52(15):8832-8844. doi: 10.1007/s10853-017-0838-7. Epub 2017 Feb 9.


Monomeric, porous type II collagen scaffolds promote chondrogenic differentiation of human bone marrow mesenchymal stem cells in vitro.

Tamaddon M, Burrows M, Ferreira SA, Dazzi F, Apperley JF, Bradshaw A, Brand DD, Czernuszka J, Gentleman E.

Sci Rep. 2017 Mar 3;7:43519. doi: 10.1038/srep43519.


Aortic valve calcification: a bone of contention.

Bertazzo S, Gentleman E.

Eur Heart J. 2017 Apr 21;38(16):1189-1193. doi: 10.1093/eurheartj/ehw071. No abstract available.


Inadequate fine-tuning of protein synthesis and failure of amino acid homeostasis following inhibition of the ATPase VCP/p97.

Parzych K, Chinn TM, Chen Z, Loaiza S, Porsch F, Valbuena GN, Kleijnen MF, Karadimitris A, Gentleman E, Keun HC, Auner HW.

Cell Death Dis. 2015 Dec 31;6:e2031. doi: 10.1038/cddis.2015.373.


Perivascular Stem Cells at the Tip of Mouse Incisors Regulate Tissue Regeneration.

Pang YW, Feng J, Daltoe F, Fatscher R, Gentleman E, Gentleman MM, Sharpe PT.

J Bone Miner Res. 2016 Mar;31(3):514-23. doi: 10.1002/jbmr.2717. Epub 2015 Oct 21.


Composition of Mineral Produced by Dental Mesenchymal Stem Cells.

Volponi AA, Gentleman E, Fatscher R, Pang YW, Gentleman MM, Sharpe PT.

J Dent Res. 2015 Nov;94(11):1568-74. doi: 10.1177/0022034515599765. Epub 2015 Aug 7.


Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials.

Autefage H, Gentleman E, Littmann E, Hedegaard MA, Von Erlach T, O'Donnell M, Burden FR, Winkler DA, Stevens MM.

Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4280-5. doi: 10.1073/pnas.1419799112. Epub 2015 Mar 23.


Wharton's jelly mesenchymal stromal/stem cells derived under chemically defined animal product-free low oxygen conditions are rich in MSCA-1(+) subpopulation.

Devito L, Badraiq H, Galleu A, Taheem DK, Codognotto S, Siow R, Khalaf Y, Briley A, Shennan A, Poston L, McGrath J, Gentleman E, Dazzi F, Ilic D.

Regen Med. 2014;9(6):723-32. doi: 10.2217/rme.14.60.


Evolving insights in cell-matrix interactions: elucidating how non-soluble properties of the extracellular niche direct stem cell fate.

Walters NJ, Gentleman E.

Acta Biomater. 2015 Jan;11:3-16. doi: 10.1016/j.actbio.2014.09.038. Epub 2014 Oct 5. Review.


Correlative spectroscopy of silicates in mineralised nodules formed from osteoblasts.

Boonrungsiman S, Fearn S, Gentleman E, Spillane L, Carzaniga R, McComb DW, Stevens MM, Porter AE.

Nanoscale. 2013 Aug 21;5(16):7544-51. doi: 10.1039/c3nr02470a.


Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification.

Bertazzo S, Gentleman E, Cloyd KL, Chester AH, Yacoub MH, Stevens MM.

Nat Mater. 2013 Jun;12(6):576-83. doi: 10.1038/nmat3627. Epub 2013 Apr 21.


Surface properties and ion release from fluoride-containing bioactive glasses promote osteoblast differentiation and mineralization in vitro.

Gentleman E, Stevens MM, Hill RG, Brauer DS.

Acta Biomater. 2013 Mar;9(3):5771-9. doi: 10.1016/j.actbio.2012.10.043. Epub 2012 Nov 2.


Characterization of porcine aortic valvular interstitial cell 'calcified' nodules.

Cloyd KL, El-Hamamsy I, Boonrungsiman S, Hedegaard M, Gentleman E, Sarathchandra P, Colazzo F, Gentleman MM, Yacoub MH, Chester AH, Stevens MM.

PLoS One. 2012;7(10):e48154. doi: 10.1371/journal.pone.0048154. Epub 2012 Oct 26.


The role of intracellular calcium phosphate in osteoblast-mediated bone apatite formation.

Boonrungsiman S, Gentleman E, Carzaniga R, Evans ND, McComb DW, Porter AE, Stevens MM.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14170-5. doi: 10.1073/pnas.1208916109. Epub 2012 Aug 9.


Anisotropic fibrous scaffolds for articular cartilage regeneration.

McCullen SD, Autefage H, Callanan A, Gentleman E, Stevens MM.

Tissue Eng Part A. 2012 Oct;18(19-20):2073-83. doi: 10.1089/ten.TEA.2011.0606. Epub 2012 Aug 3.


Strontium- and zinc-alginate hydrogels for bone tissue engineering.

Place ES, Rojo L, Gentleman E, Sardinha JP, Stevens MM.

Tissue Eng Part A. 2011 Nov;17(21-22):2713-22. doi: 10.1089/ten.TEA.2011.0059. Epub 2011 Aug 29.


Benefits and drawbacks of zinc in glass ionomer bone cements.

Brauer DS, Gentleman E, Farrar DF, Stevens MM, Hill RG.

Biomed Mater. 2011 Aug;6(4):045007. doi: 10.1088/1748-6041/6/4/045007. Epub 2011 Jun 17.


Conference scene: Challenges to commercialization.

Ilic D, Gentleman E.

Regen Med. 2010 May;5(3):341-3. doi: 10.2217/rme.10.19. No abstract available.


The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro.

Gentleman E, Fredholm YC, Jell G, Lotfibakhshaiesh N, O'Donnell MD, Hill RG, Stevens MM.

Biomaterials. 2010 May;31(14):3949-56. doi: 10.1016/j.biomaterials.2010.01.121. Epub 2010 Feb 18.


Extracellular matrix-mediated osteogenic differentiation of murine embryonic stem cells.

Evans ND, Gentleman E, Chen X, Roberts CJ, Polak JM, Stevens MM.

Biomaterials. 2010 Apr;31(12):3244-52. doi: 10.1016/j.biomaterials.2010.01.039. Epub 2010 Feb 9.


Substrate stiffness affects early differentiation events in embryonic stem cells.

Evans ND, Minelli C, Gentleman E, LaPointe V, Patankar SN, Kallivretaki M, Chen X, Roberts CJ, Stevens MM.

Eur Cell Mater. 2009 Sep 21;18:1-13; discussion 13-4.


Comparative materials differences revealed in engineered bone as a function of cell-specific differentiation.

Gentleman E, Swain RJ, Evans ND, Boonrungsiman S, Jell G, Ball MD, Shean TA, Oyen ML, Porter A, Stevens MM.

Nat Mater. 2009 Sep;8(9):763-70. doi: 10.1038/nmat2505. Epub 2009 Jul 26.


Historic and current strategies in bone tissue engineering: do we have a hope in Hench?

Gentleman E, Polak JM.

J Mater Sci Mater Med. 2006 Nov;17(11):1029-35. Epub 2006 Nov 22.


Collagen composite biomaterials resist contraction while allowing development of adipocytic soft tissue in vitro.

Gentleman E, Nauman EA, Livesay GA, Dee KC.

Tissue Eng. 2006 Jun;12(6):1639-49.


Development of ligament-like structural organization and properties in cell-seeded collagen scaffolds in vitro.

Gentleman E, Livesay GA, Dee KC, Nauman EA.

Ann Biomed Eng. 2006 May;34(5):726-36. Epub 2006 Feb 7.


Short collagen fibers provide control of contraction and permeability in fibroblast-seeded collagen gels.

Gentleman E, Nauman EA, Dee KC, Livesay GA.

Tissue Eng. 2004 Mar-Apr;10(3-4):421-7.


Mechanical characterization of collagen fibers and scaffolds for tissue engineering.

Gentleman E, Lay AN, Dickerson DA, Nauman EA, Livesay GA, Dee KC.

Biomaterials. 2003 Sep;24(21):3805-13.


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